Globular protein-coated paclitaxel nanosuspensions: Interaction mechanism, direct cytosolic delivery, and significant improvement in pharmacokinetics

Molecular Pharmaceutics

Volumn 12, Issue 5, 2015, Pages 1485-1500

  Li, Yongji ^a   Wu, Zhannan ^a   He, Wei ^a   Qin, Chao ^a   Yao, Jing ^a   Zhou, Jianping ^a   Yin, Lifang ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

cytosolic delivery; globular protein; nanosuspension; paclitaxel; pharmacokinetics; protein conformation changes; tumor therapy

Indexed keywords

CAVEOLIN; CD68 ANTIGEN; GLOBULAR PROTEIN; NANOCOATING; NANOMATERIAL; NANOPARTICLE; PACLITAXEL; PROTEIN;

ACIDITY; ALKALINITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CANCER GROWTH; CANCER SIZE; CELL PROLIFERATION; CELL VIABILITY; CIRCULATION TIME; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DENATURATION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG STABILITY; DRUG SYNTHESIS; ELIMINATION RATE CONSTANT; ENDOCYTOSIS; HALF LIFE TIME; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LIGHT SCATTERING; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; PINOCYTOSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; RAT; SURFACE AREA; SURFACE CHARGE; SURFACE PROPERTY; TUMOR SPHEROID; CELL LINE; CHEMISTRY;

CELL LINE; DRUG DELIVERY SYSTEMS; HUMANS; NANOPARTICLES; NANOSTRUCTURES; PACLITAXEL; PROTEIN CONFORMATION; PROTEINS;

EID: 84929165809     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp5008037     Document Type: Article

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