Unraveling curcumin degradation: Autoxidation proceeds through spiroepoxide and vinylether intermediates en route to the main bicyclopentadione

Journal of Biological Chemistry

Volumn 290, Issue 8, 2015, Pages 4817-4828

  Gordon, Odaine N ^a   Luis, Paula B ^a   Sintim, Herman O ^b   Schneider, Claus ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Bldg 142   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION; METABOLITES; OXIDATION;

CHEMICAL DIVERSITY; CURCUMIN; DEGRADATION PRODUCTS; EN-ROUTE; VINYL ETHERS;

REACTION INTERMEDIATES;

BICYCLOPENTADIONE; CARBON CURCUMIN C 14; CURCUMIN; CYCLOBUTYLCYCLOPENTADIONE; DIGUAIACOL; DIHYDROXYCYCLOPENTADIONE ISOMER 1; DIHYDROXYCYCLOPENTADIONE ISOMER 2; HEMIACETALCYCLOPENTADIONE; HYDROXYKETOCYCLOPENTADIONE; SPIROEPOXIDECYCLOPENTADIONE ISOMER 1; SPIROEPOXIDECYCLOPENTADIONE ISOMER 2; TRACER; UNCLASSIFIED DRUG; VINYLETHERCYCLOPENTADIONE; OXYGEN; SPIRO COMPOUND;

ARTICLE; AUTOOXIDATION; CONTROLLED STUDY; DRUG DEGRADATION; DRUG IDENTIFICATION; DRUG LABELING; DRUG STRUCTURE; DRUG TRANSFORMATION; ISOTOPE LABELING; LIPID PEROXIDATION; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; ANALOGS AND DERIVATIVES; CHEMISTRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION REDUCTION REACTION;

CURCUMIN; MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION-REDUCTION; OXYGEN ISOTOPES; SPIRO COMPOUNDS;

EID: 84929096317     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.618785     Document Type: Article

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