Alternatively activated macrophages in types 1 and 2 diabetes

Mediators of Inflammation

Volumn 2012, Issue , 2012, Pages

  Espinoza Jiménez, Arlett ^a   Peón, Alberto N ^a   Terrazas, Luis I ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CHEMOKINE RECEPTOR CCR2; GAMMA INTERFERON; GLUCOSE; GLUTAMATE DECARBOXYLASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN TYROSINE PHOSPHATASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL POPULATION; CYTOKINE PRODUCTION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; HELIGMOSOMOIDES POLYGYRUS; HUMAN; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; LIPID DIET; LIPID METABOLISM; LIPID STORAGE; LYMPHOCYTE DIFFERENTIATION; MACROPHAGE ACTIVATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PHOTOTRANSDUCTION; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; T LYMPHOCYTE; TH17 CELL; ANIMAL; IMMUNOLOGY; INFLAMMATION; MACROPHAGE; PHYSIOLOGY;

ANIMALS; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; HUMANS; INFLAMMATION; MACROPHAGE ACTIVATION; MACROPHAGES;

MLCS; MLOWN;

EID: 84872792350     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2012/815953     Document Type: Review

References (87)

1. Gordon S., Alternative activation of macrophages. Nature Reviews Immunology 2003 3 1 23 35 2-s2.0-0037265240 10.1038/nri978 (Pubitemid 37328697)
2. Gordon S., Martinez F. O., Alternative activation of macrophages: mechanism and functions. Immunity 2010 32 5 593 604 2-s2.0-77953268611 10.1016/j.immuni.2010.05.007
3. Kreider T., Anthony R. M., Urban J. F. Jr., Gause W. C., Alternatively activated macrophages in helminth infections. Current Opinion in Immunology 2007 19 4 448 453 2-s2.0-34548129526 10.1016/j.coi.2007.07.002 (Pubitemid 47299196)
4. Lumeng C. N., Bodzin J. L., Saltiel A. R., Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Journal of Clinical Investigation 2007 117 1 175 184 2-s2.0-33846026712 10.1172/JCI29881 (Pubitemid 46048464)
5. Reyes J. L., Terrazas L. I., The divergent roles of alternatively activated macrophages in helminthic infections. Parasite Immunology 2007 29 12 609 619 2-s2.0-36549022522 10.1111/j.1365-3024.2007.00973.x (Pubitemid 350179388)
6. Martinez F. O., Helming L., Gordon S., Alternative activation of macrophages: an immunologic functional perspective. Annual Review of Immunology 2009 27 451 483 2-s2.0-67650485985 10.1146/annurev.immunol.021908.132532
7. Espinoza-Jiménez A., Rivera-Montoya I., Cárdenas-Arreola R., Morán L., Terrazas L. I., Taenia crassiceps infection attenuates multiple low-dose streptozotocin-induced diabetes. Journal of Biomedicine and Biotechnology 2010 2010 11 850541 2-s2.0-77953720402 10.1155/2010/850541
8. Cooke A., Tonks P., Jones F. M., O'Shea H., Hutchings P., Fulford A. J. C., Dunne D. W., Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non-obese diabetic mice. Parasite Immunology 1999 21 4 169 176 2-s2.0-0032923558 10.1046/j.1365-3024.1999.00213.x (Pubitemid 29158763)
9. Zaccone P., Feheérvári Z., Jones F. M., Sidobre S., Kronenberg M., Dunne D. W., Cooke A., Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes. European Journal of Immunology 2003 33 5 1439 1449 2-s2.0-0038297115 10.1002/eji.200323910 (Pubitemid 36609163)
10. Zaccone P., Burton O., Miller N., Jones F. M., Dunne D. W., Cooke A., Schistosoma mansoni egg antigens induce Treg that participate in diabetes prevention in NOD mice. European Journal of Immunology 2009 39 4 1098 1107 2-s2.0-65449180031 10.1002/eji.200838871
11. El-Wakil H. S., Aboushousha T. S., El Haddad O., Gamil N. B., Mansour T., El-Said H., Effect of schistosoma mansoni egg deposition on multiple low doses streptozotocin induced insulin dependent diabetes. Journal of the Egyptian Society of Parasitology 2002 32 3 987 1002 2-s2.0-0036988718
12. Liu Q., Sundar K., Mishra P. K., Mousavi G., Liu Z., Gaydo A., Alem F., Lagunoff D., Bleich D., Gause W. C., Helminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanisms. Infection and Immunity 2009 77 12 5347 5358 2-s2.0-72449121826 10.1128/IAI.01170-08
13. Hübner M. P., Thomas Stocker J., Mitre E., Inhibition of type 1 diabetes in filaria-infected non-obese diabetic mice is associated with a T helper type 2 shift and induction of FoxP3+ regulatory T cells. Immunology 2009 127 4 512 522 2-s2.0-67650487180 10.1111/j.1365-2567.2008.02958.x
14. Saunders K. A., Raine T., Cooke A., Lawrence C. E., Inhibition of autoimmune type 1 diabetes by gastrointestinal helminth infection. Infection and Immunity 2007 75 1 397 407 2-s2.0-33845994749 10.1128/IAI.00664-06 (Pubitemid 46047916)
15. Wu D., Molofsky A. B., Liang H. E., Ricardo-Gonzalez R. R., Jouihan H. A., Bando J. K., Chawla A., Locksley R. M., Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 2011 332 6026 243 247 2-s2.0-79953815551 10.1126/science.1201475
16. Stein M., Keshav S., The versatility of macrophages. Clinical and Experimental Allergy 1992 22 1 19 27 2-s2.0-0026513717
17. Linehan S. A., Coulson P. S., Wilson R. A., Mountford A. P., Brombacher F., Martinez-Pomares L., Gordon S., IL-4 receptor signaling is required for mannose receptor expression by macrophages recruited to granulomata but not resident cells in mice infected with Schistosoma mansoni. Laboratory Investigation 2003 83 8 1223 1231 2-s2.0-0042470910 10.1097/01.LAB.0000081392. 93701.6F (Pubitemid 37013057)
18. Roy B., Bhattacharjee A., Xu B., Ford D., Maizel A. L., Cathcart M. K., IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats. Journal of Leukocyte Biology 2002 72 3 580 589 2-s2.0-0036746091
19. Donnelly S., O'Neill S. M., Sekiya M., Mulcahy G., Dalton J. P., Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages. Infection and Immunity 2005 73 1 166 173 2-s2.0-11144316758 10.1128/IAI.73.1.166-173.2005 (Pubitemid 40041106)
20. Robinson M. W., Dalton J. P., Donnelly S., Helminth pathogen cathepsin proteases: it's a family affair. Trends in Biochemical Sciences 2008 33 12 601 608 2-s2.0-56449088737 10.1016/j.tibs.2008.09.001
21. Zaccone P., Burton O. T., Gibbs S., Immune modulation by schistosoma mansoni antigens in NOD mice: effects on both innate and adaptive immune systems. Journal of Biomedicine and Biotechnology 2010 2010 11 2-s2.0-77951693260 10.1155/2010/795210 795210
22. Atochina O., Da'dara A. A., Walker M., Harn D. A., The immunomodulatory glycan LNFPIII initiates alternative activation of murine macrophages in vivo. Immunology 2008 125 1 111 121 2-s2.0-49249126123 10.1111/j.1365-2567.2008.02826. x
23. Noël W., Raes G., Ghassabeh G. H., de Baetselier P., Beschin A., Alternatively activated macrophages during parasite infections. Trends in Parasitology 2004 20 3 126 133 2-s2.0-1342264305 10.1016/j.pt.2004.01.004 (Pubitemid 38264445)
24. Voehringer D., van Rooijen N., Locksley R. M., Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages. Journal of Leukocyte Biology 2007 81 6 1434 1444 2-s2.0-34249746235 10.1189/jlb.1106686 (Pubitemid 46827966)
25. Terrazas L. I., Montero D., Terrazas C. A., Reyes J. L., Rodríguez-Sosa M., Role of the programmed Death-1 pathway in the suppressive activity of alternatively activated macrophages in experimental cysticercosis. International Journal for Parasitology 2005 35 13 1349 1358 2-s2.0-26944501955 10.1016/j.ijpara.2005.06.003 (Pubitemid 41484148)
26. Rodríguez-Sosa M., Satoskar A. R., Calderón R., Gomez-Garcia L., Saavedra R., Bojalil R., Terrazas L. I., Chronic helminth infection induces alternatively activated macrophages expressing high levels of CCR5 with low interleukin-12 production and Th2-biasing ability. Infection and Immunity 2002 70 7 3656 3664 2-s2.0-0036089534 10.1128/IAI.70.7.3656-3664.2002 (Pubitemid 34666004)
27. Loke P., MacDonald A. S., Allen J. E., Antigen-presenting cells recruited by Brugia malayi induce Th2 differentiation of naive CD4(+) T cells. European Journal of Immunology 2000 30 1127 1135 10.1002/(SICI)1521-4141(200004)30: 4<1127::AID-IMMU1127>3.0.CO;2-# (Pubitemid 30216230)
28. Loke P., Nair M. G., Parkinson J., Guiliano D., Blaxter M., Allen J. E., IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype. BMC Immunology 2002 3 7 2-s2.0-0242421851 10.1186/1471-2172-3-7 (Pubitemid 38692919)
29. Smith P., Walsh C. M., Mangan N. E., Fallon R. E., Sayers J. R., McKenzie A. N. J., Fallon P. G., Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages. Journal of Immunology 2004 173 2 1240 1248 2-s2.0-3142750528 (Pubitemid 38924302)
30. Herbert D. R., Hölscher C., Mohrs M., Arendse B., Schwegmann A., Radwanska M., Leeto M., Kirsch R., Hall P., Mossmann H., Claussen B., Förster I., Brombacher F., Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity 2004 20 5 623 635 2-s2.0-2442717844 10.1016/S1074-7613(04)00107-4 (Pubitemid 38659504)
31. Taylor M. D., Harris A., Nair M. G., Maizels R. M., Allen J. E., F4/80+ alternatively activated macrophages control CD4+ T cell hyporesponsiveness at sites peripheral to filarial infection. Journal of Immunology 2006 176 11 6918 6927 2-s2.0-33646884472 (Pubitemid 43787872)
32. Nair M. G., Cochrane D. W., Allen J. E., Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro. Immunology Letters 2003 85 2 173 180 2-s2.0-0037460123 10.1016/S0165-2478(02)00225-0 (Pubitemid 36071573)
33. Anthony R. M., Urban J. F. Jr., Alem F., Hamed H. A., Rozo C. T., Boucher J. L., van Rooijen N., Gause W. C., Memory T H 2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nature Medicine 2006 12 955 960 10.1038/nm1451 (Pubitemid 44175149)
34. Persaud R., Wang A., Reardon C., McKay D. M., Characterization of the immuno-regulatory response to the tapeworm Hymenolepis diminuta in the non-permissive mouse host. International Journal for Parasitology 2007 37 3-4 393 403 2-s2.0-33846808667 10.1016/j.ijpara.2006.09.012 (Pubitemid 46215582)
35. Mejri N., Gottstein B., Intraperitoneal Echinococcus multilocularis infection in C57BL/6 mice affects CD40 and B7 costimulator expression on peritoneal macrophages and impairs peritoneal T cell activation. Parasite Immunology 2006 28 8 373 385 2-s2.0-33746217077 10.1111/j.1365-3024.2006.00836.x (Pubitemid 44099954)
36. Denis M. C., Mahmood U., Benoist C., Mathis D., Weissleder R., Imaging inflammation of the pancreatic islets in type 1 diabetes. Proceedings of the National Academy of Sciences of the United States of America 2004 101 34 12634 12639 2-s2.0-4344714342 10.1073/pnas.0404307101 (Pubitemid 39122075)
37. Guariguata L., Whiting D., Weil C., Unwin N., The International Diabetes Federation diabetes atlas methodology for estimating global and national prevalence of diabetes in adults. Diabetes Research and Clinical Practice 2011 94 322 332 10.1016/j.diabres.2011.10.040
38. Rabinovitch A., Suarez-Pinzon W. L., Cytokines and their roles in pancreatic islet β -cell destruction and insulin-dependent diabetes mellitus. Biochemical Pharmacology 1998 55 8 1139 1149 2-s2.0-0032523104 10.1016/S0006-2952(97)00492-9 (Pubitemid 28206701)
39. Cnop M., Welsh N., Jonas J. C., Jörns A., Lenzen S., Eizirik D. L., Mechanisms of pancreatic β -cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 2005 54 supplement 2 S97 S107 2-s2.0-33644749322 10.2337/diabetes.54.suppl-2.S97 (Pubitemid 43343337)
40. Cooke A., Zaccone P., Raine T., Phillips J. M., Dunne D. W., Infection and autoimmunity: are we winning the war, only to lose the peace? Trends in Parasitology 2004 20 7 316 321 2-s2.0-2942514674 10.1016/j.pt.2004.04.010 (Pubitemid 38749074)
41. Martin A. P., Rankin S., Pitchford S., Charo I. F., Furtado G. C., Lira S. A., Increased expression of CCL2 in insulin-producing cells of transgenic mice promotes mobilization of myeloid cells from the bone marrow, marked insulitis, and diabetes. Diabetes 2008 57 11 3025 3033 2-s2.0-58149347630 10.2337/db08-0625
42. Gregory J. L., Morand E. F., McKeown S. J., Ralph J. A., Hall P., Yang Y. H., McColl S. R., Hickey M. J., Macrophage migration inhibitory factor induces macrophage recruitment via CC chemokine ligand 2. Journal of Immunology 2006 177 11 8072 8079 2-s2.0-33751570308 (Pubitemid 44846325)
43. Cvetkovic I., Al-Abed Y., Miljkovic D., Maksimovic-Ivanic D., Roth J., Bacher M., Lan H. Y., Nicoletti F., Stosic-Grujicic S., Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes. Endocrinology 2005 146 7 2942 2951 2-s2.0-22144450700 10.1210/en.2004-1393 (Pubitemid 41002801)
44. Bradshaw E. M., Raddassi K., Elyaman W., Orban T., Gottlieb P. A., Kent S. C., Hafler D. A., Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. Journal of Immunology 2009 183 7 4432 4439 2-s2.0-70449704670 10.4049/jimmunol.0900576
45. Calderon B., Suri A., Unanue E. R., In CD4+ T-cell-induced diabetes, macrophages are the final effector cells that mediate islet β -cell killing: studies from an acute model. American Journal of Pathology 2006 169 6 2137 2147 2-s2.0-34548359992 10.2353/ajpath.2006.060539 (Pubitemid 351181973)
46. Jun H. S., Yoon C. S., Zbytnuik L., van Rooijen N., Yoon J. W., The role of macrophages in T cell-mediated autoimmune diabetes in nonobese diabetic mice. Journal of Experimental Medicine 1999 189 2 347 358 2-s2.0-0033579877 10.1084/jem.189.2.347 (Pubitemid 29063256)
47. Zhu S., Qian Y., IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential. Clinical Science 2012 122 487 511 10.1042/CS20110496
48. Mensah-Brown E. P. K., Shahin A., Al-Shamisi M., Wei X., Lukic M. L., IL-23 leads to diabetes induction after subdiabetogenic treatment with multiple low doses of streptozotocin. European Journal of Immunology 2006 36 1 216 223 2-s2.0-30944455075 10.1002/eji.200535325 (Pubitemid 43116408)
49. Jun H. S., Yoon J. W., A new look at viruses in type 1 diabetes. Diabetes/Metabolism Research and Reviews 2003 19 1 8 31 2-s2.0-0037217057 10.1002/dmrr.337 (Pubitemid 36285371)
50. Richer M. J., Horwitz M. S., Coxsackievirus infection as an environmental factor in the etiology of type 1 diabetes. Autoimmunity Reviews 2009 8 7 611 615 2-s2.0-67349139853 10.1016/j.autrev.2009.02.006
51. van der Werf N., Kroese F. G. M., Rozing J., Hillebrands J. L., Viral infections as potential triggers of type 1 diabetes. Diabetes/Metabolism Research and Reviews 2007 23 3 169 183 2-s2.0-33947330461 10.1002/dmrr.695 (Pubitemid 46437842)
52. Vercelli D., Mechanisms of the hygiene hypothesis-molecular and otherwise. Current Opinion in Immunology 2006 18 6 733 737 2-s2.0-33750343646 10.1016/j.coi.2006.09.002 (Pubitemid 44635173)
53. Maizels R. M., Parasite immunomodulation and polymorphisms of the immune system. Journal of Biology 2009 8 7 62 2-s2.0-68949217899 10.1186/jbiol166
54. Maizels R. M., Balic A., Gomez-Escobar N., Nair M., Taylor M. D., Allen J. E., Helminth parasites-masters of regulation. Immunological Reviews 2004 201 89 116 2-s2.0-4844229387 10.1111/j.0105-2896.2004.00191.x (Pubitemid 39318446)
55. Zheng D., Wang Y., Cao Q., Lee V. W. S., Zheng G., Sun Y., Tan T. K., Wang Y., Alexander S. I., Harris D. C. H., Transfused macrophages ameliorate pancreatic and renal injury in murine diabetes mellitus. Nephron-Experimental Nephrology 2011 118 4 e87 e99 2-s2.0-79751527661 10.1159/000321034
56. Parsa R., Andresen P., Gillett A., Mia S., Zhang X. M., Mayans S., Holmberg D., Harris R. A., Adoptive transfer of immunomodulatory M2 macrophages prevents Type 1 diabetes in NOD mice. Diabetes 2012 61 11 2881 2892 10.2337/db11-1635
57. Wild S., Roglic G., Green A., Sicree R., King H., Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004 27 5 1047 1053 2-s2.0-2342466734 10.2337/diacare.27.5.1047 (Pubitemid 38579764)
58. Barroso I., Genetics of Type 2 diabetes. Diabetic Medicine 2005 22 5 517 535 2-s2.0-17844373857 10.1111/j.1464-5491.2005.01550.x (Pubitemid 40593126)
59. Gastaldelli A., Role of beta-cell dysfunction, ectopic fat accumulation and insulin resistance in the pathogenesis of type 2 diabetes mellitus. Diabetes Research and Clinical Practice 2011 93 supplement 1 S60 S65 10.1016/S0168-8227(11)70015-8
60. Tilg H., Moschen A. R., Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nature Reviews Immunology 2006 6 10 772 783 2-s2.0-33748992313 10.1038/nri1937 (Pubitemid 44453463)
61. Vachharajani V., Granger D. N., Adipose tissue: a motor for the inflammation associated with obesity. IUBMB Life 2009 61 4 424 430 2-s2.0-67650388375 10.1002/iub.169
62. Zeyda M., Stulnig T. M., Adipose tissue macrophages. Immunology Letters 2007 112 2 61 67 2-s2.0-34548477639 10.1016/j.imlet.2007.07.003 (Pubitemid 47379852)
63. Toso C., Emamaullee J. A., Merani S., Shapiro A. M. J., The role of macrophage migration inhibitory factor on glucose metabolism and diabetes. Diabetologia 2008 51 11 1937 1946 2-s2.0-53549104729 10.1007/s00125-008-1063-3
64. Yu R., Kim C. S., Kwon B. S., Kawada T., Mesenteric adipose tissue-derived monocyte chemoattractant protein-1 plays a crucial role in adipose tissue macrophage migration and activation in obese mice. Obesity 2006 14 8 1353 1362 2-s2.0-33750602672 10.1038/oby.2006.153 (Pubitemid 46219660)
65. Kanda H., Tateya S., Tamori Y., Kotani K., Hiasa K. I., Kitazawa R., Kitazawa S., Miyachi H., Maeda S., Egashira K., Kasuga M., MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. Journal of Clinical Investigation 2006 116 6 1494 1505 2-s2.0-33745216724 10.1172/JCI26498
66. Fu Y., Luo L., Luo N., Garvey W. T., Proinflammatory cytokine production and insulin sensitivity regulated by overexpression of resistin in 3T3-L1 adipocytes. Nutrition and Metabolism 2006 3 28 2-s2.0-33747441404 10.1186/1743-7075-3-28 (Pubitemid 44252718)
67. Davis J. E., Gabler N. K., Walker-Daniels J., Spurlock M. E., Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity 2008 16 6 1248 1255 2-s2.0-44449110675 10.1038/oby.2008.210 (Pubitemid 351770507)
68. Shi H., Kokoeva M. V., Inouye K., Tzameli I., Yin H., Flier J. S., TLR4 links innate immunity and fatty acid-induced insulin resistance. The Journal of Clinical Investigation 2006 116 3015 3025 10.1172/JCI28898 (Pubitemid 44684486)
69. Uysal K. T., Wiesbrock S. M., Marino M. W., Hotamisligil G. S., Protection from obesity-induced insulin resistance in mice lacking TNF- α function. Nature 1997 389 6651 610 614 2-s2.0-0030756346 10.1038/39335 (Pubitemid 27446179)
70. Sanchez-Zamora Y., Terrazas L. I., Vilches-Flores A., Leal E., Juárez I., Whitacre C., Kithcart A., Pruitt J., Sielecki T., Satoskar A. R., Rodriguez-Sosa M., Macrophage migration inhibitory factor is a therapeutic target in treatment of non-insulin-dependent diabetes mellitus. The FASEB Journal 2010 24 7 2583 2590 2-s2.0-77954453333 10.1096/fj.09-147066
71. Kaneto H., Matsuoka T. A., Nakatani Y., Kawamori D., Matsuhisa M., Yamasaki Y., Oxidative stress and the JNK pathway in diabetes. Current Diabetes Reviews 2005 1 1 65 72 2-s2.0-34548488370 10.2174/1573399052952613
72. Kaneto H., Matsuoka T. A., Nakatani Y., Kawamori D., Miyatsuka T., Matsuhisa M., Yamasaki Y., Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes. Journal of Molecular Medicine 2005 83 6 429 439 2-s2.0-21544471229 10.1007/s00109-005-0640-x (Pubitemid 40922165)
73. Andreasen A. S., Kelly M., Berg R. M., Moller K., Pedersen B. K., Type 2 diabetes is associated with altered NF-kappaB DNA binding activity, JNK phosphorylation, and AMPK phosphorylation in skeletal muscle after LPS. PLoS One 2011 6, article e23999
74. Leto D., Saltiel A. R., Regulation of glucose transport by insulin: traffic control of GLUT4. Nature Reviews Molecular Cell Biology 2012 13 383 396
75. Arkan M. C., Hevener A. L., Greten F. R., Maeda S., Li Z. W., Long J. M., Wynshaw-Boris A., Poli G., Olefsky J., Karin M., IKK- β links inflammation to obesity-induced insulin resistance. Nature Medicine 2005 11 2 191 198 2-s2.0-20044387026 10.1038/nm1185 (Pubitemid 40321355)
76. Weisberg S. P., McCann D., Desai M., Rosenbaum M., Leibel R. L., Ferrante A. W., Obesity is associated with macrophage accumulation in adipose tissue. Journal of Clinical Investigation 2003 112 12 1796 1808 2-s2.0-0348230958 10.1172/JCI200319246 (Pubitemid 38063703)
77. Xu H., Barnes G. T., Yang Q., Tan G., Yang D., Chou C. J., Sole J., Nichols A., Ross J. S., Tartaglia L. A., Chen H., Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. Journal of Clinical Investigation 2003 112 12 1821 1830 2-s2.0-9144223683 10.1172/JCI200319451 (Pubitemid 38063705)
78. Prieur X., Mok C. Y. L., Velagapudi V. R., Núñez V., Fuentes L., Montaner D., Ishikawa K., Camacho A., Barbarroja N., O'Rahilly S., Sethi J. K., Dopazo J., Orešič M., Ricote M., Vidal-Puig A., Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes 2011 60 3 797 809 2-s2.0-79952437112 10.2337/db10-0705
79. Lumeng C. N., DeYoung S. M., Bodzin J. L., Saltiel A. R., Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 2007 56 1 16 23 2-s2.0-33847073149 10.2337/db06-1076
80. Nio Y., Yamauchi T., Iwabu M., Okada-Iwabu M., Funata M., Yamaguchi M., Ueki K., Kadowaki T., Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice. Diabetologia 2012 55 12 3350 3358 10.1007/s00125-012-2710-2
81. Odegaard J. I., Ricardo-Gonzalez R. R., Goforth M. H., Morel C. R., Subramanian V., Mukundan L., Eagle A. R., Vats D., Brombacher F., Ferrante A. W., Chawla A., Macrophage-specific PPAR γ controls alternative activation and improves insulin resistance. Nature 2007 447 7148 1116 1120 2-s2.0-34347354309 10.1038/nature05894 (Pubitemid 47014427)
82. Yessoufou A., Wahli W., Multifaceted roles of peroxisome proliferator-activated receptors (PPARs) at the cellular and whole organism levels. Swiss Medical Weekly 2010 140 w13071 2-s2.0-79952064509
83. Chawla A., Control of macrophage activation and function by PPARs. Circulation Research 2010 106 10 1559 1569 2-s2.0-77952997178 10.1161/CIRCRESAHA.110.216523
84. Odegaard J. I., Chawla A., Mechanisms of macrophage activation in obesity-induced insulin resistance. Nature Clinical Practice. Endocrinology and Metabolism 2008 4 619 626 10.1038/ncpendmet0976
85. Ricardo-Gonzalez R. R., Eagle A. R., Odegaard J. I., Jouihan H., Morel C. R., Heredia J. E., Mukundan L., Wu D., Locksley R. M., Chawla A., IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity. Proceedings of the National Academy of Sciences of the United States of America 2010 107 52 22617 22622 2-s2.0-78651073627 10.1073/pnas.1009152108
86. Reyes J. L., Espinoza-Jiménez A. F., González M. I., Verdin L., Terrazas L. I., Taenia crassiceps infection abrogates experimental autoimmune encephalomyelitis. Cellular Immunology 2011 267 2 77 87 2-s2.0-79751529279 10.1016/j.cellimm.2010.11.006
87. Weisser S. B., Brugger H. K., Voglmaier N. S., McLarren K. W., van Rooijen N., Sly L. M., SHIP-deficient, alternatively activated macrophages protect mice during DSS-induced colitis. Journal of Leukocyte Biology 2011 90 483 492 10.1189/jlb.0311124