Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: Implications in intervertebral disc degeneration

Journal of Biological Chemistry

Volumn 288, Issue 23, 2013, Pages 16761-16774

  Wang, Hua ^a,b   Tian, Ye ^a,c   Wang, Jianru ^a   Phillips, Kate L E ^d   Binch, Abbie L A ^d   Dunn, Sara ^d   Cross, Alison ^d   Chiverton, Neil ^e   Zheng, Zhaomin ^b   Shapiro, Irving M ^a   Le Maitre, Christine L ^d   Risbud, Makarand V ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

^d SHEFFIELD HALLAM UNIVERSITY   (United Kingdom)

^e SHEFFIELD TEACHING HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE TREATMENT; DEGENERATIVE DISC DISEASE; INDUCTIVE EFFECTS; INFLAMMATORY CYTOKINES; INTER-VERTEBRAL DISC DEGENERATION; NOTCH SIGNALING; NUCLEUS PULPOSUS; PROMOTER ACTIVITIES;

CELLS; CYTOLOGY; GENE EXPRESSION; SIGNALING; TISSUE;

CELL SIGNALING;

CELL PROTEIN; FLUORESCEIN ISOTHIOCYANATE; I KAPPA B; I KAPPA B KINASE BETA; INTERLEUKIN 1BETA; JAGGED2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 11; MITOGEN ACTIVATED PROTEIN KINASE 12; MITOGEN ACTIVATED PROTEIN KINASE 13; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38 BETA2; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; PROTEIN P50; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR HES 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GAIN OF FUNCTION MUTATION; GENE; GENE INDUCTION; GENE TARGETING; HES1 GENE; HEY1 GENE; HEY2 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERVERTEBRAL DISK DEGENERATION; LOSS OF FUNCTION MUTATION; MALE; NONHUMAN; NOTCH GENE; NUCLEUS PULPOSUS; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION;

CHONDROCYTES; CYTOKINE; INTERVERTEBRAL DISC; NF-KAPPA B (NF-KB); NOTCH PATHWAY; NUCLEUS PULPOSUS; OSTEOARTHRITIS;

ADULT; AGED; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL CYCLE PROTEINS; CELL LINE; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; INTERLEUKIN-1BETA; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; MALE; MAP KINASE SIGNALING SYSTEM; MIDDLE AGED; PROMOTER REGIONS, GENETIC; RATS; RECEPTOR, NOTCH1; RECEPTOR, NOTCH2; REPRESSOR PROTEINS; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84878767656     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.446633     Document Type: Article

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