Chemically self-assembled antibody nanostructures as potential drug carriers

Molecular Pharmaceutics

Volumn 9, Issue 11, 2012, Pages 3218-3227

  Fegan, Adrian ^a   Kumarapperuma, Sidath C ^a   Wagner, Carston R ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b University of Minnesota   (United States)

Author keywords

antibody; cancer; drug delivery; nanotechnology

Indexed keywords

CHEMICALLY SELF ASSEMBLED ANTIBODY NANORING; DIMETHYL SULFOXIDE; DRUG CARRIER; FLUORESCEIN ISOTHIOCYANATE; NANOMATERIAL; TRIMETHOPRIM; UNCLASSIFIED DRUG;

ACIDIFICATION; ARTICLE; CD3+ T LYMPHOCYTE; CELL PROLIFERATION; CYCLIZATION; CYTOPLASM; DRUG CYTOTOXICITY; ENDOCYTOSIS; ENDOSOME; HYDROPHOBICITY; INTERNALIZATION; LEUKEMIA CELL; LYSOSOME; PH; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD3; CELL PROLIFERATION; CHROMATOGRAPHY, GEL; DRUG CARRIERS; FLOW CYTOMETRY; HUMANS; LEUKEMIA, T-CELL; METHOTREXATE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; NANOSTRUCTURES; RECOMBINANT FUSION PROTEINS; SINGLE-CHAIN ANTIBODIES; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 84868550881     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300303k     Document Type: Article

References (19)

1. Alley, S. C.; Okeley, N. M.; Senter, P. D. Antibody-drug conjugates: Targeted drug delivery for cancer Curr. Opin. Chem. Biol. 2010, 14, 529-37
2. Katz, J.; Janik, J. E.; Younes, A. Brentuximab Vedotin (SGN-35) Clin. Cancer Res. 2011, 17, 6428-36
3. Cheng, W. W; Allen, T. M. The use of single chain Fv as targeting agents for immunoliposomes: An update on immunoliposomal drugs for cancer treatment Expert Opin. Drug Delivery 2010, 7, 461-78
4. New, K.; Milenic, D. E.; Ray, G. L.; Kim, Y. S.; Brechbiel, M. W. Preparation of cystamine core dendrimer and antibody-dendrimer conjugates for MRI angiography Mol. Pharmaceutics 2012, 9, 374-81
5. Chattopadhyay, N.; Fonge, H.; Cai, Z.; Scollard, D.; Lechtman, E.; Done, S. J.; Pignol, J. P.; Reilly, R. M. Role of Antibody-Mediated Tumor Targeting and Route of Administration in Nanoparticle Tumor Accumulation in Vivo Mol. Pharmaceutics 2012, 9, 2168-79
6. Tivnan, A.; Orr, W. S.; Gubala, V.; Nooney, R.; Williams, D. E.; McDonagh, C.; Prenter, S.; Harvey, H.; Domingo-Fernández, R.; Bray, I. M.; Piskareva, O.; Ng, C. Y.; Lode, H. N.; Davidoff, A. M.; Stallings, R. L. Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles PLoS One 2012, 7, e38129
7. Lehtinen, J.; Raki, M.; Bergström, K. A.; Uutela, P.; Lehtinen, K.; Hiltunen, A.; Pikkarainen, J.; Liang, H.; Pitkänen, S.; Määttä, A. M.; Ketola, R. A.; Yliperttula, M.; Wirth, T.; Urtti, A. Pre-targeting and direct immunotargeting of liposomal drug carriers to ovarian carcinoma PLoS One 2012, 7, e41410
8. Melancon, M. P.; Lu, W.; Zhong, M.; Zhou, M.; Liang, G.; Elliott, A. M.; Hazle, J. D.; Myers, J. N.; Li, C.; Stafford, R. J. Targeted multifunctional gold-based nanoshells for magnetic resonance-guided laser ablation of head and neck cancer Biomaterials 2011, 32, 7600-8
9. Ruan, J.; Song, H.; Qian, Q.; Li, C.; Wang, K.; Bao, C.; Cui, D. HER2 monoclonal antibody conjugated RNase-A-associated CdTe quantum dots for targeted imaging and therapy of gastric cancer Biomaterials 2012, 33, 7093-102
10. Li, Q.; Hapka, D.; Chen, H.; Vallera, D. A.; Wagner, C. R. Self-assembly of antibodies by chemical induction Angew. Chem., Int. Ed. 2008, 47, 10179-82
11. Li, Q.; So, C. R.; Fegan, A.; Cody, V.; Sarikaya, M.; Vallera, D. A.; Wagner, C. R. Chemically Self-Assembled Antibody Nanorings (CSANs): Design and Characterization of an Anti-CD3 IgM Biomimetic J. Am. Chem. Soc. 2010, 132, 17247-57
12. Carlson, J. C. T.; Jena, S. S.; Flenniken, M.; Chou, T. F.; Siegel, R. A.; Wagner, C. R. Chemically Controlled Self-Assembly of Protein Nanorings J. Am. Chem. Soc. 2006, 128, 7630-8
13. Muzykantov, V. R.; Christofidou-Solomidou, M.; Balyasnikova, I.; Harshaw, D. W.; Schultz, L.; Fisher, A. B.; Albelda, S. M. Streptavidin facilitates internalization and pulmonary targeting of an anti-endothelial cell antibody (platelet-endothelial cell adhesion molecule 1): A strategy for vascular immunotargeting of drugs Proc. Natl. Acad. Sci. U.S.A. 1999, 96, 2379-84
14. Wiewrodt, R.; Thomas, A. P.; Cipelletti, L.; Christofidou-Solomidou, M.; Weitz, D. A.; Feinstein, S. I.; Schaffer, D.; Albelda, S. M.; Koval, M.; Muzykantov, V. R. Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells Blood 2002, 99, 912-22
15. Carlson, J. C. T.; Kanter, A.; Thuduppathy, G. R.; Cody, V.; Pineda, P. E.; McIvor, R. S.; Wagner, C. R. Designing Protein Dimerizers: The Importance of Ligand Conformational Equilibria J. Am. Chem. Soc. 2003, 125, 1501-7
16. Ercolani, G. A Model for Self-Assembly in Solution J. Phys. Chem. B 2003, 107, 5052-7
17. Dautry-Varsat, A.; Ciechanover, A.; Lodish, H. F. pH and the recycling of transferrin during receptor-mediated endocytosis Proc. Natl. Acad. Sci. U.S.A. 1983, 80, 2258-62
18. Mottram, L. F.; Boonyarattanakalin, S.; Kovel, R. E.; Peterson, B. R. The Pennsylvania Green Fluorophore: A hybrid of Oregon Green and Tokyo Green for the construction of hydrophobic and pH-insensitive molecular probes Org. Lett. 2006, 8, 581-4
19. Pineda, P.; Kanter, A.; McIvor, R. S.; Benkovic, S. J.; Rosowsky, A.; Wagner, C. R. Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate J. Med. Chem. 2003, 46, 2816-8