1-benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): A cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor

Journal of Biological Chemistry

Volumn 286, Issue 51, 2011, Pages 43951-43958

  Chen, Zehan ^a   Gopalakrishnan, Sujatha M ^a   Bui, Mai Ha ^a   Soni, Niru B ^a   Warrior, Usha ^a   Johnson, Eric F ^a   Donnelly, Jennifer B ^a   Glaser, Keith B ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-CANCER MECHANISM; ANTI-CANCER THERAPIES; ANTICANCER ACTIVITIES; ANTICANCER TARGETS; CANCER CELL GROWTH; CANCER CELLS; CELLULAR SUBSTRATES; ELONGATION FACTOR; GROWTH INHIBITION; KINASE INHIBITORS; MULTIPLE PATHWAYS; PRELIMINARY DATA; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION PATHWAYS; SMALL MOLECULES; STRESS SIGNALS;

BIOSYNTHESIS; CELL GROWTH; CELLS; DISEASES; ELONGATION; ENZYMES; GROWTH KINETICS; MAMMALS; SIGNAL TRANSDUCTION;

PHOSPHORYLATION;

1 BENZYL 3 CETYL 2 METHYLIMIDAZOLIUM IODIDE; A 484954; ANTINEOPLASTIC AGENT; ELONGATION FACTOR 2; NH 125; PROTEIN INHIBITOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; EIF-2 KINASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMIDAZOLES; NEOPLASMS; PEPTIDE ELONGATION FACTOR 2; PHOSPHORYLATION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 83755181311     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.301291     Document Type: Article

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