메뉴 건너뛰기




Volumn 6, Issue 6, 2010, Pages 784-793

A reporter cell system to monitor autophagy based on p62/SQSTM1

Author keywords

Autophagy reporter; Flow cytometry; Inducible expression; LC3; NBR1; p62

Indexed keywords

ALPHA ACTIN; AMINO ACID; GREEN FLUORESCENT PROTEIN LC3B FUSION PROTEIN; GREEN FLUORESCENT PROTEIN NBR1 FUSION PROTEIN; GREEN FLUORESCENT PROTEIN P62 FUSION PROTEIN; HYBRID PROTEIN; MEMBRANE PROTEIN; PHOSPHOTRANSFERASE; PROTEIN ATG8; PROTEIN GABARAP; PROTEIN LC3; PROTEIN MAP1; PROTEIN NBR1; PROTEIN P62; PROTEIN SQSTM1; PROTEIN ULK1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 77955863456     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.6.6.12510     Document Type: Article
Times cited : (130)

References (33)
  • 1
    • 34848886914 scopus 로고    scopus 로고
    • Autophagosome formation: Core machinery and adaptations
    • DOI 10.1038/ncb1007-1102, PII NCB1007-1102
    • Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol 2007;9:1102-9. (Pubitemid 47500484)
    • (2007) Nature Cell Biology , vol.9 , Issue.10 , pp. 1102-1109
    • Xie, Z.1    Klionsky, D.J.2
  • 2
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • DOI 10.1038/nature06639, PII NATURE06639
    • Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451:1069-75. (Pubitemid 351317450)
    • (2008) Nature , vol.451 , Issue.7182 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 3
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19:5720-8.
    • (2000) EMBO J , vol.19 , pp. 5720-5728
    • Kabeya, Y.1    Mizushima, N.2    Ueno, T.3    Yamamoto, A.4    Kirisako, T.5    Noda, T.6
  • 5
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132:27-42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 6
    • 33745751085 scopus 로고    scopus 로고
    • Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
    • Liang C, Feng P, Ku B, Dotan I, Canaani D, Oh BH, Jung JU. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol 2006; 8:688-99.
    • (2006) Nat Cell Biol , vol.8 , pp. 688-699
    • Liang, C.1    Feng, P.2    Ku, B.3    Dotan, I.4    Canaani, D.5    Oh, B.H.6    Jung, J.U.7
  • 11
    • 57049186623 scopus 로고    scopus 로고
    • How to live long and prosper: Autophagy, mitochondria and aging
    • Bethesda
    • Yen WL, Klionsky DJ. How to live long and prosper: autophagy, mitochondria and aging. Physiology (Bethesda) 2008; 23:248-62.
    • (2008) Physiology , vol.23 , pp. 248-262
    • Yen, W.L.1    Klionsky, D.J.2
  • 14
    • 65549142204 scopus 로고    scopus 로고
    • A role for ubiquitin in selective autophagy
    • Kirkin V, McEwan DG, Novak I, Dikic I. A role for ubiquitin in selective autophagy. Mol Cell 2009;34:259-69.
    • (2009) Mol Cell , vol.34 , pp. 259-269
    • Kirkin, V.1    McEwan, D.G.2    Novak, I.3    Dikic, I.4
  • 16
    • 70350450808 scopus 로고    scopus 로고
    • The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria
    • Thurston TL, Ryzhakov G, Bloor S, von Muhlinen N, Randow F. The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin- coated bacteria. Nat Immunol 2009; 10:1215-21.
    • (2009) Nat Immunol , vol.10 , pp. 1215-1221
    • Thurston, T.L.1    Ryzhakov, G.2    Bloor, S.3    Von Muhlinen, N.4    Randow, F.5
  • 17
    • 70349634805 scopus 로고    scopus 로고
    • Identification of novel autophagy regulators by a luciferase-based assay for the kinetics of autophagic flux
    • Farkas T, Hoyer-Hansen M, Jaattela M. Identification of novel autophagy regulators by a luciferase-based assay for the kinetics of autophagic flux. Autophagy 2009; 5:1018-25.
    • (2009) Autophagy , vol.5 , pp. 1018-1025
    • Farkas, T.1    Hoyer-Hansen, M.2    Jaattela, M.3
  • 18
    • 47149091700 scopus 로고    scopus 로고
    • A pathway sensor for genome-wide screens of intracellular proteolytic cleavage
    • Ketteler R, Sun Z, Kovacks KF, He WW, Seed B. A pathway sensor for genome-wide screens of intracellular proteolytic cleavage. Genome Biol 2008; 9:1-11.
    • (2008) Genome Biol , vol.9 , pp. 1-11
    • Ketteler, R.1    Sun, Z.2    Kovacks, K.F.3    He, W.W.4    Seed, B.5
  • 19
    • 46849121421 scopus 로고    scopus 로고
    • Utilizing flow cytometry to monitor autophagy in living mammalian cells
    • Shvets E, Fass E, Elazar Z. Utilizing flow cytometry to monitor autophagy in living mammalian cells. Autophagy 2008; 4:621-8.
    • (2008) Autophagy , vol.4 , pp. 621-628
    • Shvets, E.1    Fass, E.2    Elazar, Z.3
  • 20
    • 27944504351 scopus 로고    scopus 로고
    • P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • DOI 10.1083/jcb.200507002
    • Bjorkoy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 2005; 171:603-14. (Pubitemid 41668720)
    • (2005) Journal of Cell Biology , vol.171 , Issue.4 , pp. 603-614
    • Bjorkoy, G.1    Lamark, T.2    Brech, A.3    Outzen, H.4    Perander, M.5    Overvatn, A.6    Stenmark, H.7    Johansen, T.8
  • 22
    • 50249122545 scopus 로고    scopus 로고
    • Quantitation of autophagy by luciferase release assay
    • Ketteler R, Seed B. Quantitation of autophagy by luciferase release assay. Autophagy 2008; 4:801-6.
    • (2008) Autophagy , vol.4 , pp. 801-806
    • Ketteler, R.1    Seed, B.2
  • 23
    • 34548077575 scopus 로고    scopus 로고
    • Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
    • Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 2007; 3:452-60. (Pubitemid 47293726)
    • (2007) Autophagy , vol.3 , Issue.5 , pp. 452-460
    • Kimura, S.1    Noda, T.2    Yoshimori, T.3
  • 24
    • 60849099049 scopus 로고    scopus 로고
    • A role for NBR1 in autophagosomal degradation of ubiquitinated substrates
    • Kirkin V, Lamark T, Sou YS, Bjorkoy G, Nunn JL, Bruun JA, et al. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell 2009; 33:505-16.
    • (2009) Mol Cell , vol.33 , pp. 505-516
    • Kirkin, V.1    Lamark, T.2    Sou, Y.S.3    Bjorkoy, G.4    Nunn, J.L.5    Bruun, J.A.6
  • 25
    • 18744428952 scopus 로고    scopus 로고
    • Lactacystin, a specific inhibitor of the proteasome, inhibits human platelet lysosomal cathepsin a-like enzyme
    • DOI 10.1006/bbrc.1997.6434
    • Ostrowska H, Wojcik C, Omura S, Worowski K. Lactacystin, a specific inhibitor of the proteasome, inhibits human platelet lysosomal cathepsin A-like enzyme. Biochem Biophys Res Com 1997; 234:729-32. (Pubitemid 27281187)
    • (1997) Biochemical and Biophysical Research Communications , vol.234 , Issue.3 , pp. 729-732
    • Ostrowska, H.1    Wojcik, C.2    Omura, S.3    Worowski, K.4
  • 27
    • 34548482499 scopus 로고    scopus 로고
    • SiRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy
    • DOI 10.1074/jbc.M703663200
    • Chan EY, Kir S, Tooze SA. siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy. J Biol Chem 2007; 282:25464-74. (Pubitemid 47372826)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.35 , pp. 25464-25474
    • Chan, E.Y.W.1    Kir, S.2    Tooze, S.A.3
  • 28
    • 77953530939 scopus 로고    scopus 로고
    • Investigating autophagy: Quantitative morphometric analysis using electron microscopy
    • Swanlund JM, Kregel KC, Oberley TD. Investigating autophagy: Quantitative morphometric analysis using electron microscopy. Autophagy 2010; 6:270-7.
    • (2010) Autophagy , vol.6 , pp. 270-277
    • Swanlund, J.M.1    Kregel, K.C.2    Oberley, T.D.3
  • 30
    • 35848967804 scopus 로고    scopus 로고
    • How to interpret LC3 immunoblotting
    • Mizushima N, Yoshimori T. How to interpret LC3 immunoblotting. Autophagy 2007; 3:542-5.
    • (2007) Autophagy , vol.3 , pp. 542-545
    • Mizushima, N.1    Yoshimori, T.2
  • 32
    • 66349135140 scopus 로고    scopus 로고
    • Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters
    • Ju JS, Miller SE, Jackson E, Cadwell K, Piwnica- Worms D, Weihl CC. Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters. Autophagy 2009; 5:511-9.
    • (2009) Autophagy , vol.5 , pp. 511-519
    • Ju, J.S.1    Miller, S.E.2    Jackson, E.3    Cadwell, K.4    Piwnica-Worms, D.5    Weihl, C.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.