Concise review: New insights into the role of macrophages in β-cell proliferation

Stem Cells Translational Medicine

Volumn 4, Issue 6, 2015, Pages 655-658

  Xiao, Xiangwei ^a   Gittes, George K ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Diabetes; Macrophage polarization; Macrophages; Cell proliferation; Cell Regeneration

Indexed keywords

ANGIOPOIETIN; EPIDERMAL GROWTH FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 23; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; SMAD7 PROTEIN; STAT6 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ARTICLE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; DIABETES MELLITUS; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; INSULITIS; MACROPHAGE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; SIGNAL TRANSDUCTION; TH1 CELL; WNT SIGNALING PATHWAY; ANIMAL; CELL COMMUNICATION; DIABETES MELLITUS, TYPE 1; METABOLISM; PATHOLOGY;

ANIMALS; CELL COMMUNICATION; CELL PROLIFERATION; DIABETES MELLITUS, TYPE 1; HUMANS; INSULIN-SECRETING CELLS; MACROPHAGES; SIGNAL TRANSDUCTION;

EID: 84930509576     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2014-0248     Document Type: Article

References (64)

1. Pipeleers D, Keymeulen B, Chatenoud L et al. A view on beta cell transplantation in diabetes. Ann N Y Acad Sci 2002;958:69–76.
2. Zaret KS, Grompe M. Generation and re-generationofcellsoftheliver and pancreas. Science 2008;322:1490–1494.
3. Weir GC, Bonner-Weir S.Islet transplantation as a treatment for diabetes. J Am Optom Assoc 1998;69:727–732.
4. Ackermann AM, Gannon M. Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. J Mol Endocrinol 2007;38:193–206.
5. Pipeleers D, Chintinne M, Denys B et al. Restoring a functional beta-cell mass in diabetes. Diabetes Obes Metab 2008;10(suppl 4):54–62.
6. Kushner JA, Weir GC, Bonner-Weir S. Duc-tal origin hypothesisofpancreatic regeneration under attack. Cell Metab 2010;11:2–3.
7. Kopp JL, Dubois CL, Hao E et al. Progenitor cell domains in the developing and adult pancreas. Cell Cycle 2011;10:1921–1927.
8. Thorel F, Népote V, Avril I et al. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 2010;464:1149–1154.
9. Chera S, Baronnier D, Ghila L et al. Diabetes recovery by age-dependent conversion of pancreaticd-cellsintoinsulinproducers. Nature 2014;514:503–507.
10. Chung CH, Hao E,PiranRetal. Pancreatic b-cellneogenesisbydirectconversionfromma-ture a-cells. Stem Cells 2010;28:1630–1638.
11. Hao E, Lee SH, Levine F. Efficientb-cellre-generationby a combination of neogenesis and replication following b-cell ablation and reversal of pancreatic duct ligation. Stem Cells 2013;31:2388–2395.
12. Piran R, Lee SH, Li CR et al. Pharmacological induction of pancreatic islet cell transdiffer-entiation: Relevance to type I diabetes. Cell Death Dis 2014;5:e1357.
13. Baeyens L, Lemper M, Leuckx G et al. Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Nat Biotechnol 2014;32:76–83.
14. Dor Y, Brown J, Martinez OI et al. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004;429:41–46.
15. Teta M, Rankin MM, Long SY et al. Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell 2007;12:817–826.
16. Meier JJ, Butler AE, Saisho Y et al. Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetes 2008;57:1584–1594.
17. Georgia S, Bhushan A. Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest 2004; 114:963–968.
18. Xiao X, Guo P, Shiota C et al. Neurogenin3 activation is not sufficientto direct duct-to-beta cell transdifferentiation in the adult pancreas. J Biol Chem 2013;288:25297–25308.
19. Xiao X, Chen Z, Shiota C et al.Noevidence forbcell neogenesisin murine adult pancreas. J Clin Invest 2013;123:2207–2217.
20. Xiao X, Wiersch J, El-Gohary Y et al. TGFb receptor signalingisessential for inflammation-induced but not b-cell workload-induced b-cell proliferation. Diabetes 2013;62:1217–1226.
21. Rankin MM, Wilbur CJ, Rak K et al. b-Cells are not generated in pancreatic duct ligation-induced injury in adult mice. Diabetes 2013; 62:1634–1645.
22. Solar M, Cardalda C, Houbracken I et al. Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth. Dev Cell 2009;17:849–860.
23. Kopp JL, Dubois CL, Schaffer AE et al. Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development 2011;138:653–665.
24. Chintinne M, Stange´ G, Denys B et al. Beta cell count instead of beta cell mass to assess and localize growth in beta cell population following pancreatic duct ligation in mice. PLoS One 2012;7:e43959.
25. Kopinke D, Brailsford M, Shea JE et al. Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas. Development 2011;138:431–441.
26. Desai BM, Oliver-Krasinski J, De Leon DD et al. Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration. J Clin Invest 2007;117:971–977.
27. Pan FC, Bankaitis ED, Boyer D et al. Spa-tiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organo-genesis and injury-induced facultative restoration. Development 2013;140:751–764.
28. Cavelti-Weder C, Shtessel M, Reuss JE et al. Pancreatic duct ligation after almost complete b-cell loss: Exocrine regeneration but no evidence of b-cell regeneration. Endocrinology 2013;154:4493–4502.
29. Zhou Q, Brown J, Kanarek A et al. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008;455:627–632.
30. Li W, Nakanishi M, Zumsteg A et al. In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes. Elife 2014;3:e01846.
31. Hija A, Salpeter S, Klochendler A et al. G0-G1 transition and the restriction point in pancreatic b-cells in vivo. Diabetes 2014;63:578–584.
32. Salpeter SJ, Khalaileh A, Weinberg-Corem N et al. Systemic regulation of the age-related decline of pancreatic b-cell replication. Diabetes 2013;62:2843–2848.
33. Rankin MM, Kushner JA. Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes 2009;58:1365–1372.
34. Gunasekaran U, Gannon M. Type2diabe-tes and the aging pancreatic beta cell. Aging (Albany, NY Online) 2011;3:565–575.
35. Tonne JM, Sakuma T, Munoz-Gomez M et al. Beta cell regeneration after single-round immunological destruction in a mouse model. Diabetologia 2015;58:313–323.
36. Blum B, Roose AN, Barrandon O et al. Re-versalofbcell de-differentiationbyasmallmol-ecule inhibitor ofthe TGFb pathway. Elife 2014; 3:e02809.
37. Xiao X, Gaffar I, Guo P et al. M2 macro-phages promote beta-cell proliferation by up-regulation of SMAD7. Proc Natl Acad Sci USA 2014;111:E1211–E1220.
38. Criscimanna A, Coudriet GM, Gittes GK et al. Activated macrophages create lineage-specific microenvironments for pancreatic aci-nar- and b-cell regeneration in mice. Gastroen-terology 2014;147:1106–1118.e11.
39. Brissova M, Aamodt K, Brahmachary P et al. Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes b cell regeneration. Cell Metab 2014; 19:498–511.
40. Cao X, Han ZB, Zhao H et al. Transplantation of mesenchymal stem cells recruits trophic macrophages to induce pancreatic beta cell regeneration in diabetic mice. Int J Biochem Cell Biol 2014;53:372–379.
41. Flavell RA, Sanjabi S, Wrzesinski SH et al. The polarization of immune cells in the tumour environment by TGFbeta. Nat Rev Immunol 2010;10:554–567.
42. Gordon S, Taylor PR. Monocyte and mac-rophage heterogeneity. NatRev Immunol 2005; 5:953–964.
43. Pollard JW. Trophic macrophages in development and disease. Nat Rev Immunol 2009; 9:259–270.
44. Grunewald M, Avraham I, Dor Y et al. VEGF-induced adult neovascularization: Recruitment, retention, and role of accessory cells. Cell 2006;124:175–189.
45. Westwell-Roper CY, Ehses JA, Verchere CB. Resident macrophages mediate islet amyloid polypeptide-induced islet IL-1b production and b-cell dysfunction. Diabetes 2014;63:1698–1711.
46. Calderon B, Suri A, Miller MJ et al. Dendritic cells in islets of Langerhans constitutively present beta cell-derived peptides bound to their class II MHC molecules. Proc Natl Acad Sci USA 2008;105:6121–6126.
47. Lee KU, Kim MK, Amano K et al. Preferential infiltration of macrophages during early stages of insulitis in diabetes-prone BB rats. Diabetes 1988;37:1053–1058.
48. Jun HS, Yoon CS, Zbytnuik L et al. The role ofmacrophagesinTcell-mediatedautoimmune diabetes in nonobese diabetic mice. J Exp Med 1999;189:347–358.
49. Eguchi K, Manabe I. Macrophages and islet inflammation in type 2 diabetes. Diabetes Obes Metab 2013;15(suppl 3):152–158.
50. Espinoza-Jimenez A, Peon AN, Terrazas LI. Alternativelyactivated macrophagesintypes 1 and 2 diabetes. Mediators Inflamm 2012; 2012:815953.
51. Honkanen J, Nieminen JK, Gao R et al. IL-17 immunityin human type1 diabetes. J Immunol 2010;185:1959–1967.
52. Boehm BO, Rosinger S, Sauer G et al. Protease-resistant human GAD-derived altered peptide ligands decrease TNF-alpha and IL-17 production in peripheral blood cells from patients with type 1 diabetes mellitus. Mol Immunol 2009;46:2576–2584.
53. Jourdan T, Godlewski G, Cinar R et al. Ac-tivationoftheNlrp3inflammasomeininfiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. Nat Med 2013; 19:1132–1140.
54. Han MS, Jung DY, Morel C et al. JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science 2013;339:218–222.
55. Menghini R, Casagrande V, Menini S et al. TIMP3overexpressioninmacrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice. Diabetes 2012;61:454–462.
56. Koliwad SK, Streeper RS, MonettiM et al. DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation. J Clin Invest 2010;120:756–767.
57. Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 2010;72:219–246.
58. Fu W, Farache J, Clardy SM et al. Epige-netic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and b cells. Elife 2014;3:e04631.
59. Criscimanna A, Speicher JA, Houshmand G et al. Duct cells contribute to regeneration of endocrine and acinar cells following pancreatic damage in adult mice. Gastroenterology 2011; 141:1451–1462.
60. El-Gohary Y, Tulachan S, Wiersch J et al. A SMAD signaling network regulates islet cell proliferation. Diabetes 2014;63:224–236.
61. Xiao X, Prasadan K, Guo P et al. Pancreatic duct cells as a source of VEGF in mice. Diabeto-logia 2014;57:991–1000.
62. Xiao X, Guo P, Prasadan K et al. Pancreatic cell tracing, lineage tagging and targeted genetic manipulations in multiple cell types using pancreatic ductal infusion of adeno-associated viral vectors and/or cell-tagging dyes. Nat Pro-toc 2014;9:2719–2724.
63. Van Gassen N, Van Overmeire E, Leuckx G et al.Macrophage dynamicsare regulatedbylo-cal macrophage proliferation and monocyte recruitment in injured pancreas. Eur J Immunol 2015
64. Nikolova G, Jabs N, Konstantinova I et al. The vascular basement membrane: A niche for insulin gene expression and Beta cell proliferation. Dev Cell 2006;10:397–405.