Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet

FASEB Journal

Volumn 22, Issue 11, 2008, Pages 3896-3907

  Michailidou, Z ^a   Carter, R N ^a   Marshall, E ^a   Sutherland, H G ^b   Brownstein, D G ^a   Owen, E ^a   Cockett, K ^a   Kelly, V ^a   Ramage, L ^a   Al Dujaili, E A S ^c   Ross, M ^a   Maraki, I ^a   Newton, K ^b   Holmes, M C ^a   Seckl, J R ^a   Morton, N M ^a   Kenyon, C J ^a   Chapman, K E ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c QUEEN MARGARET UNIVERSITY   (United Kingdom)

Author keywords

Diet induced obesity; Glucose and lipid homeostasis; HPA axis; NR3C1

Indexed keywords

BETA GALACTOSIDASE; GLUCOCORTICOID RECEPTOR; GLUCOSE; HYBRID PROTEIN; KANAMYCIN KINASE; LIPID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; DISEASE PREDISPOSITION; EMBRYONIC STEM CELL; ENERGY BALANCE; GENETIC VARIABILITY; GLUCOSE INTOLERANCE; HUMAN; HUMAN CELL; HYPERTENSION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LIPID DIET; METABOLIC DISORDER; METABOLISM; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RNA EXTRACTION; WEIGHT GAIN;

ADIPOSITY; ALDOSTERONE; ANGIOTENSINS; ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; CELL LINE; DIET; DIETARY FATS; GLUCOSE INTOLERANCE; HUMANS; HYPERTENSION; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LIPID METABOLISM; MICE; MICE, TRANSGENIC; PITUITARY-ADRENAL SYSTEM; RECEPTORS, GLUCOCORTICOID; RENIN; WEIGHT GAIN;

MUS;

EID: 55649093353     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.08-111914     Document Type: Article

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