메뉴 건너뛰기




Volumn 12, Issue 5, 2015, Pages 253-262

Tumour and patient factors in renal cell carcinoma - Towards personalized therapy

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; PROTEIN INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; SCATTER FACTOR RECEPTOR INHIBITOR; SUNITINIB; UNCLASSIFIED DRUG;

EID: 84930767254     PISSN: 17594812     EISSN: 17594820     Source Type: Journal    
DOI: 10.1038/nrurol.2015.71     Document Type: Review
Times cited : (23)

References (134)
  • 1
    • 73349115249 scopus 로고    scopus 로고
    • Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: Final results of the FinHer Trial
    • Joensuu, H. et al. Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: final results of the FinHer Trial. J. Clin. Oncol. 27, 5685-5692 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 5685-5692
    • Joensuu, H.1
  • 2
    • 74949141693 scopus 로고    scopus 로고
    • Trastuzumab for patients with axillary-node-positive breast cancer: Results of the FNCLCC-PACS 04 trial
    • Spielmann, M. et al. Trastuzumab for patients with axillary-node-positive breast cancer: results of the FNCLCC-PACS 04 trial. J. Clin. Oncol. 27, 6129-6134 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 6129-6134
    • Spielmann, M.1
  • 3
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado, R. G. et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J. Clin. Oncol. 26, 1626-1634 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 1626-1634
    • Amado, R.G.1
  • 4
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman, P. B. et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N. Engl. J. Med. 364, 2507-2516 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2507-2516
    • Chapman, P.B.1
  • 5
    • 84879890360 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of clear cell renal cell carcinoma
    • Cancer Genome Atlas Research, Network
    • Cancer Genome Atlas Research, Network. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature 499, 43-49 (2013).
    • (2013) Nature , vol.499 , pp. 43-49
  • 6
    • 84880967722 scopus 로고    scopus 로고
    • Integrated molecular analysis of clear-cell renal cell carcinoma
    • Sato, Y. et al. Integrated molecular analysis of clear-cell renal cell carcinoma. Nat. Genet. 45, 860-867 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 860-867
    • Sato, Y.1
  • 7
    • 75149188170 scopus 로고    scopus 로고
    • Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
    • Dalgliesh, G. L. et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 463, 360-363 (2010).
    • (2010) Nature , vol.463 , pp. 360-363
    • Dalgliesh, G.L.1
  • 8
    • 84655176646 scopus 로고    scopus 로고
    • Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma
    • Guo, G. et al. Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat. Genet. 44, 17-19 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 17-19
    • Guo, G.1
  • 9
    • 84904015632 scopus 로고    scopus 로고
    • Multilayer-omics analysis of renal cell carcinoma, including the whole exome, methylome and transcriptome
    • Arai, E. et al. Multilayer-omics analysis of renal cell carcinoma, including the whole exome, methylome and transcriptome. Int. J. Cancer 135, 1330-1342 (2014).
    • (2014) Int. J. Cancer , vol.135 , pp. 1330-1342
    • Arai, E.1
  • 10
    • 84923233603 scopus 로고    scopus 로고
    • Variation in genomic landscape of clear cell renal cell carcinoma across Europe
    • Scelo, G. L. et al. Variation in genomic landscape of clear cell renal cell carcinoma across Europe. Nat. Commun. 5, 5135 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 5135
    • Scelo, G.L.1
  • 11
    • 84908695210 scopus 로고    scopus 로고
    • The somatic genomic landscape of chromophobe renal cell carcinoma
    • Davis, C. F. et al. The somatic genomic landscape of chromophobe renal cell carcinoma. Cancer Cell 26, 319-330 (2014).
    • (2014) Cancer Cell , vol.26 , pp. 319-330
    • Davis, C.F.1
  • 12
    • 85028129789 scopus 로고    scopus 로고
    • Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes
    • Durinck, S. et al. Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes. Nat. Genet. 47, 13-21 (2014).
    • (2014) Nat. Genet. , vol.47 , pp. 13-21
    • Durinck, S.1
  • 13
    • 79251635938 scopus 로고    scopus 로고
    • Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
    • Varela, I. et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 469, 539-542 (2011).
    • (2011) Nature , vol.469 , pp. 539-542
    • Varela, I.1
  • 14
    • 84900390656 scopus 로고    scopus 로고
    • The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia
    • Srigley, J. R. et al. The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. Am. J. Surg. Pathol. 37, 1469-1489 (2013).
    • (2013) Am. J. Surg. Pathol. , vol.37 , pp. 1469-1489
    • Srigley, J.R.1
  • 15
    • 47149114026 scopus 로고    scopus 로고
    • Renal cell cancer stage migration: Analysis of the National Cancer Data Base
    • Kane, C. J. et al. Renal cell cancer stage migration: analysis of the National Cancer Data Base. Cancer 113, 78-83 (2008).
    • (2008) Cancer , vol.113 , pp. 78-83
    • Kane, C.J.1
  • 16
    • 0344442746 scopus 로고    scopus 로고
    • Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease
    • Janzen, N. K. et al. Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease. Urol. Clin. North Am. 30, 843-852 (2003).
    • (2003) Urol. Clin. North Am. , vol.30 , pp. 843-852
    • Janzen, N.K.1
  • 17
    • 78649347932 scopus 로고    scopus 로고
    • Evaluation and management of the renal mass
    • Chen, D. Y. & Uzzo, R. G. Evaluation and management of the renal mass. Med. Clin. North Am. 95, 179-189 (2011).
    • (2011) Med. Clin. North Am. , vol.95 , pp. 179-189
    • Chen, D.Y.1    Uzzo, R.G.2
  • 18
    • 38049169977 scopus 로고    scopus 로고
    • Surveillance strategies for renal cell carcinoma patients following nephrectomy
    • Chin, A. I. et al. Surveillance strategies for renal cell carcinoma patients following nephrectomy. Rev. Urol. 8, 1-7 (2006).
    • (2006) Rev. Urol. , vol.8 , pp. 1-7
    • Chin, A.I.1
  • 19
    • 34248149330 scopus 로고    scopus 로고
    • Multi-institutional validation of a new renal cancer-specific survival nomogram
    • Karakiewicz, P. I. et al. Multi-institutional validation of a new renal cancer-specific survival nomogram. J. Clin. Oncol. 25, 1316-1322 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , pp. 1316-1322
    • Karakiewicz, P.I.1
  • 20
    • 0035868654 scopus 로고    scopus 로고
    • Improved prognostication of renal cell carcinoma using an integrated staging system
    • Zisman, A. et al. Improved prognostication of renal cell carcinoma using an integrated staging system. J. Clin. Oncol. 19, 1649-1657 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , pp. 1649-1657
    • Zisman, A.1
  • 21
    • 0036893892 scopus 로고    scopus 로고
    • An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: The SSIGN score
    • Frank, I. et al. An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: the SSIGN score. J. Urol. 168, 2395-2400 (2002).
    • (2002) J. Urol. , vol.168 , pp. 2395-2400
    • Frank, I.1
  • 22
    • 0037379172 scopus 로고    scopus 로고
    • Prediction of progression after radical nephrectomy for patients with clear cell renal cell carcinoma: A stratification tool for prospective clinical trials
    • Leibovich, B. C. et al. Prediction of progression after radical nephrectomy for patients with clear cell renal cell carcinoma: a stratification tool for prospective clinical trials. Cancer 97, 1663-1671 (2003).
    • (2003) Cancer , vol.97 , pp. 1663-1671
    • Leibovich, B.C.1
  • 23
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer, R. J. et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N. Engl. J. Med. 356, 115-124 (2007).
    • (2007) N. Engl. J. Med. , vol.356 , pp. 115-124
    • Motzer, R.J.1
  • 24
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier, B. et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N. Engl. J. Med. 356, 125-134 (2007).
    • (2007) N. Engl. J. Med. , vol.356 , pp. 125-134
    • Escudier, B.1
  • 25
    • 77952318310 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: Final results of CALGB 90206
    • Rini, B. I. et al. Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. J. Clin. Oncol. 28, 2137-2143 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 2137-2143
    • Rini, B.I.1
  • 26
    • 79959549917 scopus 로고    scopus 로고
    • Temsirolimus and bevacizumab, or sunitinib, or interferon alfa and bevacizumab for patients with advanced renal cell carcinoma (TORAVA): A randomised phase 2 trial
    • Negrier, S. et al. Temsirolimus and bevacizumab, or sunitinib, or interferon alfa and bevacizumab for patients with advanced renal cell carcinoma (TORAVA): a randomised phase 2 trial. Lancet Oncol. 12, 673-680 (2011).
    • (2011) Lancet Oncol. , vol.12 , pp. 673-680
    • Negrier, S.1
  • 27
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial
    • Sternberg, C. N. et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J. Clin. Oncol. 28, 1061-1068 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1061-1068
    • Sternberg, C.N.1
  • 28
    • 18944385751 scopus 로고    scopus 로고
    • Immunotherapy for advanced renal cell cancer [online]
    • Coppin, C. et al. Immunotherapy for advanced renal cell cancer [online], Cochrane Database Syst. Rev. http://dx.doi.org/10.1002/14651858.CD001425.pub2 (2004).
    • (2004) Cochrane Database Syst. Rev.
    • Coppin, C.1
  • 29
    • 0028266553 scopus 로고
    • Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2
    • Rosenberg, S. A. et al. Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2. JAMA 271, 907-913 (1994).
    • (1994) JAMA , vol.271 , pp. 907-913
    • Rosenberg, S.A.1
  • 30
    • 0032471712 scopus 로고    scopus 로고
    • Durability of complete responses in patients with metastatic cancer treated with high-dose interleukin-2: Identification of the antigens mediating response
    • Rosenberg, S. A. et al. Durability of complete responses in patients with metastatic cancer treated with high-dose interleukin-2: identification of the antigens mediating response. Ann. Surg. 228, 307-319 (1998).
    • (1998) Ann. Surg. , vol.228 , pp. 307-319
    • Rosenberg, S.A.1
  • 31
    • 77952300540 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): Final analysis of overall survival
    • Escudier, B. et al. Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival. J. Clin. Oncol. 28, 2144-2150 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 2144-2150
    • Escudier, B.1
  • 32
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
    • Motzer, R. J. et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 27, 3584-3590 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 3584-3590
    • Motzer, R.J.1
  • 33
    • 84899711381 scopus 로고    scopus 로고
    • Overall survival in renal-cell carcinoma with pazopanib versus sunitinib
    • Motzer, R. J. et al. Overall survival in renal-cell carcinoma with pazopanib versus sunitinib. N. Engl. J. Med. 370, 1769-1770 (2014).
    • (2014) N. Engl. J. Med. , vol.370 , pp. 1769-1770
    • Motzer, R.J.1
  • 34
    • 70349385645 scopus 로고    scopus 로고
    • Resistance to targeted therapy in renal-cell carcinoma
    • Rini, B. I. & Atkins, M. B. Resistance to targeted therapy in renal-cell carcinoma. Lancet Oncol. 10, 992-1000 (2009).
    • (2009) Lancet Oncol. , vol.10 , pp. 992-1000
    • Rini, B.I.1    Atkins, M.B.2
  • 35
    • 84895876130 scopus 로고    scopus 로고
    • Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
    • Gerlinger, M. et al. Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing. Nat. Genet. 46, 225-233 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 225-233
    • Gerlinger, M.1
  • 36
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger, M. et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N. Engl. J. Med. 366, 883-892 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 883-892
    • Gerlinger, M.1
  • 37
    • 0027240519 scopus 로고
    • Identification of the von Hippel-Lindau disease tumor suppressor gene
    • Latif, F. et al. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 260, 1317-1320 (1993).
    • (1993) Science , vol.260 , pp. 1317-1320
    • Latif, F.1
  • 38
    • 51049084870 scopus 로고    scopus 로고
    • Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors
    • Nickerson, M. L. et al. Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors. Clin. Cancer Res. 14, 4726-4734 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 4726-4734
    • Nickerson, M.L.1
  • 39
    • 84905403670 scopus 로고    scopus 로고
    • Molecular genetics of clear-cell renal cell carcinoma
    • Brugarolas, J. Molecular genetics of clear-cell renal cell carcinoma. J. Clin. Oncol. 32, 1968-1976 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 1968-1976
    • Brugarolas, J.1
  • 40
    • 77952263737 scopus 로고    scopus 로고
    • The genetic basis of kidney cancer: A metabolic disease
    • Linehan, W. M., Srinivasan, R. & Schmidt, L. S. The genetic basis of kidney cancer: a metabolic disease. Nat. Rev. Urol. 7, 277-285 (2010).
    • (2010) Nat. Rev. Urol. , vol.7 , pp. 277-285
    • Linehan, W.M.1    Srinivasan, R.2    Schmidt, L.S.3
  • 41
    • 84905079134 scopus 로고    scopus 로고
    • The multifaceted von Hippel-Lindau tumour suppressor protein
    • Robinson, C. M. & Ohh, M. The multifaceted von Hippel-Lindau tumour suppressor protein. FEBS Lett. 588, 2704-2711 (2014).
    • (2014) FEBS Lett. , vol.588 , pp. 2704-2711
    • Robinson, C.M.1    Ohh, M.2
  • 42
    • 84655161946 scopus 로고    scopus 로고
    • HIF1alpha and HIF2alpha: Sibling rivalry in hypoxic tumour growth and progression
    • Keith, B., Johnson, R. S. & Simon, M. C. HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression. Nat. Rev. Cancer 12, 9-22 (2012).
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 9-22
    • Keith, B.1    Johnson, R.S.2    Simon, M.C.3
  • 43
    • 68249112645 scopus 로고    scopus 로고
    • VHL loss causes spindle misorientation and chromosome instability
    • Thoma, C. R. et al. VHL loss causes spindle misorientation and chromosome instability. Nat. Cell Biol. 11, 994-1001 (2009).
    • (2009) Nat. Cell Biol. , vol.11 , pp. 994-1001
    • Thoma, C.R.1
  • 44
    • 84873081430 scopus 로고    scopus 로고
    • Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: A retrospective analysis with independent validation
    • Kapur, P. et al. Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation. Lancet Oncol. 14, 159-167 (2013).
    • (2013) Lancet Oncol. , vol.14 , pp. 159-167
    • Kapur, P.1
  • 45
    • 84884497841 scopus 로고    scopus 로고
    • A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinoma
    • Farley, M. N. et al. A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinoma. Mol. Cancer Res. 11, 1061-1071 (2013).
    • (2013) Mol. Cancer Res. , vol.11 , pp. 1061-1071
    • Farley, M.N.1
  • 46
    • 84915822435 scopus 로고    scopus 로고
    • Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis
    • Wang, S. S. et al. Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis. Proc. Natl Acad. Sci. USA 111, 16538-16543 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 16538-16543
    • Wang, S.S.1
  • 47
    • 84918821005 scopus 로고    scopus 로고
    • Validation of mammalian target of rapamycin biomarker panel in patients with clear cell renal cell carcinoma
    • Haddad, A. Q. et al. Validation of mammalian target of rapamycin biomarker panel in patients with clear cell renal cell carcinoma. Cancer 121, 43-50 (2014).
    • (2014) Cancer , vol.121 , pp. 43-50
    • Haddad, A.Q.1
  • 48
    • 84855393367 scopus 로고    scopus 로고
    • Integrative genomic analyses of sporadic clear cell renal cell carcinoma define disease subtypes and potential new therapeutic targets
    • Dondeti, V. R. et al. Integrative genomic analyses of sporadic clear cell renal cell carcinoma define disease subtypes and potential new therapeutic targets. Cancer Res. 72, 112-121 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 112-121
    • Dondeti, V.R.1
  • 49
    • 84867542519 scopus 로고    scopus 로고
    • Multilevel whole-genome analysis reveals candidate biomarkers in clear cell renal cell carcinoma
    • Girgis, A. H. et al. Multilevel whole-genome analysis reveals candidate biomarkers in clear cell renal cell carcinoma. Cancer Res. 72, 5273-5284 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 5273-5284
    • Girgis, A.H.1
  • 50
    • 66349100709 scopus 로고    scopus 로고
    • Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney
    • Beroukhim, R. et al. Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney. Cancer Res. 69, 4674-4681 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 4674-4681
    • Beroukhim, R.1
  • 51
    • 84892686207 scopus 로고    scopus 로고
    • Racial difference in histologic subtype of renal cell carcinoma
    • Olshan, A. F. et al. Racial difference in histologic subtype of renal cell carcinoma. Cancer Med. 2,744-749 (2013).
    • (2013) Cancer Med. , vol.2 , pp. 744-749
    • Olshan, A.F.1
  • 52
    • 84954365468 scopus 로고    scopus 로고
    • Renal cell cancer histologic subtype distribution differs by race and sex
    • Lipworth, L. et al. Renal cell cancer histologic subtype distribution differs by race and sex. BJU Int. http://dx.doi.org/10.1111/bju.12950 (2014).
    • (2014) BJU Int.
    • Lipworth, L.1
  • 53
    • 84883894030 scopus 로고    scopus 로고
    • Mutational signature of aristolochic acid exposure as revealed by whole-exome sequencing
    • Hoang, M. L. et al. Mutational signature of aristolochic acid exposure as revealed by whole-exome sequencing. Sci. Transl. Med. 5, 197ra102 (2013).
    • (2013) Sci. Transl. Med. , vol.5 , pp. 197ra102
    • Hoang, M.L.1
  • 54
    • 0034622082 scopus 로고    scopus 로고
    • Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi)
    • Nortier, J. L. et al. Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi). N. Engl. J. Med. 342, 1686-1692 (2000).
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1686-1692
    • Nortier, J.L.1
  • 55
    • 39449104221 scopus 로고    scopus 로고
    • Late onset of bladder urothelial carcinoma after kidney transplantation for end-stage aristolochic acid nephropathy: A case series with 15-year follow-up
    • Lemy, A. et al. Late onset of bladder urothelial carcinoma after kidney transplantation for end-stage aristolochic acid nephropathy: a case series with 15-year follow-up. Am. J. Kidney Dis. 51, 471-477 (2008).
    • (2008) Am. J. Kidney Dis. , vol.51 , pp. 471-477
    • Lemy, A.1
  • 56
    • 0043170826 scopus 로고    scopus 로고
    • UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines
    • Modena, P. et al. UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines. Oncogene 22, 4586-4593 (2003).
    • (2003) Oncogene , vol.22 , pp. 4586-4593
    • Modena, P.1
  • 57
    • 79951923157 scopus 로고    scopus 로고
    • Epigenetics of kidney cancer and bladder cancer
    • Hoffman, A. M. & Cairns, P. Epigenetics of kidney cancer and bladder cancer. Epigenomics 3, 19-34 (2011).
    • (2011) Epigenomics , vol.3 , pp. 19-34
    • Hoffman, A.M.1    Cairns, P.2
  • 58
    • 33751193656 scopus 로고    scopus 로고
    • Converting a breast cancer microarray signature into a high-throughput diagnostic test
    • Glas, A. M. et al. Converting a breast cancer microarray signature into a high-throughput diagnostic test. BMC Genomics 7, 278 (2006).
    • (2006) BMC Genomics , vol.7 , pp. 278
    • Glas, A.M.1
  • 59
    • 0035859883 scopus 로고    scopus 로고
    • Gene expression profiling of clear cell renal cell carcinoma: Gene identification and prognostic classification
    • Takahashi, M. et al. Gene expression profiling of clear cell renal cell carcinoma: gene identification and prognostic classification. Proc. Natl Acad. Sci. USA 98, 9754-9759 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 9754-9759
    • Takahashi, M.1
  • 60
    • 79958289707 scopus 로고    scopus 로고
    • A specific gene expression signature characterizes metastatic potential in clear cell renal cell carcinoma
    • Sanjmyatav, J. et al. A specific gene expression signature characterizes metastatic potential in clear cell renal cell carcinoma. J. Urol. 186, 289-294 (2011).
    • (2011) J. Urol. , vol.186 , pp. 289-294
    • Sanjmyatav, J.1
  • 61
    • 23844524767 scopus 로고    scopus 로고
    • Gene signatures of progression and metastasis in renal cell cancer
    • Jones, J. et al. Gene signatures of progression and metastasis in renal cell cancer. Clin. Cancer Res. 11, 5730-5739 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 5730-5739
    • Jones, J.1
  • 62
    • 19944430072 scopus 로고    scopus 로고
    • Gene expression in kidney cancer is associated with cytogenetic abnormalities, metastasis formation, and patient survival
    • Sultmann, H. et al. Gene expression in kidney cancer is associated with cytogenetic abnormalities, metastasis formation, and patient survival. Clin. Cancer Res. 11, 646-655 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 646-655
    • Sultmann, H.1
  • 63
    • 32144434202 scopus 로고    scopus 로고
    • Gene expression profiling predicts survival in conventional renal cell carcinoma
    • Zhao, H. et al. Gene expression profiling predicts survival in conventional renal cell carcinoma. PLoS Med. 3, e13 (2006).
    • (2006) PLoS Med. , vol.3 , pp. e13
    • Zhao, H.1
  • 64
    • 77952238828 scopus 로고    scopus 로고
    • Molecular Stratification of Clear Cell Renal Cell Carcinoma by Consensus Clustering Reveals Distinct Subtypes and Survival Patterns
    • Brannon, A. R. et al. Molecular Stratification of Clear Cell Renal Cell Carcinoma by Consensus Clustering Reveals Distinct Subtypes and Survival Patterns. Genes Cancer 1, 152-163 (2010).
    • (2010) Genes Cancer , vol.1 , pp. 152-163
    • Brannon, A.R.1
  • 65
    • 83955161686 scopus 로고    scopus 로고
    • Meta-analysis of clear cell renal cell carcinoma gene expression defines a variant subgroup and identifies gender influences on tumor biology
    • Brannon, A. R. et al. Meta-analysis of clear cell renal cell carcinoma gene expression defines a variant subgroup and identifies gender influences on tumor biology. Eur. Urol. 61, 258-268 (2012).
    • (2012) Eur. Urol. , vol.61 , pp. 258-268
    • Brannon, A.R.1
  • 66
    • 84902073050 scopus 로고    scopus 로고
    • ClearCode34: A prognostic risk predictor for localized clear cell renal cell carcinoma
    • Brooks, S. A. et al. ClearCode34: A prognostic risk predictor for localized clear cell renal cell carcinoma. Eur. Urol. 66, 77-84 (2014).
    • (2014) Eur. Urol. , vol.66 , pp. 77-84
    • Brooks, S.A.1
  • 67
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou, C. M. et al. Molecular portraits of human breast tumours. Nature 406, 747-752 (2000).
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1
  • 68
    • 0037478605 scopus 로고    scopus 로고
    • Repeated observation of breast tumor subtypes in independent gene expression data sets
    • Sorlie, T. et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc. Natl Acad. Sci. USA 100, 8418-8423 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 8418-8423
    • Sorlie, T.1
  • 69
    • 84884365015 scopus 로고    scopus 로고
    • The causes and consequences of genetic heterogeneity in cancer evolution
    • Burrell, R. A. et al. The causes and consequences of genetic heterogeneity in cancer evolution. Nature 501, 338-345 (2013).
    • (2013) Nature , vol.501 , pp. 338-345
    • Burrell, R.A.1
  • 70
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell, P. C. The clonal evolution of tumor cell populations. Science 194, 23-28 (1976).
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 71
    • 84875211731 scopus 로고    scopus 로고
    • Cancer heterogeneity: Implications for targeted therapeutics
    • Fisher, R., Pusztai, L. & Swanton, C. Cancer heterogeneity: implications for targeted therapeutics. Br. J. Cancer 108, 479-485 (2013).
    • (2013) Br. J. Cancer , vol.108 , pp. 479-485
    • Fisher, R.1    Pusztai, L.2    Swanton, C.3
  • 72
    • 78049380554 scopus 로고    scopus 로고
    • The patterns and dynamics of genomic instability in metastatic pancreatic cancer
    • Campbell, P. J. et al. The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature 467, 1109-1113 (2010).
    • (2010) Nature , vol.467 , pp. 1109-1113
    • Campbell, P.J.1
  • 73
    • 0032529439 scopus 로고    scopus 로고
    • Genetic alterations in primary bladder cancers and their metastases
    • Hovey, R. M. et al. Genetic alterations in primary bladder cancers and their metastases. Cancer Res. 58, 3555-3560 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 3555-3560
    • Hovey, R.M.1
  • 74
    • 16844387339 scopus 로고    scopus 로고
    • Genetic changes and clonality relationship between primary colorectal cancers and their pulmonary metastases-an analysis by comparative genomic hybridization
    • Jiang, J. K. et al. Genetic changes and clonality relationship between primary colorectal cancers and their pulmonary metastases-an analysis by comparative genomic hybridization. Genes Chromosomes Cancer 43, 25-36 (2005).
    • (2005) Genes Chromosomes Cancer , vol.43 , pp. 25-36
    • Jiang, J.K.1
  • 75
    • 84862776537 scopus 로고    scopus 로고
    • Clonal selection drives genetic divergence of metastatic medulloblastoma
    • Wu, X. et al. Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature 482, 529-533 (2012).
    • (2012) Nature , vol.482 , pp. 529-533
    • Wu, X.1
  • 76
    • 70349969478 scopus 로고    scopus 로고
    • Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
    • Shah, S. P. et al. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature 461, 809-813 (2009).
    • (2009) Nature , vol.461 , pp. 809-813
    • Shah, S.P.1
  • 77
    • 84946126618 scopus 로고    scopus 로고
    • Systematic Evaluation of the Prognostic Impact and Intratumour Heterogeneity of Clear Cell Renal Cell Carcinoma Biomarkers
    • Gulati, S. et al. Systematic Evaluation of the Prognostic Impact and Intratumour Heterogeneity of Clear Cell Renal Cell Carcinoma Biomarkers. Eur. Urol. 66, 936-948 (2014).
    • (2014) Eur. Urol. , vol.66 , pp. 936-948
    • Gulati, S.1
  • 78
    • 79953766940 scopus 로고    scopus 로고
    • Tumour evolution inferred by single-cell sequencing
    • Navin, N. et al. Tumour evolution inferred by single-cell sequencing. Nature 472, 90-94 (2011).
    • (2011) Nature , vol.472 , pp. 90-94
    • Navin, N.1
  • 79
    • 84906238686 scopus 로고    scopus 로고
    • Clonal evolution in breast cancer revealed by single nucleus genome sequencing
    • Wang, Y. et al. Clonal evolution in breast cancer revealed by single nucleus genome sequencing. Nature 512, 155-160 (2014).
    • (2014) Nature , vol.512 , pp. 155-160
    • Wang, Y.1
  • 80
    • 84863230091 scopus 로고    scopus 로고
    • Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor
    • Xu, X. et al. Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. Cell 148, 886-895 (2012).
    • (2012) Cell , vol.148 , pp. 886-895
    • Xu, X.1
  • 81
    • 21344446106 scopus 로고    scopus 로고
    • A molecular classification of papillary renal cell carcinoma
    • Yang, X. J et al. A molecular classification of papillary renal cell carcinoma. Cancer Res. 65, 5628-5637 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 5628-5637
    • Yang, X.J.1
  • 82
    • 0034949144 scopus 로고    scopus 로고
    • Morphologic typing of papillary renal cell carcinoma: Comparison of growth kinetics and patient survival in 66 cases
    • Delahunt, B. et al. Morphologic typing of papillary renal cell carcinoma: comparison of growth kinetics and patient survival in 66 cases. Hum. Pathol. 32, 590-595 (2001).
    • (2001) Hum. Pathol. , vol.32 , pp. 590-595
    • Delahunt, B.1
  • 83
    • 63149193393 scopus 로고    scopus 로고
    • Cytogenetic and molecular tumor profiling for type 1 and type 2 papillary renal cell carcinoma
    • Klatte, T. et al. Cytogenetic and molecular tumor profiling for type 1 and type 2 papillary renal cell carcinoma. Clin. Cancer Res. 15, 1162-1169 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 1162-1169
    • Klatte, T.1
  • 84
    • 0024495675 scopus 로고
    • Papillary renal cell carcinoma. A morphologic and cytogenetic study of 11 cases
    • Kovacs, G. Papillary renal cell carcinoma. A morphologic and cytogenetic study of 11 cases. Am. J. Pathol. 134, 27-34 (1989).
    • (1989) Am. J. Pathol. , vol.134 , pp. 27-34
    • Kovacs, G.1
  • 85
    • 0028157342 scopus 로고
    • Hereditary papillary renal cell carcinoma
    • Zbar, B. et al. Hereditary papillary renal cell carcinoma. J. Urol. 151, 561-566 (1994).
    • (1994) J. Urol. , vol.151 , pp. 561-566
    • Zbar, B.1
  • 86
    • 0035853166 scopus 로고    scopus 로고
    • Inherited susceptibility to uterine leiomyomas and renal cell cancer
    • Launonen, V. et al. Inherited susceptibility to uterine leiomyomas and renal cell cancer. Proc. Natl Acad. Sci. USA 98, 3387-3392 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 3387-3392
    • Launonen, V.1
  • 87
    • 17344381429 scopus 로고    scopus 로고
    • Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
    • Schmidt, L. et al. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nat. Genet. 16, 68-73 (1997).
    • (1997) Nat. Genet. , vol.16 , pp. 68-73
    • Schmidt, L.1
  • 88
    • 18544365990 scopus 로고    scopus 로고
    • Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
    • Tomlinson, I. P. et al. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat. Genet. 30, 406-410 (2002).
    • (2002) Nat. Genet. , vol.30 , pp. 406-410
    • Tomlinson, I.P.1
  • 89
    • 0000939691 scopus 로고    scopus 로고
    • Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dube syndrome
    • Nickerson, M. L et al. Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dube syndrome. Cancer Cell 2, 157-164 (2002).
    • (2002) Cancer Cell , vol.2 , pp. 157-164
    • Nickerson, M.L.1
  • 90
    • 78650118680 scopus 로고    scopus 로고
    • Birt-Hogg-Dube renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression
    • Klomp, J. A. et al. Birt-Hogg-Dube renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression. BMC Med. Genomics 3, 59 (2010).
    • (2010) BMC Med. Genomics , vol.3 , pp. 59
    • Klomp, J.A.1
  • 91
    • 0029890634 scopus 로고    scopus 로고
    • Allelic losses at chromosomes 1p, 2p, 6p, 10p, 13q, 17p, and 21q significantly correlate with the chromophobe subtype of renal cell carcinoma
    • Schwerdtle, R. F. et al. Allelic losses at chromosomes 1p, 2p, 6p, 10p, 13q, 17p, and 21q significantly correlate with the chromophobe subtype of renal cell carcinoma. Cancer Res. 56, 2927-2930 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 2927-2930
    • Schwerdtle, R.F.1
  • 92
    • 33846490110 scopus 로고    scopus 로고
    • Mutations in BHD and TP53 genes, but not in HNF1beta gene, in a large series of sporadic chromophobe renal cell carcinoma
    • Gad, S. et al. Mutations in BHD and TP53 genes, but not in HNF1beta gene, in a large series of sporadic chromophobe renal cell carcinoma. Br. J. Cancer 96, 336-340 (2007).
    • (2007) Br. J. Cancer , vol.96 , pp. 336-340
    • Gad, S.1
  • 93
    • 33845734138 scopus 로고    scopus 로고
    • Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes
    • Rohan, S. et al. Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes. Clin. Cancer Res. 12, 6937-6945 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , pp. 6937-6945
    • Rohan, S.1
  • 94
    • 84884368877 scopus 로고    scopus 로고
    • Influence of tumour micro-environment heterogeneity on therapeutic response
    • Junttila, M. R. & de Sauvage, F. J. Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 501, 346-354 (2013).
    • (2013) Nature , vol.501 , pp. 346-354
    • Junttila, M.R.1    De Sauvage, F.J.2
  • 95
    • 84898011066 scopus 로고    scopus 로고
    • Role of natural and adaptive immunity in renal cell carcinoma response to VEGFR-TKIs and mTOR inhibitor
    • Santoni, M. et al. Role of natural and adaptive immunity in renal cell carcinoma response to VEGFR-TKIs and mTOR inhibitor. Int. J. Cancer 134, 2772-2777 (2014).
    • (2014) Int. J. Cancer , vol.134 , pp. 2772-2777
    • Santoni, M.1
  • 96
    • 78651257523 scopus 로고    scopus 로고
    • Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3
    • Purdue, M. P. et al. Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. Nat. Genet. 43, 60-65 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 60-65
    • Purdue, M.P.1
  • 97
    • 84862777063 scopus 로고    scopus 로고
    • Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression
    • S1-2
    • Schodel, J. et al. Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression. Nat. Genet. 44, 420-425, S1-2 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 420-425
    • Schodel, J.1
  • 98
    • 70350231601 scopus 로고    scopus 로고
    • Apolipoprotein E/C1 locus variants modify renal cell carcinoma risk
    • Moore, L. E. et al. Apolipoprotein E/C1 locus variants modify renal cell carcinoma risk. Cancer Res. 69, 8001-8008 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 8001-8008
    • Moore, L.E.1
  • 99
    • 84873031321 scopus 로고    scopus 로고
    • Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer
    • Henrion, M. et al. Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer. Hum. Mol. Genet. 22, 825-831 (2013).
    • (2013) Hum. Mol. Genet. , vol.22 , pp. 825-831
    • Henrion, M.1
  • 100
    • 84855377024 scopus 로고    scopus 로고
    • A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23
    • Wu, X. et al. A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23. Hum. Mol. Genet. 21, 456-462 (2012).
    • (2012) Hum. Mol. Genet. , vol.21 , pp. 456-462
    • Wu, X.1
  • 101
    • 84891949645 scopus 로고    scopus 로고
    • Germline genetic variations at 11q13 and 12p11 locus modulate age at onset for renal cell carcinoma
    • Audenet, F. et al. Germline genetic variations at 11q13 and 12p11 locus modulate age at onset for renal cell carcinoma J. Urol. 191, 487-492 (2014).
    • (2014) J. Urol. , vol.191 , pp. 487-492
    • Audenet, F.1
  • 102
    • 84871718053 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms and risk of recurrence of renal-cell carcinoma: A cohort study
    • Schutz, F. A. et al. Single nucleotide polymorphisms and risk of recurrence of renal-cell carcinoma: a cohort study. Lancet Oncol. 14, 81-87 (2013).
    • (2013) Lancet Oncol. , vol.14 , pp. 81-87
    • Schutz, F.A.1
  • 103
    • 84933278023 scopus 로고    scopus 로고
    • Renal carcinoma pharmacogenomics and predictors of response: Steps toward treatment individualization
    • Garcia-Donas, J. et al. Renal carcinoma pharmacogenomics and predictors of response: Steps toward treatment individualization. Urol. Oncol. http://dx.doi.org/10.1016/j.urolonc.2013.09.015 (2014).
    • (2014) Urol. Oncol.
    • Garcia-Donas, J.1
  • 104
    • 34447577927 scopus 로고    scopus 로고
    • STAT3 polymorphism predicts interferon-alfa response in patients with metastatic renal cell carcinoma
    • Ito, N. et al. STAT3 polymorphism predicts interferon-alfa response in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 25, 2785-2791 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , pp. 2785-2791
    • Ito, N.1
  • 105
    • 79551701442 scopus 로고    scopus 로고
    • Genetic polymorphisms associated with a prolonged progression-free survival in patients with metastatic renal cell cancer treated with sunitinib
    • van der Veldt, A. A. et al. Genetic polymorphisms associated with a prolonged progression-free survival in patients with metastatic renal cell cancer treated with sunitinib. Clin. Cancer Res. 17, 620-629 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 620-629
    • Van Der Veldt, A.A.1
  • 106
    • 84863338437 scopus 로고    scopus 로고
    • Association of VEGF and VEGFR2 single nucleotide polymorphisms with hypertension and clinical outcome in metastatic clear cell renal cell carcinoma patients treated with sunitinib
    • Kim, J. J. et al. Association of VEGF and VEGFR2 single nucleotide polymorphisms with hypertension and clinical outcome in metastatic clear cell renal cell carcinoma patients treated with sunitinib. Cancer 118, 1946-1954 (2012).
    • (2012) Cancer , vol.118 , pp. 1946-1954
    • Kim, J.J.1
  • 107
    • 84875464258 scopus 로고    scopus 로고
    • VEGF and VEGFR polymorphisms affect clinical outcome in advanced renal cell carcinoma patients receiving first-line sunitinib
    • Scartozzi, M. et al. VEGF and VEGFR polymorphisms affect clinical outcome in advanced renal cell carcinoma patients receiving first-line sunitinib. Br. J. Cancer 108, 1126-1132 (2013).
    • (2013) Br. J. Cancer , vol.108 , pp. 1126-1132
    • Scartozzi, M.1
  • 108
    • 84875168504 scopus 로고    scopus 로고
    • Single-nucleotide polymorphisms associated with outcome in metastatic renal cell carcinoma treated with sunitinib
    • Beuselinck, B. et al. Single-nucleotide polymorphisms associated with outcome in metastatic renal cell carcinoma treated with sunitinib. Br. J. Cancer 108, 887-900 (2013).
    • (2013) Br. J. Cancer , vol.108 , pp. 887-900
    • Beuselinck, B.1
  • 109
    • 84863092492 scopus 로고    scopus 로고
    • VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: An analysis of data from the AViTA and AVOREN randomised trials
    • Lambrechts, D. et al. VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials. Lancet Oncol. 13, 724-733 (2012).
    • (2012) Lancet Oncol. , vol.13 , pp. 724-733
    • Lambrechts, D.1
  • 110
    • 84925545307 scopus 로고    scopus 로고
    • Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma
    • Motzer, R. J. et al. Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma. Cancer Chemother. Pharmacol. 74, 739-750 (2014).
    • (2014) Cancer Chemother. Pharmacol. , vol.74 , pp. 739-750
    • Motzer, R.J.1
  • 111
    • 70349342710 scopus 로고    scopus 로고
    • Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity
    • van Erp, N. P. et al. Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity. J. Clin. Oncol. 27, 4406-4412 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 4406-4412
    • Van Erp, N.P.1
  • 112
    • 81255160848 scopus 로고    scopus 로고
    • Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: A multicentre, observational, prospective study
    • Garcia-Donas, J. et al. Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study. Lancet Oncol. 12, 1143-1150 (2011).
    • (2011) Lancet Oncol. , vol.12 , pp. 1143-1150
    • Garcia-Donas, J.1
  • 113
    • 84885386248 scopus 로고    scopus 로고
    • Pharmacogenetic determinants associated with sunitinib-induced toxicity and ethnic difference in Korean metastatic renal cell carcinoma patients
    • Kim, H. R. et al. Pharmacogenetic determinants associated with sunitinib-induced toxicity and ethnic difference in Korean metastatic renal cell carcinoma patients. Cancer Chemother. Pharmacol. 72, 825-835 (2013).
    • (2013) Cancer Chemother. Pharmacol. , vol.72 , pp. 825-835
    • Kim, H.R.1
  • 115
    • 0028929682 scopus 로고
    • Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy
    • Fyfe, G. et al. Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J. Clin. Oncol. 13, 688-696 (1995).
    • (1995) J. Clin. Oncol. , vol.13 , pp. 688-696
    • Fyfe, G.1
  • 116
    • 16644401873 scopus 로고    scopus 로고
    • Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma
    • McDermott, D. F. et al. Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 23, 133-141 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 133-141
    • McDermott, D.F.1
  • 117
    • 0042914703 scopus 로고    scopus 로고
    • Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer
    • Yang, J. C. et al. Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer. J. Clin. Oncol. 21, 3127-3132 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , pp. 3127-3132
    • Yang, J.C.1
  • 118
    • 84927574518 scopus 로고    scopus 로고
    • Immune modulation for cancer therapy
    • Naidoo, J., Page, D. B. & Wolchok, J. D. Immune modulation for cancer therapy. Br. J. Cancer 111, 2214-2219 (2014).
    • (2014) Br. J. Cancer , vol.111 , pp. 2214-2219
    • Naidoo, J.1    Page, D.B.2    Wolchok, J.D.3
  • 119
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian, S. L. et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366, 2443-2454 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2443-2454
    • Topalian, S.L.1
  • 120
    • 37349072460 scopus 로고    scopus 로고
    • Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis
    • Yang, J. C. et al. Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. J. Immunother. 30, 825-830 (2007).
    • (2007) J. Immunother. , vol.30 , pp. 825-830
    • Yang, J.C.1
  • 121
    • 84880952617 scopus 로고    scopus 로고
    • Modification of the tumor microenvironment as a novel target of renal cell carcinoma therapeutics
    • Finke, J. H. et al. Modification of the tumor microenvironment as a novel target of renal cell carcinoma therapeutics. Cancer J. 19, 353-364 (2013).
    • (2013) Cancer J. , vol.19 , pp. 353-364
    • Finke, J.H.1
  • 122
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich, D. I. & Nagaraj, S. Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9, 162-174 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 123
    • 5444225991 scopus 로고    scopus 로고
    • Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis
    • Yang, L. et al. Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell 6, 409-421 (2004).
    • (2004) Cancer Cell , vol.6 , pp. 409-421
    • Yang, L.1
  • 124
    • 63549105681 scopus 로고    scopus 로고
    • Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients
    • Ko, J. S. et al. Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients. Clin. Cancer Res. 15, 2148-2157 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 2148-2157
    • Ko, J.S.1
  • 125
    • 84908089640 scopus 로고    scopus 로고
    • Axitinib augments antitumor activity in renal cell carcinoma via STAT3-dependent reversal of myeloid-derived suppressor cell accumulation
    • Yuan, H. et al. Axitinib augments antitumor activity in renal cell carcinoma via STAT3-dependent reversal of myeloid-derived suppressor cell accumulation. Biomed. Pharmacother. 68, 751-756 (2014).
    • (2014) Biomed. Pharmacother. , vol.68 , pp. 751-756
    • Yuan, H.1
  • 126
    • 84904406680 scopus 로고    scopus 로고
    • Tumor-associated macrophages: From mechanisms to therapy
    • Noy, R. & Pollard, J. W. Tumor-associated macrophages: from mechanisms to therapy. Immunity 41, 49-61 (2014).
    • (2014) Immunity , vol.41 , pp. 49-61
    • Noy, R.1    Pollard, J.W.2
  • 127
    • 84920943285 scopus 로고    scopus 로고
    • Tumor-associated macrophages as major players in the tumor microenvironment
    • Chanmee, T. et al. Tumor-associated macrophages as major players in the tumor microenvironment. Cancers (Basel) 6, 1670-1690 (2014).
    • (2014) Cancers (Basel) , vol.6 , pp. 1670-1690
    • Chanmee, T.1
  • 128
    • 81555210943 scopus 로고    scopus 로고
    • Knockdown of VEGF receptor-1 (VEGFR-1) impairs macrophage infiltration, angiogenesis and growth of clear cell renal cell carcinoma (CRCC)
    • Li, C. et al. Knockdown of VEGF receptor-1 (VEGFR-1) impairs macrophage infiltration, angiogenesis and growth of clear cell renal cell carcinoma (CRCC). Cancer Biol. Ther. 12, 872-880 (2011).
    • (2011) Cancer Biol. Ther. , vol.12 , pp. 872-880
    • Li, C.1
  • 129
    • 84855387182 scopus 로고    scopus 로고
    • Autocrine CSF-1 and CSF-1 receptor coexpression promotes renal cell carcinoma growth
    • Menke, J. et al. Autocrine CSF-1 and CSF-1 receptor coexpression promotes renal cell carcinoma growth. Cancer Res. 72, 187-200 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 187-200
    • Menke, J.1
  • 130
    • 84855221082 scopus 로고    scopus 로고
    • Characterization of kinase inhibitors using different phosphorylation states of colony stimulating factor-1 receptor tyrosine kinase
    • Kitagawa, D. et al. Characterization of kinase inhibitors using different phosphorylation states of colony stimulating factor-1 receptor tyrosine kinase. J. Biochem. 151, 47-55 (2012).
    • (2012) J. Biochem. , vol.151 , pp. 47-55
    • Kitagawa, D.1
  • 131
    • 84873047792 scopus 로고    scopus 로고
    • Sorafenib induces autophagy and suppresses activation of human macrophage
    • Lin, J. C. et al. Sorafenib induces autophagy and suppresses activation of human macrophage. Int. Immunopharmacol. 15, 333-339 (2013).
    • (2013) Int. Immunopharmacol. , vol.15 , pp. 333-339
    • Lin, J.C.1
  • 132
    • 10344220548 scopus 로고    scopus 로고
    • Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target
    • Thompson, R. H. et al. Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target. Proc. Natl Acad. Sci. USA 101, 17174-17179 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 17174-17179
    • Thompson, R.H.1
  • 133
    • 84896974949 scopus 로고    scopus 로고
    • PD-L1 expression in clear cell renal cell carcinoma: An analysis of nephrectomy and sites of metastases
    • Jilaveanu, L. B. et al. PD-L1 Expression in Clear Cell Renal Cell Carcinoma: An Analysis of Nephrectomy and Sites of Metastases. J. Cancer 5, 166-172 (2014).
    • (2014) J. Cancer , vol.5 , pp. 166-172
    • Jilaveanu, L.B.1
  • 134
    • 84893663818 scopus 로고    scopus 로고
    • Targeted therapy in renal cell carcinoma: Moving from molecular agents to specific immunotherapy
    • Bedke, J. et al. Targeted therapy in renal cell carcinoma: moving from molecular agents to specific immunotherapy. World J. Urol. 32, 31-38 (2014).
    • (2014) World J. Urol. , vol.32 , pp. 31-38
    • Bedke, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.