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Volumn 16, Issue 2, 2003, Pages 129-134

Radiation injury and neurogenesis

Author keywords

Cognition; Cranial radiation therapy; Memory; Microglia; Neural stem cells; Neuroinflammation

Indexed keywords

CANCER SURVIVAL; CELL DEATH; CELL PROLIFERATION; COGNITION; DISEASE SEVERITY; DOSE RESPONSE; GRANULE CELL; HIPPOCAMPUS; HUMAN; LEARNING; LEARNING DISORDER; MEMORY; MEMORY DISORDER; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PATHOLOGICAL ANATOMY; RADIATION INJURY; RADIOTHERAPY; REVIEW; STEM CELL; TEMPORAL LOBE; VASCULAR DISEASE; WHITE MATTER;

EID: 0037396768     PISSN: 13507540     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019052-200304000-00002     Document Type: Review
Times cited : (340)

References (46)
  • 1
    • 0028914873 scopus 로고
    • Neuropsychological effects of cranial radiation: Current knowledge and future directions
    • Roman DD, Sperduto PW. Neuropsychological effects of cranial radiation: current knowledge and future directions. Int J Radiat Oncol Biol Phys 1995; 31:983-998.
    • (1995) Int J Radiat Oncol Biol Phys , vol.31 , pp. 983-998
    • Roman, D.D.1    Sperduto, P.W.2
  • 2
    • 0033954127 scopus 로고    scopus 로고
    • Cognitive and academic outcome following cranial irradiation and chemotherapy in children: A longitudinal study
    • Anderson VA, Godber T, Smibert E, et al. Cognitive and academic outcome following cranial irradiation and chemotherapy in children: a longitudinal study. Br J Cancer 2000; 82:255-262.
    • (2000) Br J Cancer , vol.82 , pp. 255-262
    • Anderson, V.A.1    Godber, T.2    Smibert, E.3
  • 3
    • 0026754778 scopus 로고
    • Neurophysiological basis of cognitive deficits in long-term survivors of childhood cancer
    • Moore III BD, Copeland DR, Ried H, et al. Neurophysiological basis of cognitive deficits in long-term survivors of childhood cancer. Arch Neurol 1992; 49:809-817.
    • (1992) Arch Neurol , vol.49 , pp. 809-817
    • Moore B.D. III1    Copeland, D.R.2    Ried, H.3
  • 4
    • 0028356814 scopus 로고
    • Neurobehavioral sequelae of cranial irradiation in adults: A review of radiation-induced encephalopathy
    • Crossen JR, Garwood D, Glatstein E, et al. Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy. J Clin Oncol 1994; 12:627-642.
    • (1994) J Clin Oncol , vol.12 , pp. 627-642
    • Crossen, J.R.1    Garwood, D.2    Glatstein, E.3
  • 5
    • 10344263377 scopus 로고    scopus 로고
    • Pathogenesis of irradiation-induced cognitive dysfunction
    • Abayomi OK. Pathogenesis of irradiation-induced cognitive dysfunction. Acta Oncol 1996; 35:659-663.
    • (1996) Acta Oncol , vol.35 , pp. 659-663
    • Abayomi, O.K.1
  • 6
    • 0024504664 scopus 로고
    • Effects of radiation therapy on neuropsychological functioning in patients with nasopharyngeal carcinoma
    • Lee PW, Hung BK, Woo EK, et al. Effects of radiation therapy on neuropsychological functioning in patients with nasopharyngeal carcinoma. J Neurol Neurosurg Psychiatry 1989; 52:488-492.
    • (1989) J Neurol Neurosurg Psychiatry , vol.52 , pp. 488-492
    • Lee, P.W.1    Hung, B.K.2    Woo, E.K.3
  • 7
    • 0035933187 scopus 로고    scopus 로고
    • Adverse long-term effects of brain radiotherapy in adult low-grade glioma patients
    • Surma-aho O, Niemela M, Vilkki J, et al. Adverse long-term effects of brain radiotherapy in adult low-grade glioma patients. Neurology 2001; 56:1285-1290. This is an elegant study clearly linking radiotherapy to progressive cognitive decline and neuropathology in adults treated for low-grade glioma. Deficits in learning and memory correlate with radiotherapy and histopathology.
    • (2001) Neurology , vol.56 , pp. 1285-1290
    • Surma-Aho, O.1    Niemela, M.2    Vilkki, J.3
  • 9
    • 0002141873 scopus 로고    scopus 로고
    • Tumors of the central nervous system
    • Pizzo PA, Pollack IF, editors. Philadelphia, PA: Lippincott Williams and Wilkins
    • Strother DR, Pollack IF, Fisher PG, et al. Tumors of the central nervous system. In: Pizzo PA, Pollack IF, editors, Principles and practice of pediatric oncology, 4th ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2002. pp. 751-824. This is a detailed overview of brain tumor treatments strategies with an excellent discussion of treatment sequelae.
    • (2002) Principles and Practice of Pediatric Oncology, 4th Ed. , pp. 751-824
    • Strother, D.R.1    Pollack, I.F.2    Fisher, P.G.3
  • 10
    • 0036352612 scopus 로고    scopus 로고
    • Pathogenesis of cognitive decline following therapeutic irradiation for head and neck tumors
    • Abayomi OK. Pathogenesis of cognitive decline following therapeutic irradiation for head and neck tumors. Acta Oncol 2002; 41:346-351. This is a detailed extension to Abayomi's early summary on radiation-induced pathogenesis (see Ref. 5 above) with a superb survey of key literature.
    • (2002) Acta Oncol , vol.41 , pp. 346-351
    • Abayomi, O.K.1
  • 11
    • 0033152433 scopus 로고    scopus 로고
    • Inhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizure-induced mossy fiber synaptic reorganization in the rat
    • Parent JM, Tada E, Fike JR, et al. Inhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizure-induced mossy fiber synaptic reorganization in the rat. J Neurosci 1999; 19:4508-4519.
    • (1999) J Neurosci , vol.19 , pp. 4508-4519
    • Parent, J.M.1    Tada, E.2    Fike, J.R.3
  • 12
    • 0036735783 scopus 로고    scopus 로고
    • Irradiation induces neural precursor-cell dysfunction
    • Monje ML, Mizumatsu S, Fike JR, et al. Irradiation induces neural precursor-cell dysfunction. Nat Med 2002; 8:955-962. The results of this study demonstrate the failure of the neurogenic microenvironment after radiation, and the inability of the irradiated hippocampus to direct neurogenesis even after transplant of non-irradiated stem cells.
    • (2002) Nat Med , vol.8 , pp. 955-962
    • Monje, M.L.1    Mizumatsu, S.2    Fike, J.R.3
  • 14
    • 0027492237 scopus 로고
    • The hippocampus and spatial memory
    • Squire LR, The hippocampus and spatial memory. Trends Neurosci 1993; 16:56-57.
    • (1993) Trends Neurosci , vol.16 , pp. 56-57
    • Squire, L.R.1
  • 15
    • 0028203257 scopus 로고
    • Topographic organization of the reciprocal connections between the monkey entorhinal cortex and the perirhinal and parahippocampal cortices
    • Suzuki WA, Amaral DG. Topographic organization of the reciprocal connections between the monkey entorhinal cortex and the perirhinal and parahippocampal cortices. J Neurosci 1994; 14:1856-1877.
    • (1994) J Neurosci , vol.14 , pp. 1856-1877
    • Suzuki, W.A.1    Amaral, D.G.2
  • 16
    • 0030937293 scopus 로고    scopus 로고
    • More hippocampal neurons in adult mice living in an enriched environment
    • Kempermann G, Kuhn HG, Gage FH. More hippocampal neurons in adult mice living in an enriched environment. Nature 1997; 386:493-495.
    • (1997) Nature , vol.386 , pp. 493-495
    • Kempermann, G.1    Kuhn, H.G.2    Gage, F.H.3
  • 17
    • 0034623304 scopus 로고    scopus 로고
    • Analysis of neurogenesis and programmed cell death reveals a self-renewing capacity in the adult rat brain
    • Biebl M, Cooper CM, Winkler J, et al. Analysis of neurogenesis and programmed cell death reveals a self-renewing capacity in the adult rat brain. Neurosci Lett 2000; 291:17-20.
    • (2000) Neurosci Lett , vol.291 , pp. 17-20
    • Biebl, M.1    Cooper, C.M.2    Winkler, J.3
  • 18
    • 0031928119 scopus 로고    scopus 로고
    • Multipotent progenitor cells in the adult dentate gyrus
    • Gage FH, Kempermann G, Palmer TD, et al. Multipotent progenitor cells in the adult dentate gyrus. J Neurobiol 1998; 36:249-266.
    • (1998) J Neurobiol , vol.36 , pp. 249-266
    • Gage, F.H.1    Kempermann, G.2    Palmer, T.D.3
  • 19
    • 0030438734 scopus 로고    scopus 로고
    • The adult rat hippocampus contains primordial neural stem cells
    • Palmer TD, Takahashi J, Gage FH. The adult rat hippocampus contains primordial neural stem cells. Mol Cell Neurosci 1997; 8:389-404.
    • (1997) Mol Cell Neurosci , vol.8 , pp. 389-404
    • Palmer, T.D.1    Takahashi, J.2    Gage, F.H.3
  • 20
  • 21
    • 0033583580 scopus 로고    scopus 로고
    • Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles
    • Markakis EA, Gage FH. Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles. J Comp Neurol 1999; 406:449-460.
    • (1999) J Comp Neurol , vol.406 , pp. 449-460
    • Markakis, E.A.1    Gage, F.H.2
  • 22
    • 0033547185 scopus 로고    scopus 로고
    • Rapid extension of axons into the CA3 region by adult-generated granule cells
    • Hastings NB, Gould E. Rapid extension of axons into the CA3 region by adult-generated granule cells. J Comp Neurol 1999; 413:146-154.
    • (1999) J Comp Neurol , vol.413 , pp. 146-154
    • Hastings, N.B.1    Gould, E.2
  • 23
    • 0037186524 scopus 로고    scopus 로고
    • Functional neurogenesis in the adult hippocampus
    • van Praag H, Schinder AF, Christie BR, et al. Functional neurogenesis in the adult hippocampus. Nature 2002; 415:1030-1034. The first direct measurements showing that new neurons within the hippocampus become functionally integrated.
    • (2002) Nature , vol.415 , pp. 1030-1034
    • Van Praag, H.1    Schinder, A.F.2    Christie, B.R.3
  • 24
    • 0035868717 scopus 로고    scopus 로고
    • Neurogenesis in the adult is involved in the formation of trace memories
    • Shors TJ, Miesegaes G, Beylin A, et al. Neurogenesis in the adult is involved in the formation of trace memories. Nature 2001; 410:372-376.
    • (2001) Nature , vol.410 , pp. 372-376
    • Shors, T.J.1    Miesegaes, G.2    Beylin, A.3
  • 25
    • 0028364703 scopus 로고
    • Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus
    • Cameron HA, Gould E. Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus. Neuroscience 1994; 61:203-209.
    • (1994) Neuroscience , vol.61 , pp. 203-209
    • Cameron, H.A.1    Gould, E.2
  • 26
    • 0034718603 scopus 로고    scopus 로고
    • Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus
    • Lemaire V, Koehl M, Le Moal M, et al. Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus. Proc Natl Acad Sci U S A 2000; 97:11032-11037.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 11032-11037
    • Lemaire, V.1    Koehl, M.2    Le Moal, M.3
  • 27
    • 0033539607 scopus 로고    scopus 로고
    • Running enhances neurogenesis, learning, and long-term potentiation in mice
    • van Praag H, Christie BR, Sejnowski TJ, et al. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci U S A 1999; 96:13427-13431.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 13427-13431
    • Van Praag, H.1    Christie, B.R.2    Sejnowski, T.J.3
  • 28
    • 0036266738 scopus 로고    scopus 로고
    • Regulation of adult hippocampal neurogenesis - Implications for novel theories of major depression
    • Kempermann G. Regulation of adult hippocampal neurogenesis - implications for novel theories of major depression. Bipolar Disord 2002; 4:17-33. The effects of cranial radiation on the HPA axis clearly tie post-therapeutic mood disorders, i.e. depression, to the current speculations in the role of hippocampal neurogenesis in major depression.
    • (2002) Bipolar Disord , vol.4 , pp. 17-33
    • Kempermann, G.1
  • 29
    • 0029967893 scopus 로고    scopus 로고
    • Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo
    • Suhonen JO, Peterson DA, Ray J, et al. Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo. Nature 1996; 383:624-627.
    • (1996) Nature , vol.383 , pp. 624-627
    • Suhonen, J.O.1    Peterson, D.A.2    Ray, J.3
  • 30
    • 0031927325 scopus 로고    scopus 로고
    • Neuroblasts of the postnatal mammalian forebrain: Their phenotype and fate
    • Luskin MB. Neuroblasts of the postnatal mammalian forebrain: their phenotype and fate. J Neurobiol 1998; 36:221-233.
    • (1998) J Neurobiol , vol.36 , pp. 221-233
    • Luskin, M.B.1
  • 31
    • 0034597430 scopus 로고    scopus 로고
    • Vascular niche for adult hippocampal neurogenesis
    • Palmer TD, Willhoite AR, Gage FH. Vascular niche for adult hippocampal neurogenesis. J Comp Neurol 2000; 425:479-494.
    • (2000) J Comp Neurol , vol.425 , pp. 479-494
    • Palmer, T.D.1    Willhoite, A.R.2    Gage, F.H.3
  • 32
    • 0032796824 scopus 로고    scopus 로고
    • Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependyma
    • Leventhal C, Rafii S, Rafii D, et al. Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependyma. Mol Cell Neurosci 1999; 13:450-464.
    • (1999) Mol Cell Neurosci , vol.13 , pp. 450-464
    • Leventhal, C.1    Rafii, S.2    Rafii, D.3
  • 33
    • 0037007647 scopus 로고    scopus 로고
    • Astroglia induce neurogenesis from adult neural stem cells
    • Song H, Stevens CF, Gage FH. Astroglia induce neurogenesis from adult neural stem cells. Nature 2002; 417:39-44. A surprising finding suggesting that astrocytes are regionally unique in their ability to promote neurogenesis. The implication is that stem cells must not only interact with the correct cell types, but that these supporting cells must also exist in the correct 'status' to promote neurogenesis.
    • (2002) Nature , vol.417 , pp. 39-44
    • Song, H.1    Stevens, C.F.2    Gage, F.H.3
  • 34
    • 0034718139 scopus 로고    scopus 로고
    • X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats
    • Tada E, Parent JM, Lowenstein DH, et al. X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats. Neuroscience 2000; 99:33-41.
    • (2000) Neuroscience , vol.99 , pp. 33-41
    • Tada, E.1    Parent, J.M.2    Lowenstein, D.H.3
  • 35
    • 0009711059 scopus 로고    scopus 로고
    • Ionizing radiation-induced apoptosis of proliferating stem cells in the dentate gyrus of the adult rat hippocampus
    • Peissner W, Kocher M, Treuer H, et al. Ionizing radiation-induced apoptosis of proliferating stem cells in the dentate gyrus of the adult rat hippocampus. Brain Res Mol Brain Res 1999; 71:61-68.
    • (1999) Brain Res Mol Brain Res , vol.71 , pp. 61-68
    • Peissner, W.1    Kocher, M.2    Treuer, H.3
  • 36
    • 0034995459 scopus 로고    scopus 로고
    • Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus
    • Snyder JS, Kee N, Wojtowicz JM. Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus. J Neurophysiol 2001; 85:2423-2431. In addition to, or in concert with, its effects on proliferation and fate, radiation inhibits the synaptic reorganization of the existing circuitry.
    • (2001) J Neurophysiol , vol.85 , pp. 2423-2431
    • Snyder, J.S.1    Kee, N.2    Wojtowicz, J.M.3
  • 37
    • 0032033535 scopus 로고    scopus 로고
    • Late behavioural and neuropathological effects of local brain irradiation in the rat
    • Hodges H, Katzung N, Sowinski P, et al. Late behavioural and neuropathological effects of local brain irradiation in the rat. Behav Brain Res 1998; 91:99-114.
    • (1998) Behav Brain Res , vol.91 , pp. 99-114
    • Hodges, H.1    Katzung, N.2    Sowinski, P.3
  • 38
    • 0028304708 scopus 로고
    • Prenatal irradiation and spatial memory in mice: Investigation of dose-response relationship
    • Sienkiewicz ZJ, Haylock RG, Saunders RD. Prenatal irradiation and spatial memory in mice: investigation of dose-response relationship. Int J Radiat Biol 1994; 65:611-618.
    • (1994) Int J Radiat Biol , vol.65 , pp. 611-618
    • Sienkiewicz, Z.J.1    Haylock, R.G.2    Saunders, R.D.3
  • 39
    • 0037079993 scopus 로고    scopus 로고
    • Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6
    • Vallieres L, Campbell IL, Gage FH, et al. Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6. J Neurosci 2002; 22:486-492. A harbinger of a much larger array of inflammatory anti-neurogenesis mechanisms being informally reported within the adult neurogenesis field.
    • (2002) J Neurosci , vol.22 , pp. 486-492
    • Vallieres, L.1    Campbell, I.L.2    Gage, F.H.3
  • 40
    • 0035002421 scopus 로고    scopus 로고
    • Neuropathology of Alzheimer's disease and other dementias
    • Dickson DW. Neuropathology of Alzheimer's disease and other dementias. Clin Geriatr Med 2001; 17:209-228.
    • (2001) Clin Geriatr Med , vol.17 , pp. 209-228
    • Dickson, D.W.1
  • 41
    • 0034641287 scopus 로고    scopus 로고
    • Activated microglia in dementia with Lewy bodies
    • Mackenzie IR. Activated microglia in dementia with Lewy bodies. Neurology 2000; 55:132-134.
    • (2000) Neurology , vol.55 , pp. 132-134
    • Mackenzie, I.R.1
  • 42
    • 0032703399 scopus 로고    scopus 로고
    • AIDS dementia complex
    • Brew BJ. AIDS dementia complex. Neurol Clin 1999; 17:861-881.
    • (1999) Neurol Clin , vol.17 , pp. 861-881
    • Brew, B.J.1
  • 43
    • 0029006317 scopus 로고
    • Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus
    • Cameron HA, McEwen BS, Gould E. Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus. J Neurosci 1995; 15:4687-4692.
    • (1995) J Neurosci , vol.15 , pp. 4687-4692
    • Cameron, H.A.1    McEwen, B.S.2    Gould, E.3
  • 44
    • 0343052763 scopus 로고    scopus 로고
    • Adrenal steroids and N-methyl-D-aspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway
    • Cameron HA, Tanapat P, Gould E. Adrenal steroids and N-methyl-D-aspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway. Neuroscience 1998; 82:349-354.
    • (1998) Neuroscience , vol.82 , pp. 349-354
    • Cameron, H.A.1    Tanapat, P.2    Gould, E.3
  • 45
    • 0037071902 scopus 로고    scopus 로고
    • Adult neurogenesis and the vascular Nietzsche
    • Palmer TD. Adult neurogenesis and the vascular Nietzsche. Neuron 2002; 34:856-858.
    • (2002) Neuron , vol.34 , pp. 856-858
    • Palmer, T.D.1
  • 46
    • 0037214460 scopus 로고    scopus 로고
    • Copernican stem cells: Regulatory constellations in adult hippocampal neurogenesis
    • Fabel K, Toda H, Fabel K, Palmer T. Copernican stem cells: regulatory constellations in adult hippocampal neurogenesis. J Cell Biochem 2003; 88:41-50. A tongue-in-cheek review discussing the complexity of signalling that regulates neurogenesis and the startling lack of definitive information on the exact nature of neural stem cells, as they exist within the adult brain.
    • (2003) J Cell Biochem , vol.88 , pp. 41-50
    • Fabel, K.1    Toda, H.2    Fabel, K.3    Palmer, T.4


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