The ligand-binding site of bovine β-lactoglobulin: Evidence for a function?

Journal of Molecular Biology

Volumn 318, Issue 4, 2002, Pages 1043-1055

  Kontopidis, George ^a   Holt, Carl ^b   Sawyer, Lindsay ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b HANNAH RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Crystal structure; Retinoic acid; Retinol; Vitamin A; lactoglobulin

Indexed keywords

BETA LACTOGLOBULIN; BINDING PROTEIN; LIGAND; LIPOCALIN; PALMITIC ACID; RETINOIC ACID; RETINOL;

ARTICLE; BINDING COMPETITION; BINDING SITE; CRYSTAL; CRYSTAL STRUCTURE; IMAGE ANALYSIS; LIGAND BINDING; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; STRUCTURE ANALYSIS;

BOVINAE;

EID: 0036037132     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)00017-7     Document Type: Article

References (59)

1. β-Lactoglobulin
2. The core lipocalin-β-lactoglobulin
3. Interaction of fatty acids with β-lactoglobulin and albumin from ruminant milk
4. β-Lactoglobulin: Structural studies, biological clues
5. Homology between the primary structures of β-lactoglobulins and human retinol binding protein: Evidence for a similar biological function?
6. Homology of β-lactoglobulin, serum retinol-binding protein and protein HC
7. Structure and function of bovine β-lactoglobulin
8. Bovine β-lactoglobulin at 1.8 angstrom resolution - Still an enigmatic lipocalin
9. Bovine β-lactoglobulin and its variants: A three-dimensional perspective
10. Structural basis of the Tanford transition of bovine β-lactoglobulin
11. The reversible transformation of β-lactoglobulin at pH 7.5
12. 12-Bromododecanoic acid binds inside the calyx of bovine β-lactoglobulin
13. β-Lactoglobulin binds palmitate within its central cavity
14. Crystal structure of the trigonal form of bovine β-lactoglobulin and its complex with retinol at 2.5 Å resolution
15. Probing the retinol-binding site of bovine β-lactoglobulin
16. Probing the fatty-acid-binding site of β-lactoglobulins
17. Retinol and retinoic acid bind to a surface cleft in bovine beta-lactoglobulin: A method of binding site determination using fluorescence resonance energy transfer
18. Fatty acids and retinoids bind independently and simultaneously to β-lactoglobulin
19. Binding of lipophilic nutrients to β-lactoglobulin prepared by bioselective adsorption
20. SHELXL: High-resolution refinement
21. PROCHECK: A program to check the stereochemical quality of protein structures
22. The structure of β-lactoglobulin and its similarity to plasma retinol-binding protein
23. Functional implications of structural differences between variants A and B of bovine β-lactoglobulin
24. 1 - Structural differences between genetic variants A and B and features of the Tanford transition
25. Bovine β-lactoglobulin: Interaction studies with palmitic acid
26. Interaction of bovine β-lactoglobulin and other bovine and human whey proteins with retinol and fatty-acids
27. Interaction of β-lactoglobulin with small hydrophobic ligands as monitored by fluorometry and equilibrium dialysis: Nonlinear quenching effects related to protein-protein association
28. Protein and ligand adaptation in a retinoic acid binding protein
29. The lipocalin protein family - Structure and function
30. Interaction of β-lactoglobulin with retinol and fatty acids and its role as a possible biological function for this protein: A review
31. Spectroscopic characterization of β-lactoglobulin-retinol complex
32. Crystallographic refinement of human serum retinol binding protein at 2 Å resolution
33. Absorption spectra for the complexes formed from vitamin-A and β-lactoglobulin
34. 13C-β-ionones bound to β-lactoglobulin B
35. Some aspects of β-lactoglobulin structural properties in solution studied by fluorescence quenching
36. Tryptophan-19 of β-lactoglobulin, the only residue completely conserved in the lipocalin superfamily, is not essential for binding retinol, but relevant to stabilizing bound retinol and maintaining its structure
37. Solubility of retinoids in water
38. The first direct determination of a ligand binding constant in protein crystals
39. Binding of retinoids to β-lactoglobulin isolated by bioselective adsorption
40. Effect of binding of retinol and palmitic acid to bovine β-lactoglobulin on its resistance to thermal denaturation
41. Binding of long chain fatty acids to β-lactoglobulin
42. Protein concentration dependence of palmitate binding to β-lactoglobulin
43. Effect of sodium dodecyl sulfate and palmitic acid on the equilibrium unfolding of bovine β-lactoglobulin
44. Comparison of the ability to bind lipids of β-lactoglobulin and serum-albumin of milk from ruminant and non-ruminant species
45. Effect of β-lactoglobulin on the activity of pregastric lipase - A possible role for this protein in ruminant milk
46. 2+-responsive model system using acid phosphoprotein phosphatases
47. Characterization of a second, apparently inactive, copy of the bovine β-lactoglobulin gene
48. Characterization of a caprine β-lactoglobulin pseudogene, identification and chromosomal localization by in situ hybridization in goat, sheep and cow
49. Glycodelin: A reproduction-related lipocalin
50. Characterization of the gorilla carboxyl ester lipase locus, and the appearance of the carboxyl ester lipase pseudogene during primate evolution
51. Glycodelin and β-lactoglobulin, lipocalins with a high structural similarity, differ in ligand binding properties
52. Uterocalin, a lipocalin provisioning the preattachment equine conceptus: Fatty acid and retinol binding properties, and structural characterization
53. Purification and characterization of a uterine retinol-binding protein in the bitch
54. Processing of X-ray diffraction data collected in oscillation mode
55. MOLSCRIPT - A program to produce both detailed and schematic plots of protein structures
56. TreeView: An application to display phylogenetic trees on personal computers
57. The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000