Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase

Journal of Biological Chemistry

Volumn 288, Issue 24, 2013, Pages 17803-17811

  Wiseman, Shari L ^a   Shimizu, Yoshio ^b   Palfrey, Clive ^c   Nairn, Angus C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Mannari Hospital   (Japan)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVITY-DEPENDENT; ADENOSINE RECEPTOR; CONTROL MECHANISM; DEGRADATION MECHANISM; POLYUBIQUITYLATION; PROTEASOMAL DEGRADATION; PROTEASOME INHIBITORS; PROTEIN TRANSLATION;

CELLS; CYTOLOGY; DEGRADATION; ELONGATION; ENZYMES;

PROTEINS;

ADENOSINE A2A RECEPTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; ELONGATION FACTOR 2 KINASE; FORSKOLIN; PROTEASOME; SCF BETA TRCP UBIQUITIN PROTEIN LIGASE E3; SERINE; SOMATOMEDIN C; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; EMBRYO; ENZYME DEGRADATION; ENZYME REGULATION; FEMALE; INTRACELLULAR SIGNALING; NERVE CELL PLASTICITY; NONHUMAN; PC12 CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RAT; RNA TRANSLATION; UBIQUITINATION;

ΒTRCP; CYCLIC AMP (CAMP); E3 UBIQUITIN LIGASE; EEF-2; EEF-2 KINASE; PROTEASOME; TRANSLATION CONTROL; TRANSLATION ELONGATION FACTORS;

ADENOSINE; ADENOSINE A2 RECEPTOR AGONISTS; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CULLIN PROTEINS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ELONGATION FACTOR 2 KINASE; FORSKOLIN; HEK293 CELLS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; NEURONS; PC12 CELLS; PHENETHYLAMINES; PRIMARY CELL CULTURE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN STABILITY; PROTEOLYSIS; RATS; SECOND MESSENGER SYSTEMS; SKP CULLIN F-BOX PROTEIN LIGASES; UBIQUITINATION;

EUKARYOTA;

EID: 84879064983     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.477182     Document Type: Article

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