Single strand DNA breaks in rat brain cells exposed to microwave radiation

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 596, Issue 1-2 SPEC. ISS., 2006, Pages 76-80

  Paulraj, R ^a   Behari, J ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

DNA strand breaks; Microwave radiation; Single gel electrophoresis

Indexed keywords

SINGLE STRANDED DNA;

ANALYSIS OF VARIANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN CELL; BRAIN DEVELOPMENT; BRAIN TISSUE; COMET ASSAY; CONTROLLED STUDY; DNA STRAND BREAKAGE; GEL ELECTROPHORESIS; MALE; MICROWAVE RADIATION; NONHUMAN; PRIORITY JOURNAL; RADIATION EXPOSURE; RAT; STATISTICAL ANALYSIS;

ANIMALS; BRAIN; COMET ASSAY; DNA DAMAGE; DNA, SINGLE-STRANDED; DOSE-RESPONSE RELATIONSHIP, RADIATION; MALE; MICROWAVES; RATS; RATS, WISTAR; REFERENCE VALUES;

ANIMALIA; RATTUS NORVEGICUS;

EID: 33645960154     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2005.12.006     Document Type: Article

References (27)

1. Moulder J.E., Erdreich L.S., Malyapa R.S., Merritt J., Pickard W.F., and Vijayalaxmi. Cell phones and cancer: what is the evidence for connection?. Radiat. Res. 151 (1999) 513-531
2. Brusick D., Albertini R., McRee D., Peterson D., Williams G., Hanawalt P., and Preston J. Genotoxicity of radiofrequency radiation. DNA/Genetox Expert Panel. Environ. Mol. Mutagen. 32 (1998) 1-16
3. ICNIRP Report. Epidemiology of health effects of radiofrequency. Environ. Health Perspect. 112 17 (2004) 1741-1754
4. Hardell L., Mild K.H., and Carlberg M. Further aspects on cellular and cordless telephones and brain tumours. Int. J Oncol. 22 (2003) 399-407
5. Heynick L.N., Johnston S.A., Patrick A., and Mason P.A. Radio frequency electromagnetic fields: cancer, mutagenesis, and genotoxicity. Bioelctromagnetics 24 (2003) s74-s100
6. Cleary S.F. Biological effects of radiofrequency electromagnetic fields. In: Gandhi O.P. (Ed). Biological effects and Medical Applications of Electromagnetic Energy (1990), Prentice Hall, Englewood Cliffs, NJ 236-255
7. Repacholi M.H. Low level exposure to radiofrequency electromagnetic fields: health effects and research needs. Bioelectromagnetics 19 (1998) 1-19
8. Paulraj R., and Behari J. The effect of low level continuous 2.45 GHz wave on brain enzymes of developing rat brain. Electromag. Biol. Med. 21 3 (2002) 231-241
9. Bohr H., and Bohr J. Microwave enhanced kinetics observed in ORD studies of protein. Bioelectromagnetics 21 (2000) 68-72
10. Neubauer C., Phelan A.M., Kues H., and Lange D.G. Microwave irradiation of rats at 2.45 GHz activates pinocytotic-like uptake of tracer by capillary endothelial cells of cerebral cortex. Bioelectromagnetics 11 4 (1990) 261-268
11. Paulraj R., and Behari J. Radio frequency radiation effects on protein kinase C activity in rats' brain. Mut. Res. 545 (2004) 127-130
12. Kunjilwar K.K., and Behari J. Effect of amplitude modulated radiofrequency radiation on cholenergic system of developing rats. Brain Res. 601 (1993) 321
13. Lai H., Carino M.A., Horita A., and Guy A.W. Effects of a 60 Hz magnetic field on central cholinergic system of the rat. Bioelectromagnetics 14 (1993) 5-15
14. Sarkar S., Ali S., and Behari J. Effect of low power microwave on the mouse genome: a direct DNA analysis. Mut. Res. 320 (1994) 141-147
15. Lai H., and Singh N.P. Single and double strand breaks in rats brain cells after acute exposure to radio frequency electromagnetic radiation. Int. J. Radiat. Biol. 69 (1996) 513-521
16. Iliakis G. The role of DNA double strand breaks in ionizing radiation induced killing of eukaryotic cells. Bio. Essays 13 (1991) 641-648
17. McNamee J.P., Bellier P.V., Gajda G.B., Lavallée B.F., Marro L., Lemay E., and Thansandote A. No evidence for genotoxic effects from 24 h exposure of human leukocytes to 1.9 GHz radiofrequency fields. Radiat. Res. (2003) 693-697
18. Malyapa R.S., Ahern E.W., Chen Bi., Straube W.L., LaRegina M., Pickard W.F., and Roti Roti J.L. DNA damage in rat brain cells after in vivo exposure to 2450 MHz electromagnetic radiation and various methods of Euthanasia. Radiat. Res. 149 (1998) 637-645
19. Malyapa R.S., Ahern E.W., Straube W.L., Moros E.G., Pickard W.F., and Roti Roti J.L. Measurement of DNA damage after exposure to 2450 MHz electromagnetic radiation. Radiat. Res. 148 (1997) 608-617
20. Ray S., and Behari J. Physiological changes in rats after exposure to low levels of microwaves. Radiat. Res. 125 (1990) 199-201
21. Durney C.H., Johnson C.C., Barber P.W., Massoudi H., Iskander M.F., Lords J.L., Ryser D.K., Allen S.J., Mitchell J.C., Radiofrequency Radiation Dosimetry Handbook, Report SAM-TR-78-22, second ed., Brooks Air Force Base, USAF School of Aerospace Medicine, Texas 78235, 1978, p. 94.
22. Lai H., and Singh N.P. Magnetic field-induced DNA strand breaks in brain cells of rat. Environ. Health Perspect. 112 6 (2004) 687-694
23. Tice R.R., Agurell E., Anderson D., Burlinson B., Hartmann A., Kobayashi H., Miyamae Y., Rojas E., Ryu J.-C., and Sasaki Y.F. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mut. 35 (2000) 206-221
24. Maes A., Verschaeve L., Arroyo A., DeWagter C., and Vercruyssen L. In vitro cytogenetic effects of 2450 MHz waves on human peripheral blood lymphocytes. Bioelectromagnetics 14 (1993) 495-501
25. Mitchell C.L., McRee D.J., Peterson N.J., and Tilson H.A. Some behavioral effects of short-term exposure of rats to 2.45-GHz microwave radiation. Bioelectromagnetics 9 (1988) 259-268
26. Lai H., and Singh N.P. Acute low level microwave exposure increases DNA single strand breaks in rat brain cells. Bioelectromagnetics 16 (1995) 207-210
27. Risk evaluation of potential environmental hazards from low energy electromagnetic field exposure using sensitive in vitro methods (REFLEX), final report, 2004, pp. 183-242.