Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway

eLife

Volumn 3, Issue , 2014, Pages e02809-

  Blum, Barak ^a   Roose, Adam N ^a   Barrandon, Ornella ^a   Maehr, René ^a   Arvanites, Anthony C ^a   Davidow, Lance S ^a   Davis, Jeffrey C ^a   Peterson, Quinn P ^a   Rubin, Lee L ^a   Melton, Douglas A ^a  

^a Harvard University   (United States)

Author keywords

Alk5 inhibitor II; beta cells; cell biology; dedifferentiation; developmental biology; diabetes; human; mouse; stem cells; Tgf beta; Ucn3

Indexed keywords

ARTN PROTEIN, MOUSE; BIOLOGICAL MARKER; CYTOKINE; MOLECULAR LIBRARY; NERVE PROTEIN; PROTEIN SERINE THREONINE KINASE; TGF-BETA TYPE I RECEPTOR; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UROCORTIN;

ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL DEDIFFERENTIATION; DRUG EFFECTS; HUMAN; INSULIN RESISTANCE; METABOLISM; MOLECULAR LIBRARY; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PATHOLOGY; PHARMACOLOGY; PHYSIOLOGICAL STRESS; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; BIOMARKERS; CELL DEDIFFERENTIATION; CYTOKINES; DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION; UROCORTINS;

EID: 85003341559     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.02809     Document Type: Article

References (0)