Reduced amygdalar and hippocampal size in adults with generalized social phobia

Journal of Psychiatry and Neuroscience

Volumn 35, Issue 2, 2010, Pages 126-131

  Irle, Eva ^a   Ruhleder, Mirjana ^a   Lange, Claudia ^a   Seidler Brandler, Ulrich ^a   Salzer, Simone ^a   Dechent, Peter ^a   Weniger, Godehard ^b   Leibing, Eric ^a   Leichsenring, Falk ^c  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; BENZODIAZEPINE DERIVATIVE;

ADULT; AMYGDALOID NUCLEUS; ARTICLE; AVOIDANT PERSONALITY DISORDER; BRAIN SIZE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HIPPOCAMPUS; HUMAN; MALE; MULTICENTER STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; SOCIAL PHOBIA; THREE DIMENSIONAL IMAGING;

EID: 77649310690     PISSN: 11804882     EISSN: None     Source Type: Journal    
DOI: 10.1503/jpn.090041     Document Type: Article

References (39)

1. Etkin A, Wager TD. Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am J Psychiatry 2007;164:1476-88.
2. Stein MB, Philip R, Goldin MS, et al. Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Arch Gen Psychiatry 2002;59:1027-34.
3. Phan KL, Fitzgerald DA, Nathan PJ, et al. Association between amygdala hyperactivity to harsh faces and severity of social anxiety in generalized social phobia. Biol Psychiatry 2006;59:424-9.
4. Blair K, Shaywitz J, Smith BW, et al. Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders. Am J Psychiatry 2008;165:1193-202.
5. Furmark T, Tillfors M, Marteinsdottir I, et al. Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy. Arch Gen Psychiatry 2002;59:425-33.
6. Karl A, Schaefer M, Malta LS, et al. A meta-analysis of structural brain abnormalities in PTSD. Neurosci Biobehav Rev 2006;30:1004-31.
7. Campbell S, Marriott M, Nahmias C, et al. Lower hippocampal volume in patients suffering from depression: a meta-analysis. Am J Psychiatry 2004;161:598-607.
8. Hamilton JP, Siemer M, Gotlib IH. Amygdala volume in major depressive disorder: a meta-anlysis of magnetic resonance imaging studies. Mol Psychiatry 2008;13:993-1000.
9. Sapolsky RM, Uno H, Rebert CS, et al. Hippocampal damage associated with prolonged glucocorticoid exposure in primates. J Neurosci 1990;10:2897-902.
10. Gilbertson MW, Shenton ME, Ciszewski A, et al. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat Neurosci 2002;5:1242-7.
11. Taylor WD, Steffens DC, Payne ME, et al. Influence of serotonin transporter promotor region polymorphisms on hippocampal volumes in late-life depression. Arch Gen Psychiatry 2005;62:537-44.
12. Leichsenring F, Hoyer J, Beutel M, et al. The social phobia psychotherapy research network. Psychother Psychosom 2009;78:35-41.
13. Mennin DS, Fresco DM, Heimberg RG, et al. Screening for social anxiety disorder in the clinical setting using the Liebowitz Social Anxiety Scale. J Anxiety Disord 2002;16:661-73.
14. Brown TA, di Nardo P, Barlow DH. Anxiety disorders interview schedule adult version. Oxford (UK): Oxford University Press; 1994.
15. First MB, Gibbon M, Spitzer RL, et al. Structured clinical interview for DSM-IV axis II personality disorders (SCID-II). Washington (DC): American Psychiatric Press; 1997.
16. First MB, Spitzer RL, Gibbon M, et al. Structured clinical interview for DSM-IV-TR axis I disorders, research version, patient edition. (SCID-I/P) New York (NY): Biometrics Research, New York State Psychiatric Institute; 2002.
17. Liebowitz MR. Social phobia. Mod Probl Pharmacopsychiatry 1987; 22:141-73.
18. Heimberg RG, Horner KJ, Juster HR, et al. Psychometric properties of the Liebowitz Social Anxiety Scale. Psychol Med 1999;29:199-212.
19. Beidel DC, Turner SM, Cooley MR. Assessing reliable and clinically significant change in social phobia: validity of the social phobia and anxiety inventory. Behav Res Ther 1993;31:331-7.
20. Spielberger CD, Gorsuch RL, Lushene RE. Manual for the State-Trait Anxiety Inventory. Palo Alto (CA): Consulting Psychologists Press; 1970.
21. Beck AT, Ward CH, Mendelson M, et al. An inventory for measuring depression. Arch Gen Psychiatry 1961;4:561-71.
22. Hyman SM, Garcia M, Kemp K, et al. A gender specific psychometric analysis of the early trauma inventory short form in cocaine dependent adults. Addict Behav 2005;30:847-52.
23. Pruessner JC, Li LM, Serles W, et al. Volumetry of hippocampus and amygdala with high-resolution MRI and three-dimensional analysis software: minimizing the discrepancies between laboratories. Cereb Cortex 2000;10:433-42.
24. Irle E, Lange C, Sachsse U. Reduced size and abnormal asymmetry of parietal cortex in women with borderline personality disorder. Biol Psychiatry 2005;57:173-82.
25. Weniger G, Lange C, Irle E. Abnormal size of the amygdala predicts impaired emotional memory in major depressive disorder. J Affect Disord 2006;94:219-29.
26. Gray JA, McNaughton NJ. The neuropsychology of anxiety. Oxford (UK): Oxford Medical Publications; 2000.
27. Cherbuin N, Windsor TD, Anstey KJ, et al. Hippocampal volume is positively associated with behavioural inhibition (BIS) in a large community-based sample of mid-life adults: the PATH through life study. Soc Cogn Affect Neurosci 2008;3:262-9.
28. Barros-Loscertales A, Meseguer V, Sanjuan A, et al. Behavioral inhibition system activity is associated with increased amygdala and hippocampal gray matter volume: a voxel-based morphometry study. Neuroimage 2006;33:1011-5.
29. Chambers RA, Bremner JD, Moghaddam B, et al. Glutamate and post-traumatic stress disorder: toward a psychobiology of dissociation. Semin Clin Neuropsychiatry 1999;4:274-81.
30. Cameron HA, McEwen BS, Gould E. Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus. J Neurosci 1995;15:4687-92.
31. Shekhar A, Truitt W, Rainnie D, et al. Role of stress, corticotropin releasing factor (CRF) and amygdala plasticity in chronic anxiety. Stress 2005;8:209-19.
32. Munafo MR, Brown SM, Hariri AR. Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biol Psychiatry 2008;63:852-7.
33. Furmark T, Tillfors M, Garpenstrand H, et al. Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobia. Neurosci Lett 2004;362:189-92.
34. Caspi A, Sugden K, Moffitt TE, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003; 301:386-9.
35. Vermetten E, Vythilingam M, Southwick SM, et al. Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder. Biol Psychiatry 2003;54:693-702.
36. Frodl T, Jäger M, Smajstrlova I, et al. Effect of hippocampal and amygdala volume on clinical outcomes in major depression: a 3-year prospective magnetic resonance imaging study. J Psychiatry Neurosci 2008;33:423-30.
37. MacQueen GM. Magnetic resonance imaging and prediction of outcome in patients with major depressive disorders. J Psychiatry Neurosci 2009;34:343-9.
38. Stein MB, Torgrud LJ, Walker JR. Social phobia symptoms, subtypes, and severity. Findings from a community survey. Arch Gen Psychiatry 2000;57:1046-52.
39. Hamann S, Canli T. Individual differences in emotion processing. Curr Opin Neurobiol 2004;14:233-8.