Formulating food protein-stabilized indomethacin nanosuspensions into pellets by fluid-bed coating technology: Physical characterization, redispersibility, and dissolution

International Journal of Nanomedicine

Volumn 8, Issue , 2013, Pages 3119-3128

  He, Wei ^a,b   Lu, Yi ^a   Qi, Jianping ^a   Chen, Lingyun ^c   Yin, Lifang ^b   Wu, Wei ^a  

^a FUDAN UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Fluid bed coating; Food proteins; Indomethacin; Nanocrystals; Nanosuspensions; Poorly water soluble drugs

Indexed keywords

BETA LACTOGLOBULIN; INDOMETACIN; SOYBEAN PROTEIN; STABILIZING AGENT; UNCLASSIFIED DRUG; VEGETABLE PROTEIN; WATER; WHEY PROTEIN;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG COATING; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; FLUID-BED COATING TECHNOLOGY; NANOSUSPENSION; PARTICLE SIZE; PRECIPITATION; SCANNING ELECTRON MICROSCOPY; SOLID STATE; SUSPENSION; TECHNOLOGY; TRANSMISSION ELECTRON MICROSCOPY; ULTRASOUND; X RAY DIFFRACTION;

FLUID-BED COATING; FOOD PROTEINS; INDOMETHACIN; NANOCRYSTALS; NANOSUSPENSIONS; POORLY WATER-SOLUBLE DRUGS;

INDOMETHACIN; LACTOGLOBULINS; MILK PROTEINS; NANOPARTICLES; PARTICLE SIZE; POWDER DIFFRACTION; SOLUBILITY; SOYBEAN PROTEINS; SUSPENSIONS; TECHNOLOGY, PHARMACEUTICAL;

EID: 84881586268     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S46207     Document Type: Article

References (36)

1. Amidon GL, Lennernas H, Shah VP, Crison JR. A theoretical basis for a biopharmaceutic drug classification - the correlation of in-vitro drug product dissolution and in-vivo bioavailability. Pharm Res. 1995;12(3): 413-420.
2. Matteucci ME, Hotze MA, Johnston KP, Williams RO. Drug nanoparticles by antisolvent precipitation: mixing energy versus surfactant stabilization. Langmuir. 2006;22(21):8951-8959.
3. Rabinow BE. Nanosuspensions in drug delivery.Nat Rev Drug Discov. 2004;3(9):785-796.
4. Ali HS, York P, Ali AM, Blagden N.Hydrocortisone nanosuspensions for ophthalmic delivery: a comparative study between microfluidic nanoprecipitation and wet milling. J Control Release. 2011;149(2):175-181.
5. Merisko-Liversidge E, Liversidge GG. Nanosizing for oral and parenteral drug delivery: a perspective on formulating poorly-water soluble compounds using wet media milling technology. Adv Drug Deliv Rev. 2011;63(6):427-440.
6. Merisko-Liversidge E, Liversidge GG, Cooper ER. Nanosizing: a formulation approach for poorly-water-soluble compounds. Eur J Pharm Sci. 2003;18(2):113-120.
7. Shegokar R, Muller RH. Nanocrystals: industrially feasible multifunctional formulation technology for poorly soluble actives. Int J Pharm. 2011;399(1-2):129-139.
8. Wu L, Zhang J, Watanabe W. Physical and chemical stability of drug nanoparticles. Adv Drug Deliv Rev. 2011;63(6):456-469.
9. Moschwitzer J, Achleitner G, Pomper H, Muller RH. Development of an intravenously injectable chemically stable aqueous omeprazole formulation using nanosuspension technology. Eur J Pharm Biopharm. 2004;58(3):615-619.
10. Abdelwahed W, Degobert G, Stainmesse S, Fessi H. Freeze-drying of nanoparticles: Formulation, process and storage considerations. Adv Drug Deliv Rev. 2006;58(15):1688-1713.
11. D'Addio SM, Prud'homme RK. Controlling drug nanoparticle formation by rapid precipitation. Adv Drug Deliv Rev. 2011;63(6):417-426.
12. Zhang HF, Wang D, Butler R, et al. Formation and enhanced biocidal activity of water-dispersable organic nanoparticles. Nat Nanotechnol. 2008;3(8):506-511.
13. Van Eerdenbrugh B, Van den Mooter G, Augustijns P. Top-down production of drug nanocrystals: nanosuspension stabilization, miniaturization and transformation into solid products. Int J Pharm. 2008;364(1):64-75.
14. Dixit R, Puthli S. Fluidization technologies: aerodynamic principles and process engineering. J Pharm Sci. 2009;98(11):3933-3960.
15. Sun N, Wei X, Wu B, et al. Enhanced dissolution of silymarin/ polyvinylpyrrolidone solid dispersion pellets prepared by a one-step fluidbed coating technique. Powder Technology. 2008;182(1):72-80.
16. Zhang X, Sun N, Wu B, et al. Physical characterization of lansoprazole/ PVP solid dispersion prepared by fluid-bed coating technique. Powder Technology. 2008;182(3):480-485.
17. Möschwitzer J, Müller RH. Spray coated pellets as carrier system for mucoadhesive drug nanocrystals. Eur J Pharm Biopharm. 2006;62(3): 282-287.
18. Kayaert P, Anne M, Van den Mooter G. Bead layering as a process to stabilize nanosuspensions: influence of drug hydrophobicity on nanocrystal reagglomeration following in-vitro release from sugar beads. J Pharm Pharmacol. 2011;63(11):1446-1453.
19. He W, Lu Y, Qi J, et al. Food proteins as novel nanosuspension stabilizers for poorly water-soluble drugs. Int J Pharm. 2013;441:269-278.
20. Chen L, Subirade M. Chitosan/[beta]-lactoglobulin core-shell nanoparticles as nutraceutical carriers. Biomaterials. 2005;26(30):6041-6053.
21. Chen LY, Remondetto G, Rouabhia M, Subirade M. Kinetics of the breakdown of cross-linked soy protein films for drug delivery. Biomaterials. 2008;29(27):3750-3756.
22. Chen LY, Subirade M. Alginate-whey protein granular microspheres as oral delivery vehicles for bioactive compounds. Biomaterials. 2006;27(26):4646-4654.
23. Xia D, Quan P, Piao H, et al. Preparation of stable nitrendipine nanosuspensions using the precipitation:ultrasonication method for enhancement of dissolution and oral bioavailability. Eur J Pharm Sci. 2010;40(4):325-334.
24. Chu B, Wang ZL, Yu JQ. Dynamic light-scattering study of internal motions of polymer coils in dilute-solution. Macromolecules. 1991;24(26):6832-6838.
25. Lee J, Lee SJ, Choi JY, Yoo JY, Ahn CH. Amphiphilic amino acid copolymers as stabilizers for the preparation of nanocrystal dispersion. Eur J Pharm Sci. 2005;24(5):441-449.
26. Pardeike J, Muller RH. Nanosuspensions: a promising formulation for the new phospholipase A2 inhibitor PX-18. Int J Pharm. 2010;391(1-2): 322-329.
27. Lei Y, Lu Y, Qi JP, et al. Solid self-nanoemulsifying cyclosporin A pellets prepared by fluid-bed coating: preparation, characterization and in vitro redispersibility. Int J Nanomedicine. 2011;6:795-805.
28. Hu X, Lin C, Chen D, et al. Sirolimus solid self-microemulsifying pellets: formulation development, characterization and bioavailability evaluation. Int J Pharm. 2012;438(1-2):123-133.
29. He W, Lu Y, Qi J, et al. Nanoemulsion-templated shell-crosslinked nanocapsules as drug delivery systems for poorly water-soluble drugs. Int J Pharm. 2013;445(1-2):69-78.
30. He W, Tan Y, Tian Z, et al. Food protein-stabilized nanoemulsions as potential delivery systems for poorly water-soluble drugs: preparation, in vitro characterization, and pharmacokinetics in rats. Int J Nanomedicine. 2011;6:521-533.
31. Kesisoglou F, Panmai S, Wu YH. Nanosizing - oral formulation development and biopharmaceutical evaluation. Adv Drug Deliv Rev. 2007;59(7):631-644.
32. Kasper JC, Schaffert D, Ogris M, Wagner E, Friess W. Development of a lyophilized plasmid/LPEI polyplex formulation with long-term stability-a step closer from promising technology to application. J Control Release. 2011;151(3):246-255.
33. Lee J. Drug nano- and microparticles processed into solid dosage forms: physical properties. J Pharm Sci. 2003;92(10):2057-2068.
34. Chaubal MV, Popescu C. Conversion of nanosuspensions into dry powders by spray drying: a case study. Pharm Res. 2008;25(10):2302-2308.
35. Makhlof A, Miyazaki Y, Tozuka Y, Takeuchi H. Cyclodextrins as stabilizers for the preparation of drug nanocrystals by the emulsion solvent diffusion method. Int J Pharm. 2008;357(1-2):280-285.
36. Tozuka Y, Miyazaki Y, Takeuchi H. A combinational supercritical CO(2) system for nanoparticle preparation of indomethacin. Int J Pharm. 2010;386(1-2):243-248.