Cucurbitacin B inhibits the translational expression of hypoxia-inducible factor-1α

European Journal of Pharmacology

Volumn 723, Issue 1, 2014, Pages 46-54

  Ma, Juan ^a   Zi Jiang, Ying ^a   Shi, Hui ^a   Mi, Chunliu ^a   Li, Jing ^a   Xing Nan, Ji ^a   Wu, Xue ^a   Joon Lee, Jung ^a   Jin, Xuejun ^a  

^a YANBIAN UNIVERSITY   (China)

Author keywords

Antitumor activity; Cucurbitacin B; HIF 1 ; mTOR; Translation

Indexed keywords

ANTINEOPLASTIC AGENT; CUCURBITACIN B; ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; S6 KINASE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ERYTHROPOIETIN GENE; FEMALE; HUMAN; HUMAN CELL; MALIGNANT NEOPLASTIC DISEASE; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; TRANSLATION REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR GENE;

ANTITUMOR ACTIVITY; CUCURBITACIN B; HIF-1Α; MTOR; TRANSLATION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MAP KINASE SIGNALING SYSTEM; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASMS; RNA, MESSENGER; TOR SERINE-THREONINE KINASES; TRITERPENES; TUMOR BURDEN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84890828864     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.12.005     Document Type: Article

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