Developing interventions for cancer-related cognitive dysfunction in childhood cancer survivors

Journal of the National Cancer Institute

Volumn 106, Issue 8, 2014, Pages

  Castellino, Sharon M ^a,b   Ullrich, Nicole J ^c   Whelen, Megan J ^b   Lange, Beverly J ^d  

^a WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTARABINE; DEXAMETHASONE; HUMAN GROWTH HORMONE; HYDROCORTISONE; METHOTREXATE; METHYLPHENIDATE; MODAFINIL; ANTINEOPLASTIC ANTIMETABOLITE; BENZHYDRYL DERIVATIVE; CENTRAL STIMULANT AGENT; DONEPEZIL; INDAN DERIVATIVE; NOOTROPIC AGENT; PIPERIDINE DERIVATIVE; WAKEFULNESS PROMOTING AGENT;

CANCER CHEMOTHERAPY; CANCER EPIDEMIOLOGY; CANCER RADIOTHERAPY; CANCER RELATED COGNITIVE DYSFUNCTION; CANCER SURGERY; CANCER SURVIVOR; CHILDHOOD CANCER; COGNITIVE DEFECT; FEMALE; HOST; HUMAN; LEUKOENCEPHALOPATHY; MEDLINE; MEDULLOBLASTOMA; META ANALYSIS (TOPIC); MULTICENTER STUDY (TOPIC); NEUROSURGERY; PATHOPHYSIOLOGY; PATIENT EDUCATION; PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK FACTOR; SCHOOL; SEX DIFFERENCE; SKULL IRRADIATION; SYSTEMATIC REVIEW (TOPIC); ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGE; ATTENTION; BRAIN TUMOR; CHILD; COMORBIDITY; EARLY CHILDHOOD INTERVENTION; EDUCATION; HEAD AND NECK TUMOR; INFANT; INTRASPINAL DRUG ADMINISTRATION; METHODOLOGY; MILD COGNITIVE IMPAIRMENT; NEOPLASM; PRESCHOOL CHILD; PSYCHOLOGICAL ASPECT; PSYCHOMOTOR PERFORMANCE; QUALITY OF LIFE; RADIATION DOSE; SEVERITY OF ILLNESS INDEX; SHORT TERM MEMORY; SURVIVOR; THINKING; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; ANTIMETABOLITES, ANTINEOPLASTIC; ATTENTION; BENZHYDRYL COMPOUNDS; BRAIN NEOPLASMS; CENTRAL NERVOUS SYSTEM STIMULANTS; CHILD; CHILD, PRESCHOOL; COMORBIDITY; CRANIAL IRRADIATION; EARLY INTERVENTION (EDUCATION); EDUCATION, SPECIAL; HEAD AND NECK NEOPLASMS; HUMAN GROWTH HORMONE; HUMANS; INDANS; INFANT; INJECTIONS, SPINAL; MEMORY, SHORT-TERM; METHOTREXATE; METHYLPHENIDATE; MILD COGNITIVE IMPAIRMENT; NEOPLASMS; NEUROSURGICAL PROCEDURES; NOOTROPIC AGENTS; PATIENT EDUCATION AS TOPIC; PIPERIDINES; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PSYCHOMOTOR PERFORMANCE; QUALITY OF LIFE; RADIOTHERAPY DOSAGE; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SEX FACTORS; SURVIVORS; THINKING; WAKEFULNESS-PROMOTING AGENTS; YOUNG ADULT;

EID: 84930700837     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/dju186     Document Type: Review

References (257)

1. Conklin HM, Khan RB, Reddick WE, et al. Acute neurocognitive response to methylphenidate among survivors of childhood cancer: a randomized, double-blind, cross-over trial. J Pediatr Psychol. 2007;32(9):1127-1139.
2. Robinson KE, Livesay KL, Campbell LK, et al. Working memory in survivors of childhood acute lymphocytic leukemia: functional neuroimaging analyses. Pediatr Blood Cancer. 2010;54(4):585-590.
3. Mulhern RK, Butler RW. Neurocognitive sequelae of childhood cancers and their treatment. Pediatr Rehabil. 2004;7(1):1-14; discussion 15-16.
4. Duffner PK. Risk factors for cognitive decline in children treated for brain tumors. Eur J Paediatr Neurol. 2010;14(2):106-115.
5. Glauser TA, Packer RJ. Cognitive deficits in long-term survivors of childhood brain tumors. Childs Nerv Syst. 1991;7(1):2-12.
6. Mahoney DH Jr, Shuster JJ, Nitschke R, et al. Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: an association with intermediate-dose intravenous methotrexate and intrathecal triple therapy - a Pediatric Oncology Group study. J Clin Oncol. 1998;16(5):1712-1722.
7. Mariotto AB, Rowland JH, Yabroff KR, et al. Long-term survivors of childhood cancers in the United States. Cancer Epidemiol Biomarkers Prev. 2009;18(4):1033-1040.
8. Shuper A, Stark B, Kornreich L, et al. Methotrexate treatment protocols and the central nervous system: significant cure with significant neurotoxicity. J Child Neurol. 2000;15(9):573-580.
9. Janzen LA, Spiegler BJ. Neurodevelopmental sequelae of pediatric acute lymphoblastic leukemia and its treatment. Dev Disabil Res Rev. 2008;14(3):185-195.
10. Nathan PC, Patel SK, Dilley K, et al. Guidelines for identification of, advocacy for, and intervention in neurocognitive problems in survivors of childhood cancer: a report from the Children's Oncology Group. Arch Pediatr Adolesc Med. 2007;161(8):798-806.
11. Butler RW, Mulhern RK. Neurocognitive interventions for children and adolescents surviving cancer. J Pediatr Psychol. 2005;30(1):65-78.
12. Meadows AT, Gordon J, Massari DJ, et al. Declines in IQ scores and cognitive dysfunctions in children with acute lymphocytic leukaemia treated with cranial irradiation. Lancet. 1981;2(8254):1015-1018.
13. Shah AJ, Epport K, Azen C, et al. Progressive declines in neurocognitive function among survivors of hematopoietic stem cell transplantation for pediatric hematologic malignancies. J Pediatr Hematol Oncol. 2008;30(6):411-418.
14. Nazemi KJ, Butler RW. Neuropsychological rehabilitation for survivors of childhood and adolescent brain tumors: a view of the past and a vision for a promising future. J Pediatr Rehabil Med. 2011;4(1):37-46.
15. Kazak AE. Implications of survival: pediatric oncology patients and their families. In: Bearison DJ, Mulhern RK, eds. Pediatric Psychooncology: Psychological Perspectives on Children with Cancer. New York: Oxford University Press; 1994, 171-192.
16. Carlson-Green B, Morris RD, Krawiecki N. Family and illness predictors of outcome in pediatric brain tumors. J Pediatr Psychol. 1995;20(6):769-784.
17. Barr RD, Simpson T, Whitton A, et al. Health-related quality of life in survivors of tumours of the central nervous system in childhood - a preference-based approach to measurement in a cross-sectional study. Eur J Cancer. 1999;35(2):248-255.
18. Bhat SR, Goodwin TL, Burwinkle TM, et al. Profile of daily life in children with brain tumors: an assessment of health-related quality of life. J Clin Oncol. 2005;23(24):5493-5500.
19. Johnson DL, McCabe MA, Nicholson HS, et al. Quality of longterm survival in young children with medulloblastoma. J Neurosurg. 1994;80(6):1004-1010.
20. Zebrack BJ, Gurney JG, Oeffinger K, et al. Psychological outcomes in long-term survivors of childhood brain cancer: a report from the childhood cancer survivor study. J Clin Oncol. 2004;22(6):999-1006.
21. Reimers TS, Mortensen EL, Nysom K, et al. Health-related quality of life in long-term survivors of childhood brain tumors. Pediatr Blood Cancer. 2009;53(6):1086-1091.
22. Nathan PC, Ford JS, Henderson TO, et al. Health behaviors, medical care, and interventions to promote healthy living in the Childhood Cancer Survivor Study cohort. J Clin Oncol. 2009;27(14):2363-2373.
23. Conklin HM, Li C, Xiong X, et al. Predicting change in academic abilities after conformal radiation therapy for localized ependymoma. J Clin Oncol. 2008;26(24):3965-3970.
24. Harila-Saari AH, Lahteenmaki PM, Pukkala E, et al. Scholastic achievements of childhood leukemia patients: a nationwide, register-based study. J Clin Oncol. 2007;25(23):3518-3524.
25. Mabbott DJ, Spiegler BJ, Greenberg ML, et al. Serial evaluation of academic and behavioral outcome after treatment with cranial radiation in childhood. J Clin Oncol. 2005;23(10):2256-2263.
26. Butler RW, Copeland DR. Attentional processes and their remediation in children treated for cancer: a literature review and the development of a therapeutic approach. J Int Neuropsychol Soc. 2002;8(1):115-124.
27. Mulhern RK, Merchant TE, Gajjar A, et al. Late neurocognitive sequelae in survivors of brain tumours in childhood. Lancet Oncol. 2004;5(7):399-408.
28. Reddick WE, White HA, Glass JO, et al. Developmental model relating white matter volume to neurocognitive deficits in pediatric brain tumor survivors. Cancer. 2003;97(10):2512-2519.
29. Kaemingk KL, Carey ME, Moore IM, et al. Math weaknesses in survivors of acute lymphoblastic leukemia compared to healthy children. Child Neuropsychol. 2004;10(1):14-23.
30. Butler RW, Haser JK. Neurocognitive effects of treatment for childhood cancer. Ment Retard Dev Disabil Res Rev. 2006;12(3):184-191.
31. Campbell LK, Scaduto M, Sharp W, et al. A meta-analysis of the neurocognitive sequelae of treatment for childhood acute lymphocytic leukemia. Pediatr Blood Cancer. 2007;49(1):65-73.
32. Hockenberry M, Krull K, Moore K, et al. Longitudinal evaluation of fine motor skills in children with leukemia. J Pediatr Hematol Oncol. 2007;29(8):535-539.
33. Duffner PK. Long-term effects of radiation therapy on cognitive and endocrine function in children with leukemia and brain tumors. Neurologist. 2004;10(6):293-310.
34. Merchant TE. Craniopharyngioma radiotherapy: endocrine and cognitive effects. J Pediatr Endocrinol Metab. 2006;19(Suppl 1):439-446.
35. Schatz J, Kramer JH, Ablin A, et al. Processing speed, working memory, and IQ: a developmental model of cognitive deficits following cranial radiation therapy. Neuropsychology. 2000;14(2):189-200.
36. Maddrey AM, Bergeron JA, Lombardo ER, et al. Neuropsychological performance and quality of life of 10 year survivors of childhood medulloblastoma. J Neurooncol. 2005;72(3):245-253.
37. Barrera M, Schulte F. A group social skills intervention program for survivors of childhood brain tumors. J Pediatr Psychol. 2009;34(10):1108-1118.
38. Kazak AE, Barakat LP, Meeske K, et al. Posttraumatic stress, family functioning, and social support in survivors of childhood leukemia and their mothers and fathers. J Consult Clin Psychol. 1997;65(1):120-129.
39. Stuber ML, Meeske KA, Krull KR, et al. Prevalence and predictors of posttraumatic stress disorder in adult survivors of childhood cancer. Pediatrics. 2010;125(5):e1124-1134.
40. Krull KR, Okcu MF, Potter B, et al. Screening for neurocognitive impairment in pediatric cancer long-term survivors. J Clin Oncol. 2008;26(25):4138-4143.
41. Parsons SK, Phipps S, Sung L, et al. NCI, NHLBI/PBMTC First International Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation: health-related quality of life, functional, and neurocognitive outcomes. Biol Blood Marrow Transplant. 2012;18(2):162-171.
42. Wasilewski-Masker K, Mertens AC, Patterson B, et al. Severity of health conditions identified in a pediatric cancer survivor program. Pediatr Blood Cancer. 2010;54(7):976-982.
43. Butler RW, Hill JM, Steinherz PG, et al. Neuropsychologic effects of cranial irradiation, intrathecal methotrexate, and systemic methotrexate in childhood cancer. J Clin Oncol. 1994;12(12):2621-2629.
44. Packer RJ. Radiation-induced neurocognitive decline: the risks and benefits of reducing the amount of whole-brain irradiation. Curr Neurol Neurosci Rep. 2002;2(2):131-133.
45. Barrera M, Atenafu E, Andrews GS, et al. Factors related to changes in cognitive, educational and visual motor integration in children who undergo hematopoietic stem cell transplant. J Pediatr Psychol. 2008;33(5):536-546.
46. Tallia H. What's new concerning the chemobrain? Rev Neurol (Paris). 2013;169(3):216-222.
47. Jim HS, Phillips KM, Chait S, et al. Meta-analysis of cognitive functioning in breast cancer survivors previously treated with standard-dose chemotherapy. J Clin Oncol. 2012;30(29):3578-3587.
48. Vardy J, Rourke S, Tannock IF. Evaluation of cognitive function associated with chemotherapy: a review of published studies and recommendations for future research. J Clin Oncol. 2007;25(17):2455-2463.
49. Frobisher C, Lancashire ER, Winter DL, et al. Long-term populationbased marriage rates among adult survivors of childhood cancer in Britain. Int J Cancer. 2007;121(4):846-855.
50. Gurney JG, Krull KR, Kadan-Lottick N, et al. Social outcomes in the Childhood Cancer Survivor Study cohort. J Clin Oncol. 2009;27(14):2390-2395.
51. Mitby PA, Robison LL, Whitton JA, et al. Utilization of special education services and educational attainment among long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Cancer. 2003;97(4):1115-1126.
52. Armstrong GT, Liu Q, Yasui Y, et al. Long-term outcomes among adult survivors of childhood central nervous system malignancies in the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2009;101(13):946-958.
53. Gerhardt CA, Dixon M, Miller K, et al. Educational and occupational outcomes among survivors of childhood cancer during the transition to emerging adulthood. J Dev Behav Pediatr. 2007;28(6):448-455.
54. Kirchhoff AC, Leisenring W, Krull KR, et al. Unemployment among adult survivors of childhood cancer: a report from the childhood cancer survivor study. Med Care. 2010;48(11):1015-1025.
55. Henderson TO, Friedman DL, Meadows AT. Childhood cancer survivors: transition to adult-focused risk-based care. Pediatrics. 2010;126(1):129-136.
56. Hudson MM, Mertens AC, Yasui Y, et al. Health status of adult longterm survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. JAMA. 2003;290(12):1583-1592.
57. Roncadin C, Dennis M, Greenberg ML, et al. Adverse medical events associated with childhood cerebellar astrocytomas and medulloblastomas: natural history and relation to very long-term neurobehavioral outcome. Childs Nerv Syst. 2008;24(9):995-1002; discussion 1003.
58. Packer RJ, Gurney JG, Punyko JA, et al. Long-term neurologic and neurosensory sequelae in adult survivors of a childhood brain tumor: childhood cancer survivor study. J Clin Oncol. 2003;21(17):3255-3261.
59. Moleski M. Neuropsychological, neuroanatomical, and neurophysiological consequences of CNS chemotherapy for acute lymphoblastic leukemia. Arch Clin Neuropsychol. 2000;15(7):603-630.
60. Conklin HM, Reddick WE, Ashford J, et al. Long-term efficacy of methylphenidate in enhancing attention regulation, social skills, and academic abilities of childhood cancer survivors. J Clin Oncol. 2010;28(29):4465-4472.
61. Ullrich NJ, Embry L. Neurocognitive dysfunction in survivors of childhood brain tumors. Semin Pediatr Neurol. 2012;19(1):35-42.
62. Richards S, Pui CH, Gayon P. Systematic review and meta-analysis of randomized trials of central nervous system directed therapy for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2013;60(2):185-195.
63. Pui CH, Howard SC. Current management and challenges of malignant disease in the CNS in paediatric leukaemia. Lancet Oncol. 2008;9(3):257-268.
64. Pui CH, Thiel E. Central nervous system disease in hematologic malignancies: historical perspective and practical applications. Semin Oncol. 2009;36(4):S2-S16.
65. Aarsen FK, Paquier PF, Arts WF, et al. Cognitive deficits and predictors 3 years after diagnosis of a pilocytic astrocytoma in childhood. J Clin Oncol. 2009;27(21):3526-3532.
66. Dehorter N, Vinay L, Hammond C, et al. Timing of developmental sequences in different brain structures: physiological and pathological implications. Eur J Neurosci. 2012;35(12):1846-1856.
67. Luciana M, Conklin HM, Hooper CJ, et al. The development of nonverbal working memory and executive control processes in adolescents. Child Dev. 2005;76(3):697-712.
68. Johnston MV. Plasticity in the developing brain: implications for rehabilitation. Dev Disabil Res Rev. 2009;15(2):94-101.
69. Armstrong GT, Sklar CA, Hudson MM, et al. Long-term health status among survivors of childhood cancer: does sex matter? J Clin Oncol. 2007;25(28):4477-4489.
70. Ris MD, Packer R, Goldwein J, et al. Intellectual outcome after reduceddose radiation therapy plus adjuvant chemotherapy for medulloblastoma: a Children's Cancer Group study. J Clin Oncol. 2001;19(15):3470-3476.
71. Robison LL, Nesbit ME Jr, Sather HN, et al. Factors associated with IQ scores in long-term survivors of childhood acute lymphoblastic leukemia. Am J Pediatr Hematol Oncol. 1984;6(2):115-121.
72. Iuvone L, Peruzzi L, Colosimo C, et al. Pretreatment neuropsychological deficits in children with brain tumors. Neuro Oncol. 2011;13(5):517-524.
73. Rueckriegel SM, Blankenburg F, Henze G, et al. Loss of fine motor function correlates with ataxia and decline of cognition in cerebellar tumor survivors. Pediatr Blood Cancer. 2009;53(3):424-431.
74. Jansen J, Butow PN, van Weert JC, et al. Does age really matter? Recall of information presented to newly referred patients with cancer. J Clin Oncol. 2008;26(33):5450-5457.
75. Ellenberg L, Liu Q, Gioia G, et al. Neurocognitive status in long-term survivors of childhood CNS malignancies: a report from the Childhood Cancer Survivor Study. Neuropsychology. 2009;23(6):705-717.
76. Ullrich NJ. Inherited disorders as a factor and predictor of neurodevelopmental outcome in pediatric cancer. Dev Disabil Res Rev. 2008;14:229-237.
77. Krull KR, Brouwers P, Jain N, et al. Folate pathway genetic polymorphisms are related to attention disorders in childhood leukemia survivors. J Pediatr. 2008;152(1):101-105.
78. Kamdar KY, Krull KR, El-Zein RA, et al. Folate pathway polymorphisms predict deficits in attention and processing speed after childhood leukemia therapy. Pediatr Blood Cancer. 2011;57(3):454-460.
79. Cole PD, Beckwith KA, Vijayanathan V, et al. Folate homeostasis in cerebrospinal fluid during therapy for acute lymphoblastic leukemia. Pediatr Neurol. 2009;40(1):34-41.
80. Krull KR, Bhojwani D, Conklin HM, et al. Genetic mediators of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia. J Clin Oncol. 2013;31(17):2182-2188.
81. Espy KA, Moore IM, Kaufmann PM, et al. Chemotherapeutic CNS prophylaxis and neuropsychologic change in children with acute lymphoblastic leukemia: a prospective study. J Pediatr Psychol. 2001;26(1):1-9.
82. Waber DP, Queally JT, Catania L, et al. Neuropsychological outcomes of standard risk and high risk patients treated for acute lymphoblastic leukemia on Dana-Farber ALL consortium protocol 95-01 at 5 years postdiagnosis. Pediatr Blood Cancer. 2012;58(5):758-765.
83. Merchant TE, Conklin H, Wu S, et al. Late effects of conformal radiation therapy for pediatric patients with low-grade glioma: prospective evaluation of cognitive, endocrine, and hearing deficits. J Clin Oncol. 2009;27(22):3691-3697.
84. Ballesteros-Zebadua P, Chavarria A, Celis MA, et al. Radiation-induced neuroinflammation and radiation somnolence syndrome. CNS Neurol Disord Drug Targets. 2012;11(7):937-949.
85. Armstrong GT, Jain N, Liu W, et al. Region-specific radiotherapy and neuropsychological outcomes in adult survivors of childhood CNS malignancies. Neuro Oncol. 2010;12(11):1173-1186.
86. Shi L, Adams MM, Long A, et al. Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus. Radiat Res. 2006;166(6):892-899.
87. Ye ZC, Sontheimer H. Glioma cells release excitotoxic concentrations of glutamate. Cancer Res. 1999;59(17):4383-4391.
88. Soussain C, Ricard D, Fike JR, et al. CNS complications of radiotherapy and chemotherapy. Lancet. 2009;374(9701):1639-1651.
89. Kim JH, Brown SL, Jenrow KA, et al. Mechanisms of radiation-induced brain toxicity and implications for future clinical trials. J Neurooncol. 2008;87(3):279-286.
90. Parent JM, Tada E, Fike JR, et al. Inhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizure-induced mossy fiber synaptic reorganization in the rat. J Neurosci. 1999;19(11):4508-4519.
91. Peissner W, Kocher M, Treuer H, et al. Ionizing radiation-induced apoptosis of proliferating stem cells in the dentate gyrus of the adult rat hippocampus. Brain Res Mol Brain Res. 1999;71(1):61-68.
92. Tada E, Parent JM, Lowenstein DH, et al. X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats. Neuroscience. 2000;99(1):33-41.
93. Monje ML, Palmer T. Radiation injury and neurogenesis. Curr Opin Neurol. 2003;16(2):129-134.
94. Poussaint TY, Siffert J, Barnes PD, et al. Hemorrhagic vasculopathy after treatment of central nervous system neoplasia in childhood: diagnosis and follow-up. AJNR Am J Neuroradiol. 1995;16(4):693-699.
95. Brown WR, Thore CR, Moody DM, et al. Vascular damage after fractionated whole-brain irradiation in rats. Radiat Res. 2005;164(5):662-668.
96. Bowers DC, Liu Y, Leisenring W, et al. Late-occurring stroke among longterm survivors of childhood leukemia and brain tumors: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2006;24(33):5277-5282.
97. Gurney JG, Kadan-Lottick NS, Packer RJ, et al. Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood Cancer Survivor Study. Cancer. 2003;97(3):663-673.
98. Baumgartner JE, Ater JL, Ha CS, et al. Pathologically proven cavernous angiomas of the brain following radiation therapy for pediatric brain tumors. Pediatr Neurosurg. 2003;39(4):201-207.
99. Ullrich NJ, Robertson R, Kinnamon DD, et al. Moyamoya following cranial irradiation for primary brain tumors in children. Neurology. 2007;68(12):932-938.
100. Reddick WE, Russell JM, Glass JO, et al. Subtle white matter volume differences in children treated for medulloblastoma with conventional or reduced dose craniospinal irradiation. Magn Reson Imaging. 2000;18(7):787-793.
101. Reddick WE, Shan ZY, Glass JO, et al. Smaller white-matter volumes are associated with larger deficits in attention and learning among long-term survivors of acute lymphoblastic leukemia. Cancer. 2006;106(4):941-949.
102. Brinkman TM, Reddick WE, Luxton J, et al. Cerebral white matter integrity and executive function in adult survivors of childhood medulloblastoma. Neuro Oncol. 2012;14(Suppl 4):iv25-36.
103. Kirov I, Fleysher L, Babb JS, et al. Characterizing 'mild' in traumatic brain injury with proton MR spectroscopy in the thalamus: Initial findings. Brain Inj. 2007;21(11):1147-1154.
104. Aukema EJ, Caan MW, Oudhuis N, et al. White matter fractional anisotropy correlates with speed of processing and motor speed in young childhood cancer survivors. Int J Radiat Oncol Biol Phys. 2009;74(3):837-843.
105. Monje M, Thomason ME, Rigolo L, et al. Functional and structural differences in the hippocampus associated with memory deficits in adult survivors of acute lymphoblastic leukemia. Pediatr Blood Cancer. 2013;60(2):293-300.
106. Anderson FS, Kunin-Batson AS, Perkins JL, et al. White versus gray matter function as seen on neuropsychological testing following bone marrow transplant for acute leukemia in childhood. Neuropsychiatr Dis Treat. 2008;4(1):283-288.
107. Wells EM, Nageswara Rao AA, Scafidi J, et al. Neurotoxicity of biologically targeted agents in pediatric cancer trials. Pediatr Neurol. 2012;46(4):212-221.
108. Blaney SM, Balis FM, Poplack DG. Pharmacologic approaches to the treatment of meningeal malignancy. Oncology (Williston Park). 1991;5(5):107-116; discussion 123, 127.
109. Carey ME, Hockenberry MJ, Moore IM, et al. Brief report: effect of intravenous methotrexate dose and infusion rate on neuropsychological function one year after diagnosis of acute lymphoblastic leukemia. J Pediatr Psychol. 2007;32(2):189-193.
110. Kaleita TA, Reaman GH, MacLean WE, et al. Neurodevelopmental outcome of infants with acute lymphoblastic leukemia: a Children's Cancer Group report. Cancer. 1999;85(8):1859-1865.
111. Montour-Proulx I, Kuehn SM, Keene DL, et al. Cognitive changes in children treated for acute lymphoblastic leukemia with chemotherapy only according to the Pediatric Oncology Group 9605 protocol. J Child Neurol. 2005;20(2):129-133.
112. Spiegler BJ, Kennedy K, Maze R, et al. Comparison of long-term neurocognitive outcomes in young children with acute lymphoblastic leukemia treated with cranial radiation or high-dose or very high-dose intravenous methotrexate. J Clin Oncol. 2006;24(24):3858-3864.
113. Peterson CC, Johnson CE, Ramirez LY, et al. A meta-analysis of the neuropsychological sequelae of chemotherapy-only treatment for pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer. 2008;51(1):99-104.
114. Campbell LK, Scaduto M, Van Slyke D, et al. Executive function, coping, and behavior in survivors of childhood acute lymphocytic leukemia. J Pediatr Psychol. 2009;34(3):317-327.
115. Lofstad GE, Reinfjell T, Hestad K, et al. Cognitive outcome in children and adolescents treated for acute lymphoblastic leukaemia with chemotherapy only. Acta Paediatr. 2009;98(1):180-186.
116. Kadan-Lottick NS, Zeltzer LK, Liu Q, et al. Neurocognitive functioning in adult survivors of childhood non-central nervous system cancers. J Natl Cancer Inst. 2010;102(12):881-893.
117. Conklin HM, Krull KR, Reddick WE, et al. Cognitive outcomes following contemporary treatment without cranial irradiation for childhood acute lymphoblastic leukemia. J Natl Cancer Inst. 2012;104(18):1386-1395.
118. Kadan-Lottick NS, Brouwers P, Breiger D, et al. Comparison of neurocognitive functioning in children previously randomly assigned to intrathecal methotrexate compared with triple intrathecal therapy for the treatment of childhood acute lymphoblastic leukemia. J Clin Oncol. 2009;27(35):5986-5992.
119. Chilcote RR, Coccia P, Sather HN, et al. Mediastinal mass in acute lymphoblastic leukemia. Med Pediatr Oncol. 1984;12(1):9-16.
120. Turner CD, Chordas CA, Liptak CC, et al. Medical, psychological, cognitive and educational late-effects in pediatric low-grade glioma survivors treated with surgery only. Pediatr Blood Cancer. 2009;53(3):417-423.
121. Bellebaum C, Daum I. Mechanisms of cerebellar involvement in associative learning. Cortex. 2011;47(1):128-136.
122. Strick PL, Dum RP, Fiez JA. Cerebellum and nonmotor function. Ann Rev Neurosci. 2009;32:413-434.
123. De Smet HJ, Baillieux H, Wackenier P, et al. Long-term cognitive deficits following posterior fossa tumor resection: a neuropsychological and functional neuroimaging follow-up study. Neuropsychology. 2009;23(6):694-704.
124. Chen SH, Yang WJ, Fang YP, et al. A genome-wide approach identifies variations in the aspartate metabolism pathway that are associated with asparaginase sensitivity. Leukemia. 2011;25(1):66-74.
125. Beebe DW, Ris MD, Armstrong FD, et al. Cognitive and adaptive outcome in low-grade pediatric cerebellar astrocytomas: evidence of diminished cognitive and adaptive functioning in National Collaborative Research Studies (CCG 9891/POG 9130). J Clin Oncol. 2005;23(22):5198-5204.
126. Sorich MJ, Pottier N, Pei DQ, et al. In vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profile. PLoS Medicine. 2008;5(4):646-656.
127. Inaba H, Khan RB, Laningham FH, et al. Clinical and radiological characteristics of methotrexate-induced acute encephalopathy in pediatric patients with cancer. Ann Oncol. 2008;19(1):178-184.
128. Howard SC, Metzger ML, Wilimas JA, et al. Childhood cancer epidemiology in low-income countries. Cancer. 2008;112(3):461-472.
129. French D, Yang W, Cheng C, et al. Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia. Blood. 2009;113(19):4512-4520.
130. Sandlund JT, Santana VM, Hudson MM, et al. Combination of dexamethasone, high-dose cytarabine, and carboplatin is effective for advanced large-cell non-Hodgkin lymphoma of childhood. Cancer. 2008;113(4):782-790.
131. Roberson JR, Spraker HL, Shelso J, et al. Clinical consequences of hyperglycemia during remission induction therapy for pediatric acute lymphoblastic leukemia. Leukemia. 2009;23(2):245-250.
132. Hardy KK, Willard VW, Bonner MJ. Computerized cognitive training in survivors of childhood cancer: a pilot study. J Pediatr Oncol Nurs. 2011;28(1):27-33.
133. Annett RD, Erickson SJ. Feasibility of a school reintegration programme for children with acute lymphoblastic leukaemia. Eur J Cancer Care (Engl). 2009;18(4):421-428.
134. Charlton A, Pearson D, Morris-Jones PH. Children's return to school after treatment for solid tumours. Social science & medicine. 1986;22(12):1337-1346.
135. Ray P, Jallo GI, Kim RY, et al. Endoscopic third ventriculostomy for tumor-related hydrocephalus in a pediatric population. Neurosurg Focus. 2005;19(6):E8.
136. Wisoff JH, Sanford RA, Heier LA, et al. Primary neurosurgery for pediatric low-grade gliomas: a prospective multi-institutional study from the Children's Oncology Group. Neurosurgery. 2011;68(6):1548-1554; discussion 1554-1545.
137. Buizer AI, de Sonneville LM, Veerman AJ. Effects of chemotherapy on neurocognitive function in children with acute lymphoblastic leukemia: a critical review of the literature. Pediatr Blood Cancer. 2009;52(4):447-454.
138. Buizer AI, de Sonneville LM, van den Heuvel-Eibrink MM, et al. Chemotherapy and attentional dysfunction in survivors of childhood acute lymphoblastic leukemia: effect of treatment intensity. Pediatr Blood Cancer. 2005;45(3):281-290.
139. Robinson KE, Kuttesch JF, Champion JE, et al. A quantitative metaanalysis of neurocognitive sequelae in survivors of pediatric brain tumors. Pediatr Blood Cancer. 2010;55(3):525-531.
140. Fouladi M, Wallace D, Langston JW, et al. Survival and functional outcome of children with hypothalamic/chiasmatic tumors. Cancer. 2003;97(4):1084-1092.
141. Armstrong GT, Conklin HM, Huang S, et al. Survival and long-term health and cognitive outcomes after low-grade glioma. Neuro Oncol. 2011;13(2):223-234.
142. Carrie C, Grill J, Figarella-Branger D, et al. Online quality control, hyperfractionated radiotherapy alone and reduced boost volume for standard risk medulloblastoma: long-term results of MSFOP 98. J Clin Oncol. 2009;27(11):1879-1883.
143. Landier W, Kinahan KE, Shaw S, et al. Screening for late effects in brain tumor survivors. Cancer Treat Res. 2009;150:389-409.
144. Goldwein JW, Radcliffe J, Packer RJ, et al. Results of a pilot study of low-dose craniospinal radiation therapy plus chemotherapy for children younger than 5 years with primitive neuroectodermal tumors. Cancer. 1993;71(8):2647-2652.
145. Duffner PK, Horowitz ME, Krischer JP, et al. Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. N Engl J Med. 1993;328(24):1725-1731.
146. Geyer JR, Sposto R, Jennings M, et al. Multiagent chemotherapy and deferred radiotherapy in infants with malignant brain tumors: a report from the Children's Cancer Group. J Clin Oncol. 2005;23(30):7621-7631.
147. Rutkowski S, Bode U, Deinlein F, et al. Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med. 2005;352(10):978-986.
148. Dhall G, Grodman H, Ji L, et al. Outcome of children less than three years old at diagnosis with non-metastatic medulloblastoma treated with chemotherapy on the "Head Start" I and II protocols. Pediatr Blood Cancer. 2008;50(6):1169-1175.
149. Goldwein JW, Radcliffe J, Johnson J, et al. Updated results of a pilot study of low dose craniospinal irradiation plus chemotherapy for children under five with cerebellar primitive neuroectodermal tumors (medulloblastoma). Int J Radiat Oncol Biol Phys. 1996;34(4):899-904.
150. Palmer SL, Reddick WE, Gajjar A. Understanding the cognitive impact on children who are treated for medulloblastoma. J Pediatr Psychol. 2007;32(9):1040-1049.
151. Jain N, Brouwers P, Okcu MF, et al. Sex-specific attention problems in long-term survivors of pediatric acute lymphoblastic leukemia. Cancer. 2009;115(18):4238-4245.
152. Ashley DM, Merchant TE, Strother D, et al. Induction chemotherapy and conformal radiation therapy for very young children with nonmetastatic medulloblastoma: Children's Oncology Group study P9934. J Clin Oncol. 2012;30(26):3181-3186.
153. Ashley DM, Riffkin CD, Lovric MM, et al. In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs. Br J Cancer. 2008;99(2):294-304.
154. Sands SA, Oberg JA, Gardner SL, et al. Neuropsychological functioning of children treated with intensive chemotherapy followed by myeloablative consolidation chemotherapy and autologous hematopoietic cell rescue for newly diagnosed CNS tumors: an analysis of the Head Start II survivors. Pediatr Blood Cancer. 2010;54(3):429-436.
155. Qaddoumi I, Carey SS, Conklin H, et al. Characterization, treatment, and outcome of intracranial neoplasms in the first 120 days of life. J Child Neurol. 2011;26(8):988-994.
156. Leukemia & Lymphoma Society. Learning and Living with Cancer. 2013. Available at: http://www.lls.org/content/nationalcontent/resourcecenter/ freeeducationmaterials/childhoodbloodcancer/pdf/learninglivingwithcancer. pdf. Accessed January 10, 2014.
157. Children's Oncology Group. Long-term follow-up guidelines for survivors of childhood, adolescent, and young adult cancers. 2008. Available at: www. survivorshipguidelines.org. Accessed February 22, 2013.
158. af Sandeberg M, Johansson E, Bjork O, et al. Health-related quality of life relates to school attendance in children on treatment for cancer. J Pediatr Oncol Nurs. 2008;25(5):265-274.
159. Children's Oncology Group. School Support. Available at: http://www. childrensoncologygroup.org/index.php/school-support. Accessed January 10, 2014.
160. Charlton A, Larcombe IJ, Meller ST, et al. Absence from school related to cancer and other chronic conditions. Arch Dis Child. 1991;66(10):1217-1222.
161. Searle NS, Askins M, Bleyer WA. Homebound schooling is the least favorable option for continued education of adolescent cancer patients: a preliminary report. Med Pediatr Oncol. 2003;40(6):380-384.
162. Bruce BS, Newcombe J, Chapman A. School liaison program for children with brain tumors. J Pediatr Oncol Nurs. 2012;29(1):45-54.
163. Carpentieri SC, Mulhern RK. Patterns of memory dysfunction among children surviving temporal lobe tumors. Arch Clin Neuropsychol. 1993;8(4):345-357.
164. Varni JW, Katz ER, Colegrove R Jr, et al. The impact of social skills training on the adjustment of children with newly diagnosed cancer. J Pediatr Psychol. 1993;18(6):751-767.
165. Radcliffe J, Bennett D, Kazak AE, et al. Adjustment in childhood brain tumor survival: child, mother, and teacher report. J Pediatr Psychol. 1996;21(4):529-539.
166. Barakat LP, Hetzke JD, Foley B, et al. Evaluation of a social-skills training group intervention with children treated for brain tumors: a pilot study. J Pediatr Psychol. 2003;28(5):299-307.
167. Die-Trill M, Bromberg J, LaVally B, et al. Development of social skills in boys with brain tumors: a group approach. J Psychosoc Oncol. 1996;14(2):20.
168. Pai AL, Tackett A, Ittenbach RF, et al. Psychosocial Assessment Tool 2.0 General: validity of a psychosocial risk screener in a pediatric kidney transplant sample. Pediatr Transplant. 2012;16(1):92-98.
169. Cicerone KD, Dahlberg C, Malec JF, et al. Evidence-based cognitive rehabilitation: updated review of the literature from 1998 through 2002. Arch Phys Med Rehabil. 2005;86(8):1681-1692.
170. Galbiati S, Recla M, Pastore V, et al. Attention remediation following traumatic brain injury in childhood and adolescence. Neuropsychology. 2009;23(1):40-49.
171. Catroppa C, Anderson VA, Muscara F, et al. Educational skills: longterm outcome and predictors following paediatric traumatic brain injury. Neuropsychol Rehabil. 2009;19(5):716-732.
172. Fenwick T, Anderson V. Impairments of attention following childhood traumatic brain injury. Child Neuropsychol. 1999;5(4):213-223.
173. Yeates KO, Swift E, Taylor HG, et al. Short-and long-term social outcomes following pediatric traumatic brain injury. J Int Neuropsychol Soc. 2004;10(3):412-426.
174. Gioia GA, Isquith PK. Ecological assessment of executive function in traumatic brain injury. Dev Neuropsychol. 2004;25(1-2):135-158.
175. Anderson V, Catroppa C. Recovery of executive skills following paediatric traumatic brain injury (TBI): a 2 year follow-up. Brain Inj. 2005;19(6):459-470.
176. Anderson V, Catroppa C, Morse S, et al. Functional plasticity or vulnerability after early brain injury? Pediatrics. 2005;116(6):1374-1382.
177. Catroppa C, Anderson VA, Morse SA, et al. Children's attentional skills 5 years post-TBI. J Pediatr Psychol. 2007;32(3):354-369.
178. Butler RW, Copeland DR, Fairclough DL, et al. A multicenter, randomized clinical trial of a cognitive remediation program for childhood survivors of a pediatric malignancy. J Consult Clin Psychol. 2008;76(3):367-378.
179. Patel SK, Katz ER, Richardson R, et al. Cognitive and problem solving training in children with cancer: a pilot project. J Pediatr Hematol Oncol. 2009;31(9):670-677.
180. van't Hooft I, Norberg AL. SMART cognitive training combined with a parental coaching programme for three children treated for medulloblastoma. NeuroRehabilitation. 2010;26(2):105-113.
181. Moore IM, Hockenberry MJ, Anhalt C, et al. Mathematics intervention for prevention of neurocognitive deficits in childhood leukemia. Pediatr Blood Cancer. 2012;59(2):278-284.
182. Hardy KK, Willard VW, Allen TM, et al. Working memory training in survivors of pediatric cancer: a randomized pilot study. Psycho-oncology. 2013;22(8):1856-1865.
183. Reddick WE, Conklin HM. Impact of acute lymphoblastic leukemia therapy on attention and working memory in children. Expert Rev Hematol. 2010;3(6):655-659.
184. Chavez B, Sopko MA Jr, Ehret MJ, et al. An update on central nervous system stimulant formulations in children and adolescents with attentiondeficit/ hyperactivity disorder. Ann Pharmacother. 2009;43(6):1084-1095.
185. Hanwella R, Senanayake M, de Silva V. Comparative efficacy and acceptability of methylphenidate and atomoxetine in treatment of attention deficit hyperactivity disorder in children and adolescents: a meta-analysis. BMC Psychiatry. 2011;11:176.
186. Thompson SJ, Leigh L, Christensen R, et al. Immediate neurocognitive effects of methylphenidate on learning-impaired survivors of childhood cancer. J Clin Oncol. 2001;19(6):1802-1808.
187. Conklin HM, Lawford J, Jasper BW, et al. Side effects of methylphenidate in childhood cancer survivors: a randomized placebo-controlled trial. Pediatrics. 2009;124(1):226-233.
188. Jasper BW, Conklin HM, Lawford J, et al. Growth effects of methylphenidate among childhood cancer survivors: a 12-month case-matched openlabel study. Pediatr Blood Cancer. 2009;52(1):39-43.
189. Butler RW, Sahler OJ, Askins MA, et al. Interventions to improve neuropsychological functioning in childhood cancer survivors. Dev Disabil Res Rev. 2008;14(3):251-258.
190. Biederman J, Pliszka SR. Modafinil improves symptoms of attention-deficit/ hyperactivity disorder across subtypes in children and adolescents. J Pediatr. 2008;152(3):394-399.
191. Biederman J, Swanson JM, Wigal SB, et al. Efficacy and safety of modafinil film-coated tablets in children and adolescents with attention-deficit/ hyperactivity disorder: results of a randomized, double-blind, placebocontrolled, flexible-dose study. Pediatrics. 2005;116(6):e777-784.
192. Boellner SW, Earl CQ, Arora S. Modafinil in children and adolescents with attention-deficit/hyperactivity disorder: a preliminary 8-week, open-label study. Curr Med Res Opin. 2006;22(12):2457-2465.
193. Ivanenko A, Tauman R, Gozal D. Modafinil in the treatment of excessive daytime sleepiness in children. Sleep medicine. 2003;4(6):579-582.
194. Morgenthaler TI, Kapur VK, Brown T, et al. Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin. Sleep. 2007;30(12):1705-1711.
195. Rugino TA, Samsock TC. Modafinil in children with attention-deficit hyperactivity disorder. Pediatr Neurol. 2003;29(2):136-142.
196. Swanson JM, Greenhill LL, Lopez FA, et al. Modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder: results of a randomized, double-blind, placebo-controlled, fixed-dose study followed by abrupt discontinuation. J Clin Psychiatry. 2006;67(1):137-147.
197. Pataki CS, Feinberg DT, McGough JJ. New drugs for the treatment of attention-deficit/hyperactivity disorder. Expert Opin Emerg Drugs. 2004;9(2):293-302.
198. Shaw EG, Rosdhal R, D'Agostino RB Jr, et al. Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life. J Clin Oncol. 2006;24(9):1415-1420.
199. Randall DC, Shneerson JM, File SE. Cognitive effects of modafinil in student volunteers may depend on IQ. Pharmacol Biochem Behav. 2005;82(1):133-139.
200. Turner DC, Robbins TW, Clark L, et al. Cognitive enhancing effects of modafinil in healthy volunteers. Psychopharmacology (Berl). 2003;165(3):260-269.
201. Kaleita TA, Wellisch DK, Graham CA, et al. Pilot study of modafinil for treatment of neurobehavioral dysfunction and fatigue in adult patients with brain tumors. J Clin Oncol. 2006;24(18S):1503.
202. Gehring K, Patwardhan SY, Collins R, et al. A randomized trial on the efficacy of methylphenidate and modafinil for improving cognitive functioning and symptoms in patients with a primary brain tumor. J Neurooncol. 2012;107(1):165-174.
203. Passmore AP, Bayer AJ, Steinhagen-Thiessen E. Cognitive, global, and functional benefits of donepezil in Alzheimer's disease and vascular dementia: results from large-scale clinical trials. J Neurol Sci. 2005;229-230:141-146.
204. Kishnani PS, Sullivan JA, Walter BK, et al. Cholinergic therapy for Down's syndrome. Lancet. 1999;353(9158):1064-1065.
205. Kondoh T, Nakashima M, Sasaki H, et al. Pharmacokinetics of donepezil in Down syndrome. Ann Pharmacother. 2005;39(3):572-573.
206. Heller JH, Spiridigliozzi GA, Doraiswamy PM, et al. Donepezil effects on language in children with Down syndrome: results of the first 22-week pilot clinical trial. Am J Med Genet A. 2004;130(3):325-326.
207. Hardan AY, Handen BL. A retrospective open trial of adjunctive donepezil in children and adolescents with autistic disorder. J Child Adolesc Psychopharmacol. 2002;12(3):237-241.
208. Chez MG, Tremb RJ, Nowinski CV, et al. Double-blinded placebo-controlled Aricept study in children with autistic-spectrum disorder. Ann Neurol. 2001;49:S95-S96.
209. Rapp SR, Rosdhal R, D'Agostino RB, et al. Improving cognitive functioning in brain irradiated patients: A Phase II trial of an acetylcholinesterase inhibitor (donepezil). Neuro-oncol. 2004;6:357.
210. Shaw EG, Rosdhal R, D'Agostino RB, et al. A phase II study of donepezil in irradiated brain tumor patients: effect on health-related quality of life and mood. Neuro-oncol. 2004;6:358.
211. Castellino SM, Tooze JA, Flowers L, et al. Toxicity and efficacy of the acetylcholinesterase (AChe) inhibitor donepezil in childhood brain tumor survivors: a pilot study. Pediatr Blood Cancer. 2012;59(3):540-547.
212. Webb EA, O'Reilly MA, Clayden JD, et al. Effect of growth hormone deficiency on brain structure, motor function and cognition. Brain. 2012;135(Pt 1):216-227.
213. Waters MJ, Blackmore DG. Growth hormone (GH), brain development and neural stem cells. Pediatr Endocrinol Rev. 2011;9(2):549-553.
214. Huisman J, Aukema EJ, Deijen JB, et al. The usefulness of growth hormone treatment for psychological status in young adult survivors of childhood leukaemia: an open-label study. BMC Pediatr. 2008;8:25.
215. Arwert LI, Deijen JB, Witlox J, et al. The influence of growth hormone (GH) substitution on patient-reported outcomes and cognitive functions in GH-deficient patients: a meta-analysis. Growth Horm IGF Res. 2005;15(1):47-54.
216. Reimunde P, Quintana A, Castanon B, et al. Effects of growth hormone (GH) replacement and cognitive rehabilitation in patients with cognitive disorders after traumatic brain injury. Brain Inj. 2011;25(1):65-73.
217. Stephen MD, Varni JW, Limbers CA, et al. Health-related quality of life and cognitive functioning in pediatric short stature: comparison of growth-hormone-naive, growth-hormone-treated, and healthy samples. Eur J Pediatr. 2011;170(3):351-358.
218. Siemensma EP, Tummers-de Lind van Wijngaarden RF, Festen DA, et al. Beneficial effects of growth hormone treatment on cognition in children with Prader-Willi syndrome: a randomized controlled trial and longitudinal study. J Clin Endocrinol Metab. 2012;97(7):2307-2314.
219. Baker LD, Barsness SM, Borson S, et al. Effects of growth hormonereleasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial. Arch Neurol. 2012;69(11):1420-1429.
220. Jansen NC, Kingma A, Schuitema A, et al. Neuropsychological outcome in chemotherapy-only-treated children with acute lymphoblastic leukemia. J Clin Oncol. 2008;26(18):3025-3030.
221. Heilbronner RL, Sweet JJ, Attix DK, et al. Official position of the American Academy of Clinical Neuropsychology on serial neuropsychological assessments: the utility and challenges of repeat test administrations in clinical and forensic contexts. Clin Neuropsychol. 2010;24(8):1267-1278.
222. Embry L, Annett RD, Kunin-Batson A, et al. Implementation of multi-site neurocognitive assessments within a pediatric cooperative group: can it be done? Pediatr Blood Cancer. 2012;59(3):536-539.
223. Krull K, Jain N, Pan Z, et al. Executive functions in aging adult survivors of childhood leukemia. J Clin Oncol. 2010;28(15s):9011.
224. Castellino SM, Tooze JA, Flowers L, et al. The peabody picture vocabulary test as a pre-screening tool for global cognitive functioning in childhood brain tumor survivors. J Neurooncol. 2011;104(2):559-563.
225. Pejnovic LP, De Luca CR, Gentle E, et al. Feasibility of neurobehavioral screening following diagnosis of pediatric cancer. Pediatr Blood Cancer. 2012;59(2):295-300.
226. Maruff P, Thomas E, Cysique L, et al. Validity of the CogState brief battery: relationship to standardized tests and sensitivity to cognitive impairment in mild traumatic brain injury, schizophrenia, and AIDS dementia complex. Arch Clin Neuropsychol. 2009;24(2):165-178.
227. Fliessbach K, Rogowski S, Hoppe C, et al. Computer-based assessment of cognitive functions in brain tumor patients. J Neurooncol. 2010;100(3):427-437.
228. Edelstein K, D'Agostino N, Bernstein LJ, et al. Long-term neurocognitive outcomes in young adult survivors of childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2011;33(6):450-458.
229. Iverson GL. Sensitivity of computerized neuropsychological screening in depressed university students. Clin Neuropsychol. 2006;20(4):695-701.
230. National Institutes of Health; Northwestern University. NIH Toolbox: Assessment of neurological and behavioral function. Available at: www. nihtoolbox.org. Accessed January 10, 2014.
231. Hinds PS, Nuss SL, Ruccione KS, et al. PROMIS pediatric measures in pediatric oncology: Valid and clinically feasible indicators of patientreported outcomes. Pediatr Blood Cancer. 2013;60(3):402-408.
232. Lai JS, Cella D, Choi S, et al. How item banks and their application can influence measurement practice in rehabilitation medicine: a PROMIS fatigue item bank example. Arch Phys Med Rehabil. 2011;92(10 Suppl):S20-27.
233. Irwin DE, Gross HE, Stucky BD, et al. Development of six PROMIS pediatrics proxy-report item banks. Health Qual Life Outcomes. 2012;10:22.
234. Quinn GP, Murphy D, Knapp C, et al. Who decides? Decision making and fertility preservation in teens with cancer: a review of the literature. J Adolesc Health. 2011;49(4):337-346.
235. Quillen J, Crawford E, Plummer B, et al. Parental follow-through of neuropsychological recommendations for childhood-cancer survivors. J Pediatr Oncol Nurs. 2011;28(5):306-310.
236. Noll RB, Patel SK, Embry L, et al. Children's Oncology Group's 2013 blueprint for research: Behavioral science. Pediatr Blood Cancer. 2012;60(6):1048-1054.
237. Caroni P, Donato F, Muller D. Structural plasticity upon learning: regulation and functions. Nat Rev Neurosci. 2012;13(7):478-490.
238. Wang JY, Bakhadirov K, Devous MD Sr, et al. Diffusion tensor tractography of traumatic diffuse axonal injury. Arch Neurol. 2008;65(5):619-626.
239. Huisman TA, Schwamm LH, Schaefer PW, et al. Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury. AJNR Am J Neuroradiol. 2004;25(3):370-376.
240. Levin HS, Wilde EA, Chu Z, et al. Diffusion tensor imaging in relation to cognitive and functional outcome of traumatic brain injury in children. J Head Trauma Rehabil. 2008;23(4):197-208.
241. Miketova P, Kaemingk K, Hockenberry M, et al. Oxidative changes in cerebral spinal fluid phosphatidylcholine during treatment for acute lymphoblastic leukemia. Biol Res Nurs. 2005;6(3):187-195.
242. Moore IM, Miketova P, Hockenberry M, et al. Methotrexate-induced alterations in beta-oxidation correlate with cognitive abilities in children with acute lymphoblastic leukemia. Biol Res Nurs. 2008;9(4):311-319.
243. Caron JE, Krull KR, Hockenberry M, et al. Oxidative stress and executive function in children receiving chemotherapy for acute lymphoblastic leukemia. Pediatr Blood Cancer. 2009;53(4):551-556.
244. Stenzel SL, Krull KR, Hockenberry M, et al. Oxidative stress and neurobehavioral problems in pediatric acute lymphoblastic leukemia patients undergoing chemotherapy. J Pediatr Hematol Oncol. 2009;32(2):113-118.
245. Ramanan S, Kooshki M, Zhao W, et al. PPARalpha ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-kappaB and AP-1 pathways. Free Radic Biol Med. 2008;45(12):1695-1704.
246. Gehring K, Sitskoorn MM, Gundy CM, et al. Cognitive rehabilitation in patients with gliomas: a randomized, controlled trial. J Clin Oncol. 2009;27(22):3712-3722.
247. Extermann M, Chen H, Booth-Jones M, et al. Pilot testing of the computerized cognitive test Microcog in chemotherapy-treated older cancer patients. Crit Rev Oncol Hematol. 2005;54(2):137-143.
248. Gehring K, Roukema JA, Sitskoorn MM. Review of recent studies on interventions for cognitive deficits in patients with cancer. Expert Rev Anticancer Ther. 2012;12(2):255-269.
249. Krull KR, Sabin ND, Reddick WE, et al. Neurocognitive function and CNS integrity in adult survivors of childhood hodgkin lymphoma. J Clin Oncol. 2012;30(29):3618-3624.
250. Kazak AE, Brier M, Alderfer MA, et al. Screening for psychosocial risk in pediatric cancer. Pediatr Blood Cancer. 2012;59(5):822-827.
251. Moore IM, Espy KA, Kaufmann P, et al. Cognitive consequences and central nervous system injury following treatment for childhood leukemia. Semin Oncol Nurs. 2000;16(4):279-290; discussion 291-279.
252. Kerns KA, Thomson J. Implementation of a compensatory memory system in a school age child with severe memory impairment. Pediatr Rehabil. 1998;2(2):77-87.
253. Kazak AE, Simms S, Alderfer MA, et al. Feasibility and preliminary outcomes from a pilot study of a brief psychological intervention for families of children newly diagnosed with cancer. J Pediatr Psychol. 2005;30(8):644-655.
254. DeLong R, Friedman H, Friedman N, et al. Methylphenidate in neuropsychological sequelae of radiotherapy and chemotherapy of childhood brain tumors and leukemia. J Child Neurol. 1992;7(4):462-463.
255. Mulhern RK, White HA, Glass JO, et al. Attentional functioning and white matter integrity among survivors of malignant brain tumors of childhood. J Int Neuropsychol Soc. 2004;10(2):180-189.
256. Conklin HM, Helton S, Ashford J, et al. Predicting methylphenidate response in long-term survivors of childhood cancer: a randomized, double-blind, placebo-controlled, crossover trial. J Pediatr Psychol. 2010;35(2):144-155.
257. Torres CF, Korones DN, Palumbo DR, et al. Effect of methylphenidate in the postradiation attention and memory deficits in childrent. Ann Neurol. 1996;40(2):331-332.