Amygdala circuitry mediating reversible and bidirectional control of anxiety

Nature

Volumn 471, Issue 7338, 2011, Pages 358-362

  Tye, Kay M ^a   Prakash, Rohit ^a,b   Kim, Sung Yon ^a,b   Fenno, Lief E ^a,b   Grosenick, Logan ^a,b   Zarabi, Hosniya ^a   Thompson, Kimberly R ^a   Gradinaru, Viviana ^a,b   Ramakrishnan, Charu ^a   Deisseroth, Karl ^a,b  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHANNELRHODOPSIN; GLUTAMATE RECEPTOR ANTAGONIST; HALORHODOPSIN; PROTEIN C FOS; RHODOPSIN; UNCLASSIFIED DRUG;

BIDIRECTIONAL REFLECTANCE; BRAIN; CELL ORGANELLE; DEVELOPMENTAL BIOLOGY; DISEASE PREVALENCE; ETIOLOGY; GENETIC ANALYSIS; INHIBITION; MAMMAL; MICROSCOPY; OPTIMIZATION; RODENT; TWO-DIMENSIONAL MODELING;

ADENOVIRUS 5; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY DISORDER; ARTICLE; BASOLATERAL AMYGDALA; BRAIN ELECTROPHYSIOLOGY; BRAIN FUNCTION; CENTRAL NUCLEUS (AMYGDALA); COMPARATIVE STUDY; CONTROLLED STUDY; GENETICS; INTRACELLULAR SIGNALING; MAZE TEST; MOUSE; MULTIPHOTON MICROSCOPY; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; OPEN FIELD TEST; OPTOGENETICS; PATCH CLAMP; PATHOPHYSIOLOGY; PHOTOSTIMULATION; PRIORITY JOURNAL; TRANQUILIZING ACTIVITY;

AMYGDALA; ANIMALS; ANXIETY; ANXIETY DISORDERS; HALORHODOPSINS; LIGHT; MICE; MODELS, NEUROLOGICAL; NEURAL PATHWAYS; NEURONS; STRESS, PHYSIOLOGICAL; SYNAPSES;

MAMMALIA; MUS;

EID: 79952814389     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09820     Document Type: Article

References (30)

1. Lieb, R. Anxiety disorders: clinical presentation and epidemiology. Handb. Exp. Pharmacol. 169, 405-432 (2005).
2. Kessler, R. C. et al. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in theNational Comorbidity Survey Replication. Arch. Gen. Psychiatry 62, 593-602 (2005). (Pubitemid 40973434)
3. Koob, G. F. Brain stress systems in the amygdala and addiction. Brain Res. 1293, 61-75 (2009).
4. Ressler, K. J. & Mayberg, H. S. Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic. Nature Neurosci. 10, 1116-1124 (2007). (Pubitemid 47339944)
5. LeDoux, J. The emotional brain, fear, and the amygdala. Cell. Mol. Neurobiol. 23, 727-738 (2003). (Pubitemid 37071496)
6. Pare, D., Quirk, G. J.&Ledoux, J. E.Newvistas onamygdalanetworks in conditioned fear. J. Neurophysiol. 92, 1-9 (2004).
7. Tye, K. M., Stuber, G. D., deRidder, B.,Bonci, A.&Janak, P. H.Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning. Nature 453, 1253-1257 (2008). (Pubitemid 351913592)
8. Weiskrantz, L. Behavioral changes associated with ablation of the amygdaloid complex in monkeys. J. Comp. Physiol. Psychol. 49, 381-391 (1956).
9. Kalin, N. H., Shelton, S. E. & Davidson, R. J. The role of the central nucleus of the amygdala in mediating fear and anxiety in the primate. J. Neurosci. 24, 5506-5515 (2004). (Pubitemid 38812633)
10. Lesscher, H. M. et al. Amygdala protein kinase C epsilon regulates corticotropinreleasing factor and anxiety-like behavior. Genes Brain Behav. 7, 323-333 (2008). (Pubitemid 351490237)
11. Etkin,A.,Prater,K.E.,Schatzberg,A.F.,Menon,V.&Greicius,M.D. Disruptedamygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder.Arch. Gen. Psychiatry 66, 1361-1372 (2009).
12. Lyons, A. M.& Thiele, T. E. Neuropeptide Y conjugated to saporin alters anxiety-like behavior when injected into the central nucleus of the amygdala or basomedial hypothalamus in BALB/cJ mice. Peptides 31, 2193-2199 (2010).
13. Roozendaal, B., McEwen, B. S. & Chattarji, S. Stress, memory and the amygdala. Nature Rev. Neurosci. 10, 423-433 (2009).
14. Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G. & Deisseroth, K. Millisecondtimescale, genetically targeted optical control of neural activity. Nature Neurosci. 8, 1263-1268 (2005). (Pubitemid 43348147)
15. Gradinaru, V. et al. Molecular and cellular approaches for diversifying and extending optogenetics. Cell 141, 154-165 (2010).
16. Deisseroth, K. Optogenetics: controlling the brain with light. Sci. Am. 303, 48-55 (2010).
17. Woods, J. H., Katz, J. L. & Winger, G. Benzodiazepines: use, abuse, and consequences. Pharmacol. Rev. 44, 151-347 (1992).
18. Ciocchi, S. et al. Encoding of conditioned fear in central amygdala inhibitory circuits. Nature 468, 277-282 (2010).
19. Haubensak, W. et al. Genetic dissection of an amygdala microcircuit that gates conditioned fear. Nature 468, 270-276 (2010).
20. Carlsen, J.Immunocytochemical localization of glutamatedecarboxylase in the rat basolateral amygdaloid nucleus, with special reference to GABAergic innervation of amygdalostriatal projection neurons. J. Comp. Neurol. 273, 513-526 (1988).
21. Smith, Y. & Pare, D. Intra-amygdaloid projections of the lateral nucleus in the cat: PHA-L anterograde labeling combined with postembedding GABA and glutamate immunocytochemistry. J. Comp. Neurol. 342, 232-248 (1994). (Pubitemid 24100129)
22. McDonald, A. J. Cytoarchitecture of the central amygdaloid nucleus of the rat. J. Comp. Neurol. 208, 401-418 (1982). (Pubitemid 12064335)
23. Krettek, J. E.&Price, J. L.Adescriptionof theamygdaloid complex in the rat and cat with observations on intra-amygdaloid axonal connections. J. Comp. Neurol. 178, 255-279 (1978). (Pubitemid 8373125)
24. Krettek, J. E. & Price, J. L. Amygdaloid projections to subcortical structures within the basal forebrain and brainstem in the rat and cat. J. Comp. Neurol. 178, 225-253 (1978). (Pubitemid 8373124)
25. Davis, M. in The Amygdala: A Functional Analysis (ed. Aggleton, J. P.) 213-288 (Oxford Univ. Press, 2000).
26. Pitkanen, A. in The Amygdala: A Functional Analysis (ed. Aggleton, J. P.) 31-99 (Oxford Univ. Press, 2000).
27. Carola, V., D'Olimpio, F., Brunamonti, E., Mangia, F. & Renzi, P. Evaluation of the elevated plus-maze and open-field tests for the assessment of anxiety-related behaviour in inbred mice. Behav. Brain Res. 134, 49-57 (2002). (Pubitemid 34912685)
28. Davis, M., Walker, D. L., Miles, L. & Grillon, C. Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology 35, 105-135 (2010).
29. Shin, L. M. & Liberzon, I. The neurocircuitry of fear, stress, and anxiety disorders. Neuropsychopharmacology 35, 169-191 (2010).
30. Gray, J. A. & McNaughton, N. The neuropsychology of anxiety: reprise. Nebr. Symp. Motiv. 43, 61-134 (1996).