Anti-proliferative effect of 23,24-dihydrocucurbitacin F on human prostate cancer cells through induction of actin aggregation and cofilin-actin rod formation

Cancer Chemotherapy and Pharmacology

Volumn 70, Issue 3, 2012, Pages 415-424

  Ren, Shuai ^a   Ouyang, Dong Yun ^a   Saltis, Mark ^b   Xu, Li Hui ^a   Zha, Qing Bing ^a   Cai, Ji Ye ^a   He, Xian Hui ^a  

^a JINAN UNIVERSITY   (China)

^b MSI   (United States)

Author keywords

Actin aggregation; Cell cycle; Cofilin; Cofilin actin rods; Dihydrocucurbitacin F; Prostate cancer

Indexed keywords

23,24 DIHYDROCUCURBITACIN F; ACTIN; COFILIN; COFILIN 1; CUCURBITACIN; CYCLIN A; G ACTIN; PROTEIN P21; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CONTROLLED STUDY; CYTOKINESIS; CYTOTOXICITY; DRUG DETERMINATION; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME REGULATION; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROTUBULE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN AGGREGATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEOMICS; TREATMENT RESPONSE;

ACTIN DEPOLYMERIZING FACTORS; ACTINS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CUCURBITACEAE; CUCURBITACINS; CYCLIN A; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOKINESIS; DOWN-REGULATION; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MALE; PROSTATIC NEOPLASMS; UP-REGULATION;

EID: 84866356540     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-012-1921-z     Document Type: Article

References (31)

1. Duncan KL, Duncan MD, Alley MC, Sausville EA (1996) Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells. Biochem Pharmacol 52:1553-1560 (Pubitemid 26375461)
2. Jayaprakasam B, Seeram NP, Nair MG (2003) Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana. Cancer Lett 189:11-16 (Pubitemid 35351514)
3. Haritunians T, Gueller S, Zhang L, Badr R, Yin D, Xing H, Fung MC, Koeffler HP (2008) Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells. Leuk Res 32:1366-1373
4. 2/M cell cycle arrest and apoptosis augment. Cancer Biol Ther 7:1243-1249
5. Yin D, Wakimoto N, Xing H, Lu D, Huynh T, Wang X, Black KL, Koeffler HP (2008) Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme. Int J Cancer 123:1364-1375
6. Lui VW, Yau DM, Wong EY, Ng YK, Lau CP, Ho Y, Chan JP, Hong B, Ho K, Cheung CS, Tsang CM, Tsao SW, Chan AT (2009) Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells. Carcinogenesis 30:2085-2094
7. Boykin C, Zhang G, Chen YH, Zhang RW, Fan XE, Yang WM, Lu Q (2011) Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation. Br J Cancer 104:781-789
8. Zhang Y, Ouyang D, Xu L, Ji Y, Zha Q, Cai J, He X (2011) Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells. Acta Biochim Biophys Sin (Shanghai) 43:556-567
9. 2/M cell-cycle arrest and mitochondriadependent apoptosis in human breast cancer cells (Bcap37). Cancer Lett 256:267-278 (Pubitemid 47418353)
10. 2/M cell-cycle arrest and apoptosis by cucurbitacin E is associated with increased phosphorylation of eIF2α in leukemia cells. Anticancer Drugs 21:389-400
11. 2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells. Mol Nutr Food Res 54:559-565
12. Ouyang D, Zhang Y, Xu L, Li J, Zha Q, He X (2011) Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment. Acta Biochim Biophys Sin (Shanghai) 43:487-495
13. Maloney KN, Fujita M, Eggert US, Schroeder FC, Field CM, Mitchison TJ, Clardy J (2008) Actin-aggregating cucurbitacins from Physocarpus capitatus. J Nat Prod 71:1927-1929
14. Chen W, Nieh S, Chen Y, Hsia K (1975) The structures of cucurbitacin IIa and IIb from Hemsleya amabilis. Acta Chim Sin 33:49-56
15. Wu J, Wu Y, Yang BB (2002) Anticancer activity of Hemsleya amabilis extract. Life Sci 71:2161-2170
16. Nakashima S, Matsuda H, Kurume A, Oda Y, Nakamura S, Yamashita M, Yoshikawa M (2010) Cucurbitacin E as a new inhibitor of cofilin phosphorylation in human leukemia U937 cells. Bioorg Med Chem Lett 20:2994-2997
17. Ouyang DY, Ji YH, Saltis M, Xu LH, Zhang YT, Zha QB, Cai JY, He XH (2011) Valproic acid synergistically enhances the cytotoxicity of gossypol in DU145 prostate cancer cells: an iTRAQ-based quantitative proteomic analysis. J Proteomics 74:2180-2193
18. Bamburg JR, Bernstein BW (2010) Roles of ADF/cofilin in actin polymerization and beyond. F1000 Biol Rep 2: 62
19. Huang TY, DerMardirossian C, Bokoch GM (2006) Cofilin phosphatases and regulation of actin dynamics. Curr Opin Cell Biol 18:26-31 (Pubitemid 43107604)
20. Besson A, Dowdy SF, Roberts JM (2008) CDK inhibitors: cell cycle regulators and beyond. Dev Cell 14:159-169 (Pubitemid 351189186)
21. Knecht DA, LaFleur RA, Kahsai AW, Argueta CE, Beshir AB, Fenteany G (2010) Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics. PLoS One 5:e14039
22. Huang TY, Minamide LS, Bamburg JR, Bokoch GM (2008) Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation. Dev Cell 15:691-703
23. Nishida E, Iida K, Yonezawa N, Koyasu S, Yahara I, Sakai H (1987) Cofilin is a component of intranuclear and cytoplasmic actin rods induced in cultured cells. Proc Natl Acad Sci USA 84:5262-5266
24. Bamburg JR, Bernstein BW, Davis RC, Flynn KC, Goldsbury C, Jensen JR, Maloney MT, Marsden IT, Minamide LS, Pak CW, Shaw AE, Whiteman I, Wiggan O (2010) ADF/Cofilin-actin rods in neurodegenerative diseases. Curr Alzheimer Res 7:241-250
25. Minamide LS, Striegl AM, Boyle JA, Meberg PJ, Bamburg JR (2000) Neurodegenerative stimuli induce persistent ADF/cofilinactin rods that disrupt distal neurite function. Nat Cell Biol 2:628-636
26. Cichon J, Sun C, Chen B, Jiang M, Chen XA, Sun Y, Wang Y, Chen G (2012) Cofilin aggregation blocks intracellular trafficking and induces synaptic loss in hippocampal neurons. J Biol Chem 287:3919-3929
27. Jang DH, Han JH, Lee SH, Lee YS, Park H, Lee SH, Kim H, Kaang BK (2005) Cofilin expression induces cofilin-actin rod formation and disrupts synaptic structure and function in Aplysia synapses. Proc Natl Acad Sci USA 102:16072-16077 (Pubitemid 41552869)
28. Davis RC, Marsden IT, Maloney MT, Minamide LS, Podlisny M, Selkoe DJ, Bamburg JR (2011) Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation. Mol Neurodegener 6:10
29. Mohapatra S, Chu B, Zhao X, Pledger WJ (2005) Accumulation of p53 and reductions in XIAP abundance promote the apoptosis of prostate cancer cells. Cancer Res 65:7717-7723 (Pubitemid 41297246)
30. Cox LS, Lane DP (1995) Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage. BioEssays 17:501-508
31. Harper JW, Elledge SJ, Keyomarsi K, Dynlacht B, Tsai LH, Zhang P, Dobrowolski S, Bai C, Connell-Crowley L, Swindell E, Fox MP, Wei N (1995) Inhibition of cyclin-dependent kinases by p21. Mol Biol Cell 6:387-400