Bioavailability of soybean isoflavones from aglycone and glucoside forms in American women

American Journal of Clinical Nutrition

Volumn 77, Issue 6, 2003, Pages 1459-1465

  Zubik, Ligia ^a   Meydani, Mohsen ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

Aglycone; Daidzein; Equol; Genistein; Glucoside; Isoflavones

Indexed keywords

DAIDZEIN; EQUOL; GENISTEIN; GLUCOSIDE; ISOFLAVONE; CHROMAN DERIVATIVE; ISOFLAVONE DERIVATIVE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; BLOOD SAMPLING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; INTESTINE FLORA; RANDOMIZED CONTROLLED TRIAL; SEX ROLE; SOYBEAN; STATISTICAL SIGNIFICANCE; UNITED STATES; CHEMISTRY; COMPARATIVE STUDY; MIDDLE AGED; TIME;

GLYCINE MAX;

ADULT; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHROMANS; DOUBLE-BLIND METHOD; FEMALE; GENISTEIN; HUMANS; ISOFLAVONES; MIDDLE AGED; SOYBEANS; TIME FACTORS; UNITED STATES;

EID: 0037901956     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/77.6.1459     Document Type: Article

References (32)

1. Barnes S, Kirk M, Coward L. Isoflavones and their conjugates in soy foods: extraction conditions and analysis by HPL-mass spectrometry. J Agric Food Chem 1994;42:2466-74.
2. Wang HJ, Murphy PA. Isoflavone content in commercial soybean foods. J Agric Food Chem 1994;42:1666-73.
3. Adlercreutz H. Western diet and Western diseases: some hormonal and biochemical mechanisms and associations. Scand J Clin Lab Invest 1990;201:3-23.
4. Booth C, Hargreaves DF, Hadfield JA, McGown AT, Potten CS. Isoflavones inhibit intestinal epithelial cell proliferation and induce apoptosis in vitro. Br J Cancer 1999;80:1550-7.
5. Messina M, Barnes S, Setchell KD. Phyto-oestrogens and breast cancer. Lancet 1997;350:971-2.
6. Adlercreutz H, Mazur W. Phyto-oestrogens and Western diseases. Ann Med 1997;29:95-120.
7. Setchell KD. Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. Am J Clin Nutr 1998;68(suppl):1333S-46S.
8. Setchell KD, Cassidy A. Dietary isoflavones: biological effects and relevance to human health. J Nutr 1999;129:758S-67S.
9. US Department of Agriculture. Database on the isoflavone content of foods. 1999. Internet: http://www.nal.usda.gov/fnic/foodcomp/Data/ isoflav/isoflav.html (accessed 28 February 2003).
10. Xu X, Wang HJ, Murphy PA, Hendrich S. Neither background diet nor type of soy food affects short-term isoflavone bioavailability in women. J Nutr 2000;130:798-801.
11. King RA, Broadbent JL, Head RJ. Absorption and excretion of the soy isoflavone genistein in rats. J Nutr 1996;126:176-82.
12. Piskula MK, Yamakoshi J, Iwai Y. Daidzein and genistein but not their glucosides are absorbed from the rat stomach. FEBS Lett 1999;447: 287-91.
13. Piskula MK. Soy isoflavone conjugation differs in fed and food-deprived rats. J Nutr 2000;130:1766-71.
14. Xu X, Wang HJ, Murphy PA, Cook L, Hendrich S. Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women. J Nutr 1994;124:825-32.
15. Xu X, Harris KS, Wang HJ, Murphy PA, Hendrich S. Bioavailability of soybean isoflavones depends upon gut microflora in women. J Nutr 1995;125:2307-15.
16. Hutchins AM, Slavin JL, Lampe JW. Urinary isoflavonoid phytoestrogen and lignan excretion after consumption of fermented and unfermented soy products. J Am Diet Assoc 199;95:545-51.
17. Franke AA, Custer LJ. Daidzein and genistein concentrations in human milk after soy consumption. Clin Chem 1996;42:955-64.
18. Izumi T, Piskula MK, Osawa S, et al. Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humans. J Nutr 2000;130:1695-9.
19. Setchell KD, Borriello SP, Hulme P, Kirk DN, Axelson M. Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent disease. Am J Clin Nutr 1984;40:569-78.
20. Ioku K, Pongpiriyadacha Y, Konishi Y, Takei Y, Nakatani N, Terao J. beta-Glucosidase activity in the rat small intestine toward quercetin monoglucosides. Biosci Biotechnol Biochem 1998;62:1428-31
21. Day AJ, DuPont MS, Ridley S, et al. Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity. FEBS Lett 1998;436:71-5
22. Lampe JW, Karr SC, Hutchins AM, Slavin JL. Urinary equol excretion with a soy challenge: influence of habitual diet. Proc Soc Exp Biol Med 1998;217:335-9.
23. Lampe JW, Skor HE, Li S, Wahala K, Howald WN, Chen C Wheat bran and soy protein feeding do not alter urinary excretion of the isoflavan equol in premenopausal women J Nutr 2001;131:740-4.
24. Joannou GE, Kelly GE, Reeder AY, Waring M, Nelson C. A urinary profile study of dietary phytoestrogens. The identification and mode of metabolism of new isoflavonoids. J Steroid Biochem Mol Biol 1995;54:167-84.
25. Kurzer MS, Xu X. Dietary phytoestrogens. Annu Rev Nutr 1997;17: 353-81.
26. Setchell KD, Brown NM, Desai P, et al. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements J Nutr 2001;131:1362S-75S.
27. Richelle M, Pridmore-Merten S, Bodenstab S, Enslen M, Offord EA. Hydrolysis of isoflavone glycosides to aglycones by beta-glycosidase does not alter plasma and urine isoflavone pharmacokinetics in postmenopausal women. Third International Symposium on the Role of Soy in Preventing and Treating Chronic Disease. J Nutr 2002;132: 2587-92.
28. Kelly GE, Joannou GE, Reeder AY, Nelson C, Waring MA. The variable metabolic response to dietary isoflavones in humans. Proc Soc Exp Biol Med 1995;208:40-3.
29. Coward L, Barnes NC, Setchell KDR, Barnes S. Genistein and daidzein, and their β-glucosides conjugates: anti-tumor isoflavones in soy bean foods from American and Asian diets. J Agric Food Chem 1993;41:1961-7.
30. Kuhnau J. The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev Nutr Diet 1976;24:117-91.
31. King RA, Bursill DB. Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans. Am J Clin Nutr 1998;67:867-72.
32. Adlercreutz H, Fotsis T, Lampe J, et al. Quantitative determination of lignans and isoflavonoids in plasma of omnivorous and vegetarian women by isotope dilution gas chromatography-mass spectrometry. Scand J Clin Lab Invest 1993;215:5-18.