Synaptic potentiation onto habenula neurons in the learned helplessness model of depression

Nature

Volumn 470, Issue 7335, 2011, Pages 535-541

  Li, Bo ^a,b   Piriz, Joaquin ^a   Mirrione, Martine ^b,c   Chung, Chihye ^a   Proulx, Christophe D ^a   Schulz, Daniela ^c   Henn, Fritz ^b,c   Malinow, Roberto ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^c BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CYTOLOGY; NEUROLOGY; PROBABILITY; PSYCHOLOGY; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DEPRESSION; ELECTROSTIMULATION; FOREBRAIN; HABENULA; LEARNED HELPLESSNESS; MALE; MESENCEPHALON; NERVE CELL; NERVE EXCITABILITY; NERVE POTENTIAL; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE; SYNAPTIC TRANSMISSION; VENTRAL TEGMENTUM;

ANIMALS; AVOIDANCE LEARNING; DEEP BRAIN STIMULATION; DEPRESSION; DISEASE MODELS, ANIMAL; DOPAMINE; ELECTRIC STIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; HELPLESSNESS, LEARNED; MALE; MODELS, NEUROLOGICAL; NEUROANATOMICAL TRACT-TRACING TECHNIQUES; NEURONS; PRESYNAPTIC TERMINALS; RATS; RATS, SPRAGUE-DAWLEY; REWARD; SYNAPSES; SYNAPTIC TRANSMISSION; THALAMUS; VENTRAL TEGMENTAL AREA;

ANIMALIA; RATTUS; RODENTIA;

EID: 79952129505     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09742     Document Type: Article

References (30)

1. Krishnan, V.&Nestler, E. J. Themolecular neurobiology of depression. Nature 455, 894-902 (2008).
2. Matsumoto, M. & Hikosaka, O. Lateral habenula as a source of negative reward signals in dopamine neurons. Nature 447, 1111-1115 (2007). (Pubitemid 47014424)
3. Matsumoto, M.&Hikosaka, O. Representation of negativemotivational value in the primate lateral habenula. Nature Neurosci. 12, 77-84 (2009).
4. Hikosaka, O. The habenula: from stress evasion to value-based decision-making. Nature Rev. Neurosci. 11, 503-513 (2010).
5. Ji, H.&Shepard, P. D. Lateral habenula stimulationinhibits rat midbrain dopamine neurons through a GABAA receptor-mediated mechanism. J. Neurosci. 27, 6923-6930 (2007). (Pubitemid 47015898)
6. Nestler, E. J. & Carlezon, W. A. Jr. The mesolimbic dopamine reward circuit in depression. Biol. Psychiatry 59, 1151-1159 (2006). (Pubitemid 44192421)
7. Krishnan, V. et al. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 131, 391-404 (2007). (Pubitemid 47576141)
8. Mayberg, H. S. Targeted electrode-based modulation of neural circuits for depression. J. Clin. Invest. 119, 717-725 (2009).
9. Sartorius, A. et al. Remission of major depression under deep brain stimulation of the lateral habenula in a therapy-refractory patient. Biol. Psychiatry 67, e9-e11 (2010).
10. Maier, S. F. Learned helplessness and animal models of depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 8, 435-446 (1984). (Pubitemid 14051222)
11. Henn, F. A. & Vollmayr, B. Stress models of depression: forming genetically vulnerable strains. Neurosci. Biobehav. Rev. 29, 799-804 (2005). (Pubitemid 40755465)
12. Schulz, D., Mirrione, M. M. & Henn, F. A. Cognitive aspects of congenital learned helplessness and its reversal by the monoamine oxidase (MAO)-B inhibitor deprenyl. Neurobiol. Learn. Mem. 93, 291-301 (2010).
13. Porsolt, R. D., Le Pichon, M. & Jalfre, M. Depression: a new animal model sensitive to antidepressant treatments. Nature 266, 730-732 (1977). (Pubitemid 8073804)
14. Lecourtier, L. & Kelly, P. H. A conductor hidden in the orchestra? Role of the habenular complex in monoamine transmission and cognition. Neurosci. Biobehav. Rev. 31, 658-672 (2007). (Pubitemid 46680450)
15. Jhou, T. C. et al. The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. Neuron 61, 786-800 (2009).
16. Kaufling, J. et al. Afferents to the GABAergic tail of the ventral tegmental area in the rat. J. Comp. Neurol. 513, 597-621 (2009).
17. Zucker, R. S. & Regehr, W. G. Short-termsynaptic plasticity. Annu. Rev. Physiol. 64, 355-405 (2002).
18. Sartorius, A. & Henn, F. A. Deep brain stimulation of the lateral habenula in treatment resistant major depression. Med. Hypotheses 69, 1305-1308 (2007). (Pubitemid 47633054)
19. Airan, R. D. et al. High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. Science 317, 819-823 (2007). (Pubitemid 47257922)
20. Berton, O. & Nestler, E. J. New approaches to antidepressant drug discovery: beyond monoamines. Nature Rev. Neurosci. 7, 137-151 (2006). (Pubitemid 43151600)
21. Pittenger, C.&Duman, R. S. Stress,depression, andneuroplasticity: a convergence of mechanisms. Neuropsychopharmacology 33, 88-109 (2008).
22. Sahay, A. & Hen, R. Adult hippocampal neurogenesis in depression. Nature Neurosci. 10, 1110-1115 (2007). (Pubitemid 47339960)
23. Mill, J.&Petronis, A.Molecular studies ofmajor depressive disorder: the epigenetic perspective. Mol. Psychiatry 12, 799-814 (2007). (Pubitemid 47347791)
24. Morris, J. S. et al. Covariation of activity in habenula and dorsal raphe nuclei following tryptophan depletion. Neuroimage 10, 163-172 (1999). (Pubitemid 29379014)
25. Roiser, J. P. et al. The effects of tryptophan depletion on neural responses to emotional words in remitted depression. Biol. Psychiatry 66, 441-450 (2009).
26. Shumake, J. & Gonzalez-Lima, F. Brain systems underlying susceptibility to helplessness and depression. Behav. Cogn. Neurosci. Rev. 2, 198-221 (2003).
27. Caldecott-Hazard, S., Mazziotta, J. & Phelps, M. Cerebral correlates of depressed behavior in rats, visualized using 14C-2-deoxyglucose autoradiography. J. Neurosci. 8, 1951-1961 (1988).
28. Amat, J. et al. The role of the habenular complex in the elevation of dorsal raphe nucleus serotonin and the changes in the behavioral responses produced by uncontrollable stress. Brain Res. 917, 118-126 (2001). (Pubitemid 32972136)
29. Yang, L. M. et al. Lateral habenula lesions improve the behavioral response in depressed rats via increasing the serotonin level in dorsal raphe nucleus. Behav. Brain Res. 188, 84-90 (2008).
30. Winter, C. et al. Pharmacological inhibition of the lateral habenula improves depressive-like behavior in an animal model of treatment resistant depression. Behav. Brain Res. 216, 463-465 (2011).