-
1
-
-
75949101396
-
Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562
-
Chan KT, Li K, Liu SL, Chu KH, Toh M, Xie WD. Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562. Cancer Lett 2010;289:46-52.
-
(2010)
Cancer Lett
, vol.289
, pp. 46-52
-
-
Chan, K.T.1
Li, K.2
Liu, S.L.3
Chu, K.H.4
Toh, M.5
Xie, W.D.6
-
2
-
-
78649763564
-
Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway
-
Dong Y, Lu B, Zhang X, Zhang J, Lai L, Li D, Wu Y, Song Y, Luo J, Pang X, Yi Z, Liu M. Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway. Carcinogenesis 2010;31:2097-104.
-
(2010)
Carcinogenesis
, vol.31
, pp. 2097-2104
-
-
Dong, Y.1
Lu, B.2
Zhang, X.3
Zhang, J.4
Lai, L.5
Li, D.6
Wu, Y.7
Song, Y.8
Luo, J.9
Pang, X.10
Yi, Z.11
Liu, M.12
-
3
-
-
0031439364
-
Anti-inflammatory and analgesic effects of cucurbitacins from Wilbrandia ebracteata
-
Peters RR, Farias MR, Ribeiro-do-Valle RM. Anti-inflammatory and analgesic effects of cucurbitacins from Wilbrandia ebracteata. Planta Med 1997;63:525-8.
-
(1997)
Planta Med
, vol.63
, pp. 525-528
-
-
Peters, R.R.1
Farias, M.R.2
Ribeiro-Do-Valle, R.M.3
-
4
-
-
0030598398
-
Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells
-
Duncan KL, Duncan MD, Alley MC, Sausville EA. Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells. Biochem Pharmacol 1996;52:1553-60.
-
(1996)
Biochem Pharmacol
, vol.52
, pp. 1553-1560
-
-
Duncan, K.L.1
Duncan, M.D.2
Alley, M.C.3
Sausville, E.A.4
-
5
-
-
80054889550
-
Anti-inflammatory activities of cucurbitacin e isolated from Citrullus lanatus var
-
Abdelwahab SI, Hassan LE, Sirat HM, Yagi SM, Koko WS, Mohan S, Taha MM, Ahmad S, Chuen CS, Narrima P, Rais MM, Hadi AH. Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: role of reactive nitrogen species and cyclooxygenase enzyme inhibition. Fitoterapia 2011;82:1190-7.
-
(2011)
Citroides: Role of Reactive Nitrogen Species and Cyclooxygenase Enzyme Inhibition. Fitoterapia
, vol.82
, pp. 1190-1197
-
-
Abdelwahab, S.I.1
Hassan, L.E.2
Sirat, H.M.3
Yagi, S.M.4
Koko, W.S.5
Mohan, S.6
Taha, M.M.7
Ahmad, S.8
Chuen, C.S.9
Narrima, P.10
Rais, M.M.11
Hadi, A.H.12
-
6
-
-
40949123149
-
Activation of innate immunity system during aging: NF-κB signaling is the molecular culprit of inflamm-aging
-
Salminen A, Huuskonen J, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. Activation of innate immunity system during aging: NF-κB signaling is the molecular culprit of inflamm-aging. Ageing Res Rev 2008;7:83-105.
-
(2008)
Ageing Res Rev
, vol.7
, pp. 83-105
-
-
Salminen, A.1
Huuskonen, J.2
Ojala, J.3
Kauppinen, A.4
Kaarniranta, K.5
Suuronen, T.6
-
7
-
-
0022930702
-
Inducibility of K immunoglobulin enhancerbinding protein NF-κB by a posttranslational mechanism
-
Sen R, Baltimore D. Inducibility of K immunoglobulin enhancerbinding protein NF-κB by a posttranslational mechanism. Cell 1986;47:921-8.
-
(1986)
Cell
, vol.47
, pp. 921-928
-
-
Sen, R.1
Baltimore, D.2
-
8
-
-
79956128665
-
NF-κB a network hub controlling immunity, inflammation, and cancer: A subject collection from Cold Spring Harbor perspectives in biology
-
Cold Spring Harbor Laboratory Press, NY
-
Karin M, Staudt L. NF-κB a network hub controlling immunity, inflammation, and cancer: a subject collection from Cold Spring Harbor perspectives in biology. Cold Spring Harbor, Cold Spring Harbor Laboratory Press, NY; 2010. viii, p 271.
-
(2010)
Cold Spring Harbor
, vol.8
, pp. 271
-
-
Karin, M.1
Staudt, L.2
-
9
-
-
25844459154
-
NF kappa B: Linking inflammation and immunity to cancer development and progression
-
Karin M, Greten FR. NF kappa B: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005;5:749-59.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 749-759
-
-
Karin, M.1
Greten, F.R.2
-
11
-
-
79954566704
-
Cucurbitacin B suppresses the transactivation activity of RelA/p65
-
Jin HR, Jin X, Dat NT, Lee JJ. Cucurbitacin B suppresses the transactivation activity of RelA/p65. J Cell Biochem 2011;112: 1643-50.
-
(2011)
J Cell Biochem
, vol.112
, pp. 1643-1650
-
-
Jin, H.R.1
Jin, X.2
Dat, N.T.3
Lee, J.J.4
-
12
-
-
79960122371
-
Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells
-
Zhang Y, Ouyang D, Xu L, Ji Y, Zha Q, Cai J, He X. Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells. Acta Biochim Biophys Sin 2011;43:556-67.
-
(2011)
Acta Biochim Biophys Sin
, vol.43
, pp. 556-567
-
-
Zhang, Y.1
Ouyang, D.2
Xu, L.3
Ji, Y.4
Zha, Q.5
Cai, J.6
He, X.7
-
13
-
-
79960122371
-
Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells
-
Zhang YT, Ouyang DY, Xu LH, Ji YH, Zha QB, Cai JY, He XH. Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells. Acta Biochim Biophys Sin 2011;43:556-67.
-
(2011)
Acta Biochim Biophys Sin
, vol.43
, pp. 556-567
-
-
Zhang, Y.T.1
Ouyang, D.Y.2
Xu, L.H.3
Ji, Y.H.4
Zha, Q.B.5
Cai, J.Y.6
He, X.H.7
-
14
-
-
79958260109
-
Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment
-
Ouyang D, Zhang Y, Xu L, Li J, Zha Q, He X. Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment. Acta Biochim Biophys Sin 2011;43: 487-95.
-
(2011)
Acta Biochim Biophys Sin
, vol.43
, pp. 487-495
-
-
Ouyang, D.1
Zhang, Y.2
Xu, L.3
Li, J.4
Zha, Q.5
He, X.6
-
15
-
-
0031127782
-
Cucurbitacin e targets proliferating endothelia
-
Duncan MD, Duncan KL. Cucurbitacin E targets proliferating endothelia. J Surg Res 1997;69:55-60.
-
(1997)
J Surg Res
, vol.69
, pp. 55-60
-
-
Duncan, M.D.1
Duncan, K.L.2
-
16
-
-
0037427563
-
Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana
-
Jayaprakasam B, Seeram NP, Nair MG. Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana. Cancer Lett 2003;189:11-6.
-
(2003)
Cancer Lett
, vol.189
, pp. 11-16
-
-
Jayaprakasam, B.1
Seeram, N.P.2
Nair, M.G.3
-
17
-
-
0027146488
-
Pyrrolidine dithiocarbamate inhibits NF-κB mobilization and TNF production in human monocytes
-
Ziegler-Heitbrock H, Sternsdorf T, Liese J, Belohradsky B, Weber C, Wedel A, Schreck R, Bauerle P, Strobel M. Pyrrolidine dithiocarbamate inhibits NF-κB mobilization and TNF production in human monocytes. J Immunol 1993;151:6986-93.
-
(1993)
J Immunol
, vol.151
, pp. 6986-6993
-
-
Ziegler-Heitbrock, H.1
Sternsdorf, T.2
Liese, J.3
Belohradsky, B.4
Weber, C.5
Wedel, A.6
Schreck, R.7
Bauerle, P.8
Strobel, M.9
-
18
-
-
1342285692
-
Tumor necrosis factor: An apoptosis JuNKie?
-
Varfolomeev EE, Ashkenazi A. Tumor necrosis factor: an apoptosis JuNKie? Cell. 2004;116:491-7.
-
(2004)
Cell
, vol.116
, pp. 491-497
-
-
Varfolomeev, E.E.1
Ashkenazi, A.2
-
19
-
-
77950864226
-
Cucurbitacin e as a new inhibitor of cofilin phosphorylation in human leukemia U937 cells
-
Nakashima S, Matsuda H, Kurume A, Oda Y, Nakamura S, Yamashita M, Yoshikawa M. Cucurbitacin E as a new inhibitor of cofilin phosphorylation in human leukemia U937 cells. Bioorg Med Chem Lett 2010;20:2994-7.
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 2994-2997
-
-
Nakashima, S.1
Matsuda, H.2
Kurume, A.3
Oda, Y.4
Nakamura, S.5
Yamashita, M.6
Yoshikawa, M.7
-
20
-
-
84868087963
-
Eggert US
-
Sorensen PM, Iacob RE, Fritzsche M, Engen JR, Brieher WM, Charras G. Eggert US. ACS Chem Biol: The natural product cucurbitacin E inhibits depolymerization of actin filaments; 2012.
-
(2012)
ACS Chem Biol: The Natural Product Cucurbitacin e Inhibits Depolymerization of Actin Filaments
-
-
Sorensen, P.M.1
Iacob, R.E.2
Fritzsche, M.3
Engen, J.R.4
Brieher, W.M.5
Charras, G.6
-
21
-
-
37549072685
-
Direct interaction of Cucurbitacin e isolated from Alsomitra macrocarpa to actin filament
-
Momma K, Masuzawa Y, Nakai N, Chujo M, Murakami A, Kioka N, Kiyama Y, Akita T, Nagao M. Direct interaction of Cucurbitacin E isolated from Alsomitra macrocarpa to actin filament. Cytotechnology 2008;56:33-9.
-
(2008)
Cytotechnology
, vol.56
, pp. 33-39
-
-
Momma, K.1
Masuzawa, Y.2
Nakai, N.3
Chujo, M.4
Murakami, A.5
Kioka, N.6
Kiyama, Y.7
Akita, T.8
Nagao, M.9
-
22
-
-
84863057259
-
Cucurbitacin e induces G(2)/M phase arrest through STAT3/p53/p21 signaling and provokes apoptosis via Fas/CD95 and mitochondria-dependent pathways in human bladder cancer T24 cells
-
Huang WW, Yang JS, Lin MW, Chen PY, Chiou SM, Chueh FS, Lan YH, Pai SJ, Tsuzuki M, Ho WJ, Chung JG. Cucurbitacin E induces G(2)/M phase arrest through STAT3/p53/p21 signaling and provokes apoptosis via Fas/CD95 and mitochondria-dependent pathways in human bladder cancer T24 cells. Evid Based Complement Alternat Med 2012;2012:952762.
-
(2012)
Evid Based Complement Alternat Med
, vol.2012
, pp. 952762
-
-
Huang, W.W.1
Yang, J.S.2
Lin, M.W.3
Chen, P.Y.4
Chiou, S.M.5
Chueh, F.S.6
Lan, Y.H.7
Pai, S.J.8
Tsuzuki, M.9
Ho, W.J.10
Chung, J.G.11
-
23
-
-
77949356144
-
The induction of G2/M cell-cycle arrest and apoptosis by cucurbitacin e is associated with increased phosphorylation of eIF2a in leukemia cells
-
Li Y, Wang R, Ma E, Deng Y, Wang X, Xiao J, Jing Y. The induction of G2/M cell-cycle arrest and apoptosis by cucurbitacin E is associated with increased phosphorylation of eIF2a in leukemia cells. Anticancer Drugs 2010;21:389-400.
-
(2010)
Anticancer Drugs
, vol.21
, pp. 389-400
-
-
Li, Y.1
Wang, R.2
Ma, E.3
Deng, Y.4
Wang, X.5
Xiao, J.6
Jing, Y.7
-
24
-
-
0024405827
-
The biology of cachectin/TNF-A primary mediator of the host response
-
Beutler B, Cerami A. The biology of cachectin/TNF-a primary mediator of the host response. Ann Rev Immunol 1989;7:625-55.
-
(1989)
Ann Rev Immunol
, vol.7
, pp. 625-655
-
-
Beutler, B.1
Cerami, A.2
-
25
-
-
53049104824
-
TLR-4, IL-1R and TNF-R signaling to NF-κB: Variations on a common theme
-
Verstrepen L, Bekaert T, Chau TL, Tavernier J, Chariot A, Beyaert R. TLR-4, IL-1R and TNF-R signaling to NF-κB: variations on a common theme. Cell Mol Life Sci 2008;65:2964-78.
-
(2008)
Cell Mol Life Sci
, vol.65
, pp. 2964-2978
-
-
Verstrepen, L.1
Bekaert, T.2
Chau, T.L.3
Tavernier, J.4
Chariot, A.5
Beyaert, R.6
-
26
-
-
77952488171
-
Dynamic cross-talk analysis among TNF-R, TLR-4 and IL-1R signalings in TNF-A-induced inflammatory responses
-
Yang SK, Wang YC, Chao CC, Chuang YJ, Lan CY, Chen BS. Dynamic cross-talk analysis among TNF-R, TLR-4 and IL-1R signalings in TNF-α-induced inflammatory responses. BMC Med Genomics 2010;3:19.
-
(2010)
BMC Med Genomics
, vol.3
, pp. 19
-
-
Yang, S.K.1
Wang, Y.C.2
Chao, C.C.3
Chuang, Y.J.4
Lan, C.Y.5
Chen, B.S.6
-
27
-
-
79957500051
-
Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264.7 macrophages by inhibiting STAT3-mediated suppression of the NF-kappaB pathway
-
Lee KC, Chang HH, Chung YH, Lee TY. Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264.7 macrophages by inhibiting STAT3-mediated suppression of the NF-kappaB pathway. J Ethnopharmacol 2011;135:678-84.
-
(2011)
J Ethnopharmacol
, vol.135
, pp. 678-684
-
-
Lee, K.C.1
Chang, H.H.2
Chung, Y.H.3
Lee, T.Y.4
-
28
-
-
0031172065
-
NF-κB: A crucial transcription factor for glial and neuronal cell function
-
O'Neill LAJ, Kaltschmidt C. NF-κB: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci 1997;20: 252-8.
-
(1997)
Trends Neurosci
, vol.20
, pp. 252-258
-
-
O'Neill, L.A.J.1
Kaltschmidt, C.2
-
29
-
-
62449332148
-
Stimulated nuclear translocation of NF-κB and shuttling differentially depend on dynein and the dynactin complex
-
Shrum CK, Defrancisco D, Meffert MK. Stimulated nuclear translocation of NF-κB and shuttling differentially depend on dynein and the dynactin complex. Proc Natl Acad Sci USA 2009;106:2647-52.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 2647-2652
-
-
Shrum, C.K.1
Defrancisco, D.2
Meffert, M.K.3
-
30
-
-
0028964437
-
Cytoskeletal control of gene expression: Depolymerization of microtubules activates NF-kappa B
-
Rosette C, Karin M. Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B. J Cell Biol 1995;128:1111-9.
-
(1995)
J Cell Biol
, vol.128
, pp. 1111-1119
-
-
Rosette, C.1
Karin, M.2
-
31
-
-
35048812999
-
NF-κB activation as a key mechanism in ethanol-induced disruption of the F-actin cytoskeleton and monolayer barrier integrity in intestinal epithelium
-
Banan A, Keshavarzian A, Zhang L, Shaikh M, Forsyth C, Tang Y, Fields J. NF-κB activation as a key mechanism in ethanol-induced disruption of the F-actin cytoskeleton and monolayer barrier integrity in intestinal epithelium. Alcohol 2007;41:447-60.
-
(2007)
Alcohol
, vol.41
, pp. 447-460
-
-
Banan, A.1
Keshavarzian, A.2
Zhang, L.3
Shaikh, M.4
Forsyth, C.5
Tang, Y.6
Fields, J.7
|