Pancreatic duct cells as a source of VEGF in mice

Diabetologia

Volumn 57, Issue 5, 2014, Pages 991-1000

  Xiao, Xiangwei ^a   Prasadan, Krishna ^a   Guo, Ping ^a   El Gohary, Yousef ^a   Fischbach, Shane ^a   Wiersch, John ^a   Gaffar, Iljana ^a   Shiota, Chiyo ^a   Gittes, George K ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Beta cell; Duct cell; FACS; Intrapancreatic ductal infusion; Islet transplantation; Laser capture microdissection; shRNA; Vascular endothelial growth factor

Indexed keywords

SHORT HAIRPIN RNA; VASCULOTROPIN; SMALL INTERFERING RNA; SOX9 PROTEIN, MOUSE; TRANSCRIPTION FACTOR SOX9; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULOTROPIN A;

ANIMAL CELL; ARTICLE; CELL CULTURE; FLOW CYTOMETRY; GENE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PANCREAS DUCT; PANCREAS ISLET BETA CELL; PANCREATIC DUCT CELL; PRIORITY JOURNAL; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULOTROPIN GENE; ANGIOGENESIS; ANIMAL; CYTOLOGY; EPITHELIUM CELL; GENE SILENCING; GENETICS; METABOLISM; PANCREAS ISLET; PANCREAS ISLET TRANSPLANTATION;

ANIMALS; EPITHELIAL CELLS; GENE KNOCKDOWN TECHNIQUES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; PANCREATIC DUCTS; RNA, SMALL INTERFERING; SOX9 TRANSCRIPTION FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84898597757     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3179-y     Document Type: Article

References (51)

1. Cleaver O, Melton DA (2003) Endothelial signaling during development. Nat Med 9:661-668 (Pubitemid 36749214)
2. Carmeliet P, Jain RK (2011) Molecular mechanisms and clinical applications of angiogenesis. Nature 473:298-307
3. Ferrara N, Gerber HP, LeCouter J (2003) The biology of VEGF and its receptors. Nat Med 9:669-676 (Pubitemid 36749215)
4. Carmeliet P, Ferreira V, Breier G et al (1996) Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380:435-439 (Pubitemid 26102719)
5. Ferrara N (2009) Vascular endothelial growth factor. Arterioscler Thromb Vasc Biol 29:789-791
6. Stalmans I, Ng YS, Rohan R et al (2002) Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J Clin Invest 109:327-336 (Pubitemid 34141806)
7. Dor Y, Djonov V, Keshet E (2003) Making vascular networks in the adult: branching morphogenesis without a roadmap. Trends Cell Biol 13:131-136 (Pubitemid 36293785)
8. Lammert E, Cleaver O, Melton D (2001) Induction of pancreatic differentiation by signals from blood vessels. Science 294:564-567 (Pubitemid 32999547)
9. Lammert E, Gu G, McLaughlin M et al (2003) Role of VEGF-A in vascularization of pancreatic islets. Curr Biol 13:1070-1074 (Pubitemid 36726045)
10. Cleaver O, Dor Y (2012) Vascular instruction of pancreas development. Development 139:2833-2843
11. Inoue M, Hager JH, Ferrara N, Gerber HP, Hanahan D (2002) VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis. Cancer Cell 1:193-202 (Pubitemid 41039165)
12. Christofori G, Naik P, Hanahan D (1995) Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumorigenesis. Mol Endocrinol 9:1760-1770
13. Watada H (2010) Role of VEGF-A in pancreatic beta cells. Endocr J 57:185-191
14. Bonner-Weir S (1988) Morphological evidence for pancreatic polarity of beta-cell within islets of Langerhans. Diabetes 37:616-621
15. Akirav EM, Baquero MT, Opare-Addo LW et al (2011) Glucose and inflammation control islet vascular density and beta-cell function in NOD mice: control of islet vasculature and vascular endothelial growth factor by glucose. Diabetes 60:876-883
16. Agudo J, Ayuso E, Jimenez V et al (2012) Vascular endothelial growth factor-mediated islet hypervascularization and inflammation contribute to progressive reduction of beta-cell mass. Diabetes 61:2851-2861
17. Magenheim J, Ilovich O, Lazarus A et al (2011) Blood vessels restrain pancreas branching, differentiation and growth. Development 138:4743-4752
18. Iwashita N, Uchida T, Choi JB et al (2007) Impaired insulin secretion in vivo but enhanced insulin secretion from isolated islets in pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice. Diabetologia 50:380-389
19. Brissova M, Shostak A, Shiota M et al (2006) Pancreatic islet production of vascular endothelial growth factor - a is essential for islet vascularization, revascularization, and function. Diabetes 55:2974-2985 (Pubitemid 44923633)
20. Xiao X, Guo P, Chen Z et al (2013) Hypoglycemia reduces vascular endothelial growth factor a production by pancreatic Beta cells as a regulator of beta cell mass. J Biol Chem 288:8636-8646
21. Pipeleers D, Keymeulen B, Chatenoud L et al (2002) A view on beta cell transplantation in diabetes. Ann N Y Acad Sci 958:69-76 (Pubitemid 34592206)
22. Halban PA, German MS, Kahn SE, Weir GC (2010) Current status of islet cell replacement and regeneration therapy. J Clin Endocrinol Metab 95:1034-1043
23. Brissova M, Fowler M, Wiebe P et al (2004) Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets. Diabetes 53:1318-1325 (Pubitemid 38569019)
24. Nyqvist D, Kohler M, Wahlstedt H, Berggren PO (2005) Donor islet endothelial cells participate in formation of functional vessels within pancreatic islet grafts. Diabetes 54:2287-2293 (Pubitemid 41134254)
25. Lai Y, Schneider D, Kidszun A et al (2005) Vascular endothelial growth factor increases functional beta-cell mass by improvement of angiogenesis of isolated human and murine pancreatic islets. Transplantation 79:1530-1536 (Pubitemid 40847584)
26. Zhang N, Richter A, Suriawinata J et al (2004) Elevated vascular endothelial growth factor production in islets improves islet graft vascularization. Diabetes 53:963-970 (Pubitemid 38436608)
27. Shimoda M, Chen S, Noguchi H, Matsumoto S, Grayburn PA (2010) In vivo non-viral gene delivery of human vascular endothelial growth factor improves revascularisation and restoration of euglycaemia after human islet transplantation into mouse liver. Diabetologia 53:1669-1679
28. Kim SC, Kim TH, We YM, Park HY, Cho KM, Han DJ (2003) Study for improvement of early implantation and long-term graft survival in pancreatic islet cell transplantation by induction of angiogenesis with gene transfection of vascular endothelial growth factor. Transplant Proc 35:486-487 (Pubitemid 36194704)
29. Movahedi B, Gysemans C, Jacobs-Tulleneers-Thevissen D, Mathieu C, Pipeleers D (2008) Pancreatic duct cells in human islet cell preparations are a source of angiogenic cytokines interleukin-8 and vascular endothelial growth factor. Diabetes 57:2128-2136
30. Herrera PL (2000) Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development 127:2317-2322 (Pubitemid 30386571)
31. Ji B, Song J, Tsou L et al (2008) Robust acinar cell transgene expression of CreErT via BAC recombineering. Genesis 46:390-395
32. Xiao X, Guo P, Shiota C et al (2013) Neurogenin3 activation is not sufficient to direct duct-to-beta cell transdifferentiation in the adult pancreas. J Biol Chem 288:25297-25308
33. Xiao X, Wiersch J, El-Gohary Y et al (2013) TGFbeta receptor signaling is essential for inflammation-induced but not beta-cell workload-induced beta-cell proliferation. Diabetes 62:1217-1226
34. Xiao X, Chen Z, Shiota C et al (2013) No evidence for beta cell neogenesis in murine adult pancreas. J Clin Invest 123:2207-2217
35. Guo P, Xiao X, El-Gohary Y et al (2013) Specific transduction and labeling of pancreatic ducts by targeted recombinant viral infusion into mouse pancreatic ducts. Lab Invest 93:1241-1253
36. Guo P, El-Gohary Y, Prasadan K et al (2012) Rapid and simplified purification of recombinant adeno-associated virus. J Virol Methods 183:139-146
37. Guo P, Xiao X, El-Gohary Y et al (2013) A simplified purification method for AAV variant by polyethylene glycol aqueous two-phase partitioning. Bioengineered 4:103-106
38. Shima DT, Adamis AP, Ferrara N et al (1995) Hypoxic induction of endothelial cell growth factors in retinal cells: identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen. Mol Med 1:182-193
39. Cheng SY, Nagane M, Huang HS, Cavenee WK (1997) Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF165 but not VEGF189. Proc Natl Acad Sci U S A 94:12081-12087 (Pubitemid 27467846)
40. Huez I, Creancier L, Audigier S, Gensac MC, Prats AC, Prats H (1998) Two independent internal ribosome entry sites are involved in translation initiation of vascular endothelial growth factor mRNA. Mol Cell Biol 18:6178-6190 (Pubitemid 28500509)
41. Hara M, Wang X, Kawamura T et al (2003) Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells. Am J Physiol Endocrinol Metab 284:E177-E183
42. Ng YS, Rohan R, Sunday ME, Demello DE, D'Amore PA (2001) Differential expression of VEGF isoforms in mouse during development and in the adult. Dev Dyn 220:112-121 (Pubitemid 32107812)
43. Jimenez V, Ayuso E, Mallol C et al (2011) In vivo genetic engineering of murine pancreatic beta cells mediated by single-stranded adeno-associated viral vectors of serotypes 6, 8 and 9. Diabetologia 54:1075-1086
44. Kopp JL, Dubois CL, Schaffer AE et al (2011) Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development 138:653-665
45. Lynn FC, Smith SB, Wilson ME, Yang KY, Nekrep N, German MS (2007) Sox9 coordinates a transcriptional network in pancreatic progenitor cells. Proc Natl Acad Sci U S A 104:10500-10505 (Pubitemid 47185694)
46. Cai Q, Brissova M, Reinert RB et al (2012) Enhanced expression of VEGF-A in beta cells increases endothelial cell number but impairs islet morphogenesis and beta cell proliferation. Dev Biol 367:40-54
47. Zhou Q, Law AC, Rajagopal J, Anderson WJ, Gray PA, Melton DA (2007) A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell 13:103-114 (Pubitemid 46972038)
48. Villalta SA, Lang J, Kubeck S et al (2013) Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function. Diabetes 62:2870-2878
49. Crawford HC, Scoggins CR, Washington MK, Matrisian LM, Leach SD (2002) Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas. J Clin Invest 109:1437-1444 (Pubitemid 34596169)
50. Morris JP 4th, Cano DA, Sekine S, Wang SC, Hebrok M (2010) Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. J Clin Invest 120:508-520
51. Rooman I, Schuit F, Bouwens L (1997) Effect of vascular endothelial growth factor on growth and differentiation of pancreatic ductal epithelium. Lab Invest 76:225-232 (Pubitemid 27082066)