Epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma and pancreatic tumor cell lines: The role of neutrophils and neutrophil-derived elastase

Clinical and Developmental Immunology

Volumn 2012, Issue , 2012, Pages

  Große Steffen, Thomas ^a   Giese, Thomas ^a   Giese, Nathalia ^b   Longerich, Thomas ^b   Schirmacher, Peter ^b   Hänsch, G Maria ^a   Gaida, Matthias M ^a,b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; ELASTASE; KERATIN; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR ZEB1; UVOMORULIN; CADHERIN; HOMEODOMAIN PROTEIN; LEUKOCYTE ELASTASE; NUCLEAR PROTEIN; ORGANIC CATION TRANSPORTER; SOLUTE CARRIER FAMILY 22 (ORGANIC CATION TRANSPORTER), MEMBER 3; TRANSCRIPTION FACTOR; TWIST1 PROTEIN, HUMAN; ZEB1 PROTEIN, HUMAN;

ADULT; AGED; CANCER CELL; CANCER CELL CULTURE; CELL ADHESION; CELL GROWTH; CELL INFILTRATION; CELL ISOLATION; CELL NUCLEUS; CONTROLLED STUDY; DOWN REGULATION; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MESENCHYME CELL; NEUTROPHIL; PANCREAS ADENOCARCINOMA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REVIEW; UPREGULATION; ARTICLE; BIOPSY; ENZYMOLOGY; EPITHELIAL MESENCHYMAL TRANSITION; GENETICS; IMMUNOLOGY; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; METHODOLOGY; MIDDLE AGED; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BETA CATENIN; BIOPSY; CADHERINS; CARCINOMA, HEPATOCELLULAR; CARCINOMA, PANCREATIC DUCTAL; CELL ADHESION; CELL LINE, TUMOR; CELL NUCLEUS; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; KERATINS; LEUKOCYTE ELASTASE; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEUTROPHILS; NUCLEAR PROTEINS; ORGANIC CATION TRANSPORT PROTEINS; PANCREATIC NEOPLASMS; TRANSCRIPTION FACTORS; TWIST TRANSCRIPTION FACTOR;

EID: 84871388785     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2012/720768     Document Type: Review

References (40)

1. Mantovani A., Molecular pathways linking inflammation and cancer. Current Molecular Medicine 2010 10 4 369 373 2-s2.0-77953485565 10.2174/ 156652410791316968
2. Coussens L. M., Werb Z., Inflammation and cancer. Nature 2002 420 6917 860 867 2-s2.0-0037180757 10.1038/nature01322 (Pubitemid 36019639)
3. Gregory A. D., Houghton A. M., Tumor-associated neutrophils: new targets for cancer therapy. Cancer Research 2011 71 7 2411 2416 2-s2.0-79953328298 10.1158/0008-5472.CAN-10-2583
4. Warshaw A. L., Fernandez-Del Castillo C., Medical progress: pancreatic carcinoma. The New England Journal of Medicine 1992 326 7 455 465 2-s2.0-0027118569
5. Reid M. D., Basturk O., Thirabanjasak D., Hruban R. H., Klimstra D. S., Bagci P., Altinel D., Adsay V., Tumor-infiltrating neutrophils in pancreatic neoplasia. Modern Pathology 2011 24 12 1612 1619 2-s2.0-79961112443 10.1038/modpathol.2011.113
6. Khayyata S., Basturk O., Adsay N. V., Invasive micropapillary carcinomas of the ampullo-pancreatobiliary region and their association with tumor-infiltrating neutrophils. Modern Pathology 2005 18 11 1504 1511 2-s2.0-27144457645 10.1038/modpathol.3800460 (Pubitemid 41509406)
7. Gaida M. M., Günther F., Wagner C., Friess H., Giese N. A., Schmidt J., Hänsch G. M., Wente M. N., Expression of the CXCR6 on polymorphonuclear neutrophils in pancreatic carcinoma and in acute, localized bacterial infections. Clinical and Experimental Immunology 2008 154 2 216 223 2-s2.0-53349089998 10.1111/j.1365-2249.2008.03745.x
8. Gaida M. M., Welsch T., Herpel E., Tschaharganeh D. F., Fischer L., Schirmacher P., Hänsch G. M., Bergmann F., MHC class II expression in pancreatic tumors: a link to intratumoral inflammation. Virchows Archiv 2012 460 1 47 60 2-s2.0-84857039699 10.1007/s00428-011-1175-x
9. Tjomsland V., Niklasson L., Sandström P., Borch K., Druid H., Bratthäll C., Messmer D., Larsson M., Spångeus A., The desmoplastic stroma plays an essential role in the accumulation and modulation of infiltrated immune cells in pancreatic adenocarcinoma. Clinical and Developmental Immunology 2011 2011 12 212810 2-s2.0-84855590868 10.1155/2011/212810
10. De Wever O., Demetter P., Mareel M., Bracke M., Stromal myofibroblasts are drivers of invasive cancer growth. International Journal of Cancer 2008 123 10 2229 2238 2-s2.0-53449094862 10.1002/ijc.23925
11. Hay E. D., An overview of epithelio-mesenchymal transformation. Acta Anatomica 1995 154 1 8 20 2-s2.0-0029553183 (Pubitemid 26101385)
12. Kalluri R., Weinberg R. A., The basics of epithelial-mesenchymal transition. The Journal of Clinical Investigation 2009 119 6 1420 1428 2-s2.0-67650999875 10.1172/JCI39104
13. Micalizzi D. S., Farabaugh S. M., Ford H. L., Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. Journal of Mammary Gland Biology and Neoplasia 2010 15 2 117 134 2-s2.0-77954860342 10.1007/s10911-010-9178-9
14. von Burstin J., Eser S., Paul M. C., Seidler B., Brandl M., Messer M., von Werder A., Schmidt A., Mages J., Pagel P., Schnieke A., Schmid R. M., Schneider G., Saur D., E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex. Gastroenterology 2009 137 1 e361 e365 2-s2.0-67649200336 10.1053/j.gastro.2009. 04.004
15. Maier H. J., Wirth T., Beug H., Epithelial-mesenchymal transition in pancreatic carcinoma. Cancers 2010 2 4 2058 2083 2-s2.0-79952264551 10.3390/cancers2042058
16. Krantz S. B., Shields M. A., Dangi-Garimella S., Bentrem D. J., Munshi H. G., Contribution of epithelial-mesenchymal transition to pancreatic cancer progression. Cancers 2010 2 4 2084 2097 2-s2.0-79952258739 10.3390/ cancers2042084
17. De Wever O., Pauwels P., De Craene B., Sabbah M., Emami S., Redeuilh G., Gespach C., Bracke M., Berx G., Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front. Histochemistry and Cell Biology 2008 130 3 481 494 2-s2.0-50249141697 10.1007/s00418-008-0464-1
18. Kalluri R., Neilson E. G., Epithelial-mesenchymal transition and its implications for fibrosis. The Journal of Clinical Investigation 2003 112 12 1776 1784 2-s2.0-0346724511 10.1172/JCI200320530 (Pubitemid 38063698)
19. Bosman F. T., Carneiro F., Hruban R. H., Theise N. D., World Health Organisation Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System 2010 Lyon, France IARC Press
20. Ceyhan G. O., Bergmann F., Kadihasanoglu M., Erkan M., Park W., Hinz U., Müller M. W., Giese T., Büchler M. W., Giese N. A., Friess H., The neurotrophic factor artemin influences the extent of neural damage and growth in chronic pancreatitis. Gut 2007 56 4 534 544 2-s2.0-34147223954 10.1136/gut.2006.105528 (Pubitemid 46580510)
21. Gaida M. M., Bach S. T., Gunther F., Baseras B., Tschaharganeh D. F., Welsch T., Felix K., Bergmann F., Hansch G. M., Wente: M. N., Expression of galectin-3 in pancreatic ductal adenocarcinoma. Pathology & Oncology Research 2011 18 2 299 307
22. Allred D. C., Clark G. M., Elledge R., Fuqua S. A. W., Brown R. W., Chamness G. C., Osborne C. K., McGuire W. L., Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. Journal of the National Cancer Institute 1993 85 3 200 206 2-s2.0-0027394794 (Pubitemid 23046895)
23. Erkan M., Reiser-Erkan C., Michalski C. W., Kleeff J., Tumor microenvironment and progression of pancreatic cancer. Experimental Oncology 2010 32 3 128 131 2-s2.0-77957726424
24. Wang Z., Li Y., Ahmad A., Banerjee S., Azmi A. S., Kong D., Sarkar F. H., Pancreatic cancer: understanding and overcoming chemoresistance. Nature Reviews Gastroenterology and Hepatology 2011 8 1 27 33 2-s2.0-78651108985 10.1038/nrgastro.2010.188
25. Sabbah M., Emami S., Redeuilh G., Julien S., Prévost G., Zimber A., Ouelaa R., Bracke M., De Wever O., Gespach C., Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers. Drug Resistance Updates 2008 11 4-5 123 151 2-s2.0-53249130662 10.1016/j.drup.2008.07.001
26. De Wever O., Lapeire L., De Boeck A., Hendrix A., Cellular and molecular mechanisms of cancer cell invasion. Verhandelingen-Koninklijke Academie voor Geneeskunde van Belgie 2010 72 5-6 309 326 2-s2.0-79953310994
27. Zhao J. J., Pan K., Wang W., The prognostic value of tumor-infiltrating neutrophils in gastric adenocarcinoma after resection. PloS ONE 2012 7 3 e33655
28. Sarrió D., Rodriguez-Pinilla S. M., Hardisson D., Cano A., Moreno-Bueno G., Palacios J., Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype. Cancer Research 2008 68 4 989 997 2-s2.0-39449095723 10.1158/0008-5472.CAN-07-2017 (Pubitemid 351272216)
29. Natalwala A., Spychal R., Tselepis C., Epithelial-mesenchymal transition mediated tumourigenesis in the gastrointestinal tract. World Journal of Gastroenterology 2008 14 24 3792 3797 2-s2.0-54349108903 10.3748/wjg.14.3792
30. Javle M. M., Gibbs J. F., Iwata K. K., Pak Y., Rutledge P., Yu J., Black J. D., Tan D., Khoury T., Epithelial-Mesenchymal Transition (EMT) and activated extracellular signal-regulated kinase (p-Erk) in surgically resected pancreatic cancer. Annals of Surgical Oncology 2007 14 12 3527 3533 2-s2.0-36349033966 10.1245/s10434-007-9540-3 (Pubitemid 350160113)
31. Nakajima S., Doi R., Toyoda E., Tsuji S., Wada M., Koizumi M., Tulachan S. S., Ito D., Kami K., Mori T., Kawaguchi Y., Fujimoto K., Hosotani R., Imamura M., N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma. Clinical Cancer Research 2004 10 12 4125 4133 2-s2.0-3042618951 10.1158/1078-0432.CCR-0578-03 (Pubitemid 38812492)
32. Cates J. M. M., Byrd R. H., Fohn L. E., Tatsas A. D., Washington M. K., Black C. C., Epithelial-mesenchymal transition markers in pancreatic ductal adenocarcinoma. Pancreas 2009 38 1 e1 e6 2-s2.0-59649090098 10.1097/MPA. 0b013e3181878b7f
33. Wellner U., Schubert J., Burk U. C., Schmalhofer O., Zhu F., Sonntag A., Waldvogel B., Vannier C., Darling D., zur Hausen A., Brunton V. G., Morton J., Sansom O., Schüler J., Stemmler M. P., Herzberger C., Hopt U., Keck T., Brabletz S., Brabletz T., The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nature Cell Biology 2009 11 12 1487 1495 2-s2.0-73049110243
34. Mayerle J., Schnekenburger J., Krüger B., Kellermann J., Ruthenbürger M., Weiss F. U., Nalli A., Domschke W., Lerch M. M., Extracellular cleavage of E-cadherin by leukocyte elastase during acute experimental pancreatitis in rats. Gastroenterology 2005 129 4 1251 1267 2-s2.0-26844578434 10.1053/j.gastro.2005.08.002 (Pubitemid 41446864)
35. Krantz S. B., Shields M. A., Dangi-Garimella S., Munshi H. G., Bentrem D. J., Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression. Journal of Surgical Research 2012 173 1 105 112 2-s2.0-84857052013 10.1016/j.jss.2011.09.020
36. Tamiya S., Liu L., Kaplan H. J., Epithelial-mesenchymal transition and proliferation of retinal pigment epithelial cells initiated upon loss of cell-cell contact. Investigative Ophthalmology and Visual Science 2010 51 5 2755 2763 2-s2.0-77952495532 10.1167/iovs.09-4725
37. Miyoshi J., Takai Y., Structural and functional associations of apical junctions with cytoskeleton. Biochimica et Biophysica Acta 2008 1778 3 670 691 2-s2.0-39849084350 10.1016/j.bbamem.2007.12.014
38. Wheelock M. J., Shintani Y., Maeda M., Fukumoto Y., Johnson K. R., Cadherin switching. Journal of Cell Science 2008 121 6 727 735 2-s2.0-42549107446 10.1242/jcs.000455 (Pubitemid 351578108)
39. Liu Y., Dean D. C., Tumor initiation via loss of cell contact inhibition versus Ras mutation: do all roads lead to EMT? Cell Cycle 2010 9 5 897 900 2-s2.0-77953529599
40. Houghton A. M., The paradox of tumor-associated neutrophils: fueling tumor growth with cytotoxic substances. Cell Cycle 2010 9 9 1732 1737 2-s2.0-77953565568 10.4161/cc.9.9.11297