Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development

Human Molecular Genetics

Volumn 24, Issue 10, 2015, Pages 2808-2825

  Cunningham, David ^a   DeBarber, Andrea E ^b   Bir, Natalie ^a   Binkley, Laura ^a   Merkens, Louise S ^c   Steiner, Robert D ^c,d,e   Herman, Gail E ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^e UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; SONIC HEDGEHOG PROTEIN; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; NSDHL PROTEIN, MOUSE;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; CELL DEATH; CEREBELLUM CORTEX; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CULTURE MEDIUM; GRANULE CELL; INTELLECTUAL IMPAIRMENT; MALE; MOUSE; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHENOTYPE; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PURKINJE CELL; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; FEMALE; GENETICS; GROWTH, DEVELOPMENT AND AGING; MUTATION; NEURAL STEM CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ERINACEIDAE; MUS;

3-HYDROXYSTEROID DEHYDROGENASES; ALLELES; ANIMALS; CEREBELLAR CORTEX; CHOLESTEROL; FEMALE; HEDGEHOG PROTEINS; MALE; MICE; MICE, TRANSGENIC; MUTATION; NEURAL STEM CELLS; NEURONS; SIGNAL TRANSDUCTION;

EID: 84929832466     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv042     Document Type: Article

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