Comparison of neurocognitive functioning in children previously randomly assigned to intrathecal methotrexate compared with triple intrathecal therapy for the treatment of childhood acute lymphoblastic leukemia

Journal of Clinical Oncology

Volumn 27, Issue 35, 2009, Pages 5986-5992

  Kadan Lottick, Nina S ^a   Brouwers, Pim ^a   Breiger, David ^a   Kaleita, Thomas ^a   Dziura, James ^a   Northrup, Veronika ^a   Chen, Lu ^a   Nicoletti, Megan ^a   Bostrom, Bruce ^a   Stork, Linda ^a   Neglia, Joseph P ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTARABINE; DEXAMETHASONE; HYDROCORTISONE; MERCAPTOPURINE; METHOTREXATE; PREDNISONE; TIOGUANINE; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE;

ACADEMIC ACHIEVEMENT; ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; ATTENTION; CANCER COMBINATION CHEMOTHERAPY; CHILD; CLINICAL EVALUATION; CLINICAL TRIAL; COGNITION; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; HIGH RISK POPULATION; HUMAN; INTELLIGENCE QUOTIENT; MAJOR CLINICAL STUDY; MALE; MEMORY; MENTAL CONCENTRATION; NEUROPSYCHOLOGICAL TEST; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; PSYCHOLOGIST; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SCORING SYSTEM; SPECIAL EDUCATION; VISUOMOTOR COORDINATION; CROSS-SECTIONAL STUDY; DRUG EFFECT; INFANT; INTELLIGENCE TEST; INTRASPINAL DRUG ADMINISTRATION; MULTICENTER STUDY; PSYCHOMOTOR PERFORMANCE; STATISTICAL MODEL; TIME; TREATMENT OUTCOME; UNITED STATES;

ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ATTENTION; CHILD; CHILD, PRESCHOOL; COGNITION; CROSS-SECTIONAL STUDIES; CYTARABINE; FEMALE; HUMANS; HYDROCORTISONE; INFANT; INJECTIONS, SPINAL; INTELLIGENCE TESTS; LINEAR MODELS; MALE; MEMORY; METHOTREXATE; NEUROPSYCHOLOGICAL TESTS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PSYCHOMOTOR PERFORMANCE; TIME FACTORS; TREATMENT OUTCOME; UNITED STATES;

EID: 73349137662     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2009.23.5408     Document Type: Article

References (27)

1. Pui CH: Acute lymphoblastic leukemia: Introduction. Semin Hematol 46:1-2, 2009
2. Cousens P, Waters B, Said J, et al: Cognitive effects of cranial irradiation in leukaemia: A survey and meta-analysis. J Child Psychol Psychiatry 29: 839-852, 1988
3. Meadows AT, Gordon J, Massari DJ, et al: Declines in IQ scores and cognitive dysfunctions in children with acute lymphocytic leukemia treated with cranial irradiation. Lancet 2:1015-1018, 1981
4. Oberfield SE, Nirenberg A, Allen JC, et al: Hypothalamic-pituitary- adrenal function following cranial irradiation. Horm Res 47:9-16, 1997
5. Bleyer WA, Coccia PF, Sather HN, et al: Reduction in central nervous system leukemia with a pharmacokinetically derived intrathecal methotrexate dosage regimen. J Clin Oncol 1:317-325, 1983
6. Sullivan MP, Chen T, Dyment PG, et al: Equivalence of intrathecal chemotherapy and radiotherapy as central nervous system prophylaxis in children with acute lymphatic leukemia: A pediatric oncology group study. Blood 60:948-958, 1982
7. Tubergen DG, Gilchrist GS, O'Brien RT, et al: Prevention of CNS disease in intermediate-risk acute lymphoblastic leukemia: Comparison of cranial radiation and intrathecal methotrexate and the importance of systemic therapy - A Children's Cancer Group report. J Clin Oncol 11:520-526, 1993
8. Matloub Y, Lindemulder S, Gaynon PS, et al: Intrathecal triple therapy decreases central nervous system relapse but fails to improve event-free survival when compared with intrathecal methotrexate: Results of the Children's Cancer Group (CCG) 1952 study for standard-risk acute lymphoblastic leukemia - Reported by the Children's Oncology Group. Blood 108:1165-1173, 2006
9. Matloub Y, Angiolillo A, Bostrom B, et al: Double delayed intensification is equivalent to single DI in children with National Cancer Institute standard-risk acute lymphoblastic leukemia treated on Children's Cancer Group Clinical Trial 1991 (CCG 1991). American Society of Hematology Annual Meeting Abstracts 108:146-, 2006 (abstr 146)
10. Buizer AI, de Sonneville LM, van den Heuvel-Eibrink MM, et al: Chemotherapy and attentional dysfunction in survivors of childhood acute lymphoblastic leukemia: Effect of treatment intensity. Pediatr Blood Cancer 45:281-290, 2005
11. Mennes M, Stiers P, Vandenbussche E, et al: Attention and information processing in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. Pediatr Blood Cancer 44: 478-486, 2005
12. Moleski M: Neuropsychological, neuroanatomical, and neurophysiological consequences of CNS chemotherapy for acute lymphoblastic leukemia. Arch Clin Neuropsychol 15:603-630, 2000
13. Ochs J, Mulhern R, Fairclough D, et al: Comparison of neuropsychologic functioning and clinical indicators of neurotoxicity in long-term survivors of childhood leukemia given cranial radiation or parenteral methotrexate: A prospective study. J Clin Oncol 9:145-151, 1991
14. Peterson CC, Johnson CE, Ramirez LY, et al: A meta-analysis of the neuropsychological sequelae of chemotherapy-only treatment for pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer 51: 99-104, 2008
15. von der Weid N, Mosimann I, Hirt A, et al: Intellectual outcome in children and adolescents with acute lymphoblastic leukaemia treated with chemotherapy alone: Age- and sex-related differences. Eur J Cancer 39:359-365, 2003
16. Laningham FH, Kun LE, Reddick WE, et al: Childhood central nervous system leukemia: Historical perspectives, current therapy, and acute neurological sequelae. Neuroradiology 49:873-888, 2007
17. Kerr JZ, Berg S, Blaney SM: Intrathecal chemotherapy. Crit Rev Oncol Hematol 37:227-236, 2001
18. Smith M, Arthur D, Camitta B, et al: Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia. J Clin Oncol 14:18-24, 1996
19. Kaleita TA, Tubergen DG, Stehbens JA, et al: Longitudinal study of cognitive, motor, and behavioral functioning in children diagnosed with acute lymphoblastic leukemia: A report of early findings from the Children's Cancer Group. Haematol Blood Transfus 38:660-673, 1997
20. Madhyastha S, Somayaji SN, Rao MS, et al: Effect of intracerebroventricular methotrexate on brain amines. Indian J Physiol Pharmacol 49:427-435, 2005
21. Moore IM, Miketova P, Hockenberry M, et al: Methotrexate-induced alterations in beta-oxidation correlate with cognitive abilities in children with acute lymphoblastic leukemia. Biol Res Nurs 9:311-319, 2008
22. Iuvone L, Mariotti P, Colosimo C, et al: Long-term cognitive outcome, brain computed tomography scan, and magnetic resonance imaging in children cured for acute lymphoblastic leukemia. Cancer 95:2562-2570, 2002
23. Langer T, Martus P, Ottensmeier H, et al: CNS late-effects after ALL therapy in childhood. Part III: Neuropsychological performance in long-term survivors of childhood ALL - Impairments of concentration, attention, and memory. Med Pediatr Oncol 38:320-328, 2002
24. Jansen NC, Kingma A, Schuitema A, et al: Post-treatment intellectual functioning in children treated for acute lymphoblastic leukaemia (ALL) with chemotherapy only: A prospective, sibling-controlled study. Eur J Cancer 42:2765-2772, 2006
25. Wefel JS, Lenzi R, Theriault RL, et al: The cognitive sequelae of standard-dose adjuvant chemotherapy in women with breast carcinoma: Results of a prospective, randomized, longitudinal trial. Cancer 100:2292-2299, 2004
26. Vardy J, Wefel JS, Ahles T, et al: Cancer and cancer-therapy related cognitive dysfunction: An international perspective from the Venice cognitive workshop. Ann Oncol 19:623-629, 2008
27. Nathan PC, Patel SK, Dilley K, et al: Guidelines for identification of, advocacy for, and intervention in neurocognitive problems in survivors of childhood cancer: A report from the Children's Oncology Group. Arch Pediatr Adolesc Med 161:798-806, 2007