Simultaneous ingestion of high-methoxy pectin from apple can enhance absorption of quercetin in human subjects

British Journal of Nutrition

Volumn 113, Issue 10, 2015, Pages 1531-1538

  Nishijima, Tomohiko ^a,b   Takida, Yoshiki ^a   Saito, Yasuo ^a   Ikeda, Takayuki ^c   Iwai, Kunihisa ^b  

^a Limited   (Japan)

^b AOMORI UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^c FUJI WOMEN'S UNIVERSITY   (Japan)

Author keywords

Absorption; Degree of methylation; Pectin; Quercetin

Indexed keywords

APPLE PECTIN; DRUG METABOLITE; FLAVONE DERIVATIVE; ISORHAMNETIN; PECTIN; QUERCETIN; TAMARIXETIN; UNCLASSIFIED DRUG; 3-METHYLQUERCETIN; ANTIOXIDANT; DISACCHARIDE; GASTROINTESTINAL AGENT;

ADULT; ARTICLE; BEVERAGE; CHEMICAL PARAMETERS; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEGREE OF METHYLATION; DOSE RESPONSE; DRUG ABSORPTION; DRUG METABOLISM; DRUG URINE LEVEL; FLUID INTAKE; FOOD DRUG INTERACTION; HUMAN; HUMAN EXPERIMENT; MALE; METHYLATION; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; URINALYSIS; VISCOSITY; ANALOGS AND DERIVATIVES; CHEMISTRY; CLINICAL TRIAL; COMPARATIVE STUDY; DIET SUPPLEMENTATION; FRUIT; HYDROLYSIS; INTESTINE ABSORPTION; MALUS; METABOLISM; UPREGULATION; URINARY EXCRETION; URINE;

MALUS X DOMESTICA; RATTUS;

ADULT; ANTIOXIDANTS; BEVERAGES; CROSS-OVER STUDIES; DIETARY SUPPLEMENTS; DISACCHARIDES; FRUIT; GASTROINTESTINAL AGENTS; HUMANS; HYDROLYSIS; INTESTINAL ABSORPTION; MALE; MALUS; METHYLATION; PECTINS; QUERCETIN; RENAL ELIMINATION; UP-REGULATION; VISCOSITY;

EID: 84929836276     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114515000537     Document Type: Article

References (38)

1. Hertog MG, Hollman PC, Katan MB, et al. (1993) Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands. Nutr Cancer 20, 21-29.
2. Hertog MG, Kromhout D, Aravanis C, et al. (1995) Flavonoids intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Intern Med 155, 381-386.
3. Scalbert A & Williamson G (2000) Dietary intake and bioavailability of polyphenols. J Nutr 130, 2073S-2085S.
4. Zubik L & Meydani M (2003) Bioavailability of soybean isoflavones from aglycone and glucoside form in American women. Am J Clin Nutr 77, 1459-1465.
5. Bravo L (1998) Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev 56, 317-333.
6. Manach C, Williamson G, Morand C, et al. (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81, 230S-242S.
7. Tamura M, Hirayama K & Itoh K (2003) Role of intestinal flora on the metabolism, absorption, and biological activity of dietary flavonoids. Biosci Microflora 22, 125-131.
8. Setchell KD, Brown NM, Zimmer-Nechemias L, et al. (2002) Evidence for lack of absorption of soy isoflavone glycosides in human, supporting the crucial role of intestinal metabolism for bioavailability. Am J Clin Nutr 76, 447-453.
9. Day AJ, Gee JM, DuPont MS, et al. (2003) Absorption of quercetin-3-glucoside and quercetin-4′-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and sodium-dependent glucose transporter. Biochem Pharmacol 65, 1199-1206.
10. Konishi Y, Kobayashi S & Shimizu M (2003) Tea polyphenols inhibit the transport of dietary phenolic acids mediated by the monocarboxylic acid transporter (MCT) in intestinal Caco-2 cell monolayers. J Agric Food Chem 51, 7296-7302.
11. Azuma K, Ippoushi K, Ito H, et al. (2003) Enhancing effect of lipids and emulsifiers on the accumulation of quercetin metabolites in blood plasma after the short-term ingestion of onion by rats. Biosci Biotechnol Biochem 67, 2548-2555.
12. Lesser S, Cermak R & Wolffram S (2006) The fatty acid pattern of dietary fat influences the oral bioavailability of the flavonol quercetin in pigs. Br J Nutr 96, 1047-1052.
13. Matsumoto M, Matsukawa N, Chiji H, et al. (2007) Difructose anhydride III promotes absorption of the soluble flavonoid aG-rutin in rats. J Agric Food Chem 55, 4202-4208.
14. Matsumoto H, Ito K, Yonekura K, et al. (2007) Enhanced absorption of anthocyanins after oral administration of phytic acid in rats and human. J Agric Food Chem 55, 2489-2496.
15. Roura E, Andre's-Lacueva C, Estruch R, et al. (2008) The effects of milk as a food matrix for polyphenols on the excretion profile of cocoa (-)-epicatechin metabolites in healthy human subjects. Br J Nutr 100, 846-851.
16. Basu TK & Ooraikul B (1995) Lipid-lowering effects of dietary fiber. J Clin Biochem Nutr 18, 1-9.
17. González M, Rivas C, Caride B, et al. (1998) Effects of orange and apple pectin on cholesterol concentration in serum, liver and faeces. J Physiol Biochem 54, 99-104.
18. Fleming SE & Lee B (1983) Growth performance and intestinal transit time of rats fed purified and natural dietary fibers. J Nutr 113, 592-601.
19. Dongowski G, Lorenz A & Proll J (2002) The degree of methylation influences the degradation of pectin in the intestinal tract of rats and in vitro. J Nutr 132, 1935-1944.
20. Nishijima T, Iwai K, Saito Y, et al. (2009) Chronic ingestion of apple pectin can enhance the absorption of quercetin. J Agric Food Chem 57, 2583-2587.
21. Fernandez M (1995) Distinct mechanisms of plasma LDL lowering by dietary fiber in the guinea pig: specific effects of pectin, guar gum, and psyllium. J Lipid Res 36, 2394-2404.
22. Hexeberg S, Hexeberg E, Willumsen N, et al. (1994) A study on lipid metabolism in heart and liver of cholesterol-and pectin-fed rats. Br J Nutr 71, 181-192.
23. Petri N, Tannergren C, Holst B, et al. (2003) Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo. Drug Metab Dispos 31, 805-813.
24. Hollman PCH (2004) Absorption, bioavailability, and metabolism of flavonoids. Pharm Biol 42, 74-83.
25. Hollman PCH, van Trijp JMP, Buysman MNCP, et al. (1997) Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man. FEBS Lett 418, 152-156.
26. Murota K & Terao J (2003) Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism. Arch Biochem Biophys 417, 12-17.
27. Williamson G, Barron D, Shimoi K, et al. (2005) In vitro biological properties of flavonoid conjugates found in vivo. Free Radic Res 39, 457-469.
28. Yamamoto N, Moon JH, Tsushida T, et al. (1999) Inhibitory effect of quercetin metabolites and their related derivatives on copper ion-induced lipid peroxidation in human lowdensity lipoprotein. Arch Biochem Biophys 372, 347-354.
29. Moon JH, Tsushida T, Nakahara K, et al. (2001) Identification of quercetin 3-O-b-D-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin. Free Radic Biol Med 30, 1274-1285.
30. Rock CL & Swendseid ME (1992) Plasma b-carotene response in humans after meals supplemented with dietary pectin. Am J Clin Nutr 55, 96-99.
31. Thakur BR, Singh RK & Handa AK (1997) Chemistry and uses of pectin - a review. Crit Rev Food Sci Nutr 37, 47-73.
32. Flourie B, Vidon N, Florent CH, et al. (1984) Effect of pectin on jejunal glucose absorption and unstirred layer thickness in normal man. Gut 25, 936-941.
33. Hyun SA, Vahouny GV & Treadwell CR (1963) Effect of hypocholesterolemic agents on intestinal cholesterol absorption. Proc Soc Exp Biol Med 112, 496-501.
34. Hollands WJ, Hart DJ, Dainty JR, et al. (2013) Bioavailability of epicatechin and effects on nitric oxide metabolites of an apple flavanol-rich extract supplemented beverage compared to a whole apple puree: a randomized, placebocontrolled, crossover trial. Mol Nutr Food Res 57, 1209-1217.
35. Aprikian O, Duclos V, Guyot S, et al. (2003) Apple pectin and a polyphenol-rich apple concentrate are more effective together than separately on cecal fermentations and plasma lipids in rats. J Nutr 133, 1860-1865.
36. Schneeman BO (1986) Dietary fiber: physical and chemical properties, methods of analysis and physiological effects. Food Technol 40, 104-116.
37. Thanou M, Verhoef JC & Junginger HE (2001) Chitosan and its derivatives as intestinal absorption enhancers. Adv Drug Deliv Rev 50, 91-101.
38. Graf BA, Ameho C, Dolnikowski GG, et al. (2006) Rat gastrointestinal tissues metabolize quercetin. J Nutr 136, 39-44.