Chapter 2.5 Unconditioned models of fear and anxiety

Handbook of Behavioral Neuroscience

Volumn 17, Issue , 2008, Pages 81-99

  Litvin, Yoav ^a   Pentkowski, Nathan S ^b   Pobbe, Roger L ^c   Blanchard, D Caroline ^b,c   Blanchard, Robert J ^a  

^a UNIVERSITY OF HAWAII   (United States)

^b UNIVERSITY OF HAWAII   (United States)

^c Pacific Biosciences Research Center   (United States)

Author keywords

animal models; anxiety; defense; fear; high throughput; unconditioned

Indexed keywords

EID: 67649695253     PISSN: 15697339     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1569-7339(07)00006-9     Document Type: Review

References (169)

1. Adamec R., Walling S., and Burton P. Long-lasting, selective, anxiogenic effects of feline predator stress in mice. Physiol. Behav. 83 (2004) 401-410
2. Adamec R.E., and Shallow T. Lasting effects on rodent anxiety of a single exposure to a cat. Physiol. Behav. 54 (1993) 101-109
3. Allin J.T., and Banks E.M. Effects of temperature on ultrasound production by infant albino rats. Dev. Psychobiol. 4 (1971) 149-156
4. American Psychiatric Association (1994) (DSM-IV) Diagnostic and statistical manual of mental disorders, 4th edition. American Psychiatric Press Inc., Washington, DC.
5. Apfelbach R., Blanchard C.D., Blanchard R.J., Hayes R.A., and McGregor I.S. The effects of predator odors in mammalian prey species: a review of field and laboratory studies. Neurosci. Biobehav. Rev. 29 (2005) 1123-1144
6. Augustsson H., and Meyerson B.J. Exploration and risk assessment: a comparative study of male house mice (Mus musculus musculus) and two laboratory strains. Physiol. Behav. 81 (2004) 685-698
7. Barron S., Segar T.M., Yahr J.S., Baseheart B.J., and Willford J.A. The effects of neonatal ethanol and/or cocaine exposure on isolation-induced ultrasonic vocalizations. Pharmacol. Biochem. Behav. 67 (2000) 1-9
8. Bell R.W., Nitschke W., Bell N.J., and Zachman T.A. Early experience, ultrasonic vocalizations, and maternal responsiveness in rats. Dev. Psychobiol. 7 (1974) 235-242
9. Belzung C. Measuring exploratory behavior. In: Crusio W.E., and Gerlai R.T. (Eds). Handbook of Molecular Techniques for Brain and Behavior Research (Techniques in the Behavioral and Neural Sciences) (1999), Elsevier, Amsterdam
10. Belzung C. Rodent models of anxiety-like behaviors: are they predictive for compounds acting via non-benzodiazepine mechanisms?. Curr. Opin. Invest. Drugs 2 (2001) 1108-1111
11. Belzung C., Misslin R., Vogel E., Dodd R.H., and Chapouthier G. Anxiogenic effects of methyl-beta-carboline-3-carboxylate in a light/dark choice situation. Pharmacol. Biochem. Behav. 28 (1987) 29-33
12. Belzung C., Pineau N., Beuzen A., and Misslin R. PD135158, a CCK-B antagonist, reduces "state," but not "trait" anxiety in mice. Pharmacol. Biochem. Behav. 49 (1994) 433-436
13. Bertoglio L.J., Anzini C., Lino-de-Oliveira C., and Carobrez A.P. Enhanced dorsolateral periaqueductal gray activity counteracts the anxiolytic response to midazolam on the elevated plus-maze Trial 2 in rats. Behav. Brain Res. 162 (2005) 99-107
14. Biegon A., Bercovitz H., and Samuel D. Serotonin receptor concentration during the estrous cycle of the rat. Brain Res. 187 (1980) 221-225
15. Biegon A., and McEwen B.S. Modulation by estradiol of serotonin receptors in brain. J. Neurosci. 2 (1982) 199-205
16. Blanchard D.C. Stimulus, environmental and pharmacological control of defensive behaviors. In: Bouton M., and Fanselow M.S. (Eds). Learning, Motivation and Cognition. The Functional Behaviorism of Robert C. Bolles (1997), American Psychological Association, Washington, DC
17. Blanchard D.C., and Blanchard R.J. Antipredator defense. In: Whishaw I.Q., and Kolb B. (Eds). The Behavior of the Laboratory Rat (2005), Oxford University Press, New York
18. Blanchard D.C., Blanchard R.J., and Griebel G. Current protocols in neuroscience. In: Crawley J.N., Gerfen C.R., Rogawski M.A., Sibley D.R., Skolnick P., and Wray S. (Eds). Behavioral Neuroscience (2005), Wiley, New York
19. Blanchard D.C., Blanchard R.J., Tom P., and Rodgers R.J. Diazepam changes risk assessment in an anxiety/defense test battery. Psychopharmacology (Berlin) 101 (1990) 511-518
20. Blanchard D.C., Griebel G., and Blanchard R.J. Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic. Neurosci. Biobehav. Rev. 25 (2001) 205-218
21. Blanchard D.C., Griebel G., and Blanchard R.J. The mouse defense test battery: pharmacological and behavioral assays for anxiety and panic. Eur. J. Pharmacol. 463 (2003) 97-116
22. Blanchard D.C., Markham C., Yang M., Hubbard D., Madarang E., and Blanchard R.J. Failure to produce conditioning with low-dose trimethylthiazoline or cat feces as unconditioned stimuli. Behav. Neurosci. 117 (2003) 360-368
23. Blanchard D.C., Shepherd J.K., De Padua Carobrez A., and Blanchard R.J. Sex effects in defensive behavior: baseline differences and drug interactions. Neurosci. Biobehav. Rev. 15 (1991) 461-468
24. Blanchard D.C., Shepherd J.K., Rodgers R.J., and Blanchard R.J. Evidence for differential effects of 8-OH-DPAT on male and female rats in the anxiety/defense test battery. Psychopharmacology (Berlin) 106 (1992) 531-539
25. Blanchard D.C., Spencer R.L., Weiss S.M., Blanchard R.J., McEwen B., and Sakai R.R. Visible burrow system as a model of chronic social stress: behavioral and neuroendocrine correlates. Psychoneuroendocrinology 20 (1995) 117-134
26. Blanchard D.C., Yang M., Hebert M., and Blanchard R.J. Defensive behaviors. In: Fink G. (Ed). Encyclopedia of Stress. 2nd edn (2007), Academic Press, Oxford
27. Blanchard R.J., Agullana R., McGee L., Weiss S., and Blanchard D.C. Sex differences in the incidence and sonographic characteristics of antipredator ultrasonic cries in the laboratory rat (Rattus norvegicus). J. Comp. Psychol. 106 (1992) 270-277
28. Blanchard R.J., and Blanchard D.C. Crouching as an index of fear. J. Comp. Physiol. Psychol. 67 (1969) 370-375
29. Blanchard R.J., and Blanchard D.C. Defensive reactions in the albino rat. Learn. Motiv. 21 (1971) 351-362
30. Blanchard R.J., and Blanchard D.C. Defensive reactions in the albino rat. Learn. Motiv. 2 (1971) 351-362
31. Blanchard R.J., and Blanchard D.C. Antipredator defensive behaviors in a visible burrow system. J. Comp. Psychol. 103 (1989) 70-82
32. Blanchard R.J., Blanchard D.C., Agullana R., and Weiss S.M. Twenty-two kHz alarm cries to presentation of a predator, by laboratory rats living in visible burrow systems. Physiol. Behav. 50 (1991) 967-972
33. Blanchard R.J., Blanchard D.C., and Hori K. An ethoexperimental approach to the study of defense. In: Blanchard R.J., Brain P.F., Blanchard D.C., and Parmigiani S. (Eds). Ethoexpermental Approaches to the Study of Behavior (1989), Kluver Academic, Boston
34. Blanchard R.J., Blanchard D.C., and Weiss S.M. Ethanol effects in an anxiety/defense test battery. Alcohol 7 (1990) 375-381
35. Blanchard R.J., Blanchard D.C., Weiss S.M., and Meyer S. The effects of ethanol and diazepam on reactions to predatory odors. Pharmacol. Biochem. Behav. 35 (1990) 775-780
36. Blanchard R.J., Flannelly K.J., and Blanchard D.C. Defensive behavior of laboratory and wild Rattus norvegicus. J. Comp. Psychol. 100 (1986) 101-107
37. Blanchard R.J., Fukunaga K.K., and Blanchard D.C. Environmental control of defensive reactions to a cat. Bull. Psychon. Soc. 8 (1976) 179-181
38. Blanchard R.J., Griebel G., Henrie J.A., and Blanchard D.C. Differentiation of anxiolytic and panicolytic drugs by effects on rat and mouse defense test batteries. Neurosci. Biobehav. Rev. 21 (1997) 783-789
39. Blanchard R.J., Hebert M.A., Ferrari P.F., Palanza P., Figueira R., Blanchard D.C., and Parmigiani S. Defensive behaviors in wild and laboratory (Swiss) mice: the mouse defense test battery. Physiol. Behav. 65 (1998) 201-209
40. Blanchard R.J., Kelley M.J., and Blanchard D.C. Defensive reactions and exploratory behavior in rats. J. Comp. Physiol. Psychol. 87 (1974) 1129-1133
41. Blanchard R.J., Parmigiani S., Bjornson C., Masuda C., Weiss S.M., and Blanchard D.C. Antipredator behavior of Swiss-Webster mice in a visible burrow system. Aggress. Behav. 21 (1995) 123-136
42. Blanchard R.J., Shepherd J.K., Rodgers R.J., Magee L., and Blanchard D.C. Attenuation of antipredator defensive behavior in rats following chronic treatment with imipramine. Psychopharmacology (Berlin) 110 (1993) 245-253
43. Blanchard R.J., Yang M., Li C.I., Gervacio A., and Blanchard D.C. Cue and context conditioning of defensive behaviors to cat odor stimuli. Neurosci. Biobehav. Rev. 25 (2001) 587-595
44. Borsini F., Podhorna J., and Marazziti D. Do animal models of anxiety predict anxiolytic-like effects of antidepressants?. Psychopharmacology (Berlin) 163 (2002) 121-141
45. Bourin M., and Hascoet M. The mouse light/dark box test. Eur. J. Pharmacol. 463 (2003) 55-65
46. Carlsson M., and Carlsson A. A regional study of sex differences in rat brain serotonin. Prog. Neuropsychopharmacol. Biol. Psychiatry 12 (1988) 53-61
47. Carobrez A.P., and Bertoglio L.J. Ethological and temporal analyses of anxiety-like behavior: the elevated plus-maze model 20 years on. Neurosci. Biobehav. Rev. 29 (2005) 1193-1205
48. Carobrez A.P., Teixeira K.V., and Graeff F.G. Modulation of defensive behavior by periaqueductal gray NMDA/glycine-B receptor. Neurosci. Biobehav. Rev. 25 (2001) 697-709
49. Carvalho-Netto E.F., Litvin Y., Nunes-De-Souza R.L., Blanchard D.C., and Blanchard R.J. Effects of Intra-PAG infusion of ovine CRF (oCRF) on defensive behaviors in Swiss-Webster Mice. Behav. Brain Res. 176 (2007) 222-229
50. Chaouloff F., Durand M., and Mormede P. Anxiety- and activity-related effects of diazepam and chlordiazepoxide in the rat light/dark and dark/light tests. Behav. Brain Res. 85 (1997) 27-35
51. Cheeta S., Tucci S., Sandhu J., Williams A.R., Rupniak N.M., and File S.E. Anxiolytic actions of the substance P (NK1) receptor antagonist L-760735 and the 5-HT1A agonist 8-OH-DPAT in the social interaction test in gerbils. Brain Res. 915 (2001) 170-175
52. Choleris E., Thomas A.W., Kavaliers M., and Prato F.S. A detailed ethological analysis of the mouse open field test: effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field. Neurosci. Biobehav. Rev. 25 (2001) 235-260
53. Cohen H., Kaplan Z., Matar M.A., Loewenthal U., Zohar J., and Richter-Levin G. Long-lasting behavioral effects of juvenile trauma in an animal model of PTSD associated with a failure of the autonomic nervous system to recover. Eur. Neuropsychopharmacol. 17 (2007) 464-477
54. Cohen H., and Zohar J. An animal model of posttraumatic stress disorder: the use of cut-off behavioral criteria. Ann. N.Y. Acad. Sci. 1032 (2004) 167-178
55. Conely L., and Bell R.W. Neonatal ultrasounds elicited by odor cues. Dev. Psychobiol. 11 (1978) 193-197
56. Crawley J. Neuropharmacological specificity of a simple animal model for the behavioral actions of the benzodiazepines. Pharmacol. Biochem. Behav. 15 (1981) 695-699
57. Crawley J., and Goodwin F.K. Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacol. Biochem. Behav. 13 (1980) 167-170
58. Crawley J.N., and Paylor R. A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice. Horm. Behav. 31 (1997) 197-211
59. Cruz A.P., Frei F., and Graeff F.G. Ethopharmacological analysis of rat behavior on the elevated plus-maze. Pharmacol. Biochem. Behav. 49 (1994) 171-176
60. Dawson G.R., and Tricklebank M.D. Use of the elevated plus-maze in the search for novel anxiolytic agents. Trends Pharmacol. Sci. 16 (1995) 33-36
61. Deakin J.F.W., and Graeff F.G. 5-HT and mechanisms of defence. J. Psychopharmacol. 5 (1991) 305-315
62. de Angelis L., and File S.E. Acute and chronic effects of three benzodiazepines in the social interaction anxiety test in mice. Psychopharmacology (Berlin) 64 (1979) 127-129
63. De Boer S.F., and Koolhaas J.M. Defensive burying in rodents: ethology, neurobiology and psychopharmacology. Eur. J. Pharmacol. 463 (2003) 145-161
64. Diamond D.M., Campbell A.M., Park C.R., Woodson J.C., Conrad C.D., Bachstetter A.D., and Mervis R.F. Influence of predator stress on the consolidation versus retrieval of long-term spatial memory and hippocampal spinogenesis. Hippocampus 16 (2006) 571-576
65. Edinger K.L., and Frye C.A. Sexual experience of male rats influences anxiety-like behavior and androgen levels. Physiol. Behav 2 3 (2007) 443-453
66. Farrokhi, C. (2006) Comparative effects of the CRF agonist, ovine CRF, and CRF antagonist, astressin, on homecage behavior patterns and defense in the mouse. Psychology. Honolulu, University of Hawaii at Manoa.
67. File S.E. The interplay of learning and anxiety in the elevated plus-maze. Behav. Brain Res. 58 (1993) 199-202
68. File S.E. Chronic exposure to noise modifies the anxiogenic response, but not the hypoactivity, detected on withdrawal from chronic ethanol treatment. Psychopharmacology (Berlin) 116 (1994) 369-372
69. File S.E., Cheeta S., and Akanezi C. Diazepam and nicotine increase social interaction in gerbils: a test for anxiolytic action. Brain Res. 888 (2001) 311-313
70. File S.E., Gonzalez L.E., and Gallant R. Role of the basolateral nucleus of the amygdala in the formation of a phobia. Neuropsychopharmacology 19 (1998) 397-405
71. File S.E., Gonzalez L.E., and Gallant R. Role of the dorsomedial hypothalamus in mediating the response to benzodiazepines on trial 2 in the elevated plus-maze test of anxiety. Neuropsychopharmacology 21 (1999) 312-320
72. File S.E., and Seth P. A review of 25 years of the social interaction test. Eur. J. Pharmacol. 463 (2003) 35-53
73. File S.E., and Zangrossi Jr. H. "One-trial tolerance" to the anxiolytic actions of benzodiazepines in the elevated plus-maze, or the development of a phobic state?. Psychopharmacology (Berlin) 110 (1993) 240-244
74. Ford J.D., and Kidd P. Early childhood trauma and disorders of extreme stress as predictors of treatment outcome with chronic posttraumatic stress disorder. J. Trauma Stress 11 (1998) 743-761
75. Fowler H. Curiosity and exploratory behavior (1965), Macmillan, New York
76. Graeff F.G. On serotonin and experimental anxiety. Psychopharmacology (Berlin) 163 (2002) 467-476
77. Graeff F.G. Serotonin, the periaqueductal gray and panic. Neurosci. Biobehav. Rev. 28 (2004) 239-259
78. Graeff F.G., Netto C.F., and Zangrossi Jr. H. The elevated T-maze as an experimental model of anxiety. Neurosci. Biobehav. Rev. 23 (1998) 237-246
79. Graeff F.G., Viana M.B., and Tomaz C. The elevated T maze, a new experimental model of anxiety and memory: effect of diazepam. Braz. J. Med. Biol. Res. 26 (1993) 67-70
80. Graeff F.G., and Zangrossi H. Animal models of anxiety disorders. In: D'Haenen H., den Boer J.A., and Willner P. (Eds). Biological Psychiatry (2002), Wiley, Chichester
81. Griebel G. 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research. Pharmacol. Ther. 65 (1995) 319-395
82. Griebel G. Variability in the effects of 5-HT-related compounds in experimental models of anxiety: evidence for multiple mechanisms of 5-HT in anxiety or never ending story?. Pol. J. Pharmacol. 48 (1996) 129-136
83. Griebel G., Belzung C., Misslin R., and Vogel E. The free-exploratory paradigm: an effective method for measuring neophobic behaviour in mice and testing potential neophobia-reducing drugs. Behav. Pharmacol. 4 (1993) 637-644
84. Griebel G., Belzung C., Perrault G., and Sanger D.J. Differences in anxiety-related behaviours and in sensitivity to diazepam in inbred and outbred strains of mice. Psychopharmacology (Berlin) 148 (2000) 164-170
85. Griebel G., Blanchard D.C., and Blanchard R.J. Evidence that the behaviors in the mouse defense test battery relate to different emotional states: a factor analytic study. Physiol. Behav. 60 (1996) 1255-1260
86. Griebel G., Blanchard D.C., and Blanchard R.J. Predator-elicited flight responses in Swiss-Webster mice: an experimental model of panic attacks. Prog. Neuropsychopharmacol. Biol. Psychiatry 20 (1996) 185-205
87. Griebel G., Curet O., Perrault G., and Sanger D.J. Behavioral effects of phenelzine in an experimental model for screening anxiolytic and anti-panic drugs: correlation with changes in monoamine-oxidase activity and monoamine levels. Neuropharmacology 37 (1998) 927-935
88. Griebel G., Rodgers R.J., Perrault G., and Sanger D.J. Risk assessment behaviour: evaluation of utility in the study of 5-HT-related drugs in the rat elevated plus-maze test. Pharmacol. Biochem. Behav. 57 (1997) 817-827
89. Griebel G., Sanger D.J., and Perrault G. Further evidence for differences between non-selective and BZ-1 (omega 1) selective, benzodiazepine receptor ligands in murine models of "state" and "trait" anxiety. Neuropharmacology 35 (1996) 1081-1091
90. Hall C.S. Emotional behavior in the rat: I, Defecation and urination as measures of individual differences in emotionality. J. Comp. Psychol. 18 (1934) 385-403
91. Handley S.L. 5-Hydroxytryptamine pathways in anxiety and its treatment. Pharmacol. Ther. 66 (1995) 103-148
92. Handley S.L., and McBlane J.W. 5HT drugs in animal models of anxiety. Psychopharmacology (Berlin) 112 (1993) 13-20
93. Handley S.L., McBlane J.W., Critchley M.A.E., and Njung'e K. Multiple serotonin mechanisms in animal models of anxiety: environmental, emotional and cognitive factors. Behav. Brain Res. 58 (1993) 203-210
94. Handley S.L., and Mithani S. Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of 'fear'-motivated behaviour. Naunyn Schmiedebergs Arch. Pharmacol. 327 (1984) 1-5
95. Hascoet M., and Bourin M. A new approach to the light/dark test procedure in mice. Pharmacol. Biochem. Behav. 60 (1998) 645-653
96. Heim C., and Nemeroff C.B. The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol. Psychiatry 49 (2001) 1023-1039
97. Hendrie C.A., Eilam D., and Weiss S.M. Effects of diazepam and buspirone on the behaviour of wild voles (Microtus socialis) in two models of anxiety. Pharmacol. Biochem. Behav. 58 (1997) 573-576
98. Hilakivi L.A., Durcan M.J., and Lister R.G. Effects of caffeine on social behavior, exploration and locomotor activity: interactions with ethanol. Life Sci. 44 (1989) 543-553
99. Hofer M.A., and Shair H. Sensory processes in the control of isolation-induced ultrasonic vocalization by 2-week-old rats. J. Comp. Physiol. Psychol. 94 (1980) 271-279
100. Hogg S. A review of the validity and variability of the elevated plus-maze as an animal model of anxiety. Pharmacol. Biochem. Behav. 54 (1996) 21-30
101. Holmes A., Parmigiani S., Ferrari P.F., Palanza P., and Rodgers R.J. Behavioral profile of wild mice in the elevated plus-maze test for anxiety. Physiol. Behav. 71 (2000) 509-516
102. Huck U.W., and Price E.O. Differential effects of environmental enrichment on the open-field behavior of wild and domestic Norway rats. J. Comp. Physiol. Psychol. 89 (1975) 892-898
103. Insel T.R., Hill J.L., and Mayor R.B. Rat pup ultrasonic isolation calls: possible mediation by the benzodiazepine receptor complex. Pharmacol. Biochem. Behav. 24 (1986) 1263-1267
104. Iwaniuk A.N. Evolution. In: Whishaw I.Q., and Kolb B. (Eds). The Behavior of the Laboratory Rat (2005), Oxford University Press, Oxford
105. Johnson M.R., Lydiard R.B., and Ballenger J.C. Panic disorder. Pathophysiology and drug treatment. Drugs 49 (1995) 328-344
106. Johnston A.L., and File S.E. Sex differences in animal tests of anxiety. Physiol. Behav. 49 (1991) 245-250
107. Kehoe P., and Blass E.M. Opioid-mediation of separation distress in 10-day-old rats: reversal of stress with maternal stimuli. Dev. Psychobiol. 19 (1986) 385-398
108. Kopp C., Misslin R., Vogel E., Rettori M.C., Delagrange P., and Guardiola-Lemaître B. Effects of day-length variations on emotional responses toward unfamiliarity in Swiss mice. Behav. Proc. 41 (1997) 151-157
109. Lister R.G. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology (Berlin) 92 (1987) 180-185
110. Lister R.G. Ethologically-based animal models of anxiety disorders. Pharmacol. Ther. 46 (1990) 321-340
111. Lister R.G., and Hilakivi L.A. The effects of novelty, isolation, light and ethanol on the social behavior of mice. Psychopharmacology (Berlin) 96 (1988) 181-187
112. Litvin Y., Blanchard D.C., and Blanchard R.J. Rat 22 kHz ultrasonic vocalizations as alarm cries. Behav. Brain Res. 182 (2007) 166-172
113. Litvin Y., Pentkowski N.S., Blanchard D.C., and Blanchard R.J. CRF type 1 receptors in the dorsal periaqueductal gray modulate anxiety-induced defensive behaviors. Horm. Behav. 52 (2007) 244-251
114. Lowry C.A., Johnson P.L., Hay-Schmidt A., Mikkelsen J., and Shekhar A. Modulation of anxiety circuits by serotonergic systems. Stress 8 (2005) 233-246
115. Maciag C.M., Dent G., Gilligan P., He L., Dowling K., Ko T., Levine S., and Smith M.A. Effects of a non-peptide CRF antagonist (DMP696) on the behavioral and endocrine sequelae of maternal separation. Neuropsychopharmacology 26 (2002) 574-582
116. Maier S.F., and Watkins L.R. Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. Neurosci. Biobehav. Rev. 29 (2005) 829-841
117. Marcondes F.K., Miguel K.J., Melo L.L., and Spadari-Bratfisch R.C. Estrous cycle influences the response of female rats in the elevated plus-maze test. Physiol. Behav. 74 (2001) 435-440
118. Markham C.M., Blanchard D.C., Canteras N.S., Cuyno C.D., and Blanchard R.J. Modulation of predatory odor processing following lesions to the dorsal premammillary nucleus. Neurosci. Lett. 372 (2004) 22-26
119. McGregor I.S., and Dielenberg R.A. Differential anxiolytic efficacy of a benzodiazepine on first versus second exposure to a predatory odor in rats. Psychopharmacology (Berlin) 147 (1999) 174-181
120. McGregor I.S., Hargreaves G.A., Apfelbach R., and Hunt G.E. Neural correlates of cat odor-induced anxiety in rats: region-specific effects of the benzodiazepine midazolam. J. Neurosci. 24 (2004) 4134-4144
121. McKinney W.T. Animal models of depression: an overview. Psychiatry Dev. 2 (1984) 77-96
122. Miczek K.A., Weerts E.M., Vivian J.A., and Barros H.M. Aggression, anxiety and vocalizations in animals: GABAA and 5-HT anxiolytics. Psychopharmacology (Berlin) 121 (1995) 38-56
123. Montgomery K.C. The role of the exploratory drive in learning. J. Comp. Physiol. Psychol. 47 (1954) 60-64
124. Montgomery K.C. The relation between fear induced by novelty stimulation and exploratory behavior. J. Comp. Physiol. Psychol. 48 (1955) 254-260
125. Mora S., Dussaubat N., and Diaz-Veliz G. Effects of the estrous cycle and ovarian hormones on behavioral indices of anxiety in female rats. Psychoneuroendocrinology 21 (1996) 609-620
126. Nutt D.J. Anxiety and its therapy: today and tomorrow. In: Briley M., and File S.E. (Eds). New Concepts in Anxiety (1991), MacMillan Press, London
127. Oswalt G.L., and Meier G.W. Olfactory, thermal, and tactual influences on infantile ultrasonic vocalization in rats. Dev. Psychobiol. 8 (1975) 129-135
128. Pellow S., Chopin P., File S.E., and Briley M. Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Methods 14 (1985) 149-167
129. Pentkowski N.S., Blanchard D.C., Lever C., Litvin Y., and Blanchard R.J. Effects of lesions to the dorsal and ventral hippocampus on defensive behaviors in rats. Eur. J. Neurosci. 23 (2006) 2185-2196
130. Podhorna J., and Brown R.E. Flibanserin has anxiolytic effects without locomotor side effects in the infant rat ultrasonic vocalization model of anxiety. Br. J. Pharmacol. 130 (2000) 739-746
131. Poltronieri S.C., Zangrossi Jr. H., and de Barros Viana M. Antipanic-like effect of serotonin reuptake inhibitors in the elevated T-maze. Behav. Brain Res. 147 (2003) 185-192
132. Prendergast B.J., and Nelson R.J. Affective responses to changes in day length in Siberian hamsters (Phodopus sungorus). Psychoneuroendocrinology 30 (2005) 438-452
133. Price E.O. Behavioral aspects of animal domestication. Q. Rev. Biol. 59 (1984) 1-32
134. Prut L., and Belzung C. The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Eur. J. Pharmacol. 463 (2003) 3-33
135. Rex A., and Fink H. Effects of cholecystokinin-receptor agonists on cortical 5-HT release in guinea pigs on the X-maze. Peptides 19 (1998) 519-526
136. Rodgers R.J. Animal models of 'anxiety': where next?. Behav. Pharmacol. 8 (1997) 477-496 discussion 497-504
137. Rodgers R.J. More haste, considerably less speed. J. Psychopharmacol. 21 (2007) 141-143
138. Rodgers R.J., Boullier E., Chatzimichalaki P., Cooper G.D., and Shorten A. Contrasting phenotypes of C57BL/6JOlaHsd, 129S2/SvHsd and 129/SvEv mice in two exploration-based tests of anxiety-related behaviour. Physiol. Behav. 77 (2002) 301-310
139. Rodgers R.J., Dalvi A., and Holmes A. Animal models of anxiety: an ethological perspective. Braz. J. Med. Biol. Res. 30 (1997) 289-304
140. Rodgers R.J., and Johnson N.J. Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety. Pharmacol. Biochem. Behav. 52 (1995) 297-303
141. Rodgers R.J., Johnson N.J., Cole J.C., Dewar C.V., Kidd G.R., and Kimpson P.H. Plus-maze retest profile in mice: importance of initial stages of trail 1 and response to post-trail cholinergic receptor blockade. Pharmacol. Biochem. Behav. 54 (1996) 41-50
142. Roy V., and Chapillon P. Further evidences that risk assessment and object exploration behaviours are useful to evaluate emotional reactivity in rodents. Behav. Brain Res. 154 (2004) 439-448
143. Salome N., Stemmelin J., Cohen C., and Griebel G. Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils. Pharmacol. Biochem. Behav. 83 (2006) 533-539
144. Salome N., Viltart O., Darnaudery M., Salchner P., Singewald N., Landgraf R., Sequeira H., and Wigger A. Reliability of high and low anxiety-related behaviour: influence of laboratory environment and multifactorial analysis. Behav. Brain Res. 136 (2002) 227-237
145. Shair H.N. Acquisition and expression of a socially mediated separation response. Behav. Brain Res. 182 (2007) 180-192
146. Shepherd J.K., Grewal S.S., Fletcher A., Bill D.J., and Dourish C.T. Behavioural and pharmacological characterisation of the elevated "zero-maze" as an animal model of anxiety. Psychopharmacology (Berlin) 116 (1994) 56-64
147. Shimada T., Matsumoto K., Osanai M., Matsuda H., Terasawa K., and Watanabe H. The modified light/dark transition test in mice: evaluation of classic and putative anxiolytic and anxiogenic drugs. Gen. Pharmacol. 26 (1995) 205-210
148. Stanford S.C. The open field test: reinventing the wheel. J. Psychopharmacol. 21 (2007) 134-135
149. Takahashi L.K. Ontogeny of behavioral inhibition induced by unfamiliar adult male conspecifics in preweanling rats. Physiol. Behav. 52 (1992) 493-498
150. Takahashi L.K., Nakashima B.R., Hong H., and Watanabe K. The smell of danger: a behavioral and neural analysis of predator odor-induced fear. Neurosci. Biobehav. Rev. 29 (2005) 1157-1167
151. Teixeira R.C., Zangrossi H., and Graeff F.G. Behavioral effects of acute and chronic imipramine in the elevated T-maze model of anxiety. Pharmacol. Biochem. Behav. 65 (2000) 571-576
152. Tovote, P., Farrokhi, C.B., Todorovic, C., Blanchard, R.J. and Blanchard, D.C. (2006). The rat exposure test: a semi-natural model for anxiety-like behavior in the mouse. Society for Neuroscience. Atlanta, USA.
153. Treit D., Menard J., and Royan C. Anxiogenic stimuli in the elevated plus-maze. Pharmacol. Biochem. Behav. 44 (1993) 463-469
154. Treit D., and Fundytus M. Thigmotaxis as a test for anxiolytic activity in rats. Pharmacol. Biochem. Behav. 31 (1989) 959-962
155. Tucci S., Cheeta S., Seth P., and File S.E. Corticotropin releasing factor antagonist, alpha-helical CRF(9-41), reverses nicotine-induced conditioned, but not unconditioned, anxiety. Psychopharmacology (Berlin) 167 (2003) 251-256
156. Varty G.B., Morgan C.A., Cohen-Williams M.E., Coffin V.L., and Carey G.J. The gerbil elevated plus-maze I: behavioral characterization and pharmacological validation. Neuropsychopharmacology 27 (2002) 357-370
157. Viana M.B., Tomaz C., and Graeff F.G. The elevated T-maze: a new animal model of anxiety and memory. Pharmacol. Biochem. Behav. 49 (1994) 549-554
158. Wall P.M., and Messier C. Methodological and conceptual issues in the use of the elevated plus-maze as a psychological measurement instrument of animal anxiety-like behavior. Neurosci. Biobehav. Rev. 25 (2001) 275-286
159. Wallace K.J., and Rosen J.B. Predator odor as an unconditioned fear stimulus in rats: elicitation of freezing by trimethylthiazoline, a component of fox feces. Behav. Neurosci. 114 (2000) 912-922
160. Weiss S.M., Wadsworth G., Fletcher A., and Dourish C.T. Utility of ethological analysis to overcome locomotor confounds in elevated maze models of anxiety. Neurosci. Biobehav. Rev. 23 (1998) 265-271
161. Welker W.I. Escape, exploratory, and food-seeking responses of rats in a novel situation. J. Comp. Physiol. Psychol. 52 (1959) 106-111
162. Wilson R.C., Vacek T., Lanier D.L., and Dewsbury D.A. Open-field behavior in muroid rodents. Behav. Biol. 17 (1976) 495-506
163. Winslow J.T., and Insel T.R. Infant rat separation is a sensitive test for novel anxiolytics. Prog. Neuropsychopharmacol. Biol. Psychiatry 15 (1991) 745-757
164. Yang M., Augustsson H., Markham C.M., Hubbard D.T., Webster D., Wall P.M., Blanchard R.J., and Blanchard D.C. The rat exposure test: a model of mouse defensive behaviors. Physiol. Behav. 81 (2004) 465-473
165. Zangrossi Jr. H., and File S.E. Behavioral consequences in animal tests of anxiety and exploration of exposure to cat odor. Brain Res. Bull. 29 (1992) 381-388
166. Zangrossi Jr. H., and File S.E. Chlordiazepoxide reduces the generalised anxiety, but not the direct responses, of rats exposed to cat odor. Pharmacol. Biochem. Behav. 43 (1992) 1195-1200
167. Zangrossi Jr. H., and Graeff F.G. Behavioral validation of the elevated T-maze, a new animal model of anxiety. Brain Res. Bull. 44 (1997) 1-5
168. Zimmerberg B., Brunelli S.A., and Hofer M.A. Reduction of rat pup ultrasonic vocalizations by the neuroactive steroid allopregnanolone. Pharmacol. Biochem. Behav. 47 (1994) 735-738
169. Zimmerberg B., and Farley M.J. Sex differences in anxiety behavior in rats: role of gonadal hormones. Physiol. Behav. 54 (1993) 1119-1124