Effects of electromagnetic radiation produced by 3G mobile phones on rat brains: Magnetic resonance spectroscopy, biochemical, and histopathological evaluation

Human and Experimental Toxicology

Volumn 31, Issue 6, 2012, Pages 557-564

  Dogan, M ^a   Turtay, M G ^a   Oguzturk, H ^a   Samdanci, E ^a   Turkoz, Y ^a   Tasdemir, S ^a   Alkan, A ^a   Bakir, S ^a  

^a INONU UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

electromagnetic radiation; magnetic resonance spectroscopy; oxidative stress; third generation mobile phone

Indexed keywords

CATALASE; CHOLINE; CREATININE; GLUTATHIONE PEROXIDASE; N ACETYLASPARTIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOCHEMISTRY; BRAIN TISSUE; CONTROLLED STUDY; ELECTROMAGNETIC RADIATION; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; HUMAN; MALE; MOBILE PHONE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RADIATION EXPOSURE; RAT;

ANIMALS; APOPTOSIS; ASPARTIC ACID; BRAIN; CATALASE; CELLULAR PHONE; CHOLINE; CREATININE; ELECTROMAGNETIC RADIATION; GLUTATHIONE PEROXIDASE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; NEURONS; RATS; RATS, WISTAR;

RATTUS;

EID: 84861819445     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327111412092     Document Type: Article

References (39)

1. Bi Q, Brown R, Cui D, Gandhi A, et al. Performance of 1xEV-DO third generation wireless high speed data system. Bell Labs Tech J. 2003 ; 7: 97-107
2. Korhonen J. Introduction to 3G mobile communications. Korhonen J, ed. London: Artech House ; 2003: 1-8.
3. EstevesEBlackPJGurelliMI.Link adaptation techniques for high-speed packet data in third generation cellular systems. In Proc European Wireless Conference, Italy, 2002. http://www2.ing.unipi.it/ew2002/.
4. Jauchem JR.. Effects of low-level radio-frequency (3kHz to 300GHz) energy on human cardiovascular, reproductive, immune, and other systems: a review of the recent literature. Int J Hyg Environ Health. 2008 ; 211: 1-29
5. Gandhi O, Lazzi G, Furse CM.. Electromagnetic absorption in the human head and neck for mobile telephones at 835 and 1900 MHz. IEEE T Microw Theory. 1996 ; 44: 1884-1896
6. Salford LG, Brun A, Sturesson K, Eberhardt JL, et al. Permeability of the blood-brain barrier induced by 915 MHz electromagnetic radiation, continuous wave and modulated at 8, 16, 50, and 200 Hz. Microsc Res Tech. 1994 ; 27: 535-542
7. Diem E, Schwarz C, Adlkofer F, Jahn O, et al. Non-thermal DNA breakage by mobile-phone radiation (1800 MHz) in human fibroblasts and in transformed GFSH-R17 rat granulosa cells in vitro. Mutat Res. 2005 ; 583: 178-183
8. Hardell L, Hallquist A, Hansson Mild K, Carlberg M, et al. Cellular and cordless telephones and the risk for brain tumours. Eur J Cancer Prev. 2002 ; 11: 377-386
9. Tsurita G, Nagawa H, Ueno S, Watanabe S, Taki M.. Biological and morphological effects on the brain after exposure of rats to a 1439 MHz TDMA field. Bioelectromagnetics. 2000 ; 21: 364-371
10. Cosquer B, Kuster N, Cassel JC.. Whole-body exposure to 2.45 GHz electromagnetic fields does not alter 12-arm radialmaze with reduced access to spatial cues in rats. Behav Brain Res. 2005 ; 161: 331-334
11. Zeni O, Romano M, Perrotta A, Lioi MB, et al. Evaluation of genotoxic effects in human peripheral blood leukocytes following an acute in vitro exposure to 900 MHz radiofrequency fields. Bioelectromagnetics. 2005 ; 26: 258-265
12. Salford LG, Brun A, Persson B.. Brain tumour development in rats exposed to electromagnetic fields used in wireless communication. Wireless Networks. 1997 ; 3: 463-469
13. Adey W, Byus C, Cain C, Higgins R, et al. Spontaneous and nitrosourea-induced primary tumors of the central nervous system in Fisher 344 rats exposed to 836 MHz modulated microwaves. Radiat Res. 1999 ; 152: 293-302
14. Alkan A, Sarac K, Kutlu R, Yakinci C, et al. Early and late state subacute sclerosing panencephalitis: chemical shift imaging and single voxel MR spectroscopy. AJNR Am J Neuroradiol. 2003 ; 24: 501-506
15. Khiat A, Boulanger Y, Breton G.. Monitoring the effects of mobile phone use on the brain by proton magnetic resonance spectroscopy. Int J Radiat Biol. 2006 ; 82: 681-685
16. Dasdag S, Akdag MZ, Ulukaya E, Uzunlar AK, et al. Effect of mobile phone exposure on apoptotic glial cells and status of oxidative stress in rat brain. Electromagn Biol Med. 2009 ; 28: 342-354
17. Koyu A, Ozguner F, Cesur G, Özçelik N.. No effects of 900 MHz and 1800 MHz electromagnetic field emitted from cellular phone on nocturnal serum melatonin levels in rats. Toxicol Ind Health. 2005 ; 21: 27-31
18. Tahvanainen K, Niño J, Halonen P, Kuusela T, et al. Cellular phone use does not acutely affect blood pressure or heart rate of humans. Bioelectromagnetics. 2004 ; 25: 73-83
19. Meral I, Mert H, Mert N, Deger Y.. Effects of 900-MHz electromagnetic field emitted from cellular phone on brain oxidative stress and some vitamin levels of guinea pigs. Brain Res. 2007 ; 1169: 120-124
20. Gul A, Celebi H, Ufra S.. The effects of microwave emitted by cellular phones on ovarian follicles in rats. Arch Gynecol Obstet. 2009 ; 280: 729-733
21. Ilhan A, Gurel A, Armutcu F, Kamisli S, Iraz M, Akyol O, et al. Ginkgo biloba prevents mobile phone-induced oxidative stress in rat brain. Clinica Chimica Acta. 2004 ; 340: 153-162
22. Aebi H. Verlag Chemie. Bergmeyer HU, ed. Weinheim: ; 1982: 273-282.
23. Paglia D, Valentine WN.. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967 ; 70: 158-163
24. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ.. Protein measurement with the folin phenol reagent. J Biol Chem. 1951 ; 193: 265-277
25. Cecil KM, Jones BV.. Magnetic resonance spectroscopy of the pediatric brain. Magn Reson Imaging. 2001 ; 12: 435-452
26. Krouwer HG, Kim TA, Rand SD, RWl Prost.. Single-voxel proton MR spectroscopy of nonneo brain lesions suggestive of a neoplasm. AJNR Am J Neuroradiol. 1998 ; 19: 1695-1703
27. Alkan A, Kutlu R, Hallac T, Sigirci A, et al. Occupational prolonged organic solvent exposure in shoemakers: brain MR spectroscopy findings. Magn Reson Imaging. 2004 ; 22: 707-713
28. Salford LG, Brun AE, Eberhardt JL, Malmgren L, et al. Nerve cell damage in mammalian brain after exposure to microwaves from GSM mobile phones. Environ Health Perspec. 2003 ; 111: 881-883
29. Kinoshita Y, Kajwara H, Yokota A, Koga Y.. Proton magnetic resonance spectroscopy of brain tumors: an vitro study. Neurosurgery. 1994 ; 35: 606-614
30. Usineus JPR, Kauppien RA, Vainio PA, et al. Quantitative metabolite patterns of human brain tumors detection by H NMR spectroscopy in vivo and in vitro. J.Comput Assist Tomogr. 1994 ; 18: 705-713
31. Tong Z, Yamaki T, Harada K, Houkin K.. In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard. Magn Reson Imaging. 2004 ; 22: 1017-1024
32. Repacholi MH.. Radiofrequency field exposure and cancer: what do the laboratory studies suggest?. Environ Health Perspect. 1997 ; 105: 1565-1568
33. Chan KC, Khong PL, Cheung MM, Wang S, et al. MRI of late microstructural and metabolic alterations in radiation-induced brain injuries. Journal of Magn Reson Imaging. 2009 ; 29: 1013-1020
34. Castillo M, Kwock L, Mukherji SK.. Clinical applications of MR spectroscopy. AJNR Am J Neuroradiol. 1996 ; 17: 1-15
35. Ward JF.. The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: a review. Int J Radiat Biol. 1990 ; 57: 1141-1150
36. Niki E, Yoshida Y, Saito Y, et al. Lipid peroxidation: mechanisms, inhibition, and biological effects. Biochem Biophys Res Commun. 2005 ; 338: 668-676
37. Balci M, Devrim E, Durak I.. Effects of mobile phones on oxidant/antioxidant balance in cornea and lens of rats. Curr Eye Res. 2007 ; 32: 21-25
38. Meral I, Mert H, Mert N, Deger Y, et al. Effects of 900-MHz electromagnetic field emitted from cellular phone on brain oxidative stress and some vitamin levels of guinea pigs. Brain Res. 2007 ; 1169: 120-124
39. Irmak MK, Fadillioglu E, Gulec M, Erdogan H, et al. Effects of electromagnetic radiation from a cellular telephone on the oxidant and antioxidant levels in rabbits. Cell Biochem Funct. 2002 ; 20: 279-283