Transcriptional profiling of the nucleus pulposus: Say yes to notochord

Arthritis Research and Therapy

Volumn 12, Issue 3, 2010, Pages

  Shapiro, Irving M ^a   Risbud, Makarand V ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL LINEAGE; CELL LOSS; EDITORIAL; EXPERIMENTAL ANIMAL; GENE EXPRESSION PROFILING; HUMAN; INTERVERTEBRAL DISK; MARKER GENE; NONHUMAN; NOTOCHORD; NUCLEUS PULPOSUS; PHENOTYPE; ADULT; ANIMAL; ANIMAL MODEL; CATTLE; CYTOLOGY; GENETIC TRANSCRIPTION; METABOLISM; MOUSE; NOTE;

BRACHYURY PROTEIN; CYTOKERATIN 18; CYTOKERATIN 8; FETOPROTEIN; T BOX TRANSCRIPTION FACTOR;

ADULT; ANIMALS; CATTLE; FETAL PROTEINS; GENE EXPRESSION PROFILING; HUMANS; INTERVERTEBRAL DISC; KERATIN-18; KERATIN-8; MICE; MODELS, ANIMAL; NOTOCHORD; T-BOX DOMAIN PROTEINS; TRANSCRIPTION, GENETIC;

EID: 77952406185     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3003     Document Type: Editorial

References (13)

1. Minogue BM, Richardson SM, Zeef LA, Freemont AJ, Hoyland JA. Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes. Arthritis Res Ther 2010, 12:R22. 10.1186/ar2929, 20149220.
2. Hunter CJ, Matyas JR, Duncan NA. The notochordal cell in the nucleus pulposus: a review in the context of tissue engineering. Tissue Eng 2003, 9:667-677. 10.1089/107632703768247368, 13678445.
3. Alini M, Eisenstein SM, Ito K, Little C, Kettler AA, Masuda K, Melrose J, Ralphs J, Stokes I, Wilke HJ. Are animal models useful for studying human disc disorders/degeneration?. Eur Spine J 2008, 17:2-19. 2365516, 17632738, 10.1007/s00586-007-0414-y.
4. Walmsley R. The Development and growth of the intervertebral disc. Edinb Med J 1953, 60:341-364.
5. Kim KW, Lim TH, Kim JG, Jeong ST, Masuda K, An HS. The origin of chondrocytes in the nucleus pulposus and histologic findings associated with the transition of a notochordal nucleus pulposus to a fibrocartilaginous nucleus pulposus in intact rabbit intervertebral discs. Spine 2003, 28:982-990. 10.1097/00007632-200305150-00005, 12768135.
6. Stosiek P, Kasper M, Karsten U. Expression of cytokeratin and vimentin in nucleus pulposus cells. Differentiation 1988, 39:78-81. 10.1111/j.1432-0436.1988.tb00083.x, 2469613.
7. Trout JJ, Buckwalter JA, Moore KC. Ultrastructure of the human intervertebral disc: II. Cells of the nucleus pulposus. Anat Rec 1982, 204:307-314. 10.1002/ar.1092040403, 7181135.
8. Choi KS, Cohn MJ, Harfe BD. Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: implications for disk degeneration and chordoma formation. Dev Dyn 2008, 237:3953-3958. 2646501, 19035356, 10.1002/dvdy.21805.
9. Herrmann BG, Kispert A. The T genes in embryogenesis. Trends Genet 1994, 10:280-286. 10.1016/0168-9525(90)90011-T, 7940757.
10. Lee CR, Sakai D, Nakai T, Toyama K, Mochida J, Alini M, Grad S. A phenotypic comparison of intervertebral disc and articular cartilage cells in the rat. Eur Spine J 2007, 16:2174-2185. 2140128, 17786487, 10.1007/s00586-007-0475-y.
11. Sakai D, Nakai T, Mochida J, Alini M, Grad S. Differential phenotype of intervertebral disc cells: microarray and immunohistochemical analysis of canine nucleus pulposus and anulus fibrosus. Spine 2009, 34:1448-1456. 10.1097/BRS.0b013e3181a55705, 19525835.
12. Kim JH, Deasy BM, Seo HY, Studer RK, Vo NV, Georgescu HI, Sowa GA, Kang JD. Differentiation of intervertebral notochordal cells through live automated cell imaging system in vitro. Spine 2009, 34:2486-2493. 10.1097/BRS.0b013e3181b26ed1, 19841610.
13. Gilson A, Dreger M, Urban JP. Differential expression levels of cytokeratin 8 in cells of the ovine nucleus pulposus complicates the search for specific intervertebral disc cell markers. Arthritis Res Ther 2010, 12:R24. 10.1186/ar2931, 20152014.