Epithelial to mesenchymal transition: Expression of the regulators snail, slug, and twist in pancreatic cancer

Clinical Cancer Research

Volumn 13, Issue 16, 2007, Pages 4769-4776

  Hotz, Birgit ^a   Arndt, Marco ^a   Dullat, Sonja ^a   Bhargava, Sarah ^a   Buhr, Heinz J ^a   Hotz, Hubert G ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; EPITHELIUM; FEMALE; GENE ACTIVATION; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; IMMUNOHISTOCHEMISTRY; MALE; MESENCHYME; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; NUDE MOUSE; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PANCREAS TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTIGENS, CD; CADHERINS; CELL HYPOXIA; EPITHELIUM; HUMANS; IMMUNOHISTOCHEMISTRY; MESODERM; NEOPLASM INVASIVENESS; NUCLEAR PROTEINS; PANCREATIC NEOPLASMS; TRANSCRIPTION FACTORS; TWIST TRANSCRIPTION FACTOR;

EID: 34548078651     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-06-2926     Document Type: Article

References (34)

1. Parker SL, Tong T, Bolden S, Wingo PA. Cancer statistics, 1997. CA Cancer J Clin 1997;47:5-27.
2. Howard TJ. Pancreatic adenocarcinoma. Curr Probl Cancer 1996;20:281-328.
3. Yeo TP, Hruban RH, Leach SD, et al. Pancreatic cancer. Curr Probl Cancer 2002;26:176-275.
4. Rosenberg L. Pancreatic cancer: a review of emerging therapies. Drugs 2000;59:1071-89.
5. Boyer B, Valles AM, Edme N. Induction and regulation of epithelial-mesenchymal transitions. Biochem Pharmacol 2000;60:1091-9.
6. Huber MA, Kraut N, Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 2005;17:548-58.
7. Wang B, Zhang Z, Ke Y. Conversion of cadherin isoforms in cultured human gastric carcinoma cells. World J Gastroenterol 2006;12:966-70.
8. Tomita K, van Bokhoven A, van Leenders GJ, et al. Cadherin switching in human prostate cancer progression. Cancer Res 2000;60:3650-4.
9. Toyoda E, Doi R, Koizumi M, et al. Analys is of E-, N-cadherin, α-, β-, and γ-catenin expression in human pancreatic carcinoma cell lines. Pancreas 2005;30:168-73.
10. Kang Y, Massagué J. Epithelial-mesenchymal transitions: twist in development andmetastasis. Cell 2004;118:277-9.
11. Nieman MT, Prudoff RS, Johnson KR, Wheelock MJ. N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol 1999;147:631-44.
12. Nakajima S, Doi R, Toyoda E, et al. N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma. Clin Cancer Res 2004;10:4125-33.
13. Derycke LD, Bracke ME. N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion, and signalling. Int J Dev Biol 2004;48:463-76.
14. Bolos V, Peinao H, Perez-Moreno MA, Fraga MF, Estella M, Cano H. The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci 2003;116:499-511.
15. Hajra KM, Chen DY, Fearon ER. The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res 2002;62:1613-8.
16. Barrallo-Gimeno A, Nieto MA. The Snail genesas inducers of cell movement and survival: implications in development and cancer. Development 2005;132:3151-61.
17. Martin TA, Goyal A, Watkins G, Jiang WG. Expression of the transcription factors Snail, Slug, and Twist and their clinical significance in human breast cancer. Ann Surg Oncol 2005;12:1-9.
18. Kurrey NK, Amit K, Bapat SA. Snail and Slug are major determinants of ovarian cancer invasiveness at the transcriptional level. Gynecol Oncol 2005;97:155-65.
19. Nieto MA. The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 2002;3:155-66.
20. Peinado H, Portillo F, Cano A. Transcriptional regulation of cadherins during development and carcinogenesis. Int J Dev Biol 2004;48:365-75.
21. Karreth F, Tuveson DA. Twist induces an epithelial mesenchymal transition to facilitate tumor metastasis. Cancer Biol Ther 2004;3:1058-9.
22. Wittwer CT, Herrmann MG, Moss AA, Rasmussen RP. Continuous fluorescence monitoring of rapid cycle DNA amplification. Biotechniques 1997;22:130-1.
23. Yang J, Mani SA, Donaher JL, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004;117:927-39.
24. Yang J, Mani SA, Weinberg RA. Exploring a new twist on tumor metastasis. Cancer Res 2006;66:4549-52.
25. Rosivatz E, Becker J, Specht K, et al. Differential expression of the epithelial-mesenchymal transition regulators Snail, SIP1, and Twist in gastric cancer. Am J Pathol 2002;161:1881-91.
26. Alexander NR, Tran NL, Rekapally H, Summers CE, Glackin C, Heimark RL. N-cadherin gene expression in prostate carcinoma is modulated by integrin-dependent nuclear translocation of Twist1. Cancer Res 2006;66:3365-9.
27. Hotz HG, Reber HA, Hotz B, et al. An orthotopic nude mouse model for evaluating pathophysiology and therapy of pancreatic cancer. Pancreas 2003;26:e89-98.
28. Wittwer CT, Rierie KM, Andrew RV, David DA, Gundry RA, Balis UJ. The LightCycler: a microvolume multisample fluorimeter with rapid temperature control. Biotechniques 1997;22:176-81.
29. Fan X, Inda MM, Turan T, Castresana JS. Improvement of the methylation specific PCR technical conditions for the detection of p16 promoter hypermethylation in small amounts of tumor DNA. Oncol Rep 2002;9:181-3.
30. Oda H, Tsukita S, Takeichi M. Dynamic behavior of the cadherin-based cell-cell adhesion system during Drosophila gastrulation. Dev Biol 1998;203:435-50.
31. Watanabe O, Imamura IT, Schimizu T, et al. Expression of twist and wnt in human breast cancer. Anticancer Res 2004;24:3851-6.
32. Kwok WK, Ling MT, Lee TW, et al. Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target. Cancer Res 2005;65:5153-62.
33. Rajasekaran SA, Gopal J, Espineda C, Ryazantsev S, Schneeberger EE, Rajasekaran AK. HPAF-II, a cell culture model to study pancreatic epithelial cell structure and function. Pancreas 2004;29:e77-83.
34. Harris AL. Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2002;2:38-47.