Cholesterol metabolism is required for intracellular Hedgehog signal transduction in vivo

PLoS Genetics

Volumn 7, Issue 9, 2011, Pages

  Stottmann, Rolf W ^a,d   Turbe Doan, Annick ^a   Tran, Pamela ^a   Kratz, Lisa E ^b   Moran, Jennifer L ^c   Kelley, Richard I ^b   Beier, David R ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; CHOLESTEROL; HYDROXYSTEROID (17 BETA) DEHYDROGENASE 7; OXYSTEROL; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; STEROL; UNCLASSIFIED DRUG; 3 (OR 17) BETA HYDROXYSTEROID DEHYDROGENASE; 3 (OR 17)-BETA-HYDROXYSTEROID DEHYDROGENASE; ETHYLNITROSOUREA; G PROTEIN COUPLED RECEPTOR; HYDROXYSTEROID DEHYDROGENASE; SMO PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; EMBRYO; FIBROBLAST; GENE; GENE INDUCTION; GENE TARGETING; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MOUSE; MOUSE EMBRYO; MOUSE MUTANT; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHENOTYPE; PROTEIN FUNCTION; RUDOLPH GENE; ANIMAL; BONE DEVELOPMENT; CONGENITAL MALFORMATION; FOREBRAIN; GENETICS; METABOLISM; MUTAGENESIS; MUTATION; SIGNAL TRANSDUCTION;

ERINACEIDAE;

17-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; BONE DEVELOPMENT; CHOLESTEROL; ETHYLNITROSOUREA; HEDGEHOG PROTEINS; MICE; MICE, MUTANT STRAINS; MUTAGENESIS; MUTATION; PROSENCEPHALON; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 80053453979     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002224     Document Type: Article

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