Oxidative metabolites of curcumin poison human type II topoisomerases

Biochemistry

Volumn 52, Issue 1, 2013, Pages 221-227

  Ketron, Adam C ^a   Gordon, Odaine N ^a   Schneider, Claus ^a   Osheroff, Neil ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-CANCER AGENTS; ANTI-INFLAMMATORIES; CHEMOPREVENTIVE; CLINICAL TRIAL; COLOR COMPONENT; CURCUMIN; DEGRADATION PRODUCTS; DNA CLEAVAGE; DNA SCISSION; FERULIC ACIDS; HUMAN HEALTH; HUMAN TOPOISOMERASE; NATURALLY OCCURRING; OXIDATION PATHWAY; OXIDIZING AGENTS; PHYSIOLOGICAL PH; POLYPHENOLS; QUINONE METHIDE; REACTIVE INTERMEDIATE; TOPOISOMERASE II; TOPOISOMERASES; TYPE II;

DEGRADATION; DNA; FOOD PRODUCTS; METABOLITES; PH; PHENOLS; REACTION INTERMEDIATES;

OXIDATION;

CURCUMIN; DNA TOPOISOMERASE (ATP HYDROLYSING) A; DNA TOPOISOMERASE (ATP HYDROLYSING) B; ETOPOSIDE; FERULIC ACID; GENISTEIN; QUINONE DERIVATIVE; VANILLIN;

ARTICLE; CHEMOPROPHYLAXIS; DNA CLEAVAGE; DRUG POTENCY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN FOLDING; SACCHAROMYCES CEREVISIAE; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; COLORING AGENTS; CURCUMA; CURCUMIN; DNA CLEAVAGE; DNA TOPOISOMERASES, TYPE II; HUMANS; OXIDATION-REDUCTION; PLANT EXTRACTS;

CURCUMA LONGA;

EID: 84872119769     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi3014455     Document Type: Article

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