메뉴 건너뛰기




Volumn 63, Issue 1, 2014, Pages 224-236

A smad signaling network regulates islet cell proliferation

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCOSE TRANSPORTER 2; INSULIN; PANCREAS POLYPEPTIDE; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; SOMATOSTATIN; TAMOXIFEN; TRANSCRIPTION FACTOR PDX 1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

EID: 84886545834     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-0432     Document Type: Article
Times cited : (64)

References (50)
  • 1
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004;429:41-46
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 2
    • 9644266753 scopus 로고    scopus 로고
    • Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass
    • Georgia S, Bhushan A. Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest 2004;114: 963-968
    • (2004) J Clin Invest , vol.114 , pp. 963-968
    • Georgia, S.1    Bhushan, A.2
  • 3
    • 84857045118 scopus 로고    scopus 로고
    • Whole-mount imaging demonstrates hypervascularity of the pancreatic ducts and other pancreatic structures
    • El-Gohary Y, Tulachan S, Branca M, et al. Whole-mount imaging demonstrates hypervascularity of the pancreatic ducts and other pancreatic structures. Anat Rec (Hoboken) 2012;295:465-473
    • (2012) Anat Rec (Hoboken) , vol.295 , pp. 465-473
    • El-Gohary, Y.1    Tulachan, S.2    Branca, M.3
  • 4
    • 58149378342 scopus 로고    scopus 로고
    • Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth
    • Inada A, Nienaber C, Katsuta H, et al. Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc Natl Acad Sci USA 2008;105:19915-19919
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19915-19919
    • Inada, A.1    Nienaber, C.2    Katsuta, H.3
  • 5
    • 77951611220 scopus 로고    scopus 로고
    • Conversion of adult pancreatic alphacells to beta-cells after extreme beta-cell loss
    • Thorel F, Népote V, Avril I, et al. Conversion of adult pancreatic alphacells to beta-cells after extreme beta-cell loss. Nature 2010;464:1149-1154
    • (2010) Nature , vol.464 , pp. 1149-1154
    • Thorel, F.1    Népote, V.2    Avril, I.3
  • 6
    • 33744920617 scopus 로고    scopus 로고
    • Molecular control of cell cycle progression in the pancreatic beta-cell
    • Cozar-Castellano I, Fiaschi-Taesch N, Bigatel TA, et al. Molecular control of cell cycle progression in the pancreatic beta-cell. Endocr Rev 2006;27: 356-370
    • (2006) Endocr Rev , vol.27 , pp. 356-370
    • Cozar-Castellano, I.1    Fiaschi-Taesch, N.2    Bigatel, T.A.3
  • 7
    • 35348957846 scopus 로고    scopus 로고
    • Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets
    • Goto Y, Nomura M, Tanaka K, et al. Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets. Dev Dyn 2007; 236:2865-2874
    • (2007) Dev Dyn , vol.236 , pp. 2865-2874
    • Goto, Y.1    Nomura, M.2    Tanaka, K.3
  • 8
    • 30944441065 scopus 로고    scopus 로고
    • Transforming growth factor-beta pathway: Role in pancreas development and pancreatic disease
    • Rane SG, Lee JH, Lin HM. Transforming growth factor-beta pathway: role in pancreas development and pancreatic disease. Cytokine Growth Factor Rev 2006;17:107-119
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 107-119
    • Rane, S.G.1    Lee, J.H.2    Lin, H.M.3
  • 9
    • 79957580066 scopus 로고    scopus 로고
    • Differential roles of Smad2 and Smad3 in the regulation of TGF-b1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: Control by Rac1
    • Ungefroren H, Groth S, Sebens S, Lehnert H, Gieseler F, Fändrich F. Differential roles of Smad2 and Smad3 in the regulation of TGF-b1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1. Mol Cancer 2011;10:67
    • (2011) Mol Cancer , vol.10 , pp. 67
    • Ungefroren, H.1    Groth, S.2    Sebens, S.3    Lehnert, H.4    Gieseler, F.5    Fändrich, F.6
  • 10
    • 12344313566 scopus 로고    scopus 로고
    • GDF11 modulates NGN3+ islet progenitor cell number and promotes beta-cell differentiation in pancreas development
    • Harmon EB, Apelqvist AA, Smart NG, Gu X, Osborne DH, Kim SK. GDF11 modulates NGN3+ islet progenitor cell number and promotes beta-cell differentiation in pancreas development. Development 2004;131:6163-6174
    • (2004) Development , vol.131 , pp. 6163-6174
    • Harmon, E.B.1    Apelqvist, A.A.2    Smart, N.G.3    Gu, X.4    Osborne, D.H.5    Kim, S.K.6
  • 11
    • 0031916664 scopus 로고    scopus 로고
    • Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development
    • Miralles F, Czernichow P, Scharfmann R. Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development. Development 1998;125:1017-1024
    • (1998) Development , vol.125 , pp. 1017-1024
    • Miralles, F.1    Czernichow, P.2    Scharfmann, R.3
  • 12
    • 34247638529 scopus 로고    scopus 로고
    • TGF-beta isoform signaling regulates secondary transition and mesenchymal-induced endocrine development in the embryonic mouse pancreas
    • Tulachan SS, Tei E, Hembree M, et al. TGF-beta isoform signaling regulates secondary transition and mesenchymal-induced endocrine development in the embryonic mouse pancreas. Dev Biol 2007;305:508-521
    • (2007) Dev Biol , vol.305 , pp. 508-521
    • Tulachan, S.S.1    Tei, E.2    Hembree, M.3
  • 13
    • 34247539528 scopus 로고    scopus 로고
    • A tale of two proteins: Differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling
    • Brown KA, Pietenpol JA, Moses HL. A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling. J Cell Biochem 2007;101:9-33
    • (2007) J Cell Biochem , vol.101 , pp. 9-33
    • Brown, K.A.1    Pietenpol, J.A.2    Moses, H.L.3
  • 14
    • 33847256507 scopus 로고    scopus 로고
    • BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion
    • Goulley J, Dahl U, Baeza N, Mishina Y, Edlund H. BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion. Cell Metab 2007;5:207-219
    • (2007) Cell Metab , vol.5 , pp. 207-219
    • Goulley, J.1    Dahl, U.2    Baeza, N.3    Mishina, Y.4    Edlund, H.5
  • 15
    • 33244464960 scopus 로고    scopus 로고
    • Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus
    • Smart NG, Apelqvist AA, Gu X, et al. Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus. PLoS Biol 2006;4:e39
    • (2006) PLoS Biol , vol.4
    • Smart, N.G.1    Apelqvist, A.A.2    Gu, X.3
  • 16
    • 21244479759 scopus 로고    scopus 로고
    • Fine tuning and cross-talking of TGF-beta signal by inhibitory Smads
    • Park SH. Fine tuning and cross-talking of TGF-beta signal by inhibitory Smads. J Biochem Mol Biol 2005;38:9-16
    • (2005) J Biochem Mol Biol , vol.38 , pp. 9-16
    • Park, S.H.1
  • 18
    • 33845536254 scopus 로고    scopus 로고
    • Regulation of pancreatic betacell regeneration in the normoglycemic 60% partial-pancreatectomy mouse
    • Peshavaria M, Larmie BL, Lausier J, et al. Regulation of pancreatic betacell regeneration in the normoglycemic 60% partial-pancreatectomy mouse. Diabetes 2006;55:3289-3298
    • (2006) Diabetes , vol.55 , pp. 3289-3298
    • Peshavaria, M.1    Larmie, B.L.2    Lausier, J.3
  • 19
    • 84866389264 scopus 로고    scopus 로고
    • Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure
    • Talchai C, Xuan S, Lin HV, Sussel L, Accili D. Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure. Cell 2012;150:1223-1234
    • (2012) Cell , vol.150 , pp. 1223-1234
    • Talchai, C.1    Xuan, S.2    Lin, H.V.3    Sussel, L.4    Accili, D.5
  • 20
    • 0032923739 scopus 로고    scopus 로고
    • Generalized lacZ expression with the ROSA26 Cre reporter strain
    • Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 1999;21:70-71
    • (1999) Nat Genet , vol.21 , pp. 70-71
    • Soriano, P.1
  • 21
    • 0032898369 scopus 로고    scopus 로고
    • Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase
    • Postic C, Shiota M, Niswender KD, et al. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 1999; 274:305-315
    • (1999) J Biol Chem , vol.274 , pp. 305-315
    • Postic, C.1    Shiota, M.2    Niswender, K.D.3
  • 22
    • 0034121735 scopus 로고    scopus 로고
    • Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages
    • Herrera PL. Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development 2000;127:2317-2322
    • (2000) Development , vol.127 , pp. 2317-2322
    • Herrera, P.L.1
  • 23
    • 0036340074 scopus 로고    scopus 로고
    • Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    • Gu G, Dubauskaite J, Melton DA. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 2002;129:2447-2457
    • (2002) Development , vol.129 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 24
    • 2942615168 scopus 로고    scopus 로고
    • Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types
    • Schonhoff SE, Giel-Moloney M, Leiter AB. Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types. Dev Biol 2004;270:443-454
    • (2004) Dev Biol , vol.270 , pp. 443-454
    • Schonhoff, S.E.1    Giel-Moloney, M.2    Leiter, A.B.3
  • 25
    • 0036730427 scopus 로고    scopus 로고
    • The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
    • Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ, Wright CV. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet 2002;32:128-134
    • (2002) Nat Genet , vol.32 , pp. 128-134
    • Kawaguchi, Y.1    Cooper, B.2    Gannon, M.3    Ray, M.4    Macdonald, R.J.5    Wright, C.V.6
  • 26
    • 0032995686 scopus 로고    scopus 로고
    • Involvement of Smad proteins in the differentiation of pancreatic AR42J cells induced by activin A
    • Zhang YQ, Kanzaki M, Furukawa M, Shibata H, Ozeki M, Kojima I. Involvement of Smad proteins in the differentiation of pancreatic AR42J cells induced by activin A. Diabetologia 1999;42:719-727
    • (1999) Diabetologia , vol.42 , pp. 719-727
    • Zhang, Y.Q.1    Kanzaki, M.2    Furukawa, M.3    Shibata, H.4    Ozeki, M.5    Kojima, I.6
  • 27
    • 84877928075 scopus 로고    scopus 로고
    • Smad signaling pathways regulate pancreatic endocrine development
    • El-Gohary Y, Tulachan S, Guo P, et al. Smad signaling pathways regulate pancreatic endocrine development. Dev Biol 2013;378:83-93
    • (2013) Dev Biol , vol.378 , pp. 83-93
    • El-Gohary, Y.1    Tulachan, S.2    Guo, P.3
  • 28
    • 0035553963 scopus 로고    scopus 로고
    • Growth factors in development and diseases of the exocrine pancreas
    • Kiehne K, Otte JM, Fölsch UR, Herzig KH. Growth factors in development and diseases of the exocrine pancreas. Pancreatology 2001;1:15-23
    • (2001) Pancreatology , vol.1 , pp. 15-23
    • Kiehne, K.1    Otte, J.M.2    Fölsch, U.R.3    Herzig, K.H.4
  • 29
    • 0027285531 scopus 로고
    • Synthesis and expression of transforming growth factor beta-1, beta-2, and beta-3 in the endocrine and exocrine pancreas
    • Yamanaka Y, Friess H, Büchler M, Beger HG, Gold LI, Korc M. Synthesis and expression of transforming growth factor beta-1, beta-2, and beta-3 in the endocrine and exocrine pancreas. Diabetes 1993;42:746-756
    • (1993) Diabetes , vol.42 , pp. 746-756
    • Yamanaka, Y.1    Friess, H.2    Büchler, M.3    Beger, H.G.4    Gold, L.I.5    Korc, M.6
  • 30
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Shi Y, Massagué J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003;113:685-700
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massagué, J.2
  • 32
    • 0027308108 scopus 로고
    • Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide
    • Teitelman G, Alpert S, Polak JM, Martinez A, Hanahan D. Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development 1993;118:1031-1039
    • (1993) Development , vol.118 , pp. 1031-1039
    • Teitelman, G.1    Alpert, S.2    Polak, J.M.3    Martinez, A.4    Hanahan, D.5
  • 33
    • 0036005768 scopus 로고    scopus 로고
    • Defining the cell lineages of the islets of Langerhans using transgenic mice
    • Herrera PL. Defining the cell lineages of the islets of Langerhans using transgenic mice. Int J Dev Biol 2002;46:97-103
    • (2002) Int J Dev Biol , vol.46 , pp. 97-103
    • Herrera, P.L.1
  • 34
    • 0026321596 scopus 로고
    • Embryogenesis of the murine endocrine pancreas; Early expression of pancreatic polypeptide gene
    • Herrera PL, Huarte J, Sanvito F, Meda P, Orci L, Vassalli JD. Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene. Development 1991;113:1257-1265
    • (1991) Development , vol.113 , pp. 1257-1265
    • Herrera, P.L.1    Huarte, J.2    Sanvito, F.3    Meda, P.4    Orci, L.5    Vassalli, J.D.6
  • 35
    • 0034101423 scopus 로고    scopus 로고
    • Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas
    • Gannon M, Shiota C, Postic C, Wright CV, Magnuson M. Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis 2000;26:139-142
    • (2000) Genesis , vol.26 , pp. 139-142
    • Gannon, M.1    Shiota, C.2    Postic, C.3    Wright, C.V.4    Magnuson, M.5
  • 36
    • 73949140059 scopus 로고    scopus 로고
    • A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
    • Madisen L, Zwingman TA, Sunkin SM, et al. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 2010;13:133-140
    • (2010) Nat Neurosci , vol.13 , pp. 133-140
    • Madisen, L.1    Zwingman, T.A.2    Sunkin, S.M.3
  • 37
    • 30644479959 scopus 로고    scopus 로고
    • Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation
    • Ju W, Ogawa A, Heyer J, et al. Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation. Mol Cell Biol 2006;26:654-667
    • (2006) Mol Cell Biol , vol.26 , pp. 654-667
    • Ju, W.1    Ogawa, A.2    Heyer, J.3
  • 38
    • 0032934979 scopus 로고    scopus 로고
    • Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction
    • Datto MB, Frederick JP, Pan L, Borton AJ, Zhuang Y, Wang XF. Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. Mol Cell Biol 1999;19:2495-2504
    • (1999) Mol Cell Biol , vol.19 , pp. 2495-2504
    • Datto, M.B.1    Frederick, J.P.2    Pan, L.3    Borton, A.J.4    Zhuang, Y.5    Wang, X.F.6
  • 39
    • 44749087001 scopus 로고    scopus 로고
    • In vitro proliferation of cells derived from adult human beta-cells revealed by cell-lineage tracing
    • Russ HA, Bar Y, Ravassard P, Efrat S. In vitro proliferation of cells derived from adult human beta-cells revealed by cell-lineage tracing. Diabetes 2008;57:1575-1583
    • (2008) Diabetes , vol.57 , pp. 1575-1583
    • Russ, H.A.1    Bar, Y.2    Ravassard, P.3    Efrat, S.4
  • 40
    • 48249094295 scopus 로고    scopus 로고
    • Dedifferentiation for replication of human beta-cells: A division between mice and men?
    • Billestrup N, Otonkoski T. Dedifferentiation for replication of human beta-cells: a division between mice and men? Diabetes 2008;57:1457-1458
    • (2008) Diabetes , vol.57 , pp. 1457-1458
    • Billestrup, N.1    Otonkoski, T.2
  • 41
    • 80053608936 scopus 로고    scopus 로고
    • Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro
    • Russ HA, Sintov E, Anker-Kitai L, et al. Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro. PLoS ONE 2011;6:e25566
    • (2011) PLoS ONE , vol.6
    • Russ, H.A.1    Sintov, E.2    Anker-Kitai, L.3
  • 42
    • 68149156892 scopus 로고    scopus 로고
    • Epithelialmesenchymal transition in cells expanded in vitro from lineage-traced adult human pancreatic beta cells
    • Russ HA, Ravassard P, Kerr-Conte J, Pattou F, Efrat S. Epithelialmesenchymal transition in cells expanded in vitro from lineage-traced adult human pancreatic beta cells. PLoS ONE 2009;4:e6417
    • (2009) PLoS ONE , vol.4
    • Russ, H.A.1    Ravassard, P.2    Kerr-Conte, J.3    Pattou, F.4    Efrat, S.5
  • 43
    • 34247589600 scopus 로고    scopus 로고
    • Endocrine precursor cells from mouse islets are not generated by epithelial-to-mesenchymal transition of mature beta cells
    • Morton RA, Geras-Raaka E, Wilson LM, Raaka BM, Gershengorn MC. Endocrine precursor cells from mouse islets are not generated by epithelial-to-mesenchymal transition of mature beta cells. Mol Cell Endocrinol 2007;270:87-93
    • (2007) Mol Cell Endocrinol , vol.270 , pp. 87-93
    • Morton, R.A.1    Geras-Raaka, E.2    Wilson, L.M.3    Raaka, B.M.4    Gershengorn, M.C.5
  • 44
    • 0014693340 scopus 로고
    • Mitotic division in pancreatic beta cells
    • Like AA, Chick WL. Mitotic division in pancreatic beta cells. Science 1969; 163:941-943
    • (1969) Science , vol.163 , pp. 941-943
    • Like, A.A.1    Chick, W.L.2
  • 45
    • 7044235584 scopus 로고    scopus 로고
    • Interplay of glucagon-like peptide-1 and transforming growth factor-beta signaling in insulinpositive differentiation of AR42J cells
    • Yew KH, Prasadan KL, Preuett BL, et al. Interplay of glucagon-like peptide-1 and transforming growth factor-beta signaling in insulinpositive differentiation of AR42J cells. Diabetes 2004;53:2824-2835
    • (2004) Diabetes , vol.53 , pp. 2824-2835
    • Yew, K.H.1    Prasadan, K.L.2    Preuett, B.L.3
  • 46
    • 0032565859 scopus 로고    scopus 로고
    • Smad2 role in mesoderm formation, left-right patterning and craniofacial development
    • Nomura M, Li E. Smad2 role in mesoderm formation, left-right patterning and craniofacial development. Nature 1998;393:786-790
    • (1998) Nature , vol.393 , pp. 786-790
    • Nomura, M.1    Li, E.2
  • 48
    • 84891798576 scopus 로고    scopus 로고
    • Crucial roles of TGF-β signaling for pancreatic islet development and glucose-responsive insulin secretion
    • Presented at the, Snowbird, UT, 6-11 April
    • Nomura M, Teramoto N, Morinaga H, Takayanagi R. Crucial roles of TGF-β signaling for pancreatic islet development and glucose-responsive insulin secretion. Presented at the Keystone Symposium "Islet and Beta Cell Biology (Z3)," Snowbird, UT, 6-11 April 2008
    • (2008) Keystone Symposium "islet and Beta Cell Biology (Z3)
    • Nomura, M.1    Teramoto, N.2    Morinaga, H.3    Takayanagi, R.4
  • 49
    • 84875479006 scopus 로고    scopus 로고
    • TGFb receptor signaling is essential for inflammation-induced but not β-cell workload-induced β-cell proliferation
    • Xiao X, Wiersch J, El-Gohary Y, et al. TGFb receptor signaling is essential for inflammation-induced but not β-cell workload-induced β-cell proliferation. Diabetes 2013;62:1217-1226
    • (2013) Diabetes , vol.62 , pp. 1217-1226
    • Xiao, X.1    Wiersch, J.2    El-Gohary, Y.3
  • 50
    • 0032565739 scopus 로고    scopus 로고
    • Two transgenic approaches to define the cell lineages in endocrine pancreas development
    • Herrera PL, Orci L, Vassalli JD. Two transgenic approaches to define the cell lineages in endocrine pancreas development. Mol Cell Endocrinol 1998;140:45-50
    • (1998) Mol Cell Endocrinol , vol.140 , pp. 45-50
    • Herrera, P.L.1    Orci, L.2    Vassalli, J.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.