Increased amygdalar and hippocampal volumes in young adults with social anxiety

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Machado de Sousa, João Paulo ^a   De Lima Osório, Flávia ^a   Jackowski, Andrea P ^b   Bressan, Rodrigo A ^b   Chagas, Marcos H N ^a   Torro Alves, Nelson ^c   DePaula, André L D ^a   Crippa, José A S ^a   Hallak, Jaime E C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AMYGDALOID NUCLEUS; ARTICLE; BRAIN DISEASE; BRAIN ENLARGEMENT; BRAIN SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FUNCTIONAL NEUROIMAGING; HIPPOCAMPUS; HUMAN; MALE; NERVE CELL PLASTICITY; NUCLEAR MAGNETIC RESONANCE IMAGING; PSYCHOLOGIC ASSESSMENT; SOCIAL PHOBIA; VOXEL BASED MORPHOMETRY;

ADULT; AMYGDALA; ANXIETY DISORDERS; BRAIN MAPPING; CASE-CONTROL STUDIES; FEMALE; HIPPOCAMPUS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; YOUNG ADULT;

EID: 84895756736     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0088523     Document Type: Article

References (26)

1. Freitas-Ferrari MC, Hallak JE, Trzesniak C, Filho AS, Machado-de-Sousa JP, et al. (2010) Neuroimaging in social anxiety disorder: a systematic review of the literature. Prog Neuropsychopharmacol Biol Psychiatry 34: 565-580.
2. Phillips RG, LeDoux JE (1992) Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 106: 274-285.
3. Liao W, Qiu C, Gentili C, Walter M, Pan Z, et al. (2010) Altered effective connectivity network of the amygdala in social anxiety disorder: a resting-state FMRI study. PLoS One 22: e15238.
4. Hahn A, Stein P, Windischberger C, Spindelegger C, Moser E, et al. (2011) Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder. Neuroimage 56: 881-889.
5. Potts NL, Davidson JR, Krishnan KR, Doraiswamy PM (1994) Magnetic resonance imaging in social phobia. Psychiatry Res 52: 35-42. (Pubitemid 24158102)
6. Irle E, Ruhleder M, Lange C, Seidler-Brandler U, Salzer S, et al.(2010) Reduced amygdalar and hippocampal size in adults with generalized social phobia. J Psychiatry Neurosci 35: 126-131.
7. Liao W, Xu Q, Mantini D, Ding J, Machado-de-Sousa JP, et al. (2011) Altered gray matter morphometry and resting-state functional and structural connectivity in social anxiety disorder. Brain Res 4: 167-177.
8. Syal S, Hattingh CJ, Fouché JP, Spottiswoode B, Carey PD, et al. (2012) Gray matter abnormalities in social anxiety disorder: a pilot study. Metab Brain Dis 27: 299-309.
9. Frodl T, Meisenzahl EM, Zetzsche T, Born C, Jäger M, et al. (2003) Larger amygdala volumes in first depressive episode as compared to recurrent major depression and healthy control subjects. Biol Psychiatry 53: 338-344. (Pubitemid 36173963)
10. Supekar K, Uddin LQ, Prater K, Amin H, Greicius MD, et al. (2010) Development of functional and structural connectivity within the default mode network in young children. Neuroimage 52: 290-301.
11. Sheline YI, Gado MH, Price JL (1998) Amygdala core nuclei volumes are decreased in recurrent major depression. Neuroreport 13: 2436.
12. Sapolsky RM, Uno H, Rebert CS, Finch CE (1990) Hippocampal damage associated with prolonged glucocorticoid exposure in primates. J Neurosci 10: 2897-2902.
13. Baptista CA, Loureiro SR, de Lima Osório F, Zuardi AW, Magalhães PV, et al. (2012) Social phobia in Brazilian university students: prevalence, under-recognition and academic impairment in women. J Affect Disor 136: 857-861.
14. Del-Ben CM, Vilela JAA, Crippa JAS, Hallak JEC, Labate CM, et al. (2001) Test retest reliability of the Structured Clinical Interview for DSM-IV - Clinical Version (SCID-CV) translated into Portuguese. Rev Bras Psiquiatr 23: 156-159.
15. Crippa JA, de Lima Osório F, Del-Ben CM, Filho AS, da Silva Freitas MC, et al. (2008) Comparability between telephone and face-to-face structured clinical interview for DSM-IV in assessing social anxiety disorder. Perspect Psychiatr Care 44: 241-247.
16. First MB, Spitzer RL, Gibbon M, Williams JBW (1997) Structured Clinical Interview for DSM-IV Axis I Disorders - Clinical Version (SCID-CV). Washington DC: American Psychiatric Press.
17. Crum RM, Pratt LA (2001) Risk of heavy drinking and alcohol use disorders in social phobia: a prospective analysis. Am J Psychiat 158: 1693-1700. (Pubitemid 32923664)
18. Robb RA, Hanson DP, Karwoski RA, Larson AG, Workman EL, et al. (1989) ANALYZE: A comprehensive, operator-interactive software package for multidimensional medical image display and analysis. Comput Med Imaging Graph 13: 433-454. (Pubitemid 20019803)
19. Schumann CM, Hamstra J, Goodlin-Jones BL, Lotspeich LJ, Kwon H, et al. (2004) The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages. J Neurosci 24: 6392-6401. (Pubitemid 38944230)
20. Vyas A, Pillai AG, Chattarji S (2004) Recovery after chronic stress fails to reverseamygdaloid neuronal hypertrophy and enhanced anxiety-like behavior. Neurosci 128: 667-673. (Pubitemid 39298420)
21. Lakshminarasimhan H, Chattarji S (2012) Stress leads to contrasting effects on the levels of brain derived neurotrophic factor in the hippocampus and amygdala. PLoS One 7: e30481.
22. Johnson LR, Farb C, Morrison JH, McEwen BS, LeDoux JE (2005) Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala. Neuroscience 136: 289-299. (Pubitemid 41487104)
23. Chagas MH, Nardi AE, Manfro GG, Hetem LA, Andrada NC, et al. (2010) Guidelines of the Brazilian Medical Association for the diagnosis and differential diagnosis of social anxiety disorder. Rev Bras Psiquiatr 32: 444-452.
24. Campbell S, Marriott M, Nahmias C, MacQueen GM (2004) Lower hippocampal volume in patients suffering from depression: a meta-analysis. Am J Psychiatry 161: 598-607. (Pubitemid 38445502)
25. Videbech P, Ravnkilde B (2004) Hippocampal volume and depression: a metaanalysis of MRI studies. Am J Psychiatry 161: 1957-1966. (Pubitemid 39441394)
26. Hamilton JP, Siemer M, Gotlib IH (2008) Amygdala volume in major depressive disorder: a meta-analysis of magnetic resonance imaging studies. Mol Psychiatry 13: 993-1000.