메뉴 건너뛰기




Volumn 33, Issue 3, 2015, Pages 327-331

Bile acids as hormones: The FXR-FGF15/19 pathway

Author keywords

CYP7A1; Fibroblast growth factor; Ileum; Liver; Nuclear receptor

Indexed keywords

BILE ACID; CELL SURFACE RECEPTOR; CHOLESTEROL 7ALPHA MONOOXYGENASE; FARNESOID X RECEPTOR; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 15; FIBROBLAST GROWTH FACTOR 19; GLYCOGEN; INSULIN; UNCLASSIFIED DRUG; CELL RECEPTOR; CYP7A1 PROTEIN, MOUSE; FARNESOID X-ACTIVATED RECEPTOR; FGF19 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR 15, MOUSE; NUCLEAR RECEPTOR SUBFAMILY 0, GROUP B, MEMBER 2;

EID: 84930581210     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000371670     Document Type: Conference Paper
Times cited : (321)

References (51)
  • 3
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • Wang H, Chen J, Hollister K, Sowers LC, Forman BM: Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 1999; 3: 543-553.
    • (1999) Mol Cell , vol.3 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 7
    • 0034616147 scopus 로고    scopus 로고
    • Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor
    • Laffitte BA, Kast HR, Nguyen CM, Zavacki AM, Moore DD, Edwards PA: Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor. J Biol Chem 2000; 275: 10638-10647.
    • (2000) J Biol Chem , vol.275 , pp. 10638-10647
    • Laffitte, B.A.1    Kast, H.R.2    Nguyen, C.M.3    Zavacki, A.M.4    Moore, D.D.5    Edwards, P.A.6
  • 9
    • 84858796689 scopus 로고    scopus 로고
    • Transcriptional integration of metabolism by the nuclear sterolactivated receptors LXR and FXR
    • Calkin AC, Tontonoz P: Transcriptional integration of metabolism by the nuclear sterolactivated receptors LXR and FXR. Nat Rev Mol Cell Biol 2012; 13: 213-224.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 213-224
    • Calkin, A.C.1    Tontonoz, P.2
  • 10
    • 0142211282 scopus 로고    scopus 로고
    • Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: Efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein
    • Kok T, Hulzebos CV, Wolters H, Havinga R, Agellon LB, Stellaard F, Shan B, Schwarz M, Kuipers F: Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein. J Biol Chem 2003; 278: 41930-41937.
    • (2003) J Biol Chem , vol.278 , pp. 41930-41937
    • Kok, T.1    Hulzebos, C.V.2    Wolters, H.3    Havinga, R.4    Agellon, L.B.5    Stellaard, F.6    Shan, B.7    Schwarz, M.8    Kuipers, F.9
  • 11
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G, Gonzalez FJ: Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 2000; 102: 731-744.
    • (2000) Cell , vol.102 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3    Ward, J.M.4    Lambert, G.5    Gonzalez, F.J.6
  • 13
    • 70849133150 scopus 로고    scopus 로고
    • Bile acid transporters
    • Dawson PA, Lan T, Rao A: Bile acid transporters. J Lipid Res 2009; 50: 2340-2357.
    • (2009) J Lipid Res , vol.50 , pp. 2340-2357
    • Dawson, P.A.1    Lan, T.2    Rao, A.3
  • 16
    • 0034685916 scopus 로고    scopus 로고
    • Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4
    • Yu C, Wang F, Kan M, Jin C, Jones RB, Weinstein M, Deng CX, McKeehan WL: Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J Biol Chem 2000; 275: 15482-15489.
    • (2000) J Biol Chem , vol.275 , pp. 15482-15489
    • Yu, C.1    Wang, F.2    Kan, M.3    Jin, C.4    Jones, R.B.5    Weinstein, M.6    Deng, C.X.7    McKeehan, W.L.8
  • 17
    • 23644437321 scopus 로고    scopus 로고
    • Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho
    • Ito S, Fujimori T, Furuya A, Satoh J, Nabeshima Y: Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho. J Clin Invest 2005; 115: 2202-2208.
    • (2005) J Clin Invest , vol.115 , pp. 2202-2208
    • Ito, S.1    Fujimori, T.2    Furuya, A.3    Satoh, J.4    Nabeshima, Y.5
  • 18
    • 0030776762 scopus 로고    scopus 로고
    • A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1
    • McWhirter JR, Goulding M, Weiner JA, Chun J, Murre C: A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. Development 1997; 124: 3221-3232.
    • (1997) Development , vol.124 , pp. 3221-3232
    • McWhirter, J.R.1    Goulding, M.2    Weiner, J.A.3    Chun, J.4    Murre, C.5
  • 19
    • 0033579972 scopus 로고    scopus 로고
    • Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain
    • Nishimura T, Utsunomiya Y, Hoshikawa M, Ohuchi H, Itoh N: Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain. Biochim Biophys Acta 1999; 1444: 148-151.
    • (1999) Biochim Biophys Acta , vol.1444 , pp. 148-151
    • Nishimura, T.1    Utsunomiya, Y.2    Hoshikawa, M.3    Ohuchi, H.4    Itoh, N.5
  • 20
    • 1542494467 scopus 로고    scopus 로고
    • Evolutionary conservation of CCND1-ORAOV1-FGF19-FGF4 locus from zebrafish to human
    • Katoh M: Evolutionary conservation of CCND1-ORAOV1-FGF19-FGF4 locus from zebrafish to human. Int J Mol Med 2003; 12: 45-50.
    • (2003) Int J Mol Med , vol.12 , pp. 45-50
    • Katoh, M.1
  • 22
    • 33751115468 scopus 로고    scopus 로고
    • Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man
    • Lundasen T, Galman C, Angelin B, Rudling M: Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man. J Intern Med 2006; 260: 530-536.
    • (2006) J Intern Med , vol.260 , pp. 530-536
    • Lundasen, T.1    Galman, C.2    Angelin, B.3    Rudling, M.4
  • 27
    • 33846910174 scopus 로고    scopus 로고
    • Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism
    • Fang S, Miao J, Xiang L, Ponugoti B, Treuter E, Kemper JK: Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism. Mol Cell Biol 2007; 27: 1407-1424.
    • (2007) Mol Cell Biol , vol.27 , pp. 1407-1424
    • Fang, S.1    Miao, J.2    Xiang, L.3    Ponugoti, B.4    Treuter, E.5    Kemper, J.K.6
  • 28
    • 4344601668 scopus 로고    scopus 로고
    • Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP
    • Kemper JK, Kim H, Miao J, Bhalla S, Bae Y: Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP. Mol Cell Biol 2004; 24: 7707-7719.
    • (2004) Mol Cell Biol , vol.24 , pp. 7707-7719
    • Kemper, J.K.1    Kim, H.2    Miao, J.3    Bhalla, S.4    Bae, Y.5
  • 32
    • 0028278187 scopus 로고
    • Identification and characterization of a putative bile acid-responsive element in cholesterol 7 alpha-hydroxylase gene promoter
    • Chiang JY, Stroup D: Identification and characterization of a putative bile acid-responsive element in cholesterol 7 alpha-hydroxylase gene promoter. J Biol Chem 1994; 269: 17502-17507.
    • (1994) J Biol Chem , vol.269 , pp. 17502-17507
    • Chiang, J.Y.1    Stroup, D.2
  • 33
    • 0035903105 scopus 로고    scopus 로고
    • The negative effects of bile acids and tumor necrosis factoralpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: A novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors
    • De Fabiani E, Mitro N, Anzulovich AC, Pinelli A, Galli G, Crestani M: The negative effects of bile acids and tumor necrosis factoralpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: A novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors. J Biol Chem 2001; 276: 30708-30716.
    • (2001) J Biol Chem , vol.276 , pp. 30708-30716
    • De Fabiani, E.1    Mitro, N.2    Anzulovich, A.C.3    Pinelli, A.4    Galli, G.5    Crestani, M.6
  • 34
    • 84870334072 scopus 로고    scopus 로고
    • Nuclear receptors HNF4alpha and LRH-1 cooperate in regulating Cyp7a1 in vivo
    • Kir S, Zhang Y, Gerard RD, Kliewer SA, Mangelsdorf DJ: Nuclear receptors HNF4alpha and LRH-1 cooperate in regulating Cyp7a1 in vivo. J Biol Chem 2012; 287: 41334-41341.
    • (2012) J Biol Chem , vol.287 , pp. 41334-41341
    • Kir, S.1    Zhang, Y.2    Gerard, R.D.3    Kliewer, S.A.4    Mangelsdorf, D.J.5
  • 35
    • 37249015421 scopus 로고    scopus 로고
    • Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
    • Kim I, Ahn SH, Inagaki T, Choi M, Ito S, Guo GL, Kliewer SA, Gonzalez FJ: Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J Lipid Res 2007; 48: 2664-2672.
    • (2007) J Lipid Res , vol.48 , pp. 2664-2672
    • Kim, I.1    Ahn, S.H.2    Inagaki, T.3    Choi, M.4    Ito, S.5    Guo, G.L.6    Kliewer, S.A.7    Gonzalez, F.J.8
  • 40
    • 33645509321 scopus 로고    scopus 로고
    • Farnesoid X receptor is essential for normal glucose homeostasis
    • Ma K, Saha PK, Chan L, Moore DD: Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest 2006; 116: 1102-1109.
    • (2006) J Clin Invest , vol.116 , pp. 1102-1109
    • Ma, K.1    Saha, P.K.2    Chan, L.3    Moore, D.D.4
  • 43
    • 66449085572 scopus 로고    scopus 로고
    • FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action
    • Shin DJ, Osborne TF: FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action. J Biol Chem 2009; 284: 11110-11120.
    • (2009) J Biol Chem , vol.284 , pp. 11110-11120
    • Shin, D.J.1    Osborne, T.F.2
  • 50
    • 84871694003 scopus 로고    scopus 로고
    • Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats
    • Ryan KK, Kohli R, Gutierrez-Aguilar R, Gaitonde SG, Woods SC, Seeley RJ: Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats. Endocrinology 2013; 154: 9-15.
    • (2013) Endocrinology , vol.154 , pp. 9-15
    • Ryan, K.K.1    Kohli, R.2    Gutierrez-Aguilar, R.3    Gaitonde, S.G.4    Woods, S.C.5    Seeley, R.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.