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Volumn 15, Issue 3, 2015, Pages 217-225

The epithelial to mesenchymal transition in pancreatic cancer: A systematic review

Author keywords

Cancer stem cells; Emerging therapies; Epithelial to mesenchymal transition; Mesenchymal to epithelial transition; Molecular signals; Pancreatic cancer

Indexed keywords

FIBRONECTIN; UVOMORULIN; VIMENTIN; TUMOR MARKER;

EID: 84930178541     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1016/j.pan.2015.02.011     Document Type: Review
Times cited : (118)

References (98)
  • 3
    • 84889872072 scopus 로고    scopus 로고
    • Pancreatic cancer staging systems and their clinical impact
    • H. Beger, A. Warshaw, M. Buchler, R. Kozarek, M. Lerch, J. Neoptolemos, 2nd ed. Blackwell Publishing Limited
    • H. Beger, and D. Birk Pancreatic cancer staging systems and their clinical impact H. Beger, A. Warshaw, M. Buchler, R. Kozarek, M. Lerch, J. Neoptolemos, The pancreas: an integrated textbook of basic science, medicine, and Surgery 2nd ed. 2008 Blackwell Publishing Limited 678 681
    • (2008) The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery , pp. 678-681
    • Beger, H.1    Birk, D.2
  • 4
    • 0242413065 scopus 로고    scopus 로고
    • Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development
    • D. Shook, and R. Keller Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development Mech Dev 120 11 2003 1351 1383
    • (2003) Mech Dev , vol.120 , Issue.11 , pp. 1351-1383
    • Shook, D.1    Keller, R.2
  • 5
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • R. Kalluri, and R.A. Weinberg The basics of epithelial-mesenchymal transition J Clin Invest 119 6 2009 1420 1428
    • (2009) J Clin Invest , vol.119 , Issue.6 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 6
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • R. Kalluri, and E. Neilson Epithelial-mesenchymal transition and its implications for fibrosis J Clin Invest 112 12 2003 1776 1784
    • (2003) J Clin Invest , vol.112 , Issue.12 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.2
  • 7
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • J.P. Thiery Epithelial-mesenchymal transitions in tumour progression Nat Rev Cancer 2 6 2002 442 454
    • (2002) Nat Rev Cancer , vol.2 , Issue.6 , pp. 442-454
    • Thiery, J.P.1
  • 8
    • 67651005404 scopus 로고    scopus 로고
    • EMT: When epithelial cells decide to become mesenchymal-like cells
    • R. Kalluri EMT: when epithelial cells decide to become mesenchymal-like cells J Clin Invest 119 6 2009 1417 1419
    • (2009) J Clin Invest , vol.119 , Issue.6 , pp. 1417-1419
    • Kalluri, R.1
  • 9
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
    • J. Yang, and R.A. Weinberg Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis Dev Cell 14 6 2008 818 829
    • (2008) Dev Cell , vol.14 , Issue.6 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 10
    • 41549162752 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states in development and disease
    • B. Baum, J. Settleman, and M.P. Quinlan Transitions between epithelial and mesenchymal states in development and disease Semin Cell Dev Biol 19 3 2008 294 308
    • (2008) Semin Cell Dev Biol , vol.19 , Issue.3 , pp. 294-308
    • Baum, B.1    Settleman, J.2    Quinlan, M.P.3
  • 11
    • 84861527239 scopus 로고    scopus 로고
    • To differentiate or not - Routes towards metastasis
    • T. Brabletz To differentiate or not - routes towards metastasis Nat Rev Cancer 12 6 2012 425 436
    • (2012) Nat Rev Cancer , vol.12 , Issue.6 , pp. 425-436
    • Brabletz, T.1
  • 12
    • 25144488085 scopus 로고    scopus 로고
    • Wnt, hedgehog and snail: Sister pathways that control by GSK-3beta and beta-Trcp in the regulation of metastasis
    • B.P. Zhou, and M.C. Hung Wnt, hedgehog and snail: sister pathways that control by GSK-3beta and beta-Trcp in the regulation of metastasis Cell Cycle 4 6 2005 772 776
    • (2005) Cell Cycle , vol.4 , Issue.6 , pp. 772-776
    • Zhou, B.P.1    Hung, M.C.2
  • 13
    • 84876691674 scopus 로고    scopus 로고
    • Correcting the misnomers of epithelial-mesenchymal relations
    • J.K. Sicklick Correcting the misnomers of epithelial-mesenchymal relations J Surg Res 182 1 2013 36 39
    • (2013) J Surg Res , vol.182 , Issue.1 , pp. 36-39
    • Sicklick, J.K.1
  • 14
    • 84871388785 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma and pancreatic tumor cell lines: The role of neutrophils and neutrophil-derived elastase
    • T. Große-Steffen-Steffen, T. Giese, N. Giese, T. Longerich, P. Schirmacher, and G.M. Hänsch epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma and pancreatic tumor cell lines: the role of neutrophils and neutrophil-derived elastase Clin Dev Immunol 2012 2012 12
    • (2012) Clin Dev Immunol , vol.2012 , pp. 12
    • Große-Steffen-Steffen, T.1    Giese, T.2    Giese, N.3    Longerich, T.4    Schirmacher, P.5    Hänsch, G.M.6
  • 15
    • 56749095797 scopus 로고    scopus 로고
    • Transcriptional regulation of cell polarity in EMT and cancer
    • G. Moreno-Bueno, F. Portillo, and A. Cano Transcriptional regulation of cell polarity in EMT and cancer Oncogene 27 55 2008 6958 6969
    • (2008) Oncogene , vol.27 , Issue.55 , pp. 6958-6969
    • Moreno-Bueno, G.1    Portillo, F.2    Cano, A.3
  • 16
    • 58749084302 scopus 로고    scopus 로고
    • Pulsed contractions of an actin-myosin network drive apical constriction
    • A.C. Martin, M. Kaschube, and E.F. Wieschaus Pulsed contractions of an actin-myosin network drive apical constriction Nature 457 7228 2009 495 499
    • (2009) Nature , vol.457 , Issue.7228 , pp. 495-499
    • Martin, A.C.1    Kaschube, M.2    Wieschaus, E.F.3
  • 17
    • 34748812509 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and tumour invasion
    • M. Guarino Epithelial-mesenchymal transition and tumour invasion Int J Biochem Cell Biol 39 12 2007 2153 2160
    • (2007) Int J Biochem Cell Biol , vol.39 , Issue.12 , pp. 2153-2160
    • Guarino, M.1
  • 18
    • 54349108903 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition mediated tumourigenesis in the gastrointestinal tract
    • A. Natalwala, R. Spychal, and C. Tselepis Epithelial-mesenchymal transition mediated tumourigenesis in the gastrointestinal tract World J Gastroenterol 14 24 2008 3792 3797
    • (2008) World J Gastroenterol , vol.14 , Issue.24 , pp. 3792-3797
    • Natalwala, A.1    Spychal, R.2    Tselepis, C.3
  • 20
    • 35648949978 scopus 로고    scopus 로고
    • Beta-Catenin signaling in biological control and cancer
    • N. Gavert, and A. Ben-Ze'ev beta-Catenin signaling in biological control and cancer J Cell Biochem 102 4 2007 820 828
    • (2007) J Cell Biochem , vol.102 , Issue.4 , pp. 820-828
    • Gavert, N.1    Ben-Ze'Ev, A.2
  • 21
    • 0035964349 scopus 로고    scopus 로고
    • Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
    • T. Brabletz, A. Jung, S. Reu, M. Porzner, F. Hlubek, and L.A. Kunz-Schughart Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment Proc Natl Acad Sci USA 98 18 2001 10356 10361
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.18 , pp. 10356-10361
    • Brabletz, T.1    Jung, A.2    Reu, S.3    Porzner, M.4    Hlubek, F.5    Kunz-Schughart, L.A.6
  • 22
    • 0031727409 scopus 로고    scopus 로고
    • Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front
    • T. Brabletz, A. Jung, K. Hermann, K. Gunther, W. Hohenberger, and T. Kirchner Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front Pathol Res Pract 194 10 1998 701 704
    • (1998) Pathol Res Pract , vol.194 , Issue.10 , pp. 701-704
    • Brabletz, T.1    Jung, A.2    Hermann, K.3    Gunther, K.4    Hohenberger, W.5    Kirchner, T.6
  • 24
    • 84890926543 scopus 로고    scopus 로고
    • Digestive cancer surgery in the era of sentinel node and epithelial-mesenchymal transition
    • N. Peparini Digestive cancer surgery in the era of sentinel node and epithelial-mesenchymal transition World J Gastroenterol 19 47 2013 8996 9002
    • (2013) World J Gastroenterol , vol.19 , Issue.47 , pp. 8996-9002
    • Peparini, N.1
  • 25
    • 79958003343 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: Tumor budding as oncotarget
    • I. Zlobec, and A. Lugli Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget Oncotarget 1 7 2010 651 661
    • (2010) Oncotarget , vol.1 , Issue.7 , pp. 651-661
    • Zlobec, I.1    Lugli, A.2
  • 26
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • M. Zeisberg, and E.G. Neilson Biomarkers for epithelial-mesenchymal transitions J Clin Invest 119 6 2009 1429 1437
    • (2009) J Clin Invest , vol.119 , Issue.6 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 27
    • 44649163918 scopus 로고    scopus 로고
    • A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    • U. Burk, J. Schubert, U. Wellner, O. Schmalhofer, E. Vincan, and S. Spaderna A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells EMBO Rep 9 6 2008 582 589
    • (2008) EMBO Rep , vol.9 , Issue.6 , pp. 582-589
    • Burk, U.1    Schubert, J.2    Wellner, U.3    Schmalhofer, O.4    Vincan, E.5    Spaderna, S.6
  • 28
    • 24644480749 scopus 로고    scopus 로고
    • Molecular requirements for epithelial-mesenchymal transition during tumor progression
    • M.A. Huber, N. Kraut, and H. Beug Molecular requirements for epithelial-mesenchymal transition during tumor progression Curr Opin Cell Biol 17 5 2005 548 558
    • (2005) Curr Opin Cell Biol , vol.17 , Issue.5 , pp. 548-558
    • Huber, M.A.1    Kraut, N.2    Beug, H.3
  • 29
    • 10444261212 scopus 로고    scopus 로고
    • Development of TGF-beta signalling inhibitors for cancer therapy
    • J.M. Yingling, K.L. Blanchard, and J.S. Sawyer Development of TGF-beta signalling inhibitors for cancer therapy Nat Rev Drug Discov 3 12 2004 1011 1022
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.12 , pp. 1011-1022
    • Yingling, J.M.1    Blanchard, K.L.2    Sawyer, J.S.3
  • 30
    • 0035872426 scopus 로고    scopus 로고
    • Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation
    • V. Ellenrieder, S.F. Hendler, W. Boeck, T. Seufferlein, A. Menke, and C. Ruhland Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation Cancer Res 61 10 2001 4222 4228
    • (2001) Cancer Res , vol.61 , Issue.10 , pp. 4222-4228
    • Ellenrieder, V.1    Hendler, S.F.2    Boeck, W.3    Seufferlein, T.4    Menke, A.5    Ruhland, C.6
  • 31
    • 36349033966 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition (EMT) and activated extracellular signal-regulated kinase (p-Erk) in surgically resected pancreatic cancer
    • M.M. Javle, J.F. Gibbs, K.K. Iwata, Y. Pak, P. Rutledge, and J. Yu Epithelial-mesenchymal transition (EMT) and activated extracellular signal-regulated kinase (p-Erk) in surgically resected pancreatic cancer Ann Surg Oncol 14 12 2007 3527 3533
    • (2007) Ann Surg Oncol , vol.14 , Issue.12 , pp. 3527-3533
    • Javle, M.M.1    Gibbs, J.F.2    Iwata, K.K.3    Pak, Y.4    Rutledge, P.5    Yu, J.6
  • 32
    • 84871597851 scopus 로고    scopus 로고
    • Cancer stem cells, EMT, and developmental pathway activation in pancreatic tumors
    • S. Hindriksen, and M.F. Bijlsma Cancer stem cells, EMT, and developmental pathway activation in pancreatic tumors Cancers 4 4 2012 989 1035
    • (2012) Cancers , vol.4 , Issue.4 , pp. 989-1035
    • Hindriksen, S.1    Bijlsma, M.F.2
  • 33
    • 44849093562 scopus 로고    scopus 로고
    • Oncogene addiction
    • [discussion 80]
    • I.B. Weinstein, and A. Joe Oncogene addiction Cancer Res 68 9 2008 3077 3080 [discussion 80]
    • (2008) Cancer Res , vol.68 , Issue.9 , pp. 3077-3080
    • Weinstein, I.B.1    Joe, A.2
  • 34
    • 84927175475 scopus 로고    scopus 로고
    • Targeting molecular addictions in cancer
    • I. Vivanco Targeting molecular addictions in cancer Br J cancer 111 11 2014 2033 2038
    • (2014) Br J Cancer , vol.111 , Issue.11 , pp. 2033-2038
    • Vivanco, I.1
  • 35
    • 84875894714 scopus 로고    scopus 로고
    • Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
    • J. Son, C.A. Lyssiotis, H. Ying, X. Wang, S. Hua, and M. Ligorio Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway Nature 496 7443 2013 101 105
    • (2013) Nature , vol.496 , Issue.7443 , pp. 101-105
    • Son, J.1    Lyssiotis, C.A.2    Ying, H.3    Wang, X.4    Hua, S.5    Ligorio, M.6
  • 36
    • 84903984143 scopus 로고    scopus 로고
    • Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer
    • A. Kapoor, W. Yao, H. Ying, S. Hua, A. Liewen, and Q. Wang Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer Cell 158 1 2014 185 197
    • (2014) Cell , vol.158 , Issue.1 , pp. 185-197
    • Kapoor, A.1    Yao, W.2    Ying, H.3    Hua, S.4    Liewen, A.5    Wang, Q.6
  • 37
    • 65649108558 scopus 로고    scopus 로고
    • A gene expression signature associated with "k-Ras addiction" reveals regulators of EMT and tumor cell survival
    • A. Singh, P. Greninger, D. Rhodes, L. Koopman, S. Violette, and N. Bardeesy A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival Cancer Cell 15 6 2009 489 500
    • (2009) Cancer Cell , vol.15 , Issue.6 , pp. 489-500
    • Singh, A.1    Greninger, P.2    Rhodes, D.3    Koopman, L.4    Violette, S.5    Bardeesy, N.6
  • 38
    • 64049102720 scopus 로고    scopus 로고
    • Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9
    • X.Q. Wang, H. Li, V. Van Putten, R.A. Winn, L.E. Heasley, and R.A. Nemenoff Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9 Mol Biol cell 20 3 2009 791 800
    • (2009) Mol Biol Cell , vol.20 , Issue.3 , pp. 791-800
    • Wang, X.Q.1    Li, H.2    Van Putten, V.3    Winn, R.A.4    Heasley, L.E.5    Nemenoff, R.A.6
  • 39
    • 79952698464 scopus 로고    scopus 로고
    • Activated KrasG(1)(2)D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin
    • S. Rachagani, S. Senapati, S. Chakraborty, M.P. Ponnusamy, S. Kumar, and L.M. Smith Activated KrasG(1)(2)D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin Br J Cancer 104 6 2011 1038 1048
    • (2011) Br J Cancer , vol.104 , Issue.6 , pp. 1038-1048
    • Rachagani, S.1    Senapati, S.2    Chakraborty, S.3    Ponnusamy, M.P.4    Kumar, S.5    Smith, L.M.6
  • 40
    • 0344845003 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and pathologies
    • J.P. Thiery Epithelial-mesenchymal transitions in development and pathologies Curr Opin Cell Biol 15 6 2003 740 746
    • (2003) Curr Opin Cell Biol , vol.15 , Issue.6 , pp. 740-746
    • Thiery, J.P.1
  • 41
    • 84884136226 scopus 로고    scopus 로고
    • Notch signaling: Targeting cancer stem cells and epithelial-to-mesenchymal transition
    • I. Espinoza, R. Pochampally, F. Xing, K. Watabe, and L. Miele Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition Onco Targets Ther 6 2013 1249 1259
    • (2013) Onco Targets Ther , vol.6 , pp. 1249-1259
    • Espinoza, I.1    Pochampally, R.2    Xing, F.3    Watabe, K.4    Miele, L.5
  • 42
    • 33947254016 scopus 로고    scopus 로고
    • Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers
    • G. Feldmann, S. Dhara, V. Fendrich, D. Bedja, R. Beaty, and M. Mullendore Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers Cancer Res 67 5 2007 2187 2196
    • (2007) Cancer Res , vol.67 , Issue.5 , pp. 2187-2196
    • Feldmann, G.1    Dhara, S.2    Fendrich, V.3    Bedja, D.4    Beaty, R.5    Mullendore, M.6
  • 43
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • K.P. Olive, M.A. Jacobetz, C.J. Davidson, A. Gopinathan, D. McIntyre, and D. Honess Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer Science 324 5933 2009 1457 1461
    • (2009) Science , vol.324 , Issue.5933 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3    Gopinathan, A.4    McIntyre, D.5    Honess, D.6
  • 44
    • 70349974840 scopus 로고    scopus 로고
    • Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer
    • J.M. Bailey, A.M. Mohr, and M.A. Hollingsworth Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer Oncogene 28 40 2009 3513 3525
    • (2009) Oncogene , vol.28 , Issue.40 , pp. 3513-3525
    • Bailey, J.M.1    Mohr, A.M.2    Hollingsworth, M.A.3
  • 45
    • 0035991607 scopus 로고    scopus 로고
    • Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT
    • K. Kim, Z. Lu, and E.D. Hay Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT Cell Biol Int 26 5 2002 463 476
    • (2002) Cell Biol Int , vol.26 , Issue.5 , pp. 463-476
    • Kim, K.1    Lu, Z.2    Hay, E.D.3
  • 46
    • 33845996890 scopus 로고    scopus 로고
    • Beta-catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells
    • Y. Takao, T. Yokota, and H. Koide Beta-catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells Biochem Biophys Res Commun 353 3 2007 699 705
    • (2007) Biochem Biophys Res Commun , vol.353 , Issue.3 , pp. 699-705
    • Takao, Y.1    Yokota, T.2    Koide, H.3
  • 47
    • 0033606972 scopus 로고    scopus 로고
    • Notch signalling controls pancreatic cell differentiation
    • A. Apelqvist, H. Li, L. Sommer, P. Beatus, D.J. Anderson, and T. Honjo Notch signalling controls pancreatic cell differentiation Nature 400 6747 1999 877 881
    • (1999) Nature , vol.400 , Issue.6747 , pp. 877-881
    • Apelqvist, A.1    Li, H.2    Sommer, L.3    Beatus, P.4    Anderson, D.J.5    Honjo, T.6
  • 48
    • 79957487931 scopus 로고    scopus 로고
    • Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells
    • B. Bao, Z. Wang, S. Ali, D. Kong, Y. Li, and A. Ahmad Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells Cancer Lett 307 1 2011 26 36
    • (2011) Cancer Lett , vol.307 , Issue.1 , pp. 26-36
    • Bao, B.1    Wang, Z.2    Ali, S.3    Kong, D.4    Li, Y.5    Ahmad, A.6
  • 49
    • 18844393670 scopus 로고    scopus 로고
    • Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity
    • P. Hayward, K. Brennan, P. Sanders, T. Balayo, R. DasGupta, and N. Perrimon Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity Development 132 8 2005 1819 1830
    • (2005) Development , vol.132 , Issue.8 , pp. 1819-1830
    • Hayward, P.1    Brennan, K.2    Sanders, P.3    Balayo, T.4    Dasgupta, R.5    Perrimon, N.6
  • 50
    • 84863297392 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition and cancer stem cells in esophageal adenocarcinoma originating from Barrett's esophagus
    • Y. Tomizawa, T.T. Wu, and K.K. Wang Epithelial mesenchymal transition and cancer stem cells in esophageal adenocarcinoma originating from Barrett's esophagus Oncol Lett 3 5 2012 1059 1063
    • (2012) Oncol Lett , vol.3 , Issue.5 , pp. 1059-1063
    • Tomizawa, Y.1    Wu, T.T.2    Wang, K.K.3
  • 51
    • 33745297408 scopus 로고    scopus 로고
    • New signals from the invasive front
    • G. Christofori New signals from the invasive front Nature 441 7092 2006 444 450
    • (2006) Nature , vol.441 , Issue.7092 , pp. 444-450
    • Christofori, G.1
  • 52
  • 53
  • 54
    • 84857055686 scopus 로고    scopus 로고
    • Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer
    • A. Aghdassi, M. Sendler, A. Guenther, J. Mayerle, C.O. Behn, and C.D. Heidecke Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer Gut 61 3 2012 439 448
    • (2012) Gut , vol.61 , Issue.3 , pp. 439-448
    • Aghdassi, A.1    Sendler, M.2    Guenther, A.3    Mayerle, J.4    Behn, C.O.5    Heidecke, C.D.6
  • 55
    • 84857060970 scopus 로고    scopus 로고
    • A ZEB1-HDAC pathway enters the epithelial to mesenchymal transition world in pancreatic cancer
    • G. Schneider, O.H. Kramer, and D. Saur A ZEB1-HDAC pathway enters the epithelial to mesenchymal transition world in pancreatic cancer Gut 61 3 2012 329 330
    • (2012) Gut , vol.61 , Issue.3 , pp. 329-330
    • Schneider, G.1    Kramer, O.H.2    Saur, D.3
  • 56
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • J. Yang, S.A. Mani, J.L. Donaher, S. Ramaswamy, R.A. Itzykson, and C. Come Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis Cell 117 7 2004 927 939
    • (2004) Cell , vol.117 , Issue.7 , pp. 927-939
    • Yang, J.1    Mani, S.A.2    Donaher, J.L.3    Ramaswamy, S.4    Itzykson, R.A.5    Come, C.6
  • 57
    • 33947142478 scopus 로고    scopus 로고
    • Twist, a novel oncogene, is upregulated in pancreatic cancer: Clinical implication of twist expression in pancreatic juice
    • K. Ohuchida, K. Mizumoto, S. Ohhashi, H. Yamaguchi, H. Konomi, and E. Nagai Twist, a novel oncogene, is upregulated in pancreatic cancer: clinical implication of twist expression in pancreatic juice Int J Cancer 120 8 2007 1634 1640
    • (2007) Int J Cancer , vol.120 , Issue.8 , pp. 1634-1640
    • Ohuchida, K.1    Mizumoto, K.2    Ohhashi, S.3    Yamaguchi, H.4    Konomi, H.5    Nagai, E.6
  • 58
  • 59
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • D.P. Bartel MicroRNAs: target recognition and regulatory functions Cell 136 2 2009 215 233
    • (2009) Cell , vol.136 , Issue.2 , pp. 215-233
    • Bartel, D.P.1
  • 60
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • B.P. Lewis, C.B. Burge, and D.P. Bartel Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets Cell 120 1 2005 15 20
    • (2005) Cell , vol.120 , Issue.1 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 61
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - MicroRNAs with a role in cancer
    • A. Esquela-Kerscher, and F.J. Slack Oncomirs - microRNAs with a role in cancer Nat Rev Cancer 6 4 2006 259 269
    • (2006) Nat Rev Cancer , vol.6 , Issue.4 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 62
    • 43049103824 scopus 로고    scopus 로고
    • The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    • P.A. Gregory, A.G. Bert, E.L. Paterson, S.C. Barry, A. Tsykin, and G. Farshid The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 Nat Cell Biol 10 5 2008 593 601
    • (2008) Nat Cell Biol , vol.10 , Issue.5 , pp. 593-601
    • Gregory, P.A.1    Bert, A.G.2    Paterson, E.L.3    Barry, S.C.4    Tsykin, A.5    Farshid, G.6
  • 63
    • 79951813950 scopus 로고    scopus 로고
    • The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells
    • S. Brabletz, K. Bajdak, S. Meidhof, U. Burk, G. Niedermann, and E. Firat The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells EMBO J 30 4 2011 770 782
    • (2011) EMBO J , vol.30 , Issue.4 , pp. 770-782
    • Brabletz, S.1    Bajdak, K.2    Meidhof, S.3    Burk, U.4    Niedermann, G.5    Firat, E.6
  • 64
    • 77953950190 scopus 로고    scopus 로고
    • MicroRNA, hsa-miR-200c, is an independent prognostic factor in pancreatic cancer and its upregulation inhibits pancreatic cancer invasion but increases cell proliferation
    • J. Yu, K. Ohuchida, K. Mizumoto, N. Sato, T. Kayashima, and H. Fujita MicroRNA, hsa-miR-200c, is an independent prognostic factor in pancreatic cancer and its upregulation inhibits pancreatic cancer invasion but increases cell proliferation Mol Cancer 9 2010 169
    • (2010) Mol Cancer , vol.9 , pp. 169
    • Yu, J.1    Ohuchida, K.2    Mizumoto, K.3    Sato, N.4    Kayashima, T.5    Fujita, H.6
  • 66
    • 70449719361 scopus 로고    scopus 로고
    • Identification of human pancreatic cancer stem cells
    • C. Li, C.J. Lee, and D.M. Simeone Identification of human pancreatic cancer stem cells Methods Mol Biol 568 2009 161 173
    • (2009) Methods Mol Biol , vol.568 , pp. 161-173
    • Li, C.1    Lee, C.J.2    Simeone, D.M.3
  • 67
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • S.A. Mani, W. Guo, M.-J. Liao, E.N. Eaton, A. Ayyanan, and A.Y. Zhou The epithelial-mesenchymal transition generates cells with properties of stem cells Cell 133 4 2008 704 715
    • (2008) Cell , vol.133 , Issue.4 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.-J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6
  • 68
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer
    • A. Singh, and J. Settleman EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer Oncogene 29 34 2010 4741 4751
    • (2010) Oncogene , vol.29 , Issue.34 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 70
    • 84871518452 scopus 로고    scopus 로고
    • Altered expressions of embryonic stem-related genes in pancreatic cancer stem cell
    • Y.H. Lu, H. Zhu, Z.W. Wang, X.J. Fan, S.J. Zhu, and X.H. Li Altered expressions of embryonic stem-related genes in pancreatic cancer stem cell Zhonghua Yi Xue Za Zhi 91 44 2011 3107 3110
    • (2011) Zhonghua Yi Xue Za Zhi , vol.91 , Issue.44 , pp. 3107-3110
    • Lu, Y.H.1    Zhu, H.2    Wang, Z.W.3    Fan, X.J.4    Zhu, S.J.5    Li, X.H.6
  • 71
    • 38049004813 scopus 로고    scopus 로고
    • CD133: Molecule of the moment
    • D. Mizrak, M. Brittan, and M. Alison CD133: molecule of the moment J Pathol 214 1 2008 3 9
    • (2008) J Pathol , vol.214 , Issue.1 , pp. 3-9
    • Mizrak, D.1    Brittan, M.2    Alison, M.3
  • 72
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • P.C. Hermann, S.L. Huber, T. Herrler, A. Aicher, J.W. Ellwart, and M. Guba Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer Cell Stem Cell 1 3 2007 313 323
    • (2007) Cell Stem Cell , vol.1 , Issue.3 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3    Aicher, A.4    Ellwart, J.W.5    Guba, M.6
  • 73
    • 41149178767 scopus 로고    scopus 로고
    • Expression of the "stem cell marker" CD133 in pancreas and pancreatic ductal adenocarcinomas
    • H. Immervoll, D. Hoem, P.O. Sakariassen, O.J. Steffensen, and A. Molven Expression of the "stem cell marker" CD133 in pancreas and pancreatic ductal adenocarcinomas BMC Cancer 8 2008 48
    • (2008) BMC Cancer , vol.8 , pp. 48
    • Immervoll, H.1    Hoem, D.2    Sakariassen, P.O.3    Steffensen, O.J.4    Molven, A.5
  • 74
    • 4944241261 scopus 로고    scopus 로고
    • Segregation of lipid raft markers including CD133 in polarized human hematopoietic stem and progenitor cells
    • B. Giebel, D. Corbeil, J. Beckmann, J. Hohn, D. Freund, and K. Giesen Segregation of lipid raft markers including CD133 in polarized human hematopoietic stem and progenitor cells Blood 104 8 2004 2332 2338
    • (2004) Blood , vol.104 , Issue.8 , pp. 2332-2338
    • Giebel, B.1    Corbeil, D.2    Beckmann, J.3    Hohn, J.4    Freund, D.5    Giesen, K.6
  • 75
    • 84858184063 scopus 로고    scopus 로고
    • Establishment of a highly migratory subclone reveals that CD133 contributes to migration and invasion through epithelial-mesenchymal transition in pancreatic cancer
    • Q. Ding, M. Yoshimitsu, T. Kuwahata, K. Maeda, T. Hayashi, and T. Obara Establishment of a highly migratory subclone reveals that CD133 contributes to migration and invasion through epithelial-mesenchymal transition in pancreatic cancer Hum Cell 25 1 2012 1 8
    • (2012) Hum Cell , vol.25 , Issue.1 , pp. 1-8
    • Ding, Q.1    Yoshimitsu, M.2    Kuwahata, T.3    Maeda, K.4    Hayashi, T.5    Obara, T.6
  • 76
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • S. Jones, X. Zhang, D.W. Parsons, J.C. Lin, R.J. Leary, and P. Angenendt Core signaling pathways in human pancreatic cancers revealed by global genomic analyses Science 321 5897 2008 1801 1806
    • (2008) Science , vol.321 , Issue.5897 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3    Lin, J.C.4    Leary, R.J.5    Angenendt, P.6
  • 77
    • 34447131518 scopus 로고    scopus 로고
    • The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition
    • S.K. Dissanayake, M. Wade, C.E. Johnson, M.P. O'Connell, P.D. Leotlela, and A.D. French The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition J Biol Chem 282 23 2007 17259 17271
    • (2007) J Biol Chem , vol.282 , Issue.23 , pp. 17259-17271
    • Dissanayake, S.K.1    Wade, M.2    Johnson, C.E.3    O'Connell, M.P.4    Leotlela, P.D.5    French, A.D.6
  • 78
    • 79959972120 scopus 로고    scopus 로고
    • Direct activation of Bmi1 by Twist1: Implications in cancer stemness, epithelial-mesenchymal transition, and clinical significance
    • K.J. Wu Direct activation of Bmi1 by Twist1: implications in cancer stemness, epithelial-mesenchymal transition, and clinical significance Chang Gung Med J 34 3 2011 229 238
    • (2011) Chang Gung Med J , vol.34 , Issue.3 , pp. 229-238
    • Wu, K.J.1
  • 79
    • 84155173213 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and cancer stemness: The Twist1-Bmi1 connection
    • K.J. Wu, and M.H. Yang Epithelial-mesenchymal transition and cancer stemness: the Twist1-Bmi1 connection Biosci Rep 31 6 2011 449 455
    • (2011) Biosci Rep , vol.31 , Issue.6 , pp. 449-455
    • Wu, K.J.1    Yang, M.H.2
  • 80
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • I. Ben-Porath, M.W. Thomson, V.J. Carey, R. Ge, G.W. Bell, and A. Regev An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors Nat Genet 40 5 2008 499 507
    • (2008) Nat Genet , vol.40 , Issue.5 , pp. 499-507
    • Ben-Porath, I.1    Thomson, M.W.2    Carey, V.J.3    Ge, R.4    Bell, G.W.5    Regev, A.6
  • 81
    • 65649095142 scopus 로고    scopus 로고
    • Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion
    • A. Kabashima, H. Higuchi, H. Takaishi, Y. Matsuzaki, S. Suzuki, and M. Izumiya Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion Int J Cancer 124 12 2009 2771 2779
    • (2009) Int J Cancer , vol.124 , Issue.12 , pp. 2771-2779
    • Kabashima, A.1    Higuchi, H.2    Takaishi, H.3    Matsuzaki, Y.4    Suzuki, S.5    Izumiya, M.6
  • 82
    • 84930537366 scopus 로고    scopus 로고
    • Side population cells of pancreatic cancer show characteristics of cancer stem cells responsible for resistance and metastasis
    • [Epub ahead of print]
    • H. Niess, P. Camaj, A. Renner, I. Ischenko, Y. Zhao, and S. Krebs Side population cells of pancreatic cancer show characteristics of cancer stem cells responsible for resistance and metastasis Target Oncol 2014 Jun 22 [Epub ahead of print]
    • (2014) Target Oncol
    • Niess, H.1    Camaj, P.2    Renner, A.3    Ischenko, I.4    Zhao, Y.5    Krebs, S.6
  • 83
    • 2342591455 scopus 로고    scopus 로고
    • The discovery of receptor tyrosine kinases: Targets for cancer therapy
    • A. Gschwind, O.M. Fischer, and A. Ullrich The discovery of receptor tyrosine kinases: targets for cancer therapy Nat Rev Cancer 4 5 2004 361 370
    • (2004) Nat Rev Cancer , vol.4 , Issue.5 , pp. 361-370
    • Gschwind, A.1    Fischer, O.M.2    Ullrich, A.3
  • 84
    • 84883154324 scopus 로고    scopus 로고
    • Deguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial-to-mesenchymal transition in an orthotopic model
    • S.R. Boreddy, and S.K. Srivastava Deguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial-to-mesenchymal transition in an orthotopic model Oncogene 32 34 2013 3980 3991
    • (2013) Oncogene , vol.32 , Issue.34 , pp. 3980-3991
    • Boreddy, S.R.1    Srivastava, S.K.2
  • 85
    • 69249096109 scopus 로고    scopus 로고
    • Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells
    • Y. Li, T.G. VandenBoom 2nd, D. Kong, Z. Wang, S. Ali, and P.A. Philip Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells Cancer Res 69 16 2009 6704 6712
    • (2009) Cancer Res , vol.69 , Issue.16 , pp. 6704-6712
    • Li, Y.1    Vandenboom, T.G.2    Kong, D.3    Wang, Z.4    Ali, S.5    Philip, P.A.6
  • 86
    • 62449205665 scopus 로고    scopus 로고
    • Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition
    • N.A. Dallas, L. Xia, F. Fan, M.J. Gray, P. Gaur, and G. van Buren 2nd Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition Cancer Res 69 5 2009 1951 1957
    • (2009) Cancer Res , vol.69 , Issue.5 , pp. 1951-1957
    • Dallas, N.A.1    Xia, L.2    Fan, F.3    Gray, M.J.4    Gaur, P.5    Van Buren, G.6
  • 87
    • 84866325625 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition under control: Global programs to regulate epithelial plasticity
    • M.A. Nieto, and A. Cano The epithelial-mesenchymal transition under control: global programs to regulate epithelial plasticity Semin Cancer Biol 22 5-6 2012 361 368
    • (2012) Semin Cancer Biol , vol.22 , Issue.5-6 , pp. 361-368
    • Nieto, M.A.1    Cano, A.2
  • 88
    • 77950683362 scopus 로고    scopus 로고
    • Interplay of cadherin-mediated cell adhesion and canonical wnt signaling
    • J. Heuberger, and W. Birchmeier Interplay of cadherin-mediated cell adhesion and canonical wnt signaling Cold Spring Harb Perspect Biol 2 2 2010 a002915 10.1101/cshperspect.a002915
    • (2010) Cold Spring Harb Perspect Biol , vol.2 , Issue.2 , pp. a002915
    • Heuberger, J.1    Birchmeier, W.2
  • 89
    • 84899435397 scopus 로고    scopus 로고
    • Filamin A interacting protein 1-like inhibits WNT signaling and MMP expression to suppress cancer cell invasion and metastasis
    • M. Kwon, S.J. Lee, Y. Wang, Y. Rybak, A. Luna, and S. Reddy Filamin A interacting protein 1-like inhibits WNT signaling and MMP expression to suppress cancer cell invasion and metastasis Int J Cancer 135 1 2014 48 60
    • (2014) Int J Cancer , vol.135 , Issue.1 , pp. 48-60
    • Kwon, M.1    Lee, S.J.2    Wang, Y.3    Rybak, Y.4    Luna, A.5    Reddy, S.6
  • 90
    • 84901773422 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition and cancer stem cells: Emerging targets for novel cancer therapy
    • M. Kwon Epithelial-to-mesenchymal transition and cancer stem cells: emerging targets for novel cancer therapy Cancer Gene Ther 21 5 2014 179 180
    • (2014) Cancer Gene Ther , vol.21 , Issue.5 , pp. 179-180
    • Kwon, M.1
  • 91
    • 84891910660 scopus 로고    scopus 로고
    • Down-regulation of filamin A interacting protein 1-like is associated with promoter methylation and an invasive phenotype in breast, colon, lung and pancreatic cancers
    • M. Kwon, S.J. Lee, S. Reddy, Y. Rybak, A. Adem, and S.K. Libutti Down-regulation of filamin A interacting protein 1-like is associated with promoter methylation and an invasive phenotype in breast, colon, lung and pancreatic cancers PLoS One 8 12 2013 e82620
    • (2013) PLoS One , vol.8 , Issue.12 , pp. e82620
    • Kwon, M.1    Lee, S.J.2    Reddy, S.3    Rybak, Y.4    Adem, A.5    Libutti, S.K.6
  • 92
    • 36349006961 scopus 로고    scopus 로고
    • Development and characterization of gemcitabine-resistant pancreatic tumor cells
    • A.N. Shah, J.M. Summy, J. Zhang, S.I. Park, N.U. Parikh, and G.E. Gallick Development and characterization of gemcitabine-resistant pancreatic tumor cells Ann Surg Oncol 14 12 2007 3629 3637
    • (2007) Ann Surg Oncol , vol.14 , Issue.12 , pp. 3629-3637
    • Shah, A.N.1    Summy, J.M.2    Zhang, J.3    Park, S.I.4    Parikh, N.U.5    Gallick, G.E.6
  • 93
    • 65549141305 scopus 로고    scopus 로고
    • Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway
    • Z. Wang, Y. Li, D. Kong, S. Banerjee, A. Ahmad, and A.S. Azmi Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway Cancer Res 69 6 2009 2400 2407
    • (2009) Cancer Res , vol.69 , Issue.6 , pp. 2400-2407
    • Wang, Z.1    Li, Y.2    Kong, D.3    Banerjee, S.4    Ahmad, A.5    Azmi, A.S.6
  • 94
    • 65249125270 scopus 로고    scopus 로고
    • Inhibition of γ-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma
    • 1741.e6-1749.e6.
    • R. Plentz, J.S. Park, A.D. Rhim, D. Abravanel, A.F. Hezel, and S.V. Sharma Inhibition of γ-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma Gastroenterology 136 5 2009 1741.e6-1749.e6. http://dx.doi.org/10.1053/j.gastro.2009.01.008
    • (2009) Gastroenterology , vol.136 , Issue.5
    • Plentz, R.1    Park, J.S.2    Rhim, A.D.3    Abravanel, D.4    Hezel, A.F.5    Sharma, S.V.6
  • 95
    • 67650999217 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer
    • T. Arumugam, V. Ramachandran, K.F. Fournier, H. Wang, L. Marquis, and J.L. Abbruzzese Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer Cancer Res 69 14 2009 5820 5828
    • (2009) Cancer Res , vol.69 , Issue.14 , pp. 5820-5828
    • Arumugam, T.1    Ramachandran, V.2    Fournier, K.F.3    Wang, H.4    Marquis, L.5    Abbruzzese, J.L.6
  • 96
    • 84930187602 scopus 로고    scopus 로고
    • Available from
    • M. Lang Infinity Pharma halts pancreatic cancer trial 2012 Available from: http://www.bizjournals.com/boston/blog/mass-high-tech/2012/01/infinity-pharma-halts-pancreatic-cancer-trial.html
    • (2012) Infinity Pharma Halts Pancreatic Cancer Trial
    • Lang, M.1
  • 97
    • 84880071454 scopus 로고    scopus 로고
    • Final analysis of a phase IB/randomized phase II study of gemcitabine (G) plus placebo (P) or vismodegib (V), a hedgehog (Hh) pathway inhibitor, in patients (pts) with metastatic pancreatic cancer (PC): A University of Chicago Phase II Consortium Study
    • [suppl; abstr 4012]
    • D. Catenacci, N. Bahary, S.R. Nattam, R. Marsh, J. Wallace, and L. Rajdev Final analysis of a phase IB/randomized phase II study of gemcitabine (G) plus placebo (P) or vismodegib (V), a hedgehog (Hh) pathway inhibitor, in patients (pts) with metastatic pancreatic cancer (PC): a University of Chicago Phase II Consortium Study J Clin Oncol 31 2013 [suppl; abstr 4012]
    • (2013) J Clin Oncol , vol.31
    • Catenacci, D.1    Bahary, N.2    Nattam, S.R.3    Marsh, R.4    Wallace, J.5    Rajdev, L.6
  • 98
    • 84883185608 scopus 로고    scopus 로고
    • A phase i study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503)
    • S. Sahebjam, P.L. Bedard, V. Castonguay, Z. Chen, M. Reedijk, and G. Liu A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503) Br J Cancer 109 4 2013 943 949
    • (2013) Br J Cancer , vol.109 , Issue.4 , pp. 943-949
    • Sahebjam, S.1    Bedard, P.L.2    Castonguay, V.3    Chen, Z.4    Reedijk, M.5    Liu, G.6


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