메뉴 건너뛰기




Volumn 16, Issue 6, 2015, Pages 317-331

Neuronal circuits for fear and anxiety

Author keywords

[No Author keywords available]

Indexed keywords

ANXIETY; BEHAVIOR CONTROL; CENTRAL NUCLEUS (AMYGDALA); CONDITIONING; CONNECTOME; DEFENSIVE BEHAVIOR; FEAR; HIPPOCAMPUS; HUMAN; NERVE CELL; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; STRIA TERMINALIS; ANIMAL; BRAIN; NERVE TRACT; PATHOPHYSIOLOGY; PHYSIOLOGY;

EID: 84929908682     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn3945     Document Type: Review
Times cited : (1205)

References (192)
  • 1
    • 84897139176 scopus 로고    scopus 로고
    • A framework for studying emotions across species
    • A constructive, unifying view on the neuroscience of emotions
    • Anderso n, D. J. & Adolphs, R. A framework for studying emotions across species. Cell 157, 187-200 (2014). A constructive, unifying view on the neuroscience of emotions.
    • (2014) Cell , vol.157 , pp. 187-200
    • Anderso, N.D.J.1    Adolphs, R.2
  • 2
    • 0034076609 scopus 로고    scopus 로고
    • Emotion circuits in the brain
    • A classic review that covers the seminal work on the role of the amygdala in fear conditioning
    • LeDoux, J. E. Emotion circuits in the brain. Annu. Rev. Neurosci. 23, 155-184 (2000). A classic review that covers the seminal work on the role of the amygdala in fear conditioning.
    • (2000) Annu. Rev. Neurosci , vol.23 , pp. 155-184
    • Ledoux, J.E.1
  • 3
    • 84896809680 scopus 로고    scopus 로고
    • Coming to terms with fear
    • LeDoux, J. E. Coming to terms with fear. Proc. Natl Acad. Sci. USA 111, 2871-2878 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 2871-2878
    • Ledoux, J.E.1
  • 4
    • 0004228559 scopus 로고    scopus 로고
    • (ed. Aggleton, J. P.) (Oxford Univ. Press
    • Davis, M. in The Amygdala (ed. Aggleton, J. P.) 213-288 (Oxford Univ. Press, 2000).
    • (2000) The Amygdala , pp. 213-288
    • Davis, M.1
  • 5
    • 72049097678 scopus 로고    scopus 로고
    • Phasic versus sustained fear in rats and humans: Role of the extended amygdala in fear versus anxiety
    • A comprehensive review of classic research on the key role of the amygdala in anxiety
    • Davis, M., Walker, D. L., Miles , L. & Grillon, C. Phasic versus sustained fear in rats and humans: role of the extended amygdala in fear versus anxiety. Neuropsychopharmacology 35, 105-135 (2010). A comprehensive review of classic research on the key role of the amygdala in anxiety.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 105-135
    • Davis, M.1    Walker, D.L.2    Miles, L.3    Grillon, C.4
  • 6
    • 67649708292 scopus 로고    scopus 로고
    • (eds Blanchard, R. J., Blanchard, D. C., Griebel, G. & Nutt, D.) Elsevier). An instructive collection of classic experimental approaches, behavioural paradigms and influential concepts in fear and anxiety
    • Blanchard, D. C. & Blanchard, R. J. in Handbook of Anxiety and Fear (eds Blanchard, R. J., Blanchard, D. C., Griebel, G. & Nutt, D.) 63-79 (Elsevier, 2008). An instructive collection of classic experimental approaches, behavioural paradigms and influential concepts in fear and anxiety.
    • (2008) Handbook of Anxiety and Fear , pp. 63-79
    • Blanchard, D.C.1    Blanchard, R.J.2
  • 7
    • 84858662491 scopus 로고    scopus 로고
    • Optogenetic investigation of neural circuits underlying brain disease in animal models
    • Tye, K. M. & Deisseroth, K. Optogenetic investigation of neural circuits underlying brain disease in animal models. Nature Rev. Neurosci. 13, 251-266 (2012).
    • (2012) Nature Rev. Neurosci , vol.13 , pp. 251-266
    • Tye, K.M.1    Deisseroth, K.2
  • 8
    • 84904676650 scopus 로고    scopus 로고
    • Chemogenetic tools to interrogate brain functions
    • Sternson, S. M. & Roth, B. L. Chemogenetic tools to interrogate brain functions. Annu. Rev. Neurosci. 37, 387-407 (2014).
    • (2014) Annu. Rev. Neurosci , vol.37 , pp. 387-407
    • Sternson, S.M.1    Roth, B.L.2
  • 9
    • 84880427381 scopus 로고    scopus 로고
    • Ultrasensitive fluorescen t proteins for imaging neuronal activity
    • Chen, T. W. et al. Ultrasensitive fluorescen t proteins for imaging neuronal activity. Nature 499, 295-300 (2013).
    • (2013) Nature , vol.499 , pp. 295-300
    • Chen, T.W.1
  • 10
    • 84891808217 scopus 로고    scopus 로고
    • Tools for resolving functional activity and connectivity within intact neural circuits
    • Jennings, J. H. & Stuber, G. D. Tools for resolving functional activity and connectivity within intact neural circuits.Curr. Biol. 24, R41-R50 (2014).
    • (2014) Curr. Biol , vol.24 , pp. R41-R50
    • Jennings, J.H.1    Stuber, G.D.2
  • 11
    • 84879369197 scopus 로고    scopus 로고
    • Uncertainty and anticipation in anxiety: An integrated neurobiological and psychological perspective
    • Grupe, D. W. & Nitschke, J. B. Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective. Nature Rev. Neurosci. 14, 488-501 (2013).
    • (2013) Nature Rev. Neurosci , vol.14 , pp. 488-501
    • Grupe, D.W.1    Nitschke, J.B.2
  • 12
    • 79958055503 scopus 로고    scopus 로고
    • Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli
    • Lammel, S., Ion, D. I., Roeper, J. & Malenka, R. C. Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli. Neuron 70, 855-862 (2011).
    • (2011) Neuron , vol.70 , pp. 855-862
    • Lammel, S.1    Ion, D.I.2    Roeper, J.3    Malenka, R.C.4
  • 13
    • 84868621500 scopus 로고    scopus 로고
    • Input-specific control of reward and aversion in the ventral tegmental area
    • An elegant study using modern circuit-based app roaches to investigate positive and negative valence coding in the VTA
    • Lammel, S. et al. Input-specific control of reward and aversion in the ventral tegmental area. Nature 491, 212-217 (2012). An elegant study using modern circuit-based app roaches to investigate positive and negative valence coding in the VTA.
    • (2012) Nature , vol.491 , pp. 212-217
    • Lammel, S.1
  • 14
    • 34548571904 scopus 로고    scopus 로고
    • Expectation modulates neural responses to pleasant and aversive stimuli in primate amygdala
    • Belova, M. A., Paton, J. J., Morrison, S. E. & Salzman, C. D. Expectation modulates neural responses to pleasant and aversive stimuli in primate amygdala. Neuron 55, 970-984 (2007).
    • (2007) Neuron , vol.55 , pp. 970-984
    • Belova, M.A.1    Paton, J.J.2    Morrison, S.E.3    Salzman, C.D.4
  • 15
    • 32844469435 scopus 로고    scopus 로고
    • The primate amygdala represents the positive and negative value of visual stimu li during learning
    • Paton, J. J., Belova, M. A., Morrison, S. E. & Salzman, C. D. The primate amygdala represents the positive and negative value of visual stimu li during learning. Nature 439, 865-870 (2006).
    • (2006) Nature , vol.439 , pp. 865-870
    • Paton, J.J.1    Belova, M.A.2    Morrison, S.E.3    Salzman, C.D.4
  • 16
    • 8344247709 scopus 로고    scopus 로고
    • Neuronal signalling of fear memory
    • Maren, S. & Quirk, G. J. Neuronal signalling of fear memory. Nature Rev. Neurosci. 5, 844-852 (2004).
    • (2004) Nature Rev. Neurosci , vol.5 , pp. 844-852
    • Maren, S.1    Quirk, G.J.2
  • 17
    • 84901750080 scopus 로고    scopus 로고
    • Amygdala microcircuits controlling learned fear
    • Du varci, S. & Pare, D. Amygdala microcircuits controlling learned fear. Neuron 82, 966-980 (2014).
    • (2014) Neuron , vol.82 , pp. 966-980
    • Du Varci, S.1    Pare, D.2
  • 18
    • 77951041564 scopus 로고    scopus 로고
    • Plastic synaptic networks of the amygdala for the acqui sition, expression, and extinction of conditioned fear
    • Pape, H. C. & Pare, D. Plastic synaptic networks of the amygdala for the acqui sition, expression, and extinction of conditioned fear. Physiol. Rev. 90, 419-463 (2010).
    • (2010) Physiol. Rev , vol.90 , pp. 419-463
    • Pape, H.C.1    Pare, D.2
  • 19
    • 0032976615 scopus 로고    scopus 로고
    • The neuroanatomical and neurochemical basis of conditioned fear
    • Fendt, M. & Fanselow, M. S. The neuroanatomical and neurochemical basis of conditioned fear. Neurosci. Biobehav. Rev. 23, 743-760 (1999).
    • (1999) Neurosci. Biobehav. Rev , vol.23 , pp. 743-760
    • Fendt, M.1    Fanselow, M.S.2
  • 21
    • 29244447143 scopus 로고    scopus 로고
    • Neural circuits and mechanisms involved in pavlovian fear conditioning: A critical review
    • Kim, J. J. & Jung, M. W. Neural circuits and mechanisms involved in Pavlovian fear conditioning: a critical review. Neurosci. Biobehav. Rev. 30, 188-202 (2006).
    • (2006) Neurosci. Biobehav. Rev , vol.30 , pp. 188-202
    • Kim, J.J.1    Jung, M.W.2
  • 22
    • 0034927082 scopus 로고    scopus 로고
    • Neurobiology of pavlovian fear conditioning
    • Maren, S. Neurobiology of Pavlovian fear conditioning. Annu. Rev. Neurosci. 24, 897-931 (2001).
    • (2001) Annu. Rev. Neurosci , vol.24 , pp. 897-931
    • Maren, S.1
  • 23
    • 0021957698 scopus 로고
    • Immunohistochemical identification of ?-Aminobutyric acid-containing ne urons in the rat basolateral amygdala
    • McDonald, A. J. Immunohistochemical identification of ?-Aminobutyric acid-containing ne urons in the rat basolateral amygdala. Neurosci. Lett. 53, 203-207 (1985).
    • (1985) Neurosci. Lett , vol.53 , pp. 203-207
    • McDonald, A.J.1
  • 24
    • 0020416188 scopus 로고
    • Neurons of the lateral and basolateral amygdaloid nuclei: A golgi study in the rat
    • McDonald, A. J. Neurons of the lateral and basolateral amygdaloid nuclei: a Golgi study in the rat. J. Comp. Neurol. 212, 293-312 (1982).
    • (1982) J. Comp. Neurol , vol.212 , pp. 293-312
    • McDonald, A.J.1
  • 25
    • 33746933469 scopus 로고    scopus 로고
    • Physiological and morphological characterization of parvalbumin-containing interneurons of the rat basolateral amygdala
    • Rainnie, D. G., Mania, I., Mascagni, F. & McDonald, A. J. Physiological and morphological characterization of parvalbumin-containing interneurons of the rat basolateral amygdala. J. Comp.Neurol. 498, 142-161 (2006).
    • (2006) J. Comp.Neurol , vol.498 , pp. 142-161
    • Rainnie, D.G.1    Mania, I.2    Mascagni, F.3    McDonald, A.J.4
  • 26
    • 0019988538 scopus 로고
    • Cytoarchitecture of the central amygdaloid nucleus of the rat
    • McDonald, A. J. Cytoarchitecture of the central amygdaloid nucleus of the rat. J. Comp. Neurol. 208, 401-418 (1982).
    • (1982) J. Comp. Neurol , vol.208 , pp. 401-418
    • McDonald, A.J.1
  • 28
    • 0031471239 scopus 로고    scopus 로고
    • Fear conditioning induces associative long-term potentiation i n the amygdala
    • A seminal work demonstrating that amygdala neurons undergo plastic changes as a result of aversive conditioning
    • Rogan, M. T., Staubli, U. V. & LeDoux, J. E. Fear conditioning induces associative long-term potentiation i n the amygdala. Nature 390, 604-607 (1997). A seminal work demonstrating that amygdala neurons undergo plastic changes as a result of aversive conditioning.
    • (1997) Nature , vol.390 , pp. 604-607
    • Rogan, M.T.1    Staubli, U.V.2    Ledoux, J.E.3
  • 29
    • 0037061684 scopus 로고    scopus 로고
    • Fear conditioning occludes ltp-induced presynaptic enhancement of synaptic transmission in the cortical pathway to the lateral amygdala
    • Tsvetkov, E., Carlezon, W. A., Benes, F. M. , Kandel, E. R. & Bolshakov, V. Y. Fear conditioning occludes LTP-induced presynaptic enhancement of synaptic transmission in the cortical pathway to the lateral amygdala. Neuron 34, 289-300 (2002).
    • (2002) Neuron , vol.34 , pp. 289-300
    • Tsvetkov, E.1    Carlezon, W.A.2    Benes, F.M.3    Kandel, E.R.4    Bolshakov, V.Y.5
  • 30
    • 0028846007 scopus 로고
    • Fear conditioning enhances short-latency auditory responses of lateral amygdala neurons: Parallel recordings in the freely behaving rat
    • A cl assic in vivo study showing that fear conditioning induces plasticity in LA neurons
    • Quirk, G. J., Repa, C. & LeDoux, J. E. Fear conditioning enhances short-latency auditory responses of lateral amygdala neurons: parallel recordings in the freely behaving rat. Neuron 15, 1029-1039 (1995). A cl assic in vivo study showing that fear conditioning induces plasticity in LA neurons.
    • (1995) Neuron , vol.15 , pp. 1029-1039
    • Quirk, G.J.1    Repa, C.2    Ledoux, J.E.3
  • 31
    • 0037118051 scopus 로고    scopus 로고
    • Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning
    • Rosenkranz, J. A. & Grace, A. A. Dopamine-mediated modulation of odour-evoked amygdala potentials during Pavlovian conditioning. Nature 417, 282-287 (2002).
    • (2002) Nature , vol.417 , pp. 282-287
    • Rosenkranz, J.A.1    Grace, A.A.2
  • 32
    • 0030961081 scopus 로고    scopus 로고
    • Fear conditioning enhances different temporal components of tone-evoked spike trains in auditory cortex and lateral amygda la
    • A paper demonstrating that different neuronal populations in the amygdala encode different aspects of the fear memory
    • Quirk, G. J., Armony, J. L. & LeDoux, J. E. Fear conditioning enhances different temporal components of tone-evoked spike trains in auditory cortex and lateral amygda la. Neuron 19, 613-624 (1997). A paper demonstrating that different neuronal populations in the amygdala encode different aspects of the fear memory.
    • (1997) Neuron , vol.19 , pp. 613-624
    • Quirk, G.J.1    Armony, J.L.2    Ledoux, J.E.3
  • 33
    • 0034948956 scopus 로고    scopus 로고
    • Two different lateral amygdala cell populations contribute to the initiation and storage of memory
    • Repa, J. C. et al. Two different lateral amygdala cell populations contribute to the initiation and storage of memory. Nature Neurosci. 4, 724-731 (2001).
    • (2001) Nature Neurosci , vol.4 , pp. 724-731
    • Repa, J.C.1
  • 34
    • 77955457039 scopus 로고    scopus 로고
    • Optical activation of lateral amygdala pyramidal cells instructs assoc iative fear learning
    • Johansen, J. P. et al. Optical activation of lateral amygdala pyramidal cells instructs assoc iative fear learning. Proc. Natl Acad. Sci. USA 107, 12692-12697 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 12692-12697
    • Johansen, J.P.1
  • 35
    • 84904464246 scopus 로고    scopus 로고
    • Engineering a memory with ltd and ltp
    • Nabavi, S. et al. Engineering a memory with LTD and LTP. Nature 511, 348-352 (2014).
    • (2014) Nature , vol.511 , pp. 348-352
    • Nabavi, S.1
  • 36
    • 0028323343 scopus 로고
    • Response properties of single units in areas of rat auditory thalamus that project to the amygdala. Ii. Cells receiving convergent auditory and somatosensory inputs and cells antidromically activa ted by amygdala stimulation
    • Bordi, F. & LeDoux, J. E. Response properties of single units in areas of rat auditory thalamus that project to the amygdala. II. Cells receiving convergent auditory and somatosensory inputs and cells antidromically activa ted by amygdala stimulation. Exp. Brain Res. 98, 275-286 (1994).
    • (1994) Exp. Brain Res , vol.98 , pp. 275-286
    • Bordi, F.1    Ledoux, J.E.2
  • 37
    • 0033778335 scopus 로고    scopus 로고
    • Differential projection of the posterior paralaminar thalamic nuclei to the amygdaloid complex in the rat
    • Linke, R., Braune, G. & Schwegler, H. Differential projection of the posterior paralaminar thalamic nuclei to the amygdaloid complex in the rat. Exp. Brain Res. 134, 520-532 (2000).
    • (2000) Exp. Brain Res , vol.134 , pp. 520-532
    • Linke, R.1    Braune, G.2    Schwegler, H.3
  • 38
    • 0022414640 scopus 로고
    • Projections to the subcortical forebrain from anatomically defined regions of the medial geniculate b ody in the rat
    • LeDoux, J. E., Ruggiero, D. A. & Reis, D. J. Projections to the subcortical forebrain from anatomically defined regions of the medial geniculate b ody in the rat. J. Comp. Neurol. 242, 182-213 (1985).
    • (1985) J. Comp. Neurol , vol.242 , pp. 182-213
    • Ledoux, J.E.1    Ruggiero, D.A.2    Reis, D.J.3
  • 39
    • 0028219369 scopus 로고
    • Response properties of single units in areas of rat auditory thalamus that project to the amygdala. I. Acoustic dis charge patterns and frequency receptive fields
    • Bordi, F. & LeDoux, J. E. Response properties of single units in areas of rat auditory thalamus that project to the amygdala. I. Acoustic dis charge patterns and frequency receptive fields. Exp. Brain Res. 98, 261-274 (1994).
    • (1994) Exp. Brain Res , vol.98 , pp. 261-274
    • Bordi, F.1    Ledoux, J.E.2
  • 40
    • 0026354074 scopus 로고
    • Overlapping projections to the amygdala and striatum from auditory processing areas of the thalamus and cortex
    • LeDoux, J. E., Farb, C. R. & Romanski, L. M. Overlapping projections to the amygdala and striatum from auditory processing areas of the thalamus and cortex. Neurosci. Lett. 134, 139-144 (1991).
    • (1991) Neurosci. Lett , vol.134 , pp. 139-144
    • Ledoux, J.E.1    Farb, C.R.2    Romanski, L.M.3
  • 41
    • 0031548033 scopus 로고    scopus 로고
    • Cortical, thalamic, and amygdaloid projections of rat temporal cortex
    • Shi, C. J. & Cassell, M. D. Cortical, thalamic, and amygdaloid projections of rat temporal cortex. J. Comp. Neurol. 382, 153-175 (1997).
    • (1997) J. Comp. Neurol , vol.382 , pp. 153-175
    • Shi, C.J.1    Cassell, M.D.2
  • 42
    • 0027369434 scopus 로고
    • Corticoamygdaloid and corticocortical projections of the rat temporal cortex: A phaseolus vulgaris leucoagglutinin study
    • Mascagni, F., McDonald, A. J. & Coleman, J. R. Corticoamygdaloid and corticocortical projections of the rat temporal cortex: a Phaseolus vulgaris leucoagglutinin study. Neuroscience 57, 697-715 (1993).
    • (1993) Neuroscience , vol.57 , pp. 697-715
    • Mascagni, F.1    McDonald, A.J.2    Coleman, J.R.3
  • 43
    • 83555166188 scopus 로고    scopus 로고
    • A disinhibitory microcircuit for associative fear learning in the auditory cortex
    • A multidimensional study on the cortical circuit basis for auditory fear conditioning
    • Letzkus, J. J. et al. A disinhibitory microcircuit for associative fear learning in the auditory cortex. Nature 480, 331-335 (2011). A multidimensional study on the cortical circuit basis for auditory fear conditioning.
    • (2011) Nature , vol.480 , pp. 331-335
    • Letzkus, J.J.1
  • 44
    • 77955053218 scopus 로고    scopus 로고
    • Neural substrates for expectation-modulated fear learning in the amygdala and periaqueductal gray
    • Jo hansen, J. P., Tarpley, J. W., LeDoux, J. E. & Blair, H. T. Neural substrates for expectation-modulated fear learning in the amygdala and periaqueductal gray. Nature Neurosci. 13, 979-986 (2010).
    • (2010) Nature Neurosci , vol.13 , pp. 979-986
    • Jo Hansen, J.P.1    Tarpley, J.W.2    Ledoux, J.E.3    Blair, H.T.4
  • 46
    • 84893777971 scopus 로고    scopus 로고
    • The conditions that promote fear learning: Prediction error and pavlovian fear conditioning
    • Li, S. S. & McNally, G. P. Th e conditions that promote fear learning: prediction error and Pavlovian fear conditioning. Neurobiol. Learn. Mem. 108, 14-21 (2014).
    • (2014) Neurobiol. Learn. Mem , vol.108 , pp. 14-21
    • Li, S.S.1    McNally, G.P.2
  • 47
    • 55649103674 scopus 로고    scopus 로고
    • Neuroanatomi cal and neurochemical organization of projections from the central amygdaloid nucleus to the nucleus retroambiguus via the periaqueductal gray in the rat
    • Oka, T., Tsumori, T., Yokota, S. & Yasui, Y. Neuroanatomi cal and neurochemical organization of projections from the central amygdaloid nucleus to the nucleus retroambiguus via the periaqueductal gray in the rat. Neurosci. Res. 62, 286-298 (2008).
    • (2008) Neurosci. Res , vol.62 , pp. 286-298
    • Oka, T.1    Tsumori, T.2    Yokota, S.3    Yasui, Y.4
  • 48
    • 0027723577 scopus 로고
    • Effects of amygdala, hippocampus, and periaqueductal gray lesions on short-And long-term contextual fear
    • A classic study showing distinct roles for differen t brain areas in fear conditioning
    • Kim, J. J., Ri son, R. A. & Fanselow, M. S. Effects of amygdala, hippocampus, and periaqueductal gray lesions on short-And long-term contextual fear. Behav. Neurosci. 107, 1093-1098 (1993). A classic study showing distinct roles for differen t brain areas in fear conditioning.
    • (1993) Behav. Neurosci , vol.107 , pp. 1093-1098
    • Kim, J.J.1    Rison, R.A.2    Fanselow, M.S.3
  • 49
    • 0037450438 scopus 로고    scopus 로고
    • Role of ventrolateral periaqueductal gray neurons in the behavioral and cardiovascular responses to contextual conditioned fear and poststress recovery
    • Walker, P. & Carrive, P. Role of ventrolateral periaqueductal gray neurons in the behavioral and cardiovascular responses to contextual conditioned fear and poststress recovery. Neuroscience 116, 897-912 ( 2003).
    • (2003) Neuroscience , vol.116 , pp. 897-912
    • Walker, P.1    Carrive, P.2
  • 50
    • 0028101302 scopus 로고
    • Columnar organization in the midbrain periaqueductal gray: Modules for emotional expression?
    • Bandler, R. & Shipley, M. T. Columnar organization in the midbrain periaqueductal gray: modules for emotional expression? Trends Neurosci. 17, 379-389 (1994).
    • (1994) Trends Neurosci , vol.17 , pp. 379-389
    • Bandler, R.1    Shipley, M.T.2
  • 51
    • 80155157843 scopus 로고    scopus 로고
    • Molecular mechanisms of fear learning and memory
    • Joha nsen, J. P., Cain, C. K., Ostroff, L. E. & LeDoux, J. E. Molecular mechanisms of fear learning and memory. Cell 147, 509-524 (2011).
    • (2011) Cell , vol.147 , pp. 509-524
    • Johansen, J.P.1    Cain, C.K.2    Ostroff, L.E.3    Ledoux, J.E.4
  • 52
    • 84864380003 scopus 로고    scopus 로고
    • Neural and cellular mechanisms of fear and extinction memory formation
    • Orsini, C. A. & Maren, S. Neural a nd cellular mechanisms of fear and extinction memory formation. Neurosci. Biobehav. Rev. 36, 1773-1802 (2012).
    • (2012) Neurosci. Biobehav. Rev , vol.36 , pp. 1773-1802
    • Orsini, C.A.1    Maren, S.2
  • 53
    • 84655169550 scopus 로고    scopus 로고
    • Coactivation of thalamic and cortical pathways induces input timing-dependent plasticity in amygdala
    • Cho, J. H. et al. Coactivation of thalamic and cortical pathways induces input timing-dependent plasticity in amygdala. Nature Neurosci. 15, 113-122 (2012).
    • (2012) Nature Neurosci , vol.15 , pp. 113-122
    • Cho, J.H.1
  • 54
    • 0346096511 scopus 로고    scopus 로고
    • Presynaptic induction of heterosynaptic associative plastici ty in the mammalian brain
    • Humeau, Y., Shaban, H., Bissiere, S. & Luthi, A. Presynaptic induction of heterosynaptic associative plastici ty in the mammalian brain. Nature 426, 841-845 (2003).
    • (2003) Nature , vol.426 , pp. 841-845
    • Humeau, Y.1    Shaban, H.2    Bissiere, S.3    Luthi, A.4
  • 55
    • 0037096258 scopus 로고    scopus 로고
    • Nmda receptors and l-type voltage-gated calcium channels contribute to long-term potentiatio n and different components of fear memory formation in the lateral amygdala
    • Bauer, E. P., Schafe, G. E. & LeDoux, J. E. NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiatio n and different components of fear memory formation in the lateral amygdala. J. Neurosci. 22, 5239-5249 (2002).
    • (2002) J. Neurosci , vol.22 , pp. 5239-5249
    • Bauer, E.P.1    Schafe, G.E.2    Ledoux, J.E.3
  • 56
    • 0032125869 scopus 로고    scopus 로고
    • Postsynaptic induction and pka-dependent expression of ltp in the lateral amygdala
    • Huang, Y. Y. & Kandel, E. R. Postsynaptic induction and PKA-dependent expression of LTP in the lateral amygdala. Neuron 21, 169-178 (1998).
    • (1998) Neuron , vol.21 , pp. 169-178
    • Huang, Y.Y.1    Kandel, E.R.2
  • 57
    • 0026065808 scopus 로고
    • N-methyl-d-Aspartate receptor antagonist apv blocks acquisitio n but not expression of fear conditioning
    • Kim, J. J., DeCola, J. P., Landeira-Fernandez, J. & Fanselow, M. S. N-methyl-d-Aspartate receptor antagonist APV blocks acquisitio n but not expression of fear conditioning. Behav. Neurosci. 105, 126-133 (1991).
    • (1991) Behav. Neurosci , vol.105 , pp. 126-133
    • Kim, J.J.1    Decola, J.P.2    Landeira-Fernandez, J.3    Fanselow, M.S.4
  • 58
    • 0025367265 scopus 로고
    • Blocking of acquisition but not expression of cond itioned fear-potentiated startle by nmda antagonists in the amygdala
    • Miserendino, M. J., Sananes, C. B., Melia, K. R. & Davis, M. Blocking of acquisition but not expression of cond itioned fear-potentiated startle by NMDA antagonists in the amygdala. Nature 345, 716-718 (1990).
    • (1990) Nature , vol.345 , pp. 716-718
    • Miserendino, M.J.1    Sananes, C.B.2    Melia, K.R.3    Davis, M.4
  • 59
    • 15944411690 scopus 로고    scopus 로고
    • Postsynaptic receptor trafficking underly ing a form of associative learning
    • An early demonstration that AMPA receptor trafficking mediates fear memory formation
    • Rumpel, S., LeDoux, J., Zador, A. & Malinow, R. Postsynaptic receptor trafficking underly ing a form of associative learning. Science 308, 83-88 (2005). An early demonstration that AMPA receptor trafficking mediates fear memory formation.
    • (2005) Science , vol.308 , pp. 83-88
    • Rumpel, S.1    Ledoux, J.2    Zador, A.3    Malinow, R.4
  • 60
    • 34548532346 scopus 로고    scopus 로고
    • Localization of a stable neural correlate of associative memory
    • Reijmers, L. G., Perkins, B. L., Matsuo, N. & Mayford, M. Localization of a stable neural correlate of associative memory. Science 317, 1230-1233 (2007).
    • (2007) Science , vol.317 , pp. 1230-1233
    • Reijmers, L.G.1    Perkins, B.L.2    Matsuo, N.3    Mayford, M.4
  • 61
    • 48349139678 scopus 로고    scopus 로고
    • Switching on and off fear by distinct neuronal circuits
    • A report that establishes the existence of distinct neuronal subpopulations that are devoted to the encoding of fear and fear extinction
    • Herry, C. et al. Switching on and off fear by distinct neuronal circuits. Natu re 454, 600-606 (2008). A report that establishes the existence of distinct neuronal subpopulations that are devoted to the encoding of fear and fear extinction.
    • (2008) Nature , vol.454 , pp. 600-606
    • Herry, C.1
  • 62
    • 84870012192 scopus 로고    scopus 로고
    • Long-t erm neural correlates of reversible fear learning in the lateral amygdala
    • An, B., Hong, I. & Choi, S. Long-t erm neural correlates of reversible fear learning in the lateral amygdala. J. Neurosci. 32, 16845-16856 (2012).
    • (2012) J. Neurosci , vol.32 , pp. 16845-16856
    • An, B.1    Hong, I.2    Choi, S.3
  • 63
    • 84921945629 scopus 로고    scopus 로고
    • Neuronal encoding of the switch from specific to generalized fear
    • Ghosh, S. & Chattarji, S. Neuronal encoding of the switch from specific to generalized fear. Nature Neurosci. 18, 112-120 (2015).
    • (2015) Nature Neurosci , vol.18 , pp. 112-120
    • Ghosh, S.1    Chattarji, S.2
  • 64
    • 62449248195 scopus 로고    scopus 로고
    • Selective e rasure of a fear memory
    • Han, J. H. et al. Selective e rasure of a fear memory. Science 323, 1492-1496 (2009).
    • (2009) Science , vol.323 , pp. 1492-1496
    • Han, J.H.1
  • 65
    • 84893755098 scopus 로고    scopus 로고
    • Memory recall and modifications by activating neurons with elevated creb
    • Kim, J., Kwon, J. T., Kim, H. S., Josselyn, S. A. & Han, J. H. Memory recall and modifications by activating neurons with elevated CREB. Nature Neurosci. 17, 65-72 (2014).
    • (2014) Nature Neurosci , vol.17 , pp. 65-72
    • Kim, J.1    Kwon, J.T.2    Kim, H.S.3    Josselyn, S.A.4    Han, J.H.5
  • 66
    • 84859924817 scopus 로고    scopus 로고
    • Optogenetic stimulation of a hippocampal engram activates fear memory recall
    • Liu, X. et al. Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature 484, 381-385 (2012).
    • (2012) Nature , vol.484 , pp. 381-385
    • Liu, X.1
  • 67
    • 74949102638 scopus 로고    scopus 로고
    • Creb regulates excitability and the allocation of memory to subsets of neurons in the amygdala
    • Zhou, Y. et al. CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala. Nature Neurosci. 12, 1438-1443 (2009).
    • (2009) Nature Neurosci , vol.12 , pp. 1438-1443
    • Zhou, Y.1
  • 68
    • 84883392979 scopus 로고    scopus 로고
    • Assignment of model amygdala neurons to the fear memory trace depends on competitive synaptic interactions
    • Kim, D., Pare, D. & Nair, S. S. Assignment of model amygdala neurons to the fear memory trace depends on competitive synaptic interactions. J. Neurosci. 33, 14354-14358 (2013).
    • (2013) J. Neurosci , vol.33 , pp. 14354-14358
    • Kim, D.1    Pare, D.2    Nair, S.S.3
  • 69
    • 33847196473 scopus 로고    scopus 로고
    • Plasticity of inhibitory synaptic network interactions in the lateral amygdala upon fear conditioning in mice
    • Szinyei, C., Narayanan , R. T. & Pape, H. C. Plasticity of inhibitory synaptic network interactions in the lateral amygdala upon fear conditioning in mice. Eur. J. Neurosci. 25, 1205-1211 (2007).
    • (2007) Eur. J. Neurosci , vol.25 , pp. 1205-1211
    • Szinyei, C.1    Narayanan, R.T.2    Pape, H.C.3
  • 70
    • 33747610450 scopus 로고    scopus 로고
    • Generalization of amygdala ltp and conditioned fear in the absence of presynaptic inhibition
    • Shaban, H. et al. Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition. Nature Neurosci. 9, 1028-1035 (2006).
    • (2006) Nature Neurosci , vol.9 , pp. 1028-1035
    • Shaban, H.1
  • 71
    • 0037683733 scopus 로고    scopus 로고
    • Dopamine gates ltp induction in lateral amygdala by suppressing feedforward inhibition
    • Bissiere, S., Humeau, Y. & Luthi, A. Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition. Nature Neurosci. 6, 587-592 (2003).
    • (2003) Nature Neurosci , vol.6 , pp. 587-592
    • Bissiere, S.1    Humeau, Y.2    Luthi, A.3
  • 72
    • 0031019033 scopus 로고    scopus 로고
    • Similar inhibitory processes dominate the responses of cat lateral amygdaloid projection neurons to their various afferents
    • Lang, E. J.& Pare, D. Similar inhibitory processes dominate the responses of cat lateral amygdaloid projection neurons to their various afferents. J. Neurophysiol. 77, 341-352 (1997).
    • (1997) J. Neurophysiol , vol.77 , pp. 341-352
    • Lang, E.J.1    Pare, D.2
  • 73
    • 0030256881 scopus 로고    scopus 로고
    • Gabaa and gabab receptors differentially regulate synaptic transmission in the auditory thalamo-Amygdala pathway: An in vivo microiontophoretic study and a model
    • Li, X. F., Armon y, J. L. & LeDoux, J. E. GABAA and GABAB receptors differentially regulate synaptic transmission in the auditory thalamo-Amygdala pathway: an in vivo microiontophoretic study and a model. Synapse 24, 115-124 (1996).
    • (1996) Synapse , vol.24 , pp. 115-124
    • Li, X.F.1    Armony, J.L.2    Ledoux, J.E.3
  • 74
    • 35348855733 scopus 로고    scopus 로고
    • Norepinephrine enables the induction of associative long-term potentiation at thalamo-Amygdala synapses
    • Tully K.,Li Y.,Tsvetkov E.,Bolshakov V. Y Norepinephrine enables the induction of associative long-term potentiation at thalamo-Amygdala synapses. Proc. Natl Acad. Sci. USA 104 14146-14150 2 007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 14146-14150
    • Tully, K.1    Li, Y.2    Tsvetkov, E.3    Bolshakov, V.Y.4
  • 75
    • 0033493230 scopus 로고    scopus 로고
    • An inhibitory interface gates impulse traffic between the input and output stations of the amygdala
    • Important work that demonstrates the role of ITC cell masses in gating information flow in the amygdala
    • Royer, S., Martina, M. & Pare, D. An inhibitory interface gates impulse traffic between the input and output stations of the amygdala. J. Neurosci. 19, 10575-10583 (1999). Important work that demonstrates the role of ITC cell masses in gating information flow in the amygdala.
    • (1999) J. Neurosci , vol.19 , pp. 10575-10583
    • Royer, S.1    Martina, M.2    Pare, D.3
  • 76
    • 78049512440 scopus 로고    scopus 로고
    • A specific class of interneuron mediates inhibitory plastic ity in the lateral amygdala
    • Polepalli, J. S., Sullivan, R. K., Yanagawa, Y. & Sah, P. A specific class of interneuron mediates inhibitory plastic ity in the lateral amygdala. J. Neurosci. 30, 14619-14629 (2010).
    • (2010) J. Neurosci , vol.30 , pp. 14619-14629
    • Polepalli, J.S.1    Sullivan, R.K.2    Yanagawa, Y.3    Sah, P.4
  • 77
    • 84901285980 scopus 로고    scopus 로고
    • Amygdala interneuron subtypes control fear learning through disinhibition
    • A recent study taking advantage of the cellular specificity and temporal precision of optogenetics to characterize amygdala interneuron function
    • Wolff, S. B. et al. Amygdala interneuron subtypes control fear learning through disinhibition. Nature 509, 453-458 (2014). A recent study taking advantage of the cellular specificity and temporal precision of optogenetics to characterize amygdala interneuron function.
    • (2014) Nature , vol.509 , pp. 453-458
    • Wolff, S.B.1
  • 78
    • 84862682541 scopus 로고    scopus 로고
    • Cell-type-specific recruitment of amygdala interneurons to hippocampal theta rhythm and noxious stimuli in vivo
    • Bienvenu, T. C., Busti, D., Magill, P. J., Fer raguti, F. & Capogna, M. Cell-type-specific recruitment of amygdala interneurons to hippocampal theta rhythm and noxious stimuli in vivo. Neuron 74, 1059-1074 (2012).
    • (2012) Neuron , vol.74 , pp. 1059-1074
    • Bienvenu, T.C.1    Busti, D.2    Magill, P.J.3    Fer Raguti, F.4    Capogna, M.5
  • 79
    • 30144441862 scopus 로고    scopus 로고
    • Pyramidal cells of the rat basolateral amygdala: Synaptology and innervation by parvalbumin-immunoreactive interneurons
    • Muller, J. F., Ma scagni, F. & McDonald, A. J. Pyramidal cells of the rat basolateral amygdala: synaptology and innervation by parvalbumin-immunoreactive interneurons. J. Comp. Neurol. 494, 635-650 (2006).
    • (2006) J. Comp. Neurol , vol.494 , pp. 635-650
    • Muller, J.F.1    Mascagni, F.2    McDonald, A.J.3
  • 80
    • 33847005922 scopus 로고    scopus 로고
    • Postsynaptic targets of somatostatin-containing interneurons in the rat basolateral amygdala
    • Muller, J. F ., Mascagni, F. & McDonald, A. J. Postsynaptic targets of somatostatin-containing interneurons in the rat basolateral amygdala. J. Comp. Neurol. 500, 513-529 (2007).
    • (2007) J. Comp. Neurol , vol.500 , pp. 513-529
    • Muller, J.F.1    Mascagni, F.2    McDonald, A.J.3
  • 81
    • 79959812707 scopus 로고    scopus 로고
    • Ox ytocin selectively gates fear responses through distinct outputs from the central amygdala
    • Viviani, D. et al. Ox ytocin selectively gates fear responses through distinct outputs from the central amygdala. Science 333, 104-107 (2011).
    • (2011) Science , vol.333 , pp. 104-107
    • Viviani, D.1
  • 82
    • 16444367602 scopus 로고    scopus 로고
    • Vasopressin and oxytocin ex cite distinct neuronal populations in the central amygdala
    • Huber, D., Veinante, P. & Stoop, R. Vasopressin and oxytocin ex cite distinct neuronal populations in the central amygdala. Science 308, 245-248 (2005).
    • (2005) Science , vol.308 , pp. 245-248
    • Huber, D.1    Veinante, P.2    Stoop, R.3
  • 83
    • 36249012512 scopus 로고    scopus 로고
    • Serotonin-immunoreactive axon terminals innervate pyrami dal cells and interneurons in the rat basolateral amygdala
    • Muller, J. F., Mascagni, F. & McDonald, A. J. Serotonin-immunoreactive axon terminals innervate pyrami dal cells and interneurons in the rat basolateral amygdala. J. Comp. Neurol. 505, 314-335 (2007).
    • (2007) J. Comp. Neurol , vol.505 , pp. 314-335
    • Muller, J.F.1    Mascagni, F.2    McDonald, A.J.3
  • 84
    • 78751522905 scopus 로고    scopus 로고
    • Cholinergic innervation of pyramidal cells and parva lbumin-immunoreactive interneurons in the rat basolateral amygdala
    • Muller, J. F., Mascagni, F. & McDonald, A. J. Cholinergic innervation of pyramidal cells and parva lbumin-immunoreactive interneurons in the rat basolateral amygdala. J. Comp. Neurol. 519, 790-805 (2011).
    • (2011) J. Comp. Neurol , vol.519 , pp. 790-805
    • Muller, J.F.1    Mascagni, F.2    McDonald, A.J.3
  • 85
    • 56549097030 scopus 로고    scopus 로고
    • Dopaminergic inner vation of interneurons in the rat basolateral amygdala
    • Pinard, C. R., Muller, J. F., Mascagni, F. & McDonald, A. J. Dopaminergic inner vation of interneurons in the rat basolateral amygdala. Neuroscience 157, 850-863 (2008).
    • (2008) Neuroscience , vol.157 , pp. 850-863
    • Pinard, C.R.1    Muller, J.F.2    Mascagni, F.3    McDonald, A.J.4
  • 86
    • 84894250322 scopus 로고    scopus 로고
    • Dendritic inhibition in the hippocampus supports fear learning
    • Lovett-Barron, M. et al. Dendritic inhibition in the hippocampus supports fear learning. Science 34 3, 857-863 (2014).
    • (2014) Science , vol.343 , pp. 857-863
    • Lovett-Barron, M.1
  • 87
    • 84892372575 scopus 로고    scopus 로고
    • Prefrontal parvalbumin interneurons shape neuronal activity to drive fear expression
    • An elegant study that identifies a prefrontal microcircuit that is crucial for fear responses
    • Courtin, J. et al. Prefrontal parvalbumin interneurons shape neuronal activity to drive fear expression. Nature 505, 92-96 (2014). An elegant study that identifies a prefrontal microcircuit that is crucial for fear responses.
    • (2014) Nature , vol.505 , pp. 92-96
    • Courtin, J.1
  • 88
    • 84888639169 scopus 로고    scopus 로고
    • Cortical interneurons that specialize in disinhibitory control
    • Pi, H. J. et al. Cortical interneurons that specialize in disinhibitory control. Nature 503, 521-524 (2013).
    • (2013) Nature , vol.503 , pp. 521-524
    • Pi, H.J.1
  • 89
    • 36248937797 scopus 로고    scopus 로고
    • A synaptic memory trace for cortical receptive field plasticity
    • Froemke R. C.,Merzenich M. M.,Schreiner C. E. A synaptic memory trace for cortical receptive field plasticity Nature 450, 425-429, 2007)
    • (2007) Nature , vol.450 , pp. 425-429
    • Froemke, R.C.1    Merzenich, M.M.2    Schreiner, C.E.3
  • 90
    • 0028846119 scopus 로고
    • Synchronization of neuronal activity in hippocampus by individual gabaergic interneurons
    • Cobb, S. R., Buhl, E. H., Halasy, K., Paulsen, O. & Somogyi, P. Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons. Nature 378, 75-78 (1995).
    • (1995) Nature , vol.378 , pp. 75-78
    • Cobb, S.R.1    Buhl, E.H.2    Halasy, K.3    Paulsen, O.4    Somogyi, P.5
  • 91
    • 84862799975 scopus 로고    scopus 로고
    • Control of timing, rate and bursts of hippocampal place cells by dendritic and somatic inhibition
    • Royer, S. et al. Control of timing, rate and bursts of hippocampal place cells by dendritic and somatic inhibition. Nature Neurosci. 15, 769-775 (2012).
    • (2012) Nature Neurosci , vol.15 , pp. 769-775
    • Royer, S.1
  • 92
    • 33845243380 scopus 로고    scopus 로고
    • Rethinking the fear circuit: The central nucleus of the amygdala is required for the acquisition, consolidation, and expression of pavlovian fear conditioning
    • Wilensky, A. E., Schafe, G. E., Kristensen, M. P. & LeDoux, J. E. Rethinking the fear circuit: the central nucleus of the amygdala is required for the acquisition, consolidation, and expression of Pavlovian fear conditioning. J. Neurosci. 26, 12387-12396 (2006).
    • (2006) J. Neurosci , vol.26 , pp. 12387-12396
    • Wilensky, A.E.1    Schafe, G.E.2    Kristensen, M.P.3    Ledoux, J.E.4
  • 93
    • 78149433114 scopus 로고    scopus 로고
    • Encoding of conditioned fear in central amygdala inhibitory circuits
    • Ciocchi, S. et al. Encoding of conditioned fear in central amygdala inhibitory circuits. Nature 468, 277-282 (2010).
    • (2010) Nature , vol.468 , pp. 277-282
    • Ciocchi, S.1
  • 94
    • 78149420233 scopus 로고    scopus 로고
    • Genetic dissection of an amygdala microcircuit that gates conditioned fear
    • Haubensak, W. et al. Genetic dissection of an amygdala microcircuit that gates conditioned fear. Nature 468, 270-276 (2010).
    • (2010) Nature , vol.468 , pp. 270-276
    • Haubensak, W.1
  • 95
    • 84856731262 scopus 로고    scopus 로고
    • Evoked axonal oxytocin release in the central amygdal a attenuates fear response
    • Knobloch, H. S. et al. Evoked axonal oxytocin release in the central amygdal a attenuates fear response. Neuron 73, 553-566 (2012).
    • (2012) Neuron , vol.73 , pp. 553-566
    • Knobloch, H.S.1
  • 96
    • 84875904044 scopus 로고    scopus 로고
    • Experience-dependent modification of a central amygdala fear circuit
    • Li, H. et al. Experience-dependent modification of a central amygdala fear circuit. Nature Neurosci. 16, 332-339 (2013).
    • (2013) Nature Neurosci , vol.16 , pp. 332-339
    • Li, H.1
  • 97
    • 0023677407 scopus 로고
    • Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear
    • LeDoux, J. E., Iwata, J., Cicchetti, P. & Reis, D. J. Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear. J. Neurosci. 8, 2517-2529 (1988).
    • (1988) J. Neurosci , vol.8 , pp. 2517-2529
    • Ledoux, J.E.1    Iwata, J.2    Cicchetti, P.3    Reis, D.J.4
  • 98
    • 78650859970 scopus 로고    scopus 로고
    • Central amygdala activity during fear conditioning
    • Duvarci, S., Popa, D. & Pare, D. Central amygdala activity during fear conditioning. J. Neurosci. 31, 289-294 (2011).
    • (2011) J. Neurosci , vol.31 , pp. 289-294
    • Duvarci, S.1    Popa, D.2    Pare, D.3
  • 100
    • 0035693435 scopus 로고    scopus 로고
    • Topography of projections from amygdala to bed nuclei of the stria terminalis
    • Dong, H. W., Petrovich, G. D. & Swanson, L. W. Topography of projections from amygdala to bed nuclei of the stria terminalis. Brain Res. Brain Res. Rev. 38, 192-246 (2001).
    • (2001) Brain Res. Brain Res. Rev , vol.38 , pp. 192-246
    • Dong, H.W.1    Petrovich, G.D.2    Swanson, L.W.3
  • 101
    • 0030878022 scopus 로고    scopus 로고
    • Projections from the lateral part of the central amygdalar nucleus to the postulated fear conditioning circuit
    • Petrovich G. D.,Swanson L. W. Projections from the lateral part of the central amygdalar nucleus to the postulated fear conditioning circuit Brain Res. 763, 247-254, 1997).
    • (1997) Brain Res , vol.763 , pp. 247-254
    • Petrovich, G.D.1    Swanson, L.W.2
  • 102
    • 84893710114 scopus 로고    scopus 로고
    • Fear conditioning potentiates synaptic transmission onto long-range projection neurons in the lateral subdivision of central amygdala
    • P enzo, M. A., Robert, V. & Li, B. Fear conditioning potentiates synaptic transmission onto long-range projection neurons in the lateral subdivision of central amygdala. J. Neurosci. 34, 2432-2437 (2014).
    • (2014) J. Neurosci , vol.34 , pp. 2432-2437
    • Enzo M A, P.1    Robert, V.2    Li, B.3
  • 103
    • 79953303855 scopus 로고    scopus 로고
    • The medial geniculate, not the amygdala, as the root of auditory fear conditioning
    • Weinberger N. M The medial geniculate, not the amygdala, as the root of auditory fear conditioning Hear. Res. 274, 61-74, 2011).
    • (2011) Hear. Res , vol.274 , pp. 61-74
    • Weinberger, N.M.1
  • 104
    • 66149109346 scopus 로고    scopus 로고
    • Sustained conditioned responses in prelimbic prefrontal neurons are correlated with fear expression and extinction failure
    • Burgos-Robles, A., Vidal-Gonzalez, I. & Quirk, G. J. Sustained conditioned responses in prelimbic prefrontal neurons are correlated with fear expression and extinction failure. J. Neurosci. 29, 8474-8482 (2009).
    • (2009) J. Neurosci , vol.29 , pp. 8474-8482
    • Burgos-Robles, A.1    Vidal-Gonzalez, I.2    Quirk, G.J.3
  • 105
    • 0041378239 scopus 로고    scopus 로고
    • Potentiation of amygdaloid and hippocampal auditory-evoked potentials in a discriminatory fear-conditioning task in mice as a function of tone pattern and context
    • Tang, J., Wagner, S., Schachner, M., Dityatev, A. & Wotjak, C. T. Potentiation of amygdaloid and hippocampal auditory-evoked potentials in a discriminatory fear-conditioning task in mice as a function of tone pattern and context. Eur. J. Neurosci. 18, 639-650 (2003).
    • (2003) Eur. J. Neurosci , vol.18 , pp. 639-650
    • Tang, J.1    Wagner, S.2    Schachner, M.3    Dityatev, A.4    Wotjak, C.T.5
  • 106
    • 84896951504 scopus 로고    scopus 로고
    • Lesions of the posterior paraventricular nucleus of the thalamus attenuate fear expression
    • Li, Y., Dong, X., Li, S. & Kirouac, G. J. Lesions of the posterior paraventricular nucleus of the thalamus attenuate fear expression. Front. Behav. Neurosci. 8, 94 (2014).
    • (2014) Front. Behav. Neurosci , vol.8 , pp. 94
    • Li, Y.1    Dong, X.2    Li, S.3    Kirouac, G.J.4
  • 107
    • 84923589714 scopus 로고    scopus 로고
    • The paraventricular thalamus controls a central amygdala fear circuit
    • Penzo, M. A. et al. The paraventricular thalamus controls a central amygdala fear circuit. Nature 519, 455-459 (2015).
    • (2015) Nature , vol.519 , pp. 455-459
    • Penzo, M.A.1
  • 108
    • 84923536672 scopus 로고    scopus 로고
    • A temporal shift in the circuits mediating retrieval of fear memory
    • Do-Monte F. H.,Quinones-Laracuente K.,Quirk G. J. A temporal shift in the circuits mediating retrieval of fear memory Nature 519, 460-463, 2015)
    • (2015) Nature , vol.519 , pp. 460-463
    • Do-Monte, F.H.1    Quinones-Laracuente, K.2    Quirk, G.J.3
  • 109
    • 33846648800 scopus 로고    scopus 로고
    • Activity in prelimbic cortex is necessary for the expression of learned, but not innate, fears
    • Corcoran, K. A. & Quirk, G. J. Activity in prelimbic cortex is necessary for the expression of learned, but not innate, fears. J. Neurosci. 27, 840-844 (2007).
    • (2007) J. Neurosci , vol.27 , pp. 840-844
    • Corcoran, K.A.1    Quirk, G.J.2
  • 110
    • 84892698652 scopus 로고    scopus 로고
    • Long-range connectivity def ines behavioral specificity of amygdala neurons
    • Senn, V. et al. Long-range connectivity def ines behavioral specificity of amygdala neurons. Neuron 81, 428-437 (2014).
    • (2014) Neuron , vol.81 , pp. 428-437
    • Senn, V.1
  • 111
    • 84869843301 scopus 로고    scopus 로고
    • Gating of fear in prelimbic c ortex by hippocampal and amygdala inputs
    • Sotres-Bayon, F., Sierra-Mercado, D., Pardilla-Delgado, E. & Quirk, G. J. Gating of fear in prelimbic c ortex by hippocampal and amygdala inputs. Neuron 76, 804-812 (2012).
    • (2012) Neuron , vol.76 , pp. 804-812
    • Sotres-Bayon, F.1    Sierra-Mercado, D.2    Pardilla-Delgado, E.3    Quirk, G.J.4
  • 112
    • 84893750387 scopus 로고    scopus 로고
    • Prefrontal entrainment of am ygdala activity signals safety in learned fear and innate anxiety
    • Likhtik, E., Stujenske, J. M., Topiwala, M. A., Harris, A. Z. & Gordon, J. A. Prefrontal entrainment of am ygdala activity signals safety in learned fear and innate anxiety. Nature Neurosci. 17, 106-113 (2014).
    • (2014) Nature Neurosci , vol.17 , pp. 106-113
    • Likhtik, E.1    Stujenske, J.M.2    Topiwala, M.A.3    Harris, A.Z.4    Gordon, J.A.5
  • 113
    • 0042027822 scopus 로고    scopus 로고
    • Amygdalar and hipp ocampal theta rhythm synchronization during fear memory retrieval
    • An important contribution that establishes a role for synchronized oscillations between brain regions in fear conditioning
    • Seidenbecher, T., Laxmi, T. R., Stork, O. & Pape, H. C. Amygdalar and hipp ocampal theta rhythm synchronization during fear memory retrieval. Science 301, 846-850 (2003). An important contribution that establishes a role for synchronized oscillations between brain regions in fear conditioning.
    • (2003) Science , vol.301 , pp. 846-850
    • Seidenbecher, T.1    Laxmi, T.R.2    Stork, O.3    Pape, H.C.4
  • 114
    • 84899840845 scopus 로고    scopus 로고
    • Inhibition of projections from the basolateral amygdala to the entorhinal cortex disrupts the acquisition of contextual fear
    • Sparta, D. R. et al. Inhibition of projections from the basolateral amygdala to the entorhinal cortex disrupts the acquisition of contextual fear. Front. Behav. Neurosci. 8, 129 (2014).
    • (2014) Front. Behav. Neurosci , vol.8 , pp. 129
    • Sparta, D.R.1
  • 115
    • 33846478897 scopus 로고    scopus 로고
    • Mechanisms of fear extinction
    • Myers, K.M. & Davis, M. Mechanisms of fear extinction. Mol. Psychiatry 12, 120-150 (2007).
    • (2007) Mol. Psychiatry , vol.12 , pp. 120-150
    • Myers, K.M.1    Davis, M.2
  • 116
    • 80054950825 scopus 로고    scopus 로고
    • The fear circuit revisited: Contributions of the basal amygdala nuclei to conditioned fear
    • Amano, T., Duvarci, S., Popa, D. & Pare, D. The fear circuit revisited: contributions of the basal amygdala nuclei to conditioned fear. J. Neurosci. 31, 15481-15489 (2011).
    • (2011) J. Neurosci , vol.31 , pp. 15481-15489
    • Amano, T.1    Duvarci, S.2    Popa, D.3    Pare, D.4
  • 117
    • 33847629299 scopus 로고    scopus 로고
    • Acquisition of fear extinction requires activation of nr2b-containing nmda receptors in the lateral amygdala
    • Sotres-Bayon, F., Bush, D. E. & LeDoux, J. E. Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala. Neuropsychopharmacology 32, 1929-1940 (2007).
    • (2007) Neuropsychopharmacology , vol.32 , pp. 1929-1940
    • Sotres-Bayon, F.1    Bush, D.E.2    Ledoux, J.E.3
  • 118
    • 33745887221 scopus 로고    scopus 로고
    • Extinction of audi tory fear conditioning requires mapk/erk activation in the basolateral amygdala
    • Herry, C., Trifilieff, P., Micheau, J., Luthi, A. & Mons, N. Extinction of audi tory fear conditioning requires MAPK/ERK activation in the basolateral amygdala. Eur. J. Neurosci. 24, 261-269 (2006).
    • (2006) Eur. J. Neurosci , vol.24 , pp. 261-269
    • Herry, C.1    Trifilieff, P.2    Micheau, J.3    Luthi, A.4    Mons, N.5
  • 119
    • 0026552579 scopus 로고
    • Extinction of fear-potentiated startle: Blockade by infusion of an nmda antagonist into the amygdala
    • A classic neurop harmacology paper that demonstrates the necessity for NMDAR activation in fear extinction
    • Falls, W. A., Miserendino, M. J. & Davis, M. Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala. J. Neurosci. 12, 854-863 (1992). A classic neurop harmacology paper that demonstrates the necessity for NMDAR activation in fear extinction.
    • (1992) J. Neurosci , vol.12 , pp. 854-863
    • Falls, W.A.1    Miserendino, M.J.2    Davis, M.3
  • 120
    • 33748285229 scopus 로고    scopus 로고
    • Extinction training in conjunction with a partial agonist of the glycine site on t he nmda receptor erases memory trace
    • Mao, S. C., Hsiao, Y. H. & Gean, P. W. Extinction training in conjunction with a partial agonist of the glycine site on t he NMDA receptor erases memory trace. J. Neurosci. 26, 8892-8899 (2006).
    • (2006) J. Neurosci , vol.26 , pp. 8892-8899
    • Mao, S.C.1    Hsiao, Y.H.2    Gean, P.W.3
  • 121
    • 77950187815 scopus 로고    scopus 로고
    • Synaptic correlates of fear extinction in the amygdala
    • Amano, T., Unal, C. T. & Pare, D. Synaptic correlates of fear extinction in the amygdala. Nature Neurosci. 13, 489-494 (2010).
    • (2010) Nature Neurosci , vol.13 , pp. 489-494
    • Amano, T.1    Unal, C.T.2    Pare, D.3
  • 122
    • 48349130684 scopus 로고    scopus 로고
    • Amygdala intercalated neurons are required for expression of fear extinction
    • Likhtik, E., Popa, D., Apergis-Schoute, J., Fidacaro, G. A. & Pare, D. Amygdala intercalated neurons are required for expression of fear extinction. Nature 454, 642-645 (2008).
    • (2008) Nature , vol.454 , pp. 642-645
    • Likhtik, E.1    Popa, D.2    Apergis-Schoute, J.3    Fidacaro, G.A.4    Pare, D.5
  • 123
    • 0027429662 scopus 로고
    • The intercalated cell masses project to the central and medial nuclei of the amygdala in cats
    • Pare, D. & Smith, Y. The intercalated cell masses project to the central and medial nuclei of the amygdala in cats. Neuroscience 57, 1077-1090 (1993).
    • (1993) Neuroscience , vol.57 , pp. 1077-1090
    • Pare, D.1    Smith, Y.2
  • 124
    • 36949012249 scopus 로고    scopus 로고
    • Training-induced changes in the expression of gabaa-Associated genes in the amygdala after the acquisition and extinction of pavlovian fear
    • Heldt S. A.,Ressler K. J Training-induced changes in the expression of GABAA-Associated genes in the amygdala after the acquisition and extinction of Pavlovian fear. Eur. J. Neurosci. 26 3631-3644 2007 ).
    • (2007) Eur. J. Neurosci , vol.26 , pp. 3631-3644
    • Heldt, S.A.1    Ressler, K.J.2
  • 125
    • 69749090217 scopus 로고    scopus 로고
    • Block of ?-Aminobutyric acid-A receptor insertion in the amygdala impairs extinction of conditioned fear
    • Lin, H. C., Mao, S. C. & Gean, P. W. Block of ?-Aminobutyric acid-A receptor insertion in the amygdala impairs extinction of conditioned fear. Biol. Psychiatry 66, 665-673 (2009).
    • (2009) Biol. Psychiatry , vol.66 , pp. 665-673
    • Lin, H.C.1    Mao, S.C.2    Gean, P.W.3
  • 126
    • 84888018818 scopus 로고    scopus 로고
    • Fear extinction causes target-specific remodeling of perisomatic inhibitory synapses
    • Trouche S.,Sasaki J. M.,Tu T.,Reijmers L. G. Fear extinction causes target-specific remodeling of perisomatic inhibitory synapses Neuron 80 1054-1065 2013)
    • (2013) Neuron , vol.80 , pp. 1054-1065
    • Trouche, S.1    Sasaki, J.M.2    Tu, T.3    Reijmers, L.G.4
  • 127
    • 0035965676 scopus 로고    scopus 로고
    • Localization of the cb1 type cannabinoid receptor in the rat basolateral amygdala: High concentrations in a subpopulation of cholecystokinin-containing interneurons
    • McDonald, A. J. & Mascagni, F. Localization of the CB1 type cannabinoid receptor in the rat basolateral amygdala: high concentrations in a subpopulation of cholecystokinin-containing interneurons. Neuroscience 107, 6 41-652 (2001).
    • (2001) Neuroscience , vol.107 , pp. 641-652
    • McDonald, A.J.1    Mascagni, F.2
  • 128
    • 0036682222 scopus 로고    scopus 로고
    • The endogenous cannabinoid system controls extinction of aversive memories
    • Marsicano, G. et al. The endogenous cannabinoid system controls extinction of aversive memories. Nature 418, 530-534 (2002).
    • (2002) Nature , vol.418 , pp. 530-534
    • Marsicano, G.1
  • 129
    • 69749125285 scopus 로고    scopus 로고
    • Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction
    • Laurent, V. & Westb rook, R. F. Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction. Learn. Mem. 16, 520-529 (2009).
    • (2009) Learn. Mem , vol.16 , pp. 520-529
    • Laurent, V.1    Westbrook, R.F.2
  • 130
    • 0037038369 scopus 로고    scopus 로고
    • Neuro ns in medial prefrontal cortex signal memory for fear extinction
    • A seminal study that shows the involvement of the mPFC in extinction
    • Milad, M. R. & Quirk, G. J. Neuro ns in medial prefrontal cortex signal memory for fear extinction. Nature 420, 70-74 (2002). A seminal study that shows the involvement of the mPFC in extinction.
    • (2002) Nature , vol.420 , pp. 70-74
    • Milad, M.R.1    Quirk, G.J.2
  • 131
    • 33847662076 scopus 로고    scopus 로고
    • Consolidation of fear extinction requires nmda receptor-dependent bursting in the ventromedial prefrontal cortex
    • Burgos-Robles, A., Vidal-Gonzalez, I., Santini, E. & Quirk, G. J. Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex. Neuron 53, 871-8 80 (2007).
    • (2007) Neuron , vol.53 , pp. 871-880
    • Burgos-Robles, A.1    Vidal-Gonzalez, I.2    Santini, E.3    Quirk, G.J.4
  • 132
    • 0141869827 scopus 로고    scopus 로고
    • Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons
    • Quirk, G. J., Likhtik, E., Pelletier, J. G. & Pare, D. Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons. J. Neurosci. 23, 8800-8807 (2003).
    • (2003) J. Neurosci , vol.23 , pp. 8800-8807
    • Quirk, G.J.1    Likhtik, E.2    Pelletier, J.G.3    Pare, D.4
  • 133
    • 84890554863 scopus 로고    scopus 로고
    • Synaptic encoding of fear extinction in mpfc-Amygdala circuits
    • Cho, J. H., Deisseroth, K. & Bolshakov, V. Y. Synaptic encoding of fear extinction in mPFC-Amygdala circuits. Neuron 80, 1491-1507 (2013).
    • (2013) Neuron , vol.80 , pp. 1491-1507
    • Cho, J.H.1    Deisseroth, K.2    Bolshakov, V.Y.3
  • 135
    • 38149141559 scopus 로고    scopus 로고
    • Op timizing inhibitory learning during exposure therapy
    • Craske, M. G. et al. Op timizing inhibitory learning during exposure therapy. Behav. Res. Ther. 46, 5-27 (2008).
    • (2008) Behav. Res. Ther , vol.46 , pp. 5-27
    • Craske, M.G.1
  • 136
    • 0023901437 scopus 로고
    • Context and ambiguity in the extinction of emotional learning: Implications for exposure therapy
    • Bouton, M. E. Context and ambiguity in the extinction of emotional learning: implications for exposure therapy. Behav. Res.Ther. 26, 137-149 (1988).
    • (1988) Behav. Res.Ther , vol.26 , pp. 137-149
    • Bouton, M.E.1
  • 137
    • 0034095347 scopus 로고    scopus 로고
    • The hippocampus and contextual memory retrieval in pavlovian conditioning
    • Maren, S. & Holt, W. The hippocampus and contextual memory retrieval in Pavlovian conditioning. Behav. Brain Res. 110, 97-108 (2000).
    • (2000) Behav. Brain Res , vol.110 , pp. 97-108
    • Maren, S.1    Holt, W.2
  • 138
    • 78650980477 scopus 로고    scopus 로고
    • Electrical synapses control hippocampal contributions to fear learning and memory
    • Bissiere, S. et al. Electrical synapses control hippocampal contributions to fear learning and memory. Science 331, 87-91 (2011).
    • (2011) Science , vol.331 , pp. 87-91
    • Bissiere, S.1
  • 139
    • 34548560465 scopus 로고    scopus 로고
    • Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat
    • Hoover, W. B. & Vertes, R. P. Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat. Brain Struct. Funct. 212, 149-179 (2007).
    • (2007) Brain Struct. Funct , vol.212 , pp. 149-179
    • Hoover, W.B.1    Vertes, R.P.2
  • 140
    • 0026630199 scopus 로고
    • Projections of the ventral subiculum to the amy gdala, septum, and hypothalamus: A phal anterograde tract-tracing study in the rat
    • Canteras, N. S. & Swanson, L. W. Projections of the ventral subiculum to the amy gdala, septum, and hypothalamus: a PHAL anterograde tract-tracing study in the rat. J. Comp. Neurol. 324, 180-194 (1992).
    • (1992) J. Comp. Neurol , vol.324 , pp. 180-194
    • Canteras, N.S.1    Swanson, L.W.2
  • 141
    • 33645087940 scopus 로고    scopus 로고
    • Ventral hippocampal muscimol disrupts co ntext-specific fear memory retrieval after extinction in rats
    • Hobin, J. A., Ji, J. & Maren, S. Ventral hippocampal muscimol disrupts co ntext-specific fear memory retrieval after extinction in rats. Hippocampus 16, 174-182 (2006).
    • (2006) Hippocampus , vol.16 , pp. 174-182
    • Hobin, J.A.1    Ji, J.2    Maren, S.3
  • 142
    • 0141521719 scopus 로고    scopus 로고
    • Context-dependent neuronal activity in the lateral amy gdala represents fear memories after extinction
    • Hobin, J. A., Goosens, K. A. & Maren, S. Context-dependent neuronal activity in the lateral amy gdala represents fear memories after extinction. J. Neurosci. 23, 8410-8416 (2003).
    • (2003) J. Neurosci , vol.23 , pp. 8410-8416
    • Hobin, J.A.1    Goosens, K.A.2    Maren, S.3
  • 143
    • 34247225989 scopus 로고    scopus 로고
    • Hippocampal regulation of context-dependent neuronal activity in the lateral amygdala
    • Maren, S. & Hobin, J. A. Hippocampal regulation of context-dependent neuronal activity in the lateral amygdala.Learn. Mem. 14, 318-324 (2007).
    • (2007) Learn. Mem , vol.14 , pp. 318-324
    • Maren, S.1    Hobin, J.A.2
  • 144
    • 78649838481 scopus 로고    scopus 로고
    • Differences between trait fear and trait anxiety: Implications for psychopathology
    • Sylvers, P., Lilienfeld, S. O. & LaPrairie, J. L. Differences between trait fear and trait anxiety: implications for psychopathology. Clin. Psychol. Rev. 31, 122-137 (2011).
    • (2011) Clin. Psychol. Rev , vol.31 , pp. 122-137
    • Sylvers, P.1    Lilienfeld, S.O.2    Laprairie, J.L.3
  • 145
    • 69049091955 scopus 로고    scopus 로고
    • The bed nucleus of the stria terminalis mediates inter-individual variations in anxiety and fear
    • Duvarci, S., Bauer, E. P. & Pare, D. The bed nucleus of the stria terminalis mediates inter-individual variations in anxiety and fear. J. Neurosci. 29, 10357-10361 (2009).
    • (2009) J. Neurosci , vol.29 , pp. 10357-10361
    • Duvarci, S.1    Bauer, E.P.2    Pare, D.3
  • 146
    • 84876291637 scopus 로고    scopus 로고
    • Diverging neural pathways assemble a behavioural state from separable features in anxiety
    • A good example of the power of moder n optogenetic studies to reveal circuits for specific aspects of an emotional state
    • Kim, S. Y. et al. Diverging neural pathways assemble a behavioural state from separable features in anxiety. Nature 496, 219-223 (2013). A good example of the power of moder n optogenetic studies to reveal circuits for specific aspects of an emotional state.
    • (2013) Nature , vol.496 , pp. 219-223
    • Kim, S.Y.1
  • 147
    • 84876285446 scopus 로고    scopus 로고
    • Distinct extended amygdala circuits for divergent motivational states
    • Jennings, J. H. et al. Distinct extended amygdala circuits for divergent motivational states. Nature 496, 224-228 (2013).
    • (2013) Nature , vol.496 , pp. 224-228
    • Jennings, J.H.1
  • 148
    • 35748963237 scopus 로고    scopus 로고
    • Functional neuroimaging of anxiety: A meta-Analysis of emotional processing in ptsd, social anxiety disorder, and specific phobia
    • Etkin, A. & Wager, T. D. Functional neuroimaging of anxiety: a meta-Analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am. J. Psychiatry 164, 1476-1488 (2007).
    • (2007) Am. J. Psychiatry , vol.164 , pp. 1476-1488
    • Etkin, A.1    Wager, T.D.2
  • 149
    • 84895756736 scopus 로고    scopus 로고
    • Increased amygdalar and hippocampal volumes in young adults with social anxiety
    • Machado-de-Sousa, J. P. et al. Increased amygdalar and hippocampal volumes in young adults with social anxiety. PLoS ONE 9, e88523 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e88523
    • Machado-De-Sousa, J.P.1
  • 150
    • 77649310690 scopus 로고    scopus 로고
    • Reduced amygdalar and hippocampal size in adults with generalized social phobia
    • Irle, E.et al. Reduced amygdalar and hippocampal size in adults with generalized social phobia. J. Psychiatry Neurosci. 35, 126-131 (2010).
    • (2010) J. Psychiatry Neurosci , vol.35 , pp. 126-131
    • Irle, E.1
  • 151
    • 79952814389 scopus 로고    scopus 로고
    • Amygdala circuitry mediating r eversible and bidirectional control of anxiety
    • Tye, K. M. et al. Amygdala circuitry mediating r eversible and bidirectional control of anxiety. Nature 471, 358-362 (2011).
    • (2011) Nature , vol.471 , pp. 358-362
    • Tye, K.M.1
  • 152
    • 84882638498 scopus 로고    scopus 로고
    • Bla to vhpc inputs modulate anxiety-related behaviors
    • One of the first studies to apply modern approaches to study the circuit basis of anxiety
    • Felix-Ortiz, A. C. et al. BLA to vHPC inputs modulate anxiety-related behaviors. Neuron 79, 658-664 (2013). One of the first studies to apply modern approaches to study the circuit basis of anxiety.
    • (2013) Neuron , vol.79 , pp. 658-664
    • Felix-Ortiz, A.C.1
  • 153
    • 45949106835 scopus 로고    scopus 로고
    • Cellular and behavioral interactions of gabapentin with alcohol dependence
    • Roberto, M. et al. Cellular and behavioral interactions of gabapentin with alcohol dependence. J. Neur osci. 28, 5762-5771 (2008).
    • (2008) J. Neur Osci , vol.28 , pp. 5762-5771
    • Roberto, M.1
  • 154
    • 79955609669 scopus 로고    scopus 로고
    • Altered gaba transmission in a mouse model of increased trait anxiety
    • Tasan, R. O. et al. Altered GABA transmission in a mouse model of increased trait anxiety. Neuroscience 183, 71-80 (2011).
    • (2011) Neuroscience , vol.183 , pp. 71-80
    • Tasan, R.O.1
  • 155
    • 80052405316 scopus 로고    scopus 로고
    • Single units in the medial prefrontal cortex with anxiety-related firing patterns are preferentially influenced by ventral hippocampal activity
    • A powerful use of in vivo electrical recordings to gain a circuit perspective in anxiety research
    • Adhikari, A., Topiwala, M. A. & Gordon, J. A. Single units in the medial prefrontal cortex with anxiety-related firing patterns are preferentially influenced by ventral hippocampal activity. Neuron 71, 898-910 (2011). A powerful use of in vivo electrical recordings to gain a circuit perspective in anxiety research.
    • (2011) Neuron , vol.71 , pp. 898-910
    • Adhikari, A.1    Topiwala, M.A.2    Gordon, J.A.3
  • 156
    • 74549154098 scopus 로고    scopus 로고
    • Synchronized activity between the ventral hippocampus a nd the medial prefrontal cortex during anxiety
    • Adhikari, A., Topiwala, M. A. & Gordon, J. A. Synchronized activity between the ventral hippocampus a nd the medial prefrontal cortex during anxiety. Neuron 65, 257-269 (2010).
    • (2010) Neuron , vol.65 , pp. 257-269
    • Adhikari, A.1    Topiwala, M.A.2    Gordon, J.A.3
  • 157
    • 0036679424 scopus 로고    scopus 로고
    • Reduced fear expression after lesions of the ventral hippocampus
    • Kjelstrup, K. G. et al. Reduced fear expression after lesions of the ventral hippocampus. Proc. Natl Acad. Sci. USA 99, 10825-10830 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 10825-10830
    • Kjelstrup, K.G.1
  • 158
    • 3042541641 scopus 로고    scopus 로고
    • Regional dissociations within the hippocampus-memory and anxiety
    • Bannerman, D. M. et al. Regional dissociations within the hippocampus-memory and anxiety. Neurosci. Biobehav. Rev. 28, 273-283 (2004).
    • (2004) Neurosci. Biobehav. Rev , vol.28 , pp. 273-283
    • Bannerman, D.M.1
  • 159
    • 84897893858 scopus 로고    scopus 로고
    • Hippocampal synaptic plasticity, spatial memory and anxiety
    • Bannerman, D. M. et al. Hippocampal synaptic plasticity, spatial memory and anxiety. Nature Rev. Neurosci. 15, 181-192 (2014).
    • (2014) Nature Rev. Neurosci , vol.15 , pp. 181-192
    • Bannerman, D.M.1
  • 160
    • 0033913866 scopus 로고    scopus 로고
    • Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat. A review
    • Pitkanen, A., Pikkarainen, M., Nurminen, N. & Yline n, A. Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat. A review. Ann. NY Acad. Sci. 911, 369-391 (2000).
    • (2000) Ann. NY Acad. Sci , vol.911 , pp. 369-391
    • Pitkanen, A.1    Pikkarainen, M.2    Nurminen, N.3    Yline, N.A.4
  • 161
    • 84908654563 scopus 로고    scopus 로고
    • Functional organization of the hippocampal longitudinal axis
    • Strange, B. A., Witter, M. P., Lein, E. S. & Moser, E. I. Functional organization of the hippocampal longitudinal axis. Nature Rev. Neurosci. 15, 655-669 (2014).
    • (2014) Nature Rev. Neurosci , vol.15 , pp. 655-669
    • Strange, B.A.1    Witter, M.P.2    Lein, E.S.3    Moser, E.I.4
  • 162
    • 73549123839 scopus 로고    scopus 로고
    • Are the dorsal and ventral hippocampus functionally distinct structures?
    • F anselow, M. S. & Dong, H. W. Are the dorsal and ventral hippocampus functionally distinct structures? Neuron 65, 7-19 (2010).
    • (2010) Neuron , vol.65 , pp. 7-19
    • Fanselow, M.S.1    Dong, H.W.2
  • 163
    • 84905059834 scopus 로고    scopus 로고
    • Evolutionarily conserved prefrontal-Am ygdalar dysfunction in early-life anxiety
    • Birn, R. M. et al. Evolutionarily conserved prefrontal-Am ygdalar dysfunction in early-life anxiety. Mol. Psychiatry 19, 915-922 (2014).
    • (2014) Mol. Psychiatry , vol.19 , pp. 915-922
    • Birn, R.M.1
  • 164
    • 84920930228 scopus 로고    scopus 로고
    • Ventromedial prefront al cortex is critical for the regulation of amygdala activity in humans
    • Motzkin, J. C., Philippi, C. L., Wolf, R. C., Baskaya, M. K. & Koenigs, M. Ventromedial prefront al cortex is critical for the regulation of amygdala activity in humans. Biol. Psychiatry 77, 276-284 (2014).
    • (2014) Biol. Psychiatry , vol.77 , pp. 276-284
    • Motzkin, J.C.1    Philippi, C.L.2    Wolf, R.C.3    Baskaya, M.K.4    Koenigs, M.5
  • 166
    • 3843117595 scopus 로고    scopus 로고
    • Regulation of affect by the lateral septum: Implications for neuropsychiatry
    • Sheehan, T. P., Chambers, R. A. & Russell, D. S. Regulation of affect by the lateral septum: implications for neuropsychiatry. Brain Res. Brain Res. Rev. 46, 71-117 (2004).
    • (2004) Brain Res. Brain Res. Rev , Issue.46 , pp. 71-117
    • Sheehan, T.P.1    Chambers, R.A.2    Russell, D.S.3
  • 167
    • 84883464613 scopus 로고    scopus 로고
    • Fear-enhancing effects of septal oxytocin receptors
    • Guzman, Y. F. et al. Fear-enhancing effects of septal oxytocin receptors. Nature Neurosci. 16, 1185-1187 (2013).
    • (2013) Nature Neurosci , vol.16 , pp. 1185-1187
    • Guzman, Y.F.1
  • 168
    • 0344142487 scopus 로고    scopus 로고
    • Modulation of learning and anxiety by corticotropin-releasing factor (crf) and stress: Differential roles of crf receptors 1 and 2
    • Radulovic, J., Ruhmann, A., Liepold, T. & Spiess, J. Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2. J. Neurosci. 19, 5016-5025 (1999).
    • (1999) J. Neurosci , vol.19 , pp. 5016-5025
    • Radulovic, J.1    Ruhmann, A.2    Liepold, T.3    Spiess, J.4
  • 169
    • 84893452899 scopus 로고    scopus 로고
    • Control of stress-induced persistent anxiety by an extra-Amygdala septohypothalamic circuit
    • A multimethod approach that refined the role of the septohippocampal system in stress-induced anxiety
    • Anthony, T. E. et al. Control of stress-induced persistent anxiety by an extra-Amygdala septohypothalamic circuit. Cell 156, 522-536 (2014). A multimethod approach that refined the role of the septohippocampal system in stress-induced anxiety.
    • (2014) Cell , vol.156 , pp. 522-536
    • Anthony, T.E.1
  • 171
    • 71549156217 scopus 로고    scopus 로고
    • Selective participation of the bed nucleus of the stria terminalis and crf in sustained anxiety-like versus phasic fear-like responses
    • Walker, D. L., Miles, L. A. & Davis, M. Selective participation of the bed nucleus of the stria terminalis and CRF in sustained anxiety-like versus phasic fear-like responses. Prog. Neuropsychopharmacol. Biol. Psychiatry 33, 1291-1308 (2009).
    • (2009) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.33 , pp. 1291-1308
    • Walker, D.L.1    Miles, L.A.2    Davis, M.3
  • 172
    • 77957352300 scopus 로고    scopus 로고
    • The brainstem noradrenergic systems in stress, anxiety and depression
    • Itoi K.,Sugimoto N. The brainstem noradrenergic systems in stress, anxiety and depression J. Neuroendocrinol. 22 355-361 2010).
    • (2010) J. Neuroendocrinol , vol.22 , pp. 355-361
    • Itoi, K.1    Sugimoto, N.2
  • 174
    • 84858691626 scopus 로고    scopus 로고
    • Gaba neurons of the vta drive conditioned place aversion
    • Tan, K. R. et a l. GABA neurons of the VTA drive conditioned place aversion. Neuron 73, 1173-1183 (2012).
    • (2012) Neuron , vol.73 , pp. 1173-1183
    • Tan, K.R.1
  • 175
    • 34547681422 scopus 로고    scopus 로고
    • Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement
    • Fields, H. L., Hjelmstad, G. O., Margolis, E. B. & Nicola, S. M. Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement. Annu. Rev. Neurosci. 30, 289-316 (2007).
    • (2007) Annu. Rev. Neurosci , vol.30 , pp. 289-316
    • Fields, H.L.1    Hjelmstad, G.O.2    Margolis, E.B.3    Nicola, S.M.4
  • 176
    • 58149236469 scopus 로고    scopus 로고
    • Midbrain dopaminergic neurons and striatal cholinergic interneurons encode the difference between reward and aversive events at different epoch s of probabilistic classical conditioning trials
    • Joshua, M., Adler, A., Mitelman, R., Vaadia, E. & Bergman, H. Midbrain dopaminergic neurons and striatal cholinergic interneurons encode the difference between reward and aversive events at different epoch s of probabilistic classical conditioning trials. J. Neurosci. 28, 11673-11684 (2008).
    • (2008) J. Neurosci , vol.28 , pp. 11673-11684
    • Joshua, M.1    Adler, A.2    Mitelman, R.3    Vaadia, E.4    Bergman, H.5
  • 177
    • 70349102143 scopus 로고    scopus 로고
    • Dopamine is necessary for cue-dependent fear condition ing
    • Fadok, J. P., Dickerson, T. M. & Palmiter, R. D. Dopamine is necessary for cue-dependent fear condition ing. J. Neurosci. 29, 11089-11097 (2009).
    • (2009) J. Neurosci , vol.29 , pp. 11089-11097
    • Fadok, J.P.1    Dickerson, T.M.2    Palmiter, R.D.3
  • 178
    • 67349098495 scopus 로고    scopus 로고
    • Two types of dopamine neuron distinctly convey positive and negative motivational signals
    • Matsumoto, M. & Hikosaka, O. Two types of dopamine neuron distinctly convey positive and negative motivational signals. Nature 459, 837-841 (2009).
    • (2009) Nature , vol.459 , pp. 837-841
    • Matsumoto, M.1    Hikosaka, O.2
  • 179
    • 85027940786 scopus 로고    scopus 로고
    • Activation of dopamine neurons is critical for aversive conditioning and prevention of generalized anxiety
    • Zweifel, L. S. et al. Activation of dopamine neurons is critical for aversive conditioning and prevention of generalized anxiety. Nature Neurosci. 14, 620-626 (2011).
    • (2011) Nature Neurosci , vol.14 , pp. 620-626
    • Zweifel, L.S.1
  • 180
    • 54049129747 scopus 로고    scopus 로고
    • Midbrain dopamine neurons: Projection target determines action potential duration and dopamine d2 receptor inhibition
    • Margolis, E. B., Mitchell, J. M., Ishikawa, J., Hjelmstad, G. O. & Fields, H. L. Midbrain dopamine neurons: projection target determines action potential duration and dopamine D2 receptor inhibition. J. N eurosci. 28, 8908-8913 (2008).
    • (2008) J. N Eurosci , vol.28 , pp. 8908-8913
    • Margolis, E.B.1    Mitchell, J.M.2    Ishikawa, J.3    Hjelmstad, G.O.4    Fields, H.L.5
  • 181
    • 40249097514 scopus 로고    scopus 로고
    • Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system
    • Lammel, S. et al. Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system. Neuron 57, 760-773 (2008).
    • (2008) Neuron , vol.57 , pp. 760-773
    • Lammel, S.1
  • 182
    • 84903204587 scopus 로고    scopus 로고
    • Natural neural projection dynamics underlying social behavior
    • Gunaydin L. A.,et al. Natural neural projection dynamics underlying social behavior Cell 157 1535-1551, 2014).
    • (2014) Cell , vol.157 , pp. 1535-1551
    • Gunaydin, L.A.1
  • 183
    • 34347343926 scopus 로고    scopus 로고
    • Lateral habenula as a source of negative reward signals in dopamine neurons
    • Matsumoto, M. & Hikosaka, O. Lateral habenula as a source of negative reward signals in dopamine neurons. Nature 447, 1111-1115 (2007).
    • (2007) Nature , vol.447 , pp. 1111-1115
    • Matsumoto, M.1    Hikosaka, O.2
  • 184
    • 79952129505 scopus 로고    scopus 로고
    • Synaptic potentiation onto habenula neurons in the learned helplessness model of depression
    • Li, B. et al. Synaptic potentiation onto habenula neurons in the learned helplessness model of depression. Nature 470, 535-539 (2011).
    • (2011) Nature , vol.470 , pp. 535-539
    • Li, B.1
  • 185
    • 84864456653 scopus 로고    scopus 로고
    • Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance
    • Stamatakis, A. M. & Stuber, G. D. Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance. Nature Neurosci. 15, 1105-1107 (2012).
    • (2012) Nature Neurosci , vol.15 , pp. 1105-1107
    • Stamatakis, A.M.1    Stuber, G.D.2
  • 186
    • 80051565543 scopus 로고    scopus 로고
    • Negative reward signals from the lateral habenula to dopamine neurons are mediated by rostromedial tegmental n ucleus in primates
    • Hong, S., Jhou, T. C., Smith, M., Saleem, K. S. & Hikosaka, O. Negative reward signals from the lateral habenula to dopamine neurons are mediated by rostromedial tegmental n ucleus in primates. J. Neurosci. 31, 11457-11471 (2011).
    • (2011) J. Neurosci , vol.31 , pp. 11457-11471
    • Hong, S.1    Jhou, T.C.2    Smith, M.3    Saleem, K.S.4    Hikosaka, O.5
  • 187
    • 84907192039 scopus 로고    scopus 로고
    • Mood regulation gaba/glutamate co-release controls habenula ou tput and is modified by antidepressant treatment
    • Shabel, S. J., Proulx, C. D., Piriz, J. & Malinow, R. Mood regulation. GABA/glutamate co-release controls habenula ou tput and is modified by antidepressant treatment. Science 345, 1494-1498 (2014).
    • (2014) Science , vol.345 , pp. 1494-1498
    • Shabel, S.J.1    Proulx, C.D.2    Piriz, J.3    Malinow, R.4
  • 188
    • 84862861643 scopus 로고    scopus 로고
    • Aversive-bias and stage-selectivity in neurons of the primate amygdala during acquisition, extinction, and overnight retention
    • Livneh, U. & Paz, R. Aversive-bias and stage-selectivity in neurons of the primate amygdala during acquisition, extinction, and overnight retention. J. Neurosci. 32, 8598-8610 (2012).
    • (2012) J. Neurosci , vol.32 , pp. 8598-8610
    • Livneh, U.1    Paz, R.2
  • 189
    • 70349272252 scopus 로고    scopus 로고
    • Substantial similarity in amygdala neuronal activity during conditioned appetitive and aversive emotional arousal
    • Shabel, S. J. & Janak, P. H. Substantial similarity in amygdala neuronal activity during conditioned appetitive and aversive emotional arousal. Proc. Natl Acad. Sci. USA 106, 15031-15036 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 15031-15036
    • Shabel, S.J.1    Janak, P.H.2
  • 190
    • 84872062763 scopus 로고    scopus 로고
    • Functional circuits and anatomical distribution of response properties in the primate amygdala
    • Zhang W.,et al. Functional circuits and anatomical distribution of response properties in the primate amygdala J. Neurosci. 33 722-733,2013
    • (2013) J. Neurosci , vol.33 , pp. 722-733
    • Zhang, W.1
  • 191
    • 84907790422 scopus 로고    scopus 로고
    • Bidirectional switch of the valence associated with a hippocampal contextual memory engram
    • Redondo, R. L. et al. Bidirectional switch of the valence associated with a hippocampal contextual memory engram. Nature 513, 426-430 (2014).
    • (2014) Nature , vol.513 , pp. 426-430
    • Redondo, R.L.1
  • 192
    • 79960635098 scopus 로고    scopus 로고
    • Excitatory transmission from the amygdala to nu cleus accumbens facilitates reward seeking
    • Stuber, G. D. et al. Excitatory transmission from the amygdala to nu cleus accumbens facilitates reward seeking. Nature 475, 377-380 (2011).
    • (2011) Nature , vol.475 , pp. 377-380
    • Stuber, G.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.