The influence of growth hormone (GH) substitution on patient-reported outcomes and cognitive functions in GH-deficient patients: A meta-analysis

Growth Hormone and IGF Research

Volumn 15, Issue 1, 2005, Pages 47-54

  Arwert, L I ^a   Deijen, J B ^b   Witlox, J ^b   Drent, M L ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Cognitive function; Growth hormone; Health status; Insulin like growth factor; Meta analysis; Patient reported outcomes; Quality of life; Well being

Indexed keywords

GROWTH HORMONE; PLACEBO;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL STUDY; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFICACY; EVIDENCE BASED MEDICINE; FEMALE; FOLLOW UP; FUNCTIONAL ASSESSMENT; GROWTH HORMONE DEFICIENCY; HEALTH STATUS; HORMONE SUBSTITUTION; HUMAN; MAJOR CLINICAL STUDY; MALE; META ANALYSIS; OUTCOMES RESEARCH; PRIORITY JOURNAL; QUALITY OF LIFE; SELF REPORT; STATISTICAL MODEL; WELLBEING;

ADOLESCENT; ADULT; AGED; COGNITION; GROWTH HORMONE; HUMAN GROWTH HORMONE; HUMANS; MIDDLE AGED; MODELS, STATISTICAL; PLACEBOS; QUALITY OF LIFE; QUESTIONNAIRES; SOMATOMEDINS; TIME FACTORS; TREATMENT OUTCOME;

EID: 13544256539     PISSN: 10966374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ghir.2004.11.004     Document Type: Article

References (48)

1. H. de Boer G.J. Blok E.A. van der Veen Clinical aspects of growth hormone deficiency in adults Endocr. Rev. 1995 63-86
2. H.B. Baum B.M. Biller J.S. Finkelstein et al. Effects of physiologic growth hormone therapy on bone density and body composition in patients with adult-onset growth hormone deficiency. A randomized, placebo-controlled trial Ann. Intern. Med. 1996 883-890
3. P.V. Carroll E.R. Christ B.A. Bengtsson et al. Growth hormone deficiency in adulthood and the effects of growth hormone replacement: A review. Growth Hormone Research Society Scientific Committee J. Clin. Endocrinol. Metab. 1998 382-395
4. J.B. Deijen H. de Boer E.A. van der Veen Cognitive changes during growth hormone replacement in adult men Psychoneuroendocrinology 1998 45-55
5. S. van Dam A. Aleman Insulin-like growth factor-I, cognition and brain aging Eur. J. Pharmacol. 2004 87-95
6. P. Burman J. Hetta L. Wide J.E. Mansson R. Ekman F.A. Karlsson Growth hormone treatment affects brain neurotransmitters and thyroxine (see comment) Clin. Endocrinol. (Oxf) 1996 319-324
7. A. Adem S.S. Jossan R. d'Argy et al. Insulin-like growth factor 1 (IGF-1) receptors in the human brain: Quantitative autoradiographic localization Brain Res. 1989 299-303
8. F. Nyberg Growth hormone in the brain: Characteristics of specific brain targets for the hormone and their functional significance Front. Neuroendocrinol. 2000 330-348
9. J.O. Johansson G. Larson M. Andersson et al. Treatment of growth hormone-deficient adults with recombinant human growth hormone increases the concentration of growth hormone in the cerebrospinal fluid and affects neurotransmitters Neuroendocrinology 1995 57-66
10. J.B. Deijen H. de Boer G.J. Blok E.A. van der Veen Cognitive impairments and mood disturbances in growth hormone deficient men Psychoneuroendocrinology 1996 313-322
11. C.M. Buchanan J.S. Eccles J.B. Becker Are adolescents the victims of raging hormones: Evidence for activational effects of hormones on moods and behavior at adolescence Psychol. Bull. 1992 62-107
12. P.J. Stouthart J.B. Deijen M. Roffel H.A. Delemarre-van de Waal Quality of life of growth hormone (GH) deficient young adults during discontinuation and restart of GH therapy Psychoneuroendocrinology 2003 612-626
13. M. Bleuler The psychopathology of acromegaly J. Nerv. Ment. Dis. 1951 497-511
14. S. Richert A. Strauss R. Fahlbusch R. Oeckler K. von Werder Psychopathologic symptoms and personality traits in patients with florid acromegaly Schweiz. Arch. Neurol. Psychiatr. 1987 61-86
15. D.M. Erlanger K.C. Kutner A.R. Jacobs Hormones and cognition: Current concepts and issues in neuropsychology Neuropsychol. Rev. 1999 175-207
16. K.W. Smith N.E. Avis S.F. Assmann Distinguishing between quality of life and health status in quality of life research: A meta-analysis Qual. Life Res. 1999 447-459
17. S. Bjork B. Jonsson O. Westphal J.E. Levin Quality of life of adults with growth hormone deficiency: A controlled study Acta Paediatr. Scand. Suppl. 1989 55-59
18. G.A. McGauley R.C. Cuneo F. Salomon P.H. Sonksen Psychological well-being before and after growth hormone treatment in adults with growth hormone deficiency Horm. Res. 1990 52-54
19. C.M. Mitchell S. Joyce A.J. Johanson A retrospective evaluation of psychosocial impact of long-term growth hormone therapy Clin. Pediatr. (Phila) 1986 17-23
20. T. Rosen L. Wiren L. Wilhelmsen I. Wiklund B.A. Bengtsson Decreased psychological well-being in adult patients with growth hormone deficiency Clin. Endocrinol. (Oxf) 1994 111-116
21. J. Cohen A power primer Psychol. Bull. 1992 155-159
22. S.M. Hunt S.P. McKenna J. McEwen J. Williams E. Papp The Nottingham Health Profile: Subjective health status and medical consultations Soc. Sci. Med. A 1981 221-229
23. H.J. Dupuy The psychological general well-being (PGWB) index In: M.E. Matsson C.D. Furberg I. Elinson (Eds.) Assessment of Quality of Life in Clinical Trials of Cardiovascular Therapy 1984 Le Jacq Publications New York
24. L.R. Derogatis R.S. Lipman K. Rickels E.H. Uhlenhuth I. Covi The Hopkins symptom checklist Pharmapsychiatry 1974 79-110
25. S. Shacham A shortened version of the Profile of Mood States J. Pers. Assess. 1983 305-306
26. C.D. Spielberger Test Manual for the State-Trait Anxiety Inventory - STAI Form 1980 Y Consulting Psychologist Press Palo Alto, California
27. S.P. McKenna L.C. Doward J. Alonso et al. The QoL-AGHDA: An instrument for the assessment of quality of life in adults with growth hormone deficiency Qual. Life Res. 1999 373-383
28. H.H. Emmen E.M.G. Hogendijk J. Hooisma J.F. Orlebeke S.H.J. Uitdehaage Adaptation of two standardized international test batteries for use in The Netherlands for detection of exposure to neurotoxic compounds 1988 Medisch Biologisch Laboratorium, TNO Rijswijk, The Netherlands
29. J. Bouma, J. Lindeboom, Klinisch neuropsychologische assesment, een Handleiding voor de praktijk, Internal Report, Vrije Universiteit, Amsterdam, The Netherlands, 1988
30. D. Wechsler, The Wechsler Adult Intelligence Scale Psychological Corporation, New York, 1955
31. A. Aleman H.J. Verhaar E.H. de Haan et al. Insulin-like growth factor-I and cognitive function in healthy older men J. Clin. Endocrinol. Metab. 1999 471-475
32. M.G. Dik S.M. Pluijm C. Jonker D.J. Deeg M.Z. Lomecky P. Lips Insulin-like growth factor I (IGF-I) cognitive decline in older persons Neurobiol. Aging 2003 573-581
33. S. Kalmijn J.A. Janssen H.A. Pols S.W. Lamberts M.M. Breteler A prospective study on circulating insulin-like growth factor I (IGF-I), IGF-binding proteins, and cognitive function in the elderly J. Clin. Endocrinol. Metab. 2000 4551-4555
34. A. Rollero G. Murialdo S. Fonzi et al. Relationship between cognitive function, growth hormone and insulin-like growth factor I plasma levels in aged subjects Neuropsychobiology 1998 73-79
35. J.C. Nunnally, I.H. Bernstein, Psychometric Theory, third ed., New York, 2000
36. A.M. Ahmad M.T. Hopkins J. Thomas H. Ibrahim W.D. Fraser J.P. Vora Body composition and quality of life in adults with growth hormone deficiency; effects of low-dose growth hormone replacement Clin. Endocrinol. (Oxf) 2001 709-717
37. H.B. Baum L. Katznelson J.C. Sherman et al. Effects of physiological growth hormone (GH) therapy on cognition and quality of life in patients with adult-onset GH deficiency J. Clin. Endocrinol. Metab. 1998 3184-3189
38. P. Burman J.E. Broman J. Hetta et al. Quality of life in adults with growth hormone (GH) deficiency: Response to treatment with recombinant human GH in a placebo-controlled 21-month trial J. Clin. Endocrinol. Metab. 1995 3585-3590
39. P.V. Carroll R. Littlewood A.J. Weissberger et al. The effects of two doses of replacement growth hormone on the biochemical, body composition and psychological profiles of growth hormone-deficient adults Eur. J. Endocrinol. 1997 146-153
40. R.C. Cuneo S. Judd J.D. Wallace et al. The Australian multicenter trial of growth hormone (GH) treatment in GH-deficient adults J. Clin. Endocrinol. Metab. 1998 107-116
41. M. Degerblad O. Almkvist R. Grunditz et al. Physical and psychological capabilities during substitution therapy with recombinant growth hormone in adults with growth hormone deficiency Acta Endocrinol. (Copenh) 1990 185-193
42. M. Giusti I. Meineri D. Malagamba et al. Impact of recombinant human growth hormone treatment on psychological profiles in hypopituitary patients with adult-onset growth hormone deficiency Eur. J. Clin. Invest. 1998 13-19
43. E. Hernberg-Stahl A. Luger R. Abs et al. Healthcare consumption decreases in parallel with improvements in quality of life during GH replacement in hypopituitary adults with GH deficiency J. Clin. Endocrinol. Metab. 2001 5277-5281
44. R.D. Murray C.J. Skillicorn S.J. Howell et al. Influences on quality of life in GH deficient adults and their effect on response to treatment Clin. Endocrinol. (Oxf) 1999 565-573
45. A. Sartorio E. Molinari G. Riva A. Conti F. Morabito G. Faglia Growth hormone treatment in adults with childhood onset growth hormone deficiency: Effects on psychological capabilities Horm. Res. 1995 6-11
46. C.N. Soares N.R. Musolino N.M. Cunha et al. Impact of recombinant human growth hormone. A placebo-controlled trial (RH-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults Arq. Neuropsiquiatr. 1999 182-189
47. M.E. Wallymahmed P. Foy D. Shaw R. Hutcheon R.H. Edwards I.A. MacFarlane Quality of life, body composition and muscle strength in adult growth hormone deficiency: The influence of growth hormone replacement therapy for up to 3 years Clin. Endocrinol. (Oxf) 1997 439-446
48. L. Wiren B.A. Bengtsson G. Johannsson Beneficial effects of long-term GH replacement therapy on quality of life in adults with GH deficiency Clin. Endocrinol. (Oxf) 1998 613-620