Vanillin and ferulic acid: Not the major degradation products of curcumin

Trends in Molecular Medicine

Volumn 18, Issue 7, 2012, Pages 361-363

  Gordon, Odaine N ^a   Schneider, Claus ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 14; CURCUMIN; CYCLOPENTADIENE DERIVATIVE; DRUG METABOLITE; FERULIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATE BUFFERED SALINE; VANILLIN;

AUTOOXIDATION; DRUG DEGRADATION; DRUG STABILITY; DRUG TRANSFORMATION; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; LETTER; LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; MICHAEL ADDITION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ALZHEIMER DISEASE; ANIMALS; CURCUMIN; HUMANS; NEOPLASMS;

EID: 84863090612     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2012.04.011     Document Type: Letter

References (9)

1. Shen L., Ji H.F. The pharmacology of curcumin: is it the degradation products?. Trends Mol. Med. 2012, 18:138-144.
2. Tønnesen H.H., Karlsen J. Studies on curcumin and curcuminoids. V. Alkaline degradation of curcumin. Z. Lebensm. Unters. Forsch. 1985, 180:132-134.
3. Tønnesen H.H., Karlsen J. Studies on curcumin and curcuminoids.VI. Kinetics of curcumin degradation in aqueous solution. Z. Lebensm. Unters. Forsch. 1985, 180:402-404.
4. Pfeiffer E., et al. Studies on the stability of turmeric constituents. J. Food Eng. 2003, 56:257-259.
5. Wang Y.J., et al. Stability of curcumin in buffer solutions and characterization of its degradation products. J. Pharm. Biomed. Anal. 1997, 15:1867-1876.
6. Griesser M., et al. Autoxidative and cyclooxygenase-2 catalyzed transformation of the dietary chemopreventive agent curcumin. J. Biol. Chem. 2011, 286:1114-1124.
7. Schneider C., et al. 2-[(4'-Hydroxy-3'-methoxy)-phenoxyl]-4-(4'-hydroxy-3'-methoxyphenyl)-8-hydroxy-6-oxo-3-oxabicyclo[3.3.0]-7-octene: unusual product of the soybean lipoxygenase-catalyzed oxygenation of curcumin. J. Mol. Catalysis B: Enzymatic 1998, 4:219-227.
8. Thompson D.C., et al. Biological and toxicological consequences of quinone methide formation. Chem. Biol. Interact. 1993, 86:129-162.
9. Plummer S.M., et al. Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex. Oncogene 1999, 18:6013-6020.