-
2
-
-
39749087795
-
Randomized phase II trial of erlotinib or standard chemotherapy in patients with advanced non-small-cell lung cancer and a performance status of 2
-
DOI 10.1200/JCO.2007.13.2720
-
Lilenbaum R, Axelrod R, Thomas S, et al. Randomized phase II trial of erlotinib or standard chemotherapy in patients with advanced non-small-cell lung cancer and a performance status of 2. J Clin Oncol 2008;26:863-9. (Pubitemid 351398077)
-
(2008)
Journal of Clinical Oncology
, vol.26
, Issue.6
, pp. 863-869
-
-
Lilenbaum, R.1
Axelrod, R.2
Thomas, S.3
Dowlati, A.4
Seigel, L.5
Albert, D.6
Witt, K.7
Botkin, D.8
-
3
-
-
67651102970
-
Phase I study of concurrent whole brain radiotherapy and erlotinib for multiple brain metastases from non-small-cell lung cancer
-
Lind JS, Lagerwaard FJ, Smit EF, Senan S. Phase I study of concurrent whole brain radiotherapy and erlotinib for multiple brain metastases from non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 2009;74:1391-6.
-
(2009)
Int J Radiat Oncol Biol Phys
, vol.74
, pp. 1391-1396
-
-
Lind, J.S.1
Lagerwaard, F.J.2
Smit, E.F.3
Senan, S.4
-
4
-
-
34547852270
-
Phase II study of FOLFOX, bevacizumab and erlotinib as first-line therapy for patients with metastastic colorectal cancer
-
DOI 10.1093/annonc/mdm124
-
Meyerhardt JA, Stuart K, Fuchs CS, et al. Phase II study of FOLFOX, bevacizumab and erlotinib as first-line therapy for patients with metastatic colorectal cancer. Ann Oncol 2007;18:1185-9. (Pubitemid 47244364)
-
(2007)
Annals of Oncology
, vol.18
, Issue.7
, pp. 1185-1189
-
-
Meyerhardt, J.A.1
Stuart, K.2
Fuchs, C.S.3
Zhu, A.X.4
Earle, C.C.5
Bhargava, P.6
Blaszkowsky, L.7
Enzinger, P.8
Mayer, R.J.9
Battu, S.10
Lawrence, C.11
Ryan, D.P.12
-
5
-
-
54449085941
-
Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: A Children's Oncology Group phase I consortium study
-
Jakacki RI, Hamilton M, Gilbertson RJ, et al. Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: A Children's Oncology Group phase I consortium study. J Clin Oncol 2008;26:4921-7.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4921-4927
-
-
Jakacki, R.I.1
Hamilton, M.2
Gilbertson, R.J.3
-
6
-
-
59449092893
-
Phase I and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma
-
Broniscer A, Baker SJ, Stewart CF, et al. Phase I and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma. Clin Cancer Res 2009;15:701-7.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 701-707
-
-
Broniscer, A.1
Baker, S.J.2
Stewart, C.F.3
-
7
-
-
79951611374
-
Innovative Therapies for Children with Cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing/refractory brain tumors
-
ITCC (Innovative Therapies for Children with Cancer) European Consortium
-
Geoerger B, Hargrave D, Thomas F, et al. ITCC (Innovative Therapies for Children With Cancer) European Consortium. Innovative Therapies for Children With Cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing/refractory brain tumors. Neurol Oncol 2011;13:109-18.
-
(2011)
Neurol Oncol
, vol.13
, pp. 109-118
-
-
Geoerger, B.1
Hargrave, D.2
Thomas, F.3
-
8
-
-
10644261471
-
Overview of the tolerability of gefitinib (IRESSA) monotherapy: Clinical experience in non-small-cell lung cancer
-
DOI 10.2165/00002018-200427140-00002
-
Forsythe B, Faulkner K. Overview of the tolerability of gefitinib (Iressa) monotherapy: Clinical experience in non-small-cell lung cancer. Drug Saf 2004;27:1081-92. (Pubitemid 39647851)
-
(2004)
Drug Safety
, vol.27
, Issue.14
, pp. 1081-1092
-
-
Forsythe, B.1
Faulkner, K.2
-
9
-
-
58149267547
-
High incidence of oral dysesthesias on a trial of gefitinib, paclitaxel, and concurrent external beam radiation for locally advanced head and neck cancers
-
Sharp H, Morris JC, Van Waes C, Gius D, Cooley-Zgela T, Singh AK. High incidence of oral dysesthesias on a trial of gefitinib, paclitaxel, and concurrent external beam radiation for locally advanced head and neck cancers. Am J Clin Oncol 2008;31:557-60.
-
(2008)
Am J Clin Oncol
, vol.31
, pp. 557-560
-
-
Sharp, H.1
Morris, J.C.2
Van Waes, C.3
Gius, D.4
Cooley-Zgela, T.5
Singh, A.K.6
-
10
-
-
77649328978
-
Hemorrhage of brain metastasis from non-small cell lung cancer post gefitinib therapy: Two case reports and review of the literature
-
Yan DF, Yan SX, Yang JS, et al. Hemorrhage of brain metastasis from non-small cell lung cancer post gefitinib therapy: Two case reports and review of the literature. BMC Cancer 2010;10:49.
-
(2010)
BMC Cancer
, vol.10
, pp. 49
-
-
Yan, D.F.1
Yan, S.X.2
Yang, J.S.3
-
11
-
-
64649097892
-
Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck
-
Stewart JS, Cohen EE, Licitra L, et al. Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck. J Clin Oncol 2009;27:1864-71.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1864-1871
-
-
Stewart, J.S.1
Cohen, E.E.2
Licitra, L.3
-
12
-
-
24944519394
-
Phase I and pharmacokinetic study of gefitinib in children with refractory solid tumors: A Children's Oncology Group study
-
Daw NC, Furman WL, Stewart CF, et al. Phase I and pharmacokinetic study of gefitinib in children with refractory solid tumors: A Children's Oncology Group study. J Clin Oncol 2005;23:6172-80.
-
(2005)
J Clin Oncol
, vol.23
, pp. 6172-6180
-
-
Daw, N.C.1
Furman, W.L.2
Stewart, C.F.3
-
13
-
-
78649632132
-
A phase I and biology study of gefitinib and radiation in children with newly diagnosed brain stem gliomas or supratentorial malignant gliomas
-
Geyer JR, Stewart CF, Kocak M, et al. A phase I and biology study of gefitinib and radiation in children with newly diagnosed brain stem gliomas or supratentorial malignant gliomas. Eur J Cancer 2010;46:3287-93.
-
(2010)
Eur J Cancer
, vol.46
, pp. 3287-3293
-
-
Geyer, J.R.1
Stewart, C.F.2
Kocak, M.3
-
14
-
-
76749168084
-
Tyrosine kinase inhibitor enhances the bioavailability of oral irinotecan in pediatric patients with refractory solid tumors
-
Furman WL, Navid F, Daw NC, et al. Tyrosine kinase inhibitor enhances the bioavailability of oral irinotecan in pediatric patients with refractory solid tumors. J Clin Oncol 2009;27:4599-604.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4599-4604
-
-
Furman, W.L.1
Navid, F.2
Daw, N.C.3
-
15
-
-
79955751294
-
A phase II study of gefitinib and irradiation in children with newly diagnosed brainstem gliomas: A report from the Pediatric Brain Tumor Consortium
-
Pollack IF, Stewart CF, Kocak M, et al. A phase II study of gefitinib and irradiation in children with newly diagnosed brainstem gliomas: A report from the Pediatric Brain Tumor Consortium. Neurol Oncol 2011;13:290-7.
-
(2011)
Neurol Oncol
, vol.13
, pp. 290-297
-
-
Pollack, I.F.1
Stewart, C.F.2
Kocak, M.3
-
16
-
-
77953426044
-
Role of lapatinib in the first-line treatment of patients with metastatic breast cancer
-
Oakman C, Pestrin M, Zafarana E, Cantisani E, Di Leo A. Role of lapatinib in the first-line treatment of patients with metastatic breast cancer. Cancer Manag Res 2010;2:13-25.
-
(2010)
Cancer Manag Res
, vol.2
, pp. 13-25
-
-
Oakman, C.1
Pestrin, M.2
Zafarana, E.3
Cantisani, E.4
Di Leo, A.5
-
17
-
-
77957961667
-
Phase I trial of lapatinib in children with refractory CNS malignancies: A Pediatric Brain Tumor Consortium study
-
Fouladi M, Stewart CF, Blaney SM, et al. Phase I trial of lapatinib in children with refractory CNS malignancies: A Pediatric Brain Tumor Consortium study. J Clin Oncol 2010;28:4221-7.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4221-4227
-
-
Fouladi, M.1
Stewart, C.F.2
Blaney, S.M.3
-
18
-
-
79959589199
-
Subdural hematomas in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia receiving imatinib mesylate in conjunction with systemic and intrathecal chemotherapy
-
Patel SB, Gojo I, Tidwell ML, Sausville EA, Baer MR. Subdural hematomas in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia receiving imatinib mesylate in conjunction with systemic and intrathecal chemotherapy. Leuk Lymphoma 2011;52:1211-4.
-
(2011)
Leuk Lymphoma
, vol.52
, pp. 1211-1214
-
-
Patel, S.B.1
Gojo, I.2
Tidwell, M.L.3
Sausville, E.A.4
Baer, M.R.5
-
19
-
-
79551698022
-
Administration of imatinib in the first 90 days after allogeneic hematopoietic cell transplantation in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia
-
Engl
-
Chen H, Liu KY, Xu LP, et al. Administration of imatinib in the first 90 days after allogeneic hematopoietic cell transplantation in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Chin Med J [Engl] 2011;124:246-52.
-
(2011)
Chin Med J
, vol.124
, pp. 246-252
-
-
Chen, H.1
Liu, K.Y.2
Xu, L.P.3
-
20
-
-
70449711127
-
Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: A Children's Oncology Group study
-
Schultz KR, Bowman WP, Aledo A, et al. Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: A Children's Oncology Group study. J Clin Oncol 2009;27:5175-81.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5175-5181
-
-
Schultz, K.R.1
Bowman, W.P.2
Aledo, A.3
-
21
-
-
79960983264
-
Children's Oncology Group phase 1 study: Imatinib mesylate (STI571) for treatment of children with Philadelphia chromosome-positive leukemia: Results from a Children's Oncology Group phase 1 study
-
Champagne MA, Capdeville R, Krailo M, et al. Children's Oncology Group phase 1 study: Imatinib mesylate (STI571) for treatment of children with Philadelphia chromosome-positive leukemia: Results from a Children's Oncology Group phase 1 study. Clin Cancer Res 2011;17:5113-22.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 5113-5122
-
-
Champagne, M.A.1
Capdeville, R.2
Krailo, M.3
-
22
-
-
34147202548
-
Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: A Pediatric Brain Tumor Consortium report
-
DOI 10.1215/15228517-2006-031
-
Pollack IF, Jakacki RI, Blaney SM, et al. Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: A Pediatric Brain Tumor Consortium report. Neurol Oncol 2007;9:145-60. (Pubitemid 46580316)
-
(2007)
Neuro-Oncology
, vol.9
, Issue.2
, pp. 145-160
-
-
Pollack, I.F.1
Jakacki, R.I.2
Blaney, S.M.3
Hancock, M.L.4
Kieran, M.W.5
Phillips, P.6
Kun, L.E.7
Friedman, H.8
Packer, R.9
Banerjee, A.10
Geyer, J.R.11
Goldman, S.12
Poussaint, T.Y.13
Krasin, M.J.14
Wang, Y.15
Hayes, M.16
Murgo, A.17
Weiner, S.18
Boyett, J.M.19
-
23
-
-
80052790433
-
H. Distinct impact of imatinib on growth at prepubertal and pubertal ages of children with chronic myeloid leukemia
-
Shima H, Tokuyama M, Tanizawa A, et al. H. Distinct impact of imatinib on growth at prepubertal and pubertal ages of children with chronic myeloid leukemia. J Pediatr 2011;159:676-81.
-
(2011)
J Pediatr
, vol.159
, pp. 676-681
-
-
Shima, H.1
Tokuyama, M.2
Tanizawa, A.3
-
25
-
-
77951269420
-
Risk of cardiac ischemia and arterial thromboembolic events with the angiogenesis inhibitor bevacizumab in cancer patients: A meta-analysis of randomized controlled trials
-
Ranpura V, Hapani S, Chuang J, Wu S. Risk of cardiac ischemia and arterial thromboembolic events with the angiogenesis inhibitor bevacizumab in cancer patients: A meta-analysis of randomized controlled trials. Acta Oncol 2010;49:287-97.
-
(2010)
Acta Oncol
, vol.49
, pp. 287-297
-
-
Ranpura, V.1
Hapani, S.2
Chuang, J.3
Wu, S.4
-
26
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
DOI 10.1056/NEJMoa032691
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335-42. (Pubitemid 38702844)
-
(2004)
New England Journal of Medicine
, vol.350
, Issue.23
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
Cartwright, T.4
Hainsworth, J.5
Heim, W.6
Berlin, J.7
Baron, A.8
Griffing, S.9
Holmgren, E.10
Ferrara, N.11
Fyfe, G.12
Rogers, B.13
Ross, R.14
Kabbinavar, F.15
-
27
-
-
34249294557
-
Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
-
DOI 10.1038/nrc2152, PII NRC2152
-
Verheul HM, Pinedo HM. Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition. Nat Rev Cancer 2007;7:475-85. (Pubitemid 46809172)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.6
, pp. 475-485
-
-
Verheul, H.M.W.1
Pinedo, H.M.2
-
28
-
-
77749336334
-
Bevacizumab for malignant gliomas
-
Iwamoto FM, Fine HA. Bevacizumab for malignant gliomas. Arch Neurol 2010;67:285-8.
-
(2010)
Arch Neurol
, vol.67
, pp. 285-288
-
-
Iwamoto, F.M.1
Fine, H.A.2
-
29
-
-
33645449812
-
Mechanisms of hypertension associated with BAY 43-9006
-
DOI 10.1200/JCO.2005.02.0503
-
Veronese ML, Mosenkis A, Flaherty KT, et al. Mechanisms of hypertension associated with BAY 43-9006. J Clin Oncol 2006;24:1363-9. (Pubitemid 46621999)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.9
, pp. 1363-1369
-
-
Veronese, M.L.1
Mosenkis, A.2
Flaherty, K.T.3
Gallagher, M.4
Stevenson, J.P.5
Townsend, R.R.6
O'Dwyer, P.J.7
-
30
-
-
79958236195
-
Unexpected late radiation neurotoxicity following bevacizumab use: A case series
-
Kelly PJ, Dinkin MJ, Drappatz J, O'Regan KN, Weiss SE. Unexpected late radiation neurotoxicity following bevacizumab use: A case series. J Neurooncol 2011;102:485-90.
-
(2011)
J Neurooncol
, vol.102
, pp. 485-490
-
-
Kelly, P.J.1
Dinkin, M.J.2
Drappatz, J.3
O'Regan, K.N.4
Weiss, S.E.5
-
31
-
-
33846194568
-
Effect of bevacizumab on radiation necrosis of the brain
-
DOI 10.1016/j.ijrobp.2006.10.010, PII S0360301606032494
-
Gonzalez J, Kumar AJ, Conrad CA, Levin VA. Effect of bevacizumab on radiation necrosis of the brain. Int J Radiat Oncol Biol Phys 2007;67:323-6. (Pubitemid 46108339)
-
(2007)
International Journal of Radiation Oncology Biology Physics
, vol.67
, Issue.2
, pp. 323-326
-
-
Gonzalez, J.1
Kumar, A.J.2
Conrad, C.A.3
Levin, V.A.4
-
32
-
-
79952698481
-
Randomized double-blind placebo-controlled trial of bevacizumab therapy for radiation necrosis of the central nervous system
-
Levin VA, Bidaut L, Hou P, et al. Randomized double-blind placebo-controlled trial of bevacizumab therapy for radiation necrosis of the central nervous system. Int J Radiat Oncol Biol Phys 2011;79:1487-95.
-
(2011)
Int J Radiat Oncol Biol Phys
, vol.79
, pp. 1487-1495
-
-
Levin, V.A.1
Bidaut, L.2
Hou, P.3
-
33
-
-
0037208589
-
Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
-
Kabbinavar F, Hurwitz HI, Fehrenbacher L, et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003;21:60-5.
-
(2003)
J Clin Oncol
, vol.21
, pp. 60-65
-
-
Kabbinavar, F.1
Hurwitz, H.I.2
Fehrenbacher, L.3
-
34
-
-
0142121282
-
Bevacizumab, bleeding, thrombosis, and warfarin
-
Kilickap S, Abali H, Celik I. Bevacizumab, bleeding, thrombosis, and warfarin. J Clin Oncol 2003;21:3542-3.
-
(2003)
J Clin Oncol
, vol.21
, pp. 3542-3543
-
-
Kilickap, S.1
Abali, H.2
Celik, I.3
-
35
-
-
52949130889
-
What is the risk of intracranial bleeding during anti-VEGF therapy?
-
Carden CP, Larkin JM, Rosenthal MA. What is the risk of intracranial bleeding during anti-VEGF therapy? Neurol Oncol 2008;10:624-30.
-
(2008)
Neurol Oncol
, vol.10
, pp. 624-630
-
-
Carden, C.P.1
Larkin, J.M.2
Rosenthal, M.A.3
-
36
-
-
56649123212
-
Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: A meta-analysis
-
Nalluri SR, Chu D, Keresztes R, Zhu X, Wu S. Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: A meta-analysis. JAMA 2008;300:2277-85.
-
(2008)
JAMA
, vol.300
, pp. 2277-2285
-
-
Nalluri, S.R.1
Chu, D.2
Keresztes, R.3
Zhu, X.4
Wu, S.5
-
37
-
-
52949097474
-
Safety of anti-coagulation use and bevacizumab in patients with glioma
-
Nghiemphu PL, Green RM, Pope WB, Lai A, Cloughesy TF. Safety of anti-coagulation use and bevacizumab in patients with glioma. Neurol Oncol 2008;10:355-60.
-
(2008)
Neurol Oncol
, vol.10
, pp. 355-360
-
-
Nghiemphu, P.L.1
Green, R.M.2
Pope, W.B.3
Lai, A.4
Cloughesy, T.F.5
-
38
-
-
79551604466
-
Bleeding events in bevacizumab-treated cancer patients who received full-dose anticoagulation and remained on study
-
Leighl NB, Bennouna J, Yi J, Moore N, Hambleton J, Hurwitz H. Bleeding events in bevacizumab-treated cancer patients who received full-dose anticoagulation and remained on study. Br J Cancer 2011;104:413-8.
-
(2011)
Br J Cancer
, vol.104
, pp. 413-418
-
-
Leighl, N.B.1
Bennouna, J.2
Yi, J.3
Moore, N.4
Hambleton, J.5
Hurwitz, H.6
-
39
-
-
70350461699
-
Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
-
Friedman HS, Prados MD, Wen PY, et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol 2009;27:4733-40.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4733-4740
-
-
Friedman, H.S.1
Prados, M.D.2
Wen, P.Y.3
-
40
-
-
79959781204
-
Treatment of children with recurrent high grade gliomas with a bevacizumab containing regimen
-
Parekh C, Jubran R, Erdreich-Epstein A, et al. Treatment of children with recurrent high grade gliomas with a bevacizumab containing regimen. J Neurooncol 2011;103:673-80.
-
(2011)
J Neurooncol
, vol.103
, pp. 673-680
-
-
Parekh, C.1
Jubran, R.2
Erdreich-Epstein, A.3
-
41
-
-
77954134452
-
Bevacizumab in recurrent high-grade pediatric gliomas
-
Narayana A, Kunnakkat S, Chacko-Mathew J, et al. Bevacizumab in recurrent high-grade pediatric gliomas. Neurol Oncol 2010;12:985-90.
-
(2010)
Neurol Oncol
, vol.12
, pp. 985-990
-
-
Narayana, A.1
Kunnakkat, S.2
Chacko-Mathew, J.3
-
42
-
-
77954578108
-
Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: A Pediatric Brain Tumor Consortium study
-
Gururangan S, Chi SN, Young Poussaint T, et al. Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: A Pediatric Brain Tumor Consortium study. J Clin Oncol 2010;28:3069-75.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3069-3075
-
-
Gururangan, S.1
Chi, S.N.2
Young Poussaint, T.3
-
43
-
-
66749085796
-
Objective response of multiply recurrent low-grade gliomas to bevacizumab and irinotecan
-
Packer RJ, Jakacki R, Horn M, et al. Objective response of multiply recurrent low-grade gliomas to bevacizumab and irinotecan. Pediatr Blood Cancer 2009;52:791-5.
-
(2009)
Pediatr Blood Cancer
, vol.52
, pp. 791-795
-
-
Packer, R.J.1
Jakacki, R.2
Horn, M.3
-
44
-
-
0038352147
-
Phase II study of the efficacy and tolerability of two dosing regimens of the farnesyl transferase inhibitor, R115777, in advanced breast cancer
-
DOI 10.1200/JCO.2003.10.064
-
Johnston SR, Hickish T, Ellis P, et al. Phase II study of the efficacy and tolerability of two dosing regimens of the farnesyl transferase inhibitor, R115777, in advanced breast cancer. J Clin Oncol 2003;21:2492-9. (Pubitemid 46606330)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.13
, pp. 2492-2499
-
-
Johnston, S.R.D.1
Hickish, T.2
Ellis, P.3
Houston, S.4
Kelland, L.5
Dowsett, M.6
Salter, J.7
Michiels, B.8
Perez-Ruixo, J.J.9
Palmer, P.10
Howes, A.11
-
45
-
-
2142712474
-
Phase II study of R115777, a farnesyl transferase inhibitor, in myelodysplastic syndrome
-
DOI 10.1200/JCO.2004.08.082
-
Kurzrock R, Albitar M, Cortes JE, et al. Phase II study of R115777, a farnesyl transferase inhibitor, in myelodysplastic syndrome. J Clin Oncol 2004;22:1287-92. (Pubitemid 41079843)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.7
, pp. 1287-1292
-
-
Kurzrock, R.1
Albitar, M.2
Cortes, J.E.3
Estey, E.H.4
Faderl, S.H.5
Garcia-Manero, G.6
Thomas, D.A.7
Giles, F.J.8
Ryback, M.E.9
Thibault, A.10
De Porre, P.11
Kantarjian, H.M.12
-
46
-
-
34447308545
-
Exposure-toxicity relationships for tipifarnib in cancer patients
-
DOI 10.1111/j.1365-2125.2007.02883.x
-
Perez-Ruixo JJ, Chen W, Zhang S, Hayes S, Chow A. Exposure-toxicity relationships for tipifarnib in cancer patients. Br J Clin Pharmacol 2007;64:219-32. (Pubitemid 47063250)
-
(2007)
British Journal of Clinical Pharmacology
, vol.64
, Issue.2
, pp. 219-232
-
-
Perez-Ruixo, J.J.1
Chen, W.2
Zhang, S.3
Hayes, S.4
Chow, A.5
-
47
-
-
33747058029
-
Phase II trial of tipifarnib in patients with recurrent malignant glioma either receiving or not receiving enzyme-inducing antiepileptic drugs: A North American Brain Tumor Consortium study
-
DOI 10.1200/JCO.2006.06.2323
-
Cloughesy TF, Wen PY, Robins HI, et al. Phase II trial of tipifarnib in patients with recurrent malignant glioma either receiving or not receiving enzyme-inducing antiepileptic drugs: A North American Brain Tumor Consortium study. J Clin Oncol 2006;24:3651-6. (Pubitemid 46630540)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.22
, pp. 3651-3656
-
-
Cloughesy, T.F.1
Wen, P.Y.2
Robins, H.I.3
Chang, S.M.4
Groves, M.D.5
Fink, K.L.6
Junck, L.7
Schiff, D.8
Abrey, L.9
Gilbert, M.R.10
Lieberman, F.11
Kuhn, J.12
DeAngelis, L.M.13
Mehta, M.14
Raizer, J.J.15
Yung, W.K.A.16
Aldape, K.17
Wright, J.18
Lamborn, K.R.19
Prados, M.D.20
more..
-
48
-
-
60549100910
-
Phase II preradiation R115777 (tipifarnib) in newly diagnosed GBM with residual enhancing disease
-
New Approaches to Brain Tumor Therapy CNS Consortium
-
Lustig R, Mikkelsen T, Lesser G, et al. New Approaches to Brain Tumor Therapy CNS Consortium. Phase II preradiation R115777 (tipifarnib) in newly diagnosed GBM with residual enhancing disease. Neurol Oncol 2008;10:1004-9.
-
(2008)
Neurol Oncol
, vol.10
, pp. 1004-1009
-
-
Lustig, R.1
Mikkelsen, T.2
Lesser, G.3
-
49
-
-
33750586717
-
A phase I safety, pharmacological and biological study of the farnesyl protein transferase inhibitor, tipifarnib and capecitabine in advanced solid tumors
-
DOI 10.1093/annonc/mdl282
-
Gore L, Holden SN, Cohen RB, et al. A phase I safety, pharmacological and biological study of the farnesyl protein transferase inhibitor, tipifarnib and capecitabine in advanced solid tumors. Ann Oncol 2006;17:1709-17. (Pubitemid 44680894)
-
(2006)
Annals of Oncology
, vol.17
, Issue.11
, pp. 1709-1717
-
-
Gore, L.1
Holden, S.N.2
Cohen, R.B.3
Morrow, M.4
Pierson, A.S.5
O'Bryant, C.L.6
Persky, M.7
Gustafson, D.8
Mikule, C.9
Zhang, S.10
Palmer, P.A.11
Eckhardt, S.G.12
-
50
-
-
78650091355
-
Phase 1 trial and pharmacokinetic study of the farnesyl transferase inhibitor tipifarnib in children and adolescents with refractory leukemias: A report from the Children's Oncology Group
-
Widemann BC, Arceci RJ, Jayaprakash N, et al. Phase 1 trial and pharmacokinetic study of the farnesyl transferase inhibitor tipifarnib in children and adolescents with refractory leukemias: A report from the Children's Oncology Group. Pediatr Blood Cancer 2011;56:226-33.
-
(2011)
Pediatr Blood Cancer
, vol.56
, pp. 226-233
-
-
Widemann, B.C.1
Arceci, R.J.2
Jayaprakash, N.3
-
51
-
-
84859527240
-
Phase I trial of tipifarnib in children with newly diagnosed intrinsic diffuse brainstem glioma
-
Haas-Kogan DA, Banerjee A, Kocak M, et al. Phase I trial of tipifarnib in children with newly diagnosed intrinsic diffuse brainstem glioma. Cancer 2007;110:2535-41.
-
(2007)
Cancer
, vol.110
, pp. 2535-2541
-
-
Haas-Kogan, D.A.1
Banerjee, A.2
Kocak, M.3
-
52
-
-
33644838556
-
Phase I trial and pharmacokinetic study of the farnesyltransferase inhibitor tipifarnib in children with refractory solid tumors or neurofibromatosis type I and plexiform neurofibromas
-
DOI 10.1200/JCO.2005.03.8638
-
Widemann BC, Salzer WL, Arceci RJ, et al. Phase I trial and pharmacokinetic study of the farnesyltransferase inhibitor tipifarnib in children with refractory solid tumors or neurofibromatosis type I and plexiform neurofibromas. J Clin Oncol 2006;24:507-16. (Pubitemid 46630471)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.3
, pp. 507-516
-
-
Widemann, B.C.1
Salzer, W.L.2
Arceci, R.J.3
Blaney, S.M.4
Fox, E.5
End, D.6
Gillespie, A.7
Whitcomb, P.8
Palumbo, J.S.9
Pitney, A.10
Jayaprakash, N.11
Zannikos, P.12
Balis, F.M.13
-
53
-
-
36448939729
-
A Phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high-grade glioma, medulloblastoma/ primitive neuroectodermal tumor, or brainstem glioma: A children's oncology group study
-
DOI 10.1002/cncr.23078
-
Fouladi M, Nicholson HS, Zhou T, et al. A phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high-grade glioma, medulloblastoma/primitive neuroectodermal tumor, or brainstem glioma: A Children's Oncology Group study. Cancer 2007;110:2535-41. (Pubitemid 350174941)
-
(2007)
Cancer
, vol.110
, Issue.11
, pp. 2535-2541
-
-
Fouladi, M.1
Nicholson, H.S.2
Zhou, T.3
Laningham, F.4
Helton, K.J.5
Holmes, E.6
Cohen, K.7
Speights, R.A.8
Wright, J.9
Pollack, I.F.10
-
54
-
-
33750589845
-
Reversible posterior leukoencephalopathy syndrome induced by RAF kinase inhibitor BAY 43-9006
-
Govindarajan R, Adusumilli J, Baxter DL, El-Khoueiry A, Harik SI. Reversible posterior leukoencephalopathy syndrome induced by RAF kinase inhibitor BAY 43-9006. J Clin Oncol 2006;24:e48.
-
(2006)
J Clin Oncol
, vol.24
-
-
Govindarajan, R.1
Adusumilli, J.2
Baxter, D.L.3
El-Khoueiry, A.4
Harik, S.I.5
-
55
-
-
34848922067
-
Sunitinib induced hypertension, thrombotic microangiopathy and reversible posterior leukencephalopathy syndrome [3]
-
DOI 10.1093/annonc/mdm454
-
Kapiteijn E, Brand A, Kroep J, Gelderblom H. Sunitinib induced hypertension, thrombotic microangiopathy and reversible posterior leukencephalopathy syndrome. Ann. Oncol 2007;18:1745-7. (Pubitemid 47506266)
-
(2007)
Annals of Oncology
, vol.18
, Issue.10
, pp. 1745-1747
-
-
Kapiteijn, E.1
Brand, A.2
Kroep, J.3
Gelderblom, H.4
-
56
-
-
34548169627
-
Reversible posterior leukoencephalopathy syndrome induced by sunitinib
-
Martin G, Bellido L, Cruz JJ. Reversible posterior leukoencephalopathy syndrome induced by sunitinib. J Clin Oncol 2007;25:35-59.
-
(2007)
J Clin Oncol
, vol.25
, pp. 35-59
-
-
Martin, G.1
Bellido, L.2
Cruz, J.J.3
-
57
-
-
70350002279
-
Adverse effects of anticancer agents that target the VEGF pathway
-
Chen HX, Cleck JN. Adverse effects of anticancer agents that target the VEGF pathway. Nat Rev Clin Oncol 2009;6:465-77.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 465-477
-
-
Chen, H.X.1
Cleck, J.N.2
-
58
-
-
77953033291
-
Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: Results of a pharmacokinetic/pharmacodynamic meta-analysis
-
Houk BE, Bello CL, Poland B, et al. Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: Results of a pharmacokinetic/pharmacodynamic meta-analysis. Cancer Chemother Pharmacol 2010;66:357-71.
-
(2010)
Cancer Chemother Pharmacol
, vol.66
, pp. 357-371
-
-
Houk, B.E.1
Bello, C.L.2
Poland, B.3
-
59
-
-
49249113484
-
Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity
-
Azad NS, Posadas EM, Kwitkowski VE, et al. Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity. J Clin Oncol 2008;26:3709-14.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3709-3714
-
-
Azad, N.S.1
Posadas, E.M.2
Kwitkowski, V.E.3
-
60
-
-
79955767772
-
Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib
-
Rini BI, Cohen DP, Lu DR, et al. Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib. JNCI 2011;103:763-73.
-
(2011)
JNCI
, vol.103
, pp. 763-773
-
-
Rini, B.I.1
Cohen, D.P.2
Lu, D.R.3
-
61
-
-
39149120621
-
Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer
-
DOI 10.1200/JCO.2007.13.9303
-
Socinski MA, Novello S, Brahmer JR, et al. Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer. J Clin Oncol 2008;26:650-6. (Pubitemid 351264362)
-
(2008)
Journal of Clinical Oncology
, vol.26
, Issue.4
, pp. 650-656
-
-
Socinski, M.A.1
Novello, S.2
Brahmer, J.R.3
Rosell, R.4
Sanchez, J.M.5
Belani, C.P.6
Govindan, R.7
Atkins, J.N.8
Gillenwater, H.H.9
Pallares, C.10
Tye, L.11
Selaru, P.12
Chao, R.C.13
Scagliotti, G.V.14
-
62
-
-
79953064777
-
Simultaneous anti-angiogenic therapy and single-fraction radiosurgery in clinically relevant metastases from renal cell carcinoma
-
Staehler M, Haseke N, Nuhn P, et al. Simultaneous anti-angiogenic therapy and single-fraction radiosurgery in clinically relevant metastases from renal cell carcinoma. BJU Int 2011;108:673-8.
-
(2011)
BJU Int
, vol.108
, pp. 673-678
-
-
Staehler, M.1
Haseke, N.2
Nuhn, P.3
-
63
-
-
79960983264
-
Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: A Children's Oncology Group study
-
Dubois SG, Shusterman S, Ingle AM, et al. Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: A Children's Oncology Group study. Clin Cancer Res 2011;17:5113-22.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 5113-5122
-
-
Dubois, S.G.1
Shusterman, S.2
Ingle, A.M.3
-
64
-
-
77649137632
-
The first-in-human study of the hydrogen sulfate (Hyd-sulfate) capsule of the MEK1/2 inhibitor AZD6244 (ARRY-142886): A phase I open-label multicenter trial in patients with advanced cancer
-
Banerji U, Camidge DR, Verheul HM, et al. The first-in-human study of the hydrogen sulfate (Hyd-sulfate) capsule of the MEK1/2 inhibitor AZD6244 (ARRY-142886): A phase I open-label multicenter trial in patients with advanced cancer. Clin Cancer Res 2010;16:1613-23.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1613-1623
-
-
Banerji, U.1
Camidge, D.R.2
Verheul, H.M.3
-
65
-
-
79960587911
-
Clinical activity of mammalian target of rapamycin inhibitors in solid tumors
-
Alvarado Y, Mita MM, Vemulapalli S, Mahalingam D, Mita AC. Clinical activity of mammalian target of rapamycin inhibitors in solid tumors. Target Oncol 2011;6:69-94.
-
(2011)
Target Oncol
, vol.6
, pp. 69-94
-
-
Alvarado, Y.1
Mita, M.M.2
Vemulapalli, S.3
Mahalingam, D.4
Mita, A.C.5
-
66
-
-
80555133300
-
Rapamycin-induced posterior reversible encephalopathy in a kidney transplantation patient
-
Qin W, Tan CY, Huang X, Huang Z, Tao Y, Fu P. Rapamycin-induced posterior reversible encephalopathy in a kidney transplantation patient. Int Urol Nephrol 2011;43:913-6.
-
(2011)
Int Urol Nephrol
, vol.43
, pp. 913-916
-
-
Qin, W.1
Tan, C.Y.2
Huang, X.3
Huang, Z.4
Tao, Y.5
Fu, P.6
-
67
-
-
64749103991
-
No major neurologic complications with sirolimus use in heart transplant recipients
-
van de Beek D, Kremers WK, Kushwaha SS, McGregor CG, Wijdicks EF. No major neurologic complications with sirolimus use in heart transplant recipients. Mayo Clin Proc 2009;84:330-2.
-
(2009)
Mayo Clin Proc
, vol.84
, pp. 330-332
-
-
Van De Beek, D.1
Kremers, W.K.2
Kushwaha, S.S.3
McGregor, C.G.4
Wijdicks, E.F.5
-
68
-
-
33644827461
-
Rapamycin causes regression of astrocytomas in tuberous sclerosis complex
-
DOI 10.1002/ana.20784
-
Franz DN, Leonard J, Tudor C, et al. Rapamycin causes regression of astrocytomas in tuberous sclerosis complex. Ann Neurol 2006;59:490-8. (Pubitemid 43358069)
-
(2006)
Annals of Neurology
, vol.59
, Issue.3
, pp. 490-498
-
-
Franz, D.N.1
Leonard, J.2
Tudor, C.3
Chuck, G.4
Care, M.5
Sethuraman, G.6
Dinopoulos, A.7
Thomas, G.8
Crone, K.R.9
-
69
-
-
2942735384
-
Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
-
DOI 10.1200/JCO.2004.08.116
-
Raymond E, Alexandre J, Faivre S, et al. Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J Clin Oncol 2004;22:2336-47. (Pubitemid 41115390)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.12
, pp. 2336-2347
-
-
Raymond, E.1
Alexandre, J.2
Faivre, S.3
Vera, K.4
Materman, E.5
Boni, J.6
Leister, C.7
Korth-Bradley, J.8
Hanauske, A.9
Armand, J.-P.10
-
70
-
-
35848959875
-
A randomized, phase II trial of two dose levels of temsirolimus (CCI-779) in patients with extensive-stage small-cell lung cancer who have responding or stable disease after induction chemotherapy: A trial of the Eastern Cooperative Oncology Group (E1500)
-
DOI 10.1097/JTO.0b013e318155a439, PII 0124389420071100000009
-
Pandya KJ, Dahlberg S, Hidalgo M, et al. A randomized, phase II trial of two dose levels of temsirolimus (CCI-779) in patients with extensive-stage small-cell lung cancer who have responding or stable disease after induction chemotherapy: A trial of the Eastern Cooperative Oncology Group (E1500). J Thorac Oncol 2007;2:1036-41. (Pubitemid 350059580)
-
(2007)
Journal of Thoracic Oncology
, vol.2
, Issue.11
, pp. 1036-1041
-
-
Pandya, K.J.1
Dahlberg, S.2
Hidalgo, M.3
Cohen, R.B.4
Lee, M.W.5
Schiller, J.H.6
Johnson, D.H.7
-
71
-
-
1542398693
-
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
-
DOI 10.1200/JCO.2004.08.185
-
Atkins MB, Hidalgo M, Stadler WM, et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol 2004;22:909-18. (Pubitemid 41103603)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.5
, pp. 909-918
-
-
Atkins, M.B.1
Hidalgo, M.2
Stadler, W.M.3
Logan, T.F.4
Dutcher, J.P.5
Hudes, G.R.6
Park, Y.7
Liou, S.-H.8
Marshall, B.9
Boni, J.P.10
Dukart, G.11
Sherman, M.L.12
-
72
-
-
23944481410
-
Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma
-
DOI 10.1200/JCO.2005.13.466
-
Witzig TE, Geyer SM, Ghobrial I, et al. Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma. J Clin Oncol 2005;23:5347-56. (Pubitemid 46206988)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.23
, pp. 5347-5356
-
-
Witzig, T.E.1
Geyer, S.M.2
Ghobrial, I.3
Inwards, D.J.4
Fonseca, R.5
Kurtin, P.6
Ansell, S.M.7
Luyun, R.8
Flynn, P.J.9
Morton, R.F.10
Dakhil, S.R.11
Gross, H.12
Kaufmann, S.H.13
-
73
-
-
23944439945
-
Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer
-
DOI 10.1200/JCO.2005.66.130
-
Chan S, Scheulen ME, Johnston S, et al. Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer. J Clin Oncol 2005;23:5314-22. (Pubitemid 46206985)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.23
, pp. 5314-5322
-
-
Chan, S.1
Scheulen, M.E.2
Johnston, S.3
Mross, K.4
Cardoso, F.5
Dittrich, C.6
Eiermann, W.7
Hess, D.8
Morant, R.9
Semiglazov, V.10
Borner, M.11
Salzberg, M.12
Ostapenko, V.13
Illiger, H.-J.14
Behringer, D.15
Bardy-Bouxin, N.16
Boni, J.17
Kong, S.18
Cincotta, M.19
Moore, L.20
more..
-
74
-
-
23944453425
-
Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A north central cancer treatment group study
-
DOI 10.1200/JCO.2005.23.622
-
Galanis E, Buckner JC, Maurer MJ, et al. Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group study. J Clin Oncol 2005;23:5294-304. (Pubitemid 46206983)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.23
, pp. 5294-5304
-
-
Galanis, E.1
Buckner, J.C.2
Maurer, M.J.3
Kreisberg, J.I.4
Ballman, K.5
Boni, J.6
Peralba, J.M.7
Jenkins, R.B.8
Dakhil, S.R.9
Morton, R.F.10
Jaeckle, K.A.11
Scheithauer, B.W.12
Dancey, J.13
Hidalgo, M.14
Walsh, D.J.15
-
75
-
-
21044431575
-
Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme
-
DOI 10.1007/s10637-005-1444-0
-
Chang SM, Wen P, Cloughesy T, et al North American Brain Tumor Consortium and the National Cancer Institute. Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme. Invest New Drugs 2005;23:357-61. (Pubitemid 40980358)
-
(2005)
Investigational New Drugs
, vol.23
, Issue.4
, pp. 357-361
-
-
Chang, S.M.1
Wen, P.2
Cloughesy, T.3
Greenberg, H.4
Schiff, D.5
Conrad, C.6
Fink, K.7
Robins, H.I.8
De Angelis, L.9
Raizer, J.10
Hess, K.11
Aldape, K.12
Lamborn, K.R.13
Kuhn, J.14
Dancey, J.15
Prados, M.D.16
-
76
-
-
58749107489
-
Safety and pharmacokinetics of paclitaxel and the oral mTOR inhibitor everolimus in advanced solid tumours
-
Campone M, Levy V, Bourbouloux E, et al. Safety and pharmacokinetics of paclitaxel and the oral mTOR inhibitor everolimus in advanced solid tumours. Br J Cancer 2009;100:315-21.
-
(2009)
Br J Cancer
, vol.100
, pp. 315-321
-
-
Campone, M.1
Levy, V.2
Bourbouloux, E.3
-
77
-
-
78049510428
-
Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis
-
Krueger DA, Care MM, Holland K, et al. Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N Engl J Med 2010;363:1801-11.
-
(2010)
N Engl J Med
, vol.363
, pp. 1801-1811
-
-
Krueger, D.A.1
Care, M.M.2
Holland, K.3
-
78
-
-
43549101188
-
Single-institute phase 2 study of thalidomide treatment for refractory or relapsed multiple myeloma: Prognostic factors and unique toxicity profile
-
DOI 10.1111/j.1349-7006.2008.00792.x
-
Hattori Y, Okamoto S, Shimada N, et al. Single-institute phase 2 study of thalidomide treatment for refractory or relapsed multiple myeloma: Prognostic factors and unique toxicity profile. Cancer Sci 2008;99:1243-50. (Pubitemid 351676638)
-
(2008)
Cancer Science
, vol.99
, Issue.6
, pp. 1243-1250
-
-
Hattori, Y.1
Okamoto, S.-I.2
Shimada, N.3
Kakimoto, T.4
Morita, K.5
Tanigawara, Y.6
Ikeda, Y.7
-
79
-
-
33846570911
-
Efficacy and safety of thalidomide in children and young adults with intractable inflammatory bowel disease: Long-term results
-
DOI 10.1111/j.1365-2036.2006.03211.x
-
Lazzerini M, Martelossi S, Marchetti F, et al. Efficacy and safety of thalidomide in children and young adults with intractable inflammatory bowel disease: Long-term results. Aliment Pharmacol Ther 2007;25:419-27. (Pubitemid 46184455)
-
(2007)
Alimentary Pharmacology and Therapeutics
, vol.25
, Issue.4
, pp. 419-427
-
-
Lazzerini, M.1
Martelossi, S.2
Marchetti, F.3
Scabar, A.4
Bradaschia, F.5
Ronfani, L.6
Ventura, A.7
-
80
-
-
34249871359
-
Thalidomide for rheumatic disease: The best of both worlds?
-
DOI 10.1038/ncprheum0504, PII NCPRHEUM0504
-
Lehman TJ. Thalidomide for rheumatic disease: The best of both worlds? Nat Clin Pract Rheumatol 2007;3:308-9. (Pubitemid 46864880)
-
(2007)
Nature Clinical Practice Rheumatology
, vol.3
, Issue.6
, pp. 308-309
-
-
Lehman, T.J.A.1
-
81
-
-
34547747328
-
A phase II trial of thalidomide and cyclophosphamide in patients with recurrent or refractory pediatric malignancies
-
DOI 10.1002/pbc.21045
-
Gilheeney SW, Lyden DC, Sgouros S, et al. A phase II trial of thalidomide and cyclophosphamide in patients with recurrent or refractory pediatric malignancies. Pediatr Blood Cancer 2007;49:261-5. (Pubitemid 47236214)
-
(2007)
Pediatric Blood and Cancer
, vol.49
, Issue.3
, pp. 261-265
-
-
Gilheeney, S.W.1
Lyden, D.C.2
Sgouros, S.3
Antunes, N.4
Gerald, W.5
Kramer, K.6
Lis, E.7
Meyers, P.8
Rosen, N.9
Thaler, H.T.10
Trippett, T.11
Wexler, L.12
Dunkel, I.J.13
-
82
-
-
36349023319
-
Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma
-
DOI 10.1056/NEJMoa070594
-
Dimopoulos M, Spencer A, Attal M, et al. Multiple Myeloma (010) Study Investigators. Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma. N Engl J Med 2007;357:2123-32 [Erratum in N Engl J Med 2009;361:544]. (Pubitemid 350146107)
-
(2007)
New England Journal of Medicine
, vol.357
, Issue.21
, pp. 2123-2132
-
-
Dimopoulos, M.1
Spencer, A.2
Attal, M.3
Prince, H.M.4
Harousseau, J.-L.5
Dmoszynska, A.6
San, M.J.7
Hellmann, A.8
Facon, T.9
Foa, R.10
Corso, A.11
Masliak, Z.12
Olesnyckyj, M.13
Yu, Z.14
Patin, J.15
Zeldis, J.B.16
Knight, R.D.17
-
83
-
-
79955855079
-
Optimizing the use of lenalidomide in relapsed or refractory multiple myeloma: Consensus statement
-
Dimopoulos MA, Palumbo A, Attal M, et al. Optimizing the use of lenalidomide in relapsed or refractory multiple myeloma: Consensus statement. Leukemia 2011;25:749-60.
-
(2011)
Leukemia
, vol.25
, pp. 749-760
-
-
Dimopoulos, M.A.1
Palumbo, A.2
Attal, M.3
-
84
-
-
79951986245
-
Phase I trial of lenalidomide in pediatric patients with recurrent, refractory, or progressive primary CNS tumors: Pediatric Brain Tumor Consortium study PBTC-018
-
Warren KE, Goldman S, Pollack IF, et al. Phase I trial of lenalidomide in pediatric patients with recurrent, refractory, or progressive primary CNS tumors: Pediatric Brain Tumor Consortium study PBTC-018. J Clin Oncol 2011;29:324-9.
-
(2011)
J Clin Oncol
, vol.29
, pp. 324-329
-
-
Warren, K.E.1
Goldman, S.2
Pollack, I.F.3
-
85
-
-
79951977934
-
Safety, pharmacokinetics, and immunomodulatory effects of lenalidomide in children and adolescents with relapsed/refractory solid tumors or myelodysplastic syndrome: A Children's Oncology Group phase I consortium report
-
Berg SL, Cairo MS, Russell H, et al. Safety, pharmacokinetics, and immunomodulatory effects of lenalidomide in children and adolescents with relapsed/refractory solid tumors or myelodysplastic syndrome: A Children's Oncology Group phase I consortium report. J Clin Oncol 2011;29:316-23.
-
(2011)
J Clin Oncol
, vol.29
, pp. 316-323
-
-
Berg, S.L.1
Cairo, M.S.2
Russell, H.3
-
86
-
-
70349238733
-
Inhibition of the Hedgehog pathway in advanced basal cell carcinoma
-
Von Hoff DD, LoRusso PM, Rudin CM, et al. Inhibition of the Hedgehog pathway in advanced basal cell carcinoma. N Engl J Med 2009;361:1164-72.
-
(2009)
N Engl J Med
, vol.361
, pp. 1164-1172
-
-
Von Hoff, D.D.1
LoRusso, P.M.2
Rudin, C.M.3
-
87
-
-
79954611501
-
Phase I trial of Hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors
-
LoRusso PM, Rudin CM, Reddy JC, et al. Phase I trial of Hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. Clin Cancer Res 2011;17:2502-11.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 2502-2511
-
-
LoRusso, P.M.1
Rudin, C.M.2
Reddy, J.C.3
-
88
-
-
70349244812
-
Treatment of medulloblastoma with Hedgehog pathway inhibitor GDC-0449
-
Rudin CM, Hann CL, Laterra J, et al. Treatment of medulloblastoma with Hedgehog pathway inhibitor GDC-0449. N Engl J Med 2009;361:1173-8.
-
(2009)
N Engl J Med
, vol.361
, pp. 1173-1178
-
-
Rudin, C.M.1
Hann, C.L.2
Laterra, J.3
-
89
-
-
33947214529
-
Notch signaling, gamma-secretase inhibitors, and cancer therapy
-
Shih IM, Wang TL. Notch signaling, gamma-secretase inhibitors, and cancer therapy. Cancer Res 2007;67:1879-82.
-
(2007)
Cancer Res
, vol.67
, pp. 1879-1882
-
-
Shih, I.M.1
Wang, T.L.2
-
90
-
-
49449101906
-
Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease
-
Fleisher AS, Raman R, Siemers ER, et al. Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease. Arch Neurol 2008;65:1031-8.
-
(2008)
Arch Neurol
, vol.65
, pp. 1031-1038
-
-
Fleisher, A.S.1
Raman, R.2
Siemers, E.R.3
-
91
-
-
79952529991
-
What the halted phase III γ-secretase inhibitor trial may (or may not) be telling us
-
Schor NF. What the halted phase III γ-secretase inhibitor trial may (or may not) be telling us. Ann Neurol 2011;69:237-9.
-
(2011)
Ann Neurol
, vol.69
, pp. 237-239
-
-
Schor, N.F.1
-
92
-
-
33645234720
-
Gamma-secretase inhibitors for Alzheimer's disease: Balancing efficacy and toxicity
-
Barten DM, Meredith JE Jr, Zaczek R, Houston JG, Albright CF. Gamma-secretase inhibitors for Alzheimer's disease: Balancing efficacy and toxicity. Drugs Res Dev 2006;7:87-97.
-
(2006)
Drugs Res Dev
, vol.7
, pp. 87-97
-
-
Barten, D.M.1
Meredith Jr., J.E.2
Zaczek, R.3
Houston, J.G.4
Albright, C.F.5
-
93
-
-
70349633604
-
A phase 2 study of vorinostat in acute myeloid leukemia
-
Mayo P2C Phase II Consortium
-
Schaefer EW, Loaiza-Bonilla A, Juckett M, et al. Mayo P2C Phase II Consortium. A phase 2 study of vorinostat in acute myeloid leukemia. Haematologica 2009;94:1375-82.
-
(2009)
Haematologica
, vol.94
, pp. 1375-1382
-
-
Schaefer, E.W.1
Loaiza-Bonilla, A.2
Juckett, M.3
-
94
-
-
65349141942
-
Phase II trial of vorinostat in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group study
-
Erratum in J Clin Oncol 2009;27:3262-3
-
Galanis E, Jaeckle KA, Maurer MJ, et al. Phase II trial of vorinostat in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group study. J Clin Oncol 2009;27:2052-8 [Erratum in J Clin Oncol 2009;27:3262-3].
-
(2009)
J Clin Oncol
, vol.27
, pp. 2052-2058
-
-
Galanis, E.1
Jaeckle, K.A.2
Maurer, M.J.3
-
95
-
-
73949140461
-
Carboplatin and paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer
-
Ramalingam SS, Maitland ML, Frankel P, et al. Carboplatin and paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer. J Clin Oncol 2010;28:56-62.
-
(2010)
J Clin Oncol
, vol.28
, pp. 56-62
-
-
Ramalingam, S.S.1
Maitland, M.L.2
Frankel, P.3
-
96
-
-
33847239896
-
Assessment of developmental toxicity of vorinostat, a histone deacetylase inhibitor, in Sprague-Dawley rats and Dutch Belted rabbits
-
Wise LD, Turner KJ, Kerr JS. Assessment of developmental toxicity of vorinostat, a histone deacetylase inhibitor, in Sprague-Dawley rats and Dutch Belted rabbits. Birth Defects Res [B] Dev Reprod Toxicol 2007;80:57-68.
-
(2007)
Birth Defects Res [B] Dev Reprod Toxicol
, vol.80
, pp. 57-68
-
-
Wise, L.D.1
Turner, K.J.2
Kerr, J.S.3
-
97
-
-
77955900071
-
Pediatric phase I trial and pharmacokinetic study of vorinostat: A Children's Oncology Group phase I consortium report
-
Fouladi M, Park JR, Stewart CF, et al. Pediatric phase I trial and pharmacokinetic study of vorinostat: A Children's Oncology Group phase I consortium report. J Clin Oncol 2010;28:3623-9.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3623-3629
-
-
Fouladi, M.1
Park, J.R.2
Stewart, C.F.3
-
98
-
-
56249124221
-
Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma
-
Wolff JE, Kramm C, Kortmann RD, et al. Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma. J Neurooncol 2008;90:309-14.
-
(2008)
J Neurooncol
, vol.90
, pp. 309-314
-
-
Wolff, J.E.1
Kramm, C.2
Kortmann, R.D.3
-
99
-
-
79551691082
-
Phase 1 study of valproic acid in pediatric patients with refractory solid or CNS tumors: A Children's Oncology Group report
-
Su JM, Li XN, Thompson P, et al. Phase 1 study of valproic acid in pediatric patients with refractory solid or CNS tumors: A Children's Oncology Group report. Clin Cancer Res 2011;17:589-97.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 589-597
-
-
Su, J.M.1
Li, X.N.2
Thompson, P.3
-
100
-
-
34548183776
-
Neurotoxicity of bortezomib therapy in multiple myeloma: A single-center experience and review of the literature
-
DOI 10.1002/cncr.22921
-
Badros A, Golubeva O, Dalal JS. Neurotoxicity of bortezomib therapy in multiple myeloma: A single-center experience and review of the literature. Cancer 2007;110:1042-9. (Pubitemid 47312870)
-
(2007)
Cancer
, vol.110
, Issue.5
, pp. 1042-1049
-
-
Badros, A.1
Goloubeva, O.2
Dalal, J.S.3
Can, I.4
Thompson, J.5
Rapoport, A.P.6
Heyman, M.7
Akpek, G.8
Fenton, R.G.9
-
101
-
-
16544389047
-
Phase I study of the proteasome inhibitor bortezomib in pediatric patients with refractory solid tumors: A Children's Oncology Group study (ADVL0015)
-
Erratum in J Clin Oncol 2005;23:248
-
Blaney SM, Bernstein M, Neville K, et al. Phase I study of the proteasome inhibitor bortezomib in pediatric patients with refractory solid tumors: A Children's Oncology Group study (ADVL0015). J Clin Oncol 2004;22:4804-9 [Erratum in J Clin Oncol 2005;23:248].
-
(2004)
J Clin Oncol
, vol.22
, pp. 4804-4809
-
-
Blaney, S.M.1
Bernstein, M.2
Neville, K.3
-
102
-
-
33947362982
-
A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: A children's oncology group study
-
DOI 10.1158/1078-0432.CCR-06-2173
-
Horton TM, Pati D, Plon SE, et al. A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: A Children's Oncology Group study. Clin Cancer Res 2007;13:1516-22. (Pubitemid 46450443)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.5
, pp. 1516-1522
-
-
Horton, T.M.1
Pati, D.2
Plon, S.E.3
Thompson, P.A.4
Bomgaars, L.R.5
Adamson, P.C.6
Ingle, A.M.7
Wright, J.8
Brockman, A.H.9
Paton, M.10
Blaney, S.M.11
-
103
-
-
77955108100
-
Phase I study of bortezomib combined with chemotherapy in children with relapsed childhood acute lymphoblastic leukemia (ALL): A report from the Therapeutic Advances in Childhood Leukemia (TACL) Consortium
-
Messinger Y, Gaynon P, Raetz E, et al. Phase I study of bortezomib combined with chemotherapy in children with relapsed childhood acute lymphoblastic leukemia (ALL): A report from the Therapeutic Advances in Childhood Leukemia (TACL) Consortium. Pediatr Blood Cancer 2010;55:254-9.
-
(2010)
Pediatr Blood Cancer
, vol.55
, pp. 254-259
-
-
Messinger, Y.1
Gaynon, P.2
Raetz, E.3
-
104
-
-
79959848266
-
Phase I study of bortezomib plus ICE (BICE) for the treatment of relapsed/refractory Hodgkin lymphoma
-
Fanale M, Fayad L, Pro B, et al. Phase I study of bortezomib plus ICE (BICE) for the treatment of relapsed/refractory Hodgkin lymphoma. Br J Haematol 2011;154:284-6.
-
(2011)
Br J Haematol
, vol.154
, pp. 284-286
-
-
Fanale, M.1
Fayad, L.2
Pro, B.3
-
105
-
-
59449085305
-
Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors
-
Plummer R, Jones C, Middleton M, et al. Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors. Clin Cancer Res 2008;14:7917-23.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7917-7923
-
-
Plummer, R.1
Jones, C.2
Middleton, M.3
-
106
-
-
84866731386
-
Safety and tolerability of the poly(ADP-ribose) polymerase (PARP) inhibitor, olaparib (AZD2281) in combination with topotecan for the treatment of patients with advanced solid tumors: A phase I study
-
May 18 (Epub ahead of print)
-
Samol J, Ranson M, Scott E, et al. Safety and tolerability of the poly(ADP-ribose) polymerase (PARP) inhibitor, olaparib (AZD2281) in combination with topotecan for the treatment of patients with advanced solid tumors: A phase I study. Invest New Drugs; 2011. May 18 (Epub ahead of print).
-
(2011)
Invest New Drugs
-
-
Samol, J.1
Ranson, M.2
Scott, E.3
-
107
-
-
77951445939
-
Poly(ADP-ribose) polymerase inhibitors: A novel drug class with a promising future
-
Gartner EM, Burger AM, Lorusso PM. Poly(ADP-ribose) polymerase inhibitors: A novel drug class with a promising future. Cancer J 2010;16:83-90.
-
(2010)
Cancer J
, vol.16
, pp. 83-90
-
-
Gartner, E.M.1
Burger, A.M.2
Lorusso, P.M.3
-
108
-
-
77952038836
-
Poly(ADP-ribose) polymerase inhibitor can attenuate the neuronal death after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice
-
Yokoyama H, Kuroiwa H, Tsukada T, Uchida H, Kato H, Araki T. Poly(ADP-ribose) polymerase inhibitor can attenuate the neuronal death after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice. J Neurosci Res 2010;88:1522-36.
-
(2010)
J Neurosci Res
, vol.88
, pp. 1522-1536
-
-
Yokoyama, H.1
Kuroiwa, H.2
Tsukada, T.3
Uchida, H.4
Kato, H.5
Araki, T.6
-
109
-
-
79954484430
-
Neural stem/progenitors and glioma stem-like cells have differential sensitivity to chemotherapy
-
Gong X, Schwartz PH, Linskey ME, Bota DA. Neural stem/progenitors and glioma stem-like cells have differential sensitivity to chemotherapy. Neurology 2011;76:1126-34.
-
(2011)
Neurology
, vol.76
, pp. 1126-1134
-
-
Gong, X.1
Schwartz, P.H.2
Linskey, M.E.3
Bota, D.A.4
|