Effects of cellular phone- and Wi-Fi-induced electromagnetic radiation on oxidative stress and molecular pathways in brain

Systems Biology of Free Radicals and Antioxidants

Volumn , Issue , 2012, Pages 2431-2449

  NazIroʇlu, Mustafa ^a   Akman, Hatice ^a  

^a SULEYMAN DEMIREL UNIVERSITY   (Turkey)

Author keywords

Antioxidants; Brain; Calcium ion; Oxidative stress; Wi Fi

Indexed keywords

EID: 84929138362     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-30018-9_210     Document Type: Chapter

References (79)

1. Aït-Aïssa S, Billaudel B, De Gannes FP, Hurtier A, Haro E, Taxile M, Ruffie G, Athane A, Veyret B, Lagroye I (2010) In situ detection of gliosis and apoptosis in the brains of young rats exposed in utero to a Wi-Fi signal. Comptes Rendus Phys 11:592-601
2. Ammari M, Jacquet A, Lecomte A, Sakly M, Abdelmelek H, de Seze R (2008) Effect of head-only sub-chronic and chronic exposure to 900-MHz GSM electromagnetic fields on spatial memory in rats. Brain Inj 22(13-14):1021-1029
3. Avci B, Akar A, Bilgici B, Tunçel O K (2012) Oxidative stress induced by 1.8 GHz radio frequency electromagnetic radiation and effects of garlic extract in rats. Int J Radiat Biol 88(11):799-805
4. Behari J (2010) Biological responses of mobile phone frequency exposure. Indian J Exp Biol 48(10):959-981
5. Bejarano I, Espino J, Barriga C, Reiter RJ, Pariente JA, Rodríguez AB (2011) Pro-oxidant effect of melatonin in tumour leucocytes: relation with its cytotoxic and pro-Apoptotic effects. Basic Clin Pharmacol Toxicol 108(1):14-20
6. Borek C (2001) Antioxidant health effects of aged garlic extract. J Nutr 131(3s):1010S-1015S
7. Bowman GL (2012) Ascorbic acid, cognitive function, and Alzheimer's disease: A current review and future direction. Biofactors 38(2):114-122
8. Bridi R, Crossetti FP, Steffen VM, Henriques AT (2001) The antioxidant activity of standardized extract of Ginkgo biloba (EGb 761) in rats. Phytother Res 15(5):449-451
9. Byus CV, Kartun K, Pieper S, Adey WR (1988) Increased ornithine decarboxylase activity in cultured cells exposed to low energy modulated microwave fields and phorbol ester tumor promoters. Cancer Res 48:4222-4226
10. Cassel JC, Cosquer B, Galani R, Kuster N (2004) Whole-body exposure to 2.45 GHz electromagnetic fields does not alter radial-maze performance in rats. Behav Brain Res 155:37-43
11. Cl B (2009) Radiofrequency and microwave ablation of the liver, lung, kidney, and bone: what are the differences? Curr Probl Diagn Radiol 38:135-143
12. Cobb BL, Jauchem JR, Adair ER (2004) Radial arm maze performance of rats following repeated low level microwave radiation exposure. Bioelectromagnetics 25:49-57
13. Cosquer B, Galani R, Kuster N, Cassel JC (2005) Whole-body exposure to 2.45 GHz electromagnetic fields does not alter anxiety responses in rats: A plus-maze study including test validation. Behav Brain Res 156:65-74
14. Dasdag S, Akdag MZ, Ulukaya E, Uzunlar AK, Ocak AR (2009) Effect of mobile phone exposure on apoptotic glial cells and status of oxidative stress in rat brain. Electromagn Biol Med 28(4):342-354
15. Dasdag S, Akdag MZ, Kizil G, Kizil M, Cakir DU, Yokus B (2012) Effect of 900 MHz radio frequency radiation on beta amyloid protein, protein carbonyl, and malondialdehyde in the brain. Electromagn Biol Med 31(1):67-74
16. Dogan M, Turtay MG, Oguzturk H, Samdanci E, Turkoz Y, Tasdemir S, Alkan A, Bakir S (2012) Effects of electromagnetic radiation produced by 3G mobile phones on rat brains: magnetic resonance spectroscopy, biochemical, and histopathological evaluation. Hum Exp Toxicol 31(6):557-564
17. Dubreuil D, Jay T, Edeline JM (2002) Does head-only exposure to GSM-900 electromagnetic fields affect the performance of rats in spatial learning tasks? Behav Brain Res 129:203-210
18. Dubreuil D, Jay T, Edeline JM (2003) Head-only exposure to GSM 900-MHz electromagnetic fields does not alter rat's memory in spatial and non-spatial tasks. Behav Brain Res 145:51-61
19. Eberhardt JL, Persson BR, Brun AE, Salford LG, Malmgren LO (2008) Blood-brain barrier permeability and nerve cell damage in rat brain 14 and 28 days after exposure to microwaves from GSM mobile phones. Electromagn Biol Med 27(3):215-129
20. Ekmekcioglu C (2006) Melatonin receptors in humans: biological role and clinical relevance. Biomed Pharmacother 60:97-108
21. Espino J, Bejarano I, Paredes SD, Barriga C, Rodríguez AB, Pariente JA (2011) Protective effect of melatonin against human leukocyte apoptosis induced by intracellular calcium overload: relation with its antioxidant actions. J Pineal Res 51(2):195-206
22. Espino J, Pariente JA, Rodríguez AB (2012) Oxidative stress and immunosenescence: therapeutic effects of melatonin. Oxid Med Cell Longev 2012:670294. doi:10.1155/2012/670294
23. Foster KR, Glaser R (2007) Thermal mechanisms of interaction of radiofrequency energy with biological systems with relevance to exposure guidelines. Health Phys 92(6):609-620
24. Fragopoulou AF, Samara A, Antonelou MH, Xanthopoulou A, Papadopoulou A, Vougas K, Koutsogiannopoulou E, Anastasiadou E, Stravopodis DJ, Tsangaris GT, Margaritis LH (2012) Brain proteome response following whole body exposure of mice to mobile phone or wireless DECT base radiation. Electromagn Biol Med 31(4):250-274
25. Franke H, Ringelstein E, Stögbauer F (2005) Electromagnetic Fields (GSM 1800) do not alter blood-brain barrier permeability to sucrose in models in vitro with high barrier tightness. Bioelectromagnetics 26:529-535
26. Grafström G, Nittby H, Brun A, Malmgren L, Persson BRR, Salford LG, Eberhardt J (2008) Histopathological examinations of rat brains after long-term exposure to GSM-900 mobile phone radiation. Brain Res Bull 77:257-263
27. Gumral N, Naziroglu M, Koyu A, Ongel K, Celik O, Saygin M, Kahriman M, Caliskan S, Kayan M, Gencel O, Others A (2009) Effects of selenium and L-carnitine on oxidative stress in blood of rat induced by 2.45-GHz radiation from wireless devices. Biol Trace Elem Res 132:153-163
28. Ilhan A, Gurel A, Armutcu F, Kamisli S, Iraz M, Akyol O, Ozen S (2004) Ginkgo biloba prevents mobile phone-induced oxidative stress in rat brain. Clin Chim Acta 340:153-162
29. Irmak MK, Fadillioʇlu E, Güleç M, Erdoʇan H, Yaʇmurca M, Akyol O (2002) Effects of electromagnetic radiation from a cellular telephone on the oxidant and antioxidant levels in rabbits. Cell Biochem Funct 20(4):279-283
30. Jing J, Yuhua Z, Xiao-qian Y, Rongping J, Dong-mei G, Xi C (2012) The influence of microwave radiation from cellular phone on fetal rat brain. Electromagn Biol Med 31(1):57-66
31. Jl E, Brr P, Ae B, Lg S, Log M (2008) Blood-brain barrier permeability and nerve cell damage in rat brain 14 and 28 days after exposure to microwaves from GSM mobile phones. Electromag Biol Med 27:215-229
32. Johnson WM, Wilson-Delfosse AL, Mieyal JJ (2012) Dysregulation of glutathione homeostasis in neurodegenerative diseases. Nutrients 4(10):1399-1440
33. Kesari KK, Behari J, Kumar S (2010) Mutagenic response of 2.45 GHz radiation exposure on rat brain. Int J Radiat Biol 86(4):334-343
34. Kesari KK, Kumar S, Behari J (2012) Pathophysiology of microwave radiation: effect on rat brain. Appl Biochem Biotechnol 166(2):379-388
35. Köylü H, Mollaoglu H, Ozguner F, Naziroʇlu M, Delibas N (2006) Melatonin modulates 900 Mhz microwave-induced lipid peroxidation changes in rat brain. Toxicol Ind Health 22(5):211-216
36. Kumar S, Kesari KK, Behari J (2011) The therapeutic effect of a pulsed electromagnetic field on the reproductive patterns of male Wistar rats exposed to a 2.45-GHz microwave field. Clinics (Sao Paulo) 66(7):1237-1245
37. Kumlin T, Iivonen H, Miettinen P, Juvonen A, Van Groen T, Puranen L, Pitkäaho R, Juutilainen J, Tanila H (2007) Mobile phone radiation and the developing brain: behavioral and morphological effects in juvenile rats. Radiat Res 168:471-479
38. Lai H, Singh NP (1996) Single-And double-strand DNA breaks in rat brain cells after acute exposure to radiofrequency electromagnetic radiation. Int J Radiat Biol 69(4):513-521
39. Lai H, Singh NP (2004) Magnetic-field-induced DNA strand breaks in brain cells of the rat. Environ Health Perspect 112(6):687-694
40. Maganioti AE, Hountala CD, Papageorgiou CC, Kyprianou MA, Rabavilas AD, Capsalis CN (2010) Principal component analysis of the P600 waveform: RF and gender effects. Neurosci Lett 478(1):19-23
41. Martens L, De Moerloose J, De Zutter D, De Poorter J, De Wagter C (1995) Calculation of the electromagnetic fields induced in the head of an operator of a cordless telephone. Radio Sci 30:283-290
42. Martínez-Búrdalo M, Martín A, Sanchis A, Villar R (2009) FDTD assessment of human exposure to electromagnetic fields from WiFi and bluetooth devices in some operating situations. Bioelectromagnetics 30(2):142-151
43. Masuda H, Ushiyama A, Takahashi M, Wang J, Fujiwara O, Hikage T, Nojima T, Fujita K, Kudo M, Ohkubo C (2009) Effects of 915 MHZ electromagnetic-field radiation in tem cell on the blood-brain barrier and neurons in the rat brain. Radiat Res 172:66-73
44. Mattson MP, Chan SL (2001) Dysregulation of cellular calcium homeostasis in Alzheimer's Disease. J Mol Neurosci 17:205-224
45. Mcquade JMS, Merritt JH, Miller SA, Scholin T, Cook MC, Salazar A, Rahimi OB, Murphy MR, Mason PA (2009) Radiofrequency-radiation exposure does not induce detectable leakage of albumin across the blood-brain barrier. Radiat Res 171:615-621
46. Meral I, Mert H, Mert N, Deger Y, Yoruk I, Yetkin A, Keskin S (2007) Effects of 900-MHz electromagnetic field emitted from cellular phone on brain oxidative stress and some vitamin levels of guinea pigs. Brain Res 1169:120-124
47. Naziroʇlu M (2007a) Molecular Mechanisms of vitamin E on intracellular signaling pathways in brain. In: Goth L (ed) Reactive Oxygen Species and Diseases. Research Signpost Press, Kerala, pp 239-256
48. Naziroʇlu M (2007b) New molecular mechanisms on the activation of TRPM2 channels by Oxidative Stress and ADP-Ribose. Neurochem Res 32:1990-2001
49. NazirogluM(2009) Role of selenium on calcium signaling and oxidative stress-induced molecular pathways in epilepsy. Neurochem Res 34(12):2181-2191
50. NaziroʇluM(2011) TRPM2 cation channels, oxidative stress and neurological diseases: where are we now? Neurochem Res 36(3):355-366
51. NaziroʇluM(2012)Molecular role of catalase on oxidative stress-induced Ca(2+) signaling and TRP cation channel activation in nervous system. J Recept Signal Transduct Res 32(3):134-141
52. Naziroʇlu M, Gümral N (2009) Modulator effects of L-carnitine and selenium on wireless devices (2.45 GHz)-induced oxidative stress and electroencephalography records in brain of rat. Int J Radiat Biol 85(8):680-689
53. Naziroʇlu M, Ç iʇ B, Doʇan S, Uʇuz AC, Dilek S, Faouzi D (2012a) 2.45-GHz wireless devices induce oxidative stress and proliferation through cytosolic Ca2+ influx in human leukemia cancer cells. Int J Radiat Biol 88:449-456
54. Naziroʇlu M, Tokat S, Demirci S (2012b) Role of melatonin on electromagnetic radiation-induced oxidative stress and Ca2+ signaling molecular pathways in breast cancer. J Recept Signal Transduct Res 32(6):290-297
55. Naziroʇlu M, Dikici DM, Dursun S (2012c) Role of oxidative stress and Ca2+ signaling on molecular pathways of neuropathic pain in diabetes: focus on TRP channels. Neurochem Res 37(10):2065-2075
56. Naziroʇlu M, Ç elik O , Ö zgül C, Ç iʇ B, Doʇan S, Bal R, Gümral N, Rodríguez AB, Pariente JA (2012d) Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca(2+) channels in brain and dorsal root ganglion in rat. Physiol Behav 105:683-692
57. Naziroʇlu M, Yildiz K, Tamtürk B, Erturan I, Flores-Arce M(2012e) Selenium and psoriasis. Biol Trace Elem Res 150(1-3):3-9
58. Naziroʇlu M, Yoldaş N, Uzgur EN, Kayan M (2013) Role of contrast media on oxidative stress, Ca(2+) signaling and apoptosis in kidney. J Membr Biol 246:91-100
59. Nikolova T, Czyz J, Rolletschek A, Blyszczuk P, Fuchs J, Jovtchev G, Schuderer J, Kuster N, Wobus AM (2005) Electromagnetic fields affect transcript levels of apoptosisrelated genes in embryonic stem cell-derived neural progenitor cells. FASEB J 19(12): 1686-1688
60. Nittby H, Grafström G, Tian DP, Malmgren L, Brun A, Persson BR, Salford LG, Eberhardt J (2008) Cognitive impairment in rats after long-term exposure to GSM-900 mobile phone radiation. Bioelectromagnetics 29(3):219-232
61. Nittby H, Brun A, Eberhardt J, Malmgren L, Persson BR, Salford LG (2009) Increased blood-brain barrier permeability in mammalian brain 7 days after exposure to the radiation from a GSM-900 mobile phone. Pathophysiology 16(2-3):103-112
62. O'Connor RP, Madison SD, Leveque P, Roderick HL, Bootman MD (2010) Exposure to GSM RF fields does not affect calcium homeostasis in human endothelial cells, rat pheochromocytoma cells or rat hippocampal neurons. PLoS One 5(7):e11828
63. Omura Y, Losco M (1993) Electro-magnetic fields in the home environment (color TV, computer monitor, microwave oven, cellular phone, etc) as potential contributing factors for the induction of oncogen C-Fos Ab1, oncogen C-Fos Ab2, integrin alpha 5 beta 1 and development of cancer, as well as effects of microwave on amino acid composition of food and living human brain. Acupunct Electrother Res 18:33-73
64. Ozmen I, Naziroʇlu M, Alici HA, Sahin F, Cengiz M, Eren I (2007) Spinal morphine administration reduces the fatty acid contents in spinal cord and brain by increasing oxidative stress. Neurochem Res 32(1):19-25
65. Parekh AB, Putney JW (2005) Store-operated calcium channels. Physiol Rev 85:757-810
66. Paulraj R, Behari J (2006a) Single strand DNA breaks in rat brain cells exposed to microwave radiation. Mutat Res 596(1-2):76-80
67. Paulraj R, Behari J (2006b) Protein kinase C activity in developing rat brain cells exposed to 2.45 GHz radiation. Electromagn Biol Med 25(1):61-70
68. Pinto R, Lopresto V, Galloni P, Marino C, Mancini S, Lodato R, Pioli C, Lovisolo G (2010) Dosimetry of a set-up for the exposure of newborn mice to 2.45-GHz WiFi frequencies. Radiat Prot Dosimetry 140(4):326-332
69. Platano D, Mesirca P, Paffi A, Pellegrino M, Liberti M, Apollonio F, Bersani F, Aicardi G (2007) Acute exposure to low-level CW and GSM-modulated 900 MHz radiofrequency does not affect Ba2+ currents through voltage-gated calcium channels in rat cortical neurons. Bioelectromagnetics 28:599-607
70. Poulletier De Gannes F, Billaudel B, Taxile M, Haro E, Ruffie G, Leveque P, Veyret B, Lagroye I (2009) Effects of head-only exposure of rats to GSM-900 on blood-brain barrier permeability and neuronal degeneration. Radiat Res 172:359-367
71. Salford LG, Brun A, Kjellén E, Pero RW, Persson RB (1997) Whole-body hyperthermia and ADPRT inhibition in experimental treatment of brain tumors. Ann N Y Acad Sci 835:194-202
72. Salford LG, Brun AE, Eberhardt JL, Malmgren L, Persson BR (2003) Nerve cell damage in mammalian brain after exposure to microwaves from GSM mobile phones. Environ Health Perspect 111(7):881-883
73. Salford LG, Nittby H, Brun A, Grafström G, Eberhardt JL, Malmgren L, Persson BRR (2007) Non-thermal effects of EMF upon the mammalian brain: The lund experience. The Environmentalist 27:493-500
74. Shahin S, Singh VP, Shukla RK, Dhawan A, Gangwar RK, Singh SP, Chaturvedi CM (2013) 2.45 GHz microwave irradiation-induced oxidative stress affects implantation or pregnancy in mice, mus musculus. Appl Biochem Biotechnol 169(5):1727-1751
75. Sienkiewicz ZJ, Blackwell RP, Haylock RGE, Saunders RD, Cobb BL (2000) Low-level exposure to pulsed 900 MHz microwave radiation does not cause deficits in the performance of a spatial learning task in mice. Bioelectromagnetics 21:151-158
76. Sokolovic D, Djindjic B, Nikolic J, Bjelakovic G, Pavlovic D, Kocic G, Krstic D, Cvetkovic T, Pavlovic V (2008) Melatonin reduces oxidative stress induced by chronic exposure of microwave radiation from mobile phones in rat brain. J Radiat Res 49(6):579-586
77. Tatsuo S (1994) 1994. Protein kinases involved in the expression of long-term potentiation. Int J Biochem 26:735-744
78. Yang XS, He GL, Hao YT, Xiao Y, Chen CH, Zhang GB, Yu ZP (2012) Exposure to 2.45 GHz electromagnetic fields elicits an HSP-related stress response in rat hippocampus. Brain Res Bull 88(4):371-378
79. Yioultsis T, Kosmanis T, Kosmidou E, Zygiridis T, Kantartzis N, Xenos T, Tsiboukis T (2002) A comparative study of the biological effects of various mobile phone and wireless LAN antennas. IEEE Trans Magn 38:777-780