Enhancement of mucoadhesive property of polymers for drug delivery applications: A critical review

Reviews of Adhesion and Adhesives

Volumn 1, Issue 2, 2013, Pages 271-290

  Singh, Inderbir ^a   Rana, Vikas ^a  

^a PUNJABI UNIVERSITY   (India)

Author keywords

Drug delivery; Lectins; Mucoadhesion; Mucoadhesive polymers; Thiomers

Indexed keywords

BIOCHEMISTRY; CHEMICAL MODIFICATION; CONTROLLED DRUG DELIVERY; MEDICAMENTS; POLYMERIC MATERIALS; TARGETED DRUG DELIVERY;

CONTROLLED RELEASE; CRITICAL REVIEW; DRUG DELIVERY APPLICATIONS; DRUG-DELIVERY SYSTEMS; MUCOADHESION; MUCOADHESIVE POLYMERS; MUCOADHESIVE PROPERTIES; MUCOADHESIVES; SYSTEMIC DELIVERIES; THIOMERS;

PROTEINS;

EID: 84928984488     PISSN: 21680965     EISSN: 21680973     Source Type: Journal    
DOI: 10.7569/RAA.2013.097307     Document Type: Article

References (73)

1. J. Woodley, Bioadhesion: New possibilities for drug administration. Clin. Pharmacokinet. 40, 77-84 (2001).
2. S. Roy, K. Pal, A. Anis, K. Pramanik, and B. Prabhakar, Polymers in mucoadhesive drug delivery system: A brief note. Designed Monomers Polymers 12, 483-495 (2009).
3. F. Madsen, K. Eberth, and J. Smart, A rheological assessment of the nature of interactions between mucoadhesive polymers and a homogenised mucus gel. Biomaterials 19, 1083-1092 (1998).
4. I. Singh, and V. Rana, Techniques for the assessment of mucoadhesion in drug delivery systems: An overview. J. Adhesion Sci. Technol. 26, 2251-2267 (2012).
5. G.P. Andrews, T.P. Laverty, and D.S. Jones, Mucoadhesive polymeric platforms for controlled drug delivery. Eur. J. Pharm. Biopharm. 71, 505-518 (2009).
6. V. Bansal, P.K. Sharma, N. Sharma, O.P. Pal, and R. Malviya, Applications of chitosan and chitosan derivatives in drug delivery. Adv. Biol. Res. 5, 28-37 (2011).
7. A. Bernkop-Schnürch, Chitosan and its derivatives: Potential excipients for peroral peptide delivery systems. Int. J. Pharm. 194, 1-13 (2000).
8. C. Lehr, Lectin-mediated drug delivery: The second generation of bioadhesives. J. Controlled Release 65, 19-29 (2000).
9. M.A. Clark, B. Hirst, and M. Jepson, Lectin-mediated mucosal delivery of drugs and microparticles. Adv. Drug Deliv. Rev. 43, 207-223 (2000).
10. M. Wirth, K. Gerhardt, C. Wurm, and F. Gabor, Lectin-mediated drug delivery: Influence of mucin on cytoadhesion of plant lectins in vitro. J. Controlled Release 79, 183-191 (2002).
11. M.J. Montisci, A. Dembri, G. Giovannuci, H. Chacun, D. Duchêne, and G. Ponchel, Gastrointestinal transit and mucoadhesion of colloidal suspensions of Lycopersicon esculentum L. and Lotus tetragonolobus lectin-PLA microsphere conjugates in rats. Pharm. Res. 18, 829-837 (2001).
12. S.K. Jain, and M.S. Jangdey, Lectin conjugated gastroretentive multiparticulate delivery system of clarithromycin for the effective treatment of helicobacter pylori. Mol. Pharm. 6, 295-304 (2009).
13. A. Sharma, S. Sharma, and G.K. Khuller, Lectin-functionalized poly ( lactide-co-glycolide) nanoparticles as oral/aerosolized antitubercular drug carriers for treatment of tuberculosis. J. Antimicrob. Chemother. 54, 761-766 (2004).
14. C.M. Lehr, J.A. Bouwstra, W. Kok, A.B.J. Noach, A.G. de Boer, and H.E. Junginger, Bioadhesion by means of specific binding of tomato lectin. Pharm. Res. 9, 574-553 (1992).
15. D.C. Savage, Microbial ecology of the gastrointestinal tract. Annu. Rev. Microbiol. 31, 107-133 (1977).
16. A. Bernkop-Schnürch, F. Gabor, M. Szostak, and W. Lubitz, An adhesive drug delivery system based on K99-fimbriae. Eur. J. Pharm. Sci. 3, 293-299 (1995).
17. Y.L. Ong, A. Razatos, G. Georgiou, and M.M. Sharma, Adhesion forces between E. coli bacteria and biomaterial surfaces. Langmuir 15, 2719-2725 (1999).
18. R.J. Emerson IV, and T.A. Camesano, Nanoscale investigation of pathogenic microbial adhesion to a biomaterial. Appl. Environ. Microbiol. 70, 6012-6022 (2004).
19. Y.H. An, and R.J. Friedman, Concise review of mechanisms of bacterial adhesion to biomaterial surfaces. J. Biomed. Mater. Res. 43, 338-348 (1998).
20. M. Katsikogianni, and Y.F. Missirlis. Concise review of mechanisms of bacterial adhesion to biomaterials and of techniques used in estimating bacteria-material interactions. Eur. Cells Mater. 8, 37-57 (2004).
21. J.K. Vasir, K. Tambwekar, and S. Garg, Review: Bioadhesive microspheres as a controlled drug delivery system. Int. J. Pharm. 255, 13-32 (2003).
22. A. Bernkop-Schnürch, V. Schwarz, and S. Steininger, Polymers with thiol groups: A new generation of mucoadhesive polymers. Pharm. Res. 16, 876-881 (1999).
23. A.G. Mikos, and N.A. Peppas, Kinetics of Mucus-Polymer Interactions, in Bioadhesion-Possibilities and Future Trends, R. Gurny and H.E. Junginger, (Eds.), pp. 65-85, Wissenschaftliche Verlagsges, Stuttgart, Germany (1990).
24. A. Bernkop-Schnürch, A.H. Krauland, V.M. Leitner, and T. Palmberger, Thiomers: Potential excipients for non-invasive peptide delivery systems. Eur. J. Pharm. Biopharm.58, 253-263 (2004).
25. J. Iqbal, G. Shahnaz, S. Dünnhaupt, C. Müller, F. Hintzen, and A. Bernkop-Schnürch, Preactivated thiomers as mucoadhesive polymers for drug delivery. Biomaterials 33, 1528-1535 (2012).
26. M. Thanou, B.I. Florea, M.W. Langemeyer, J.C. Verhoef, and H.E. Junginger, N-trimethylated chitosan chloride (TMC) improves the intestinal permeation of the peptide drug buserelin in vitro (Caco-2 cells) and in vivo (rats). Pharm. Res. 17, 27-31(2000).
27. M. Thanou, M.T. Nihot, M. Jansen, J.C. Verhoef, and H.E. Junginger, Mono-Ncarboxymethyl chitosan (MCC), a polyampholytic chitosan derivative, enhances the intestinal absorption of low molecular weight heparin across intestinal epithelia in vitro and in vivo. J. Pharm. Sci. 90, 38-46 (2001).
28. H. Baumann, and V. Faust, Concepts for improved regioselective placement of O-sulfo, N-sulfo, N-acetyl, and N-carboxymethyl groups in chitosan derivatives. Carbohydrate Res. 331, 43-57 (2001).
29. A. Bernkop-Schnürch, and M.E. Krajicek, Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: Synthesis and evaluation of different chitosan-EDTA conjugates. J. Controlled Release 50, 215-223 (1998).
30. L. Yin, J. Ding, C. He, L. Cui, C. Tang, and C. Yin, Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery. Biomaterials 30, 5691-5700 (2009).
31. N.D. Catron, H. Lee, and P.B. Messersmith, Enhancement of poly (ethylene glycol) mucoadsorption by biomimetic end group functionalization. Biointerphases 1, 134-141 (2006).
32. J. Wang, Y. Tabata, D. Bi, and K. Morimoto, Evaluation of gastric mucoadhesive properties of aminated gelatin microspheres. J. Controlled Release 73, 223-231 (2001).
33. A. Bernkop-Schnürch, C.E. Kast, and M.F. Richter, Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine. J. Controlled Release 71, 277-285 (2001).
34. G. Ruiz, and E.S. Ghaly, Mucoadhesive delivery systems using carrageenan and Eudragit RLPO. Vitae, Revista Facultad Química Farmacéutica 13, 31-39 (2006).
35. W.J. Lee, S. Cha, M. Shin, M. Jung, M.A. Islam, C. Cho, and H.S. Yoo, Efficacy of thiolated Eudragit microspheres as an oral vaccine delivery system to induce mucosal immunity against enterotoxigenic Escherichia coli in mice. Eur. J Pharm. Biopharm. 81, 43-48 (2012).
36. S. Sajeesh, K. Bouchemal, C.P. Sharma, and C. Vauthier, Surface-functionalized polymethacrylic acid based hydrogel microparticles for oral drug delivery. Eur. J Pharm. Biopharm. 74, 209-218 (2010).
37. S. Horvát, A. Fehér, H. Wolburg, P. Sipos, S. Veszelka, A. Tóth, L. Kis, A. Kurunczi, G. Balogh, L. Kürti, I. Eros, P. Szabó-Révész, and M.A. Deli, Sodium hyaluronate as a mucoadhesive component in nasal formulation enhances delivery of molecules to brain tissue. Eur. J. Pharm. Biopharm. 72, 252-259 (2009).
38. B. Albertini, N. Passerini, M.D. Sabatino, B. Vitali, P. Brigidi, and L. Rodriguez, Polymer-lipid based mucoadhesive microspheres prepared by spray-congealing for the vaginal delivery of econazole nitrate. Eur. J. Pharm. Sci. 36, 591-601 (2009).
39. M. Davidovich-Pinhas, and H. Bianco-Peled, Physical and structural characteristics of acrylated poly (ethylene glycol)-alginate conjugates. Acta Biomater. 7, 2817-2825 (2011).
40. M.L. Manca, G. Loy, M. Zaru, A.M. Fadda, and S.G. Antimisiaris, Release of rifampicin from chitosan, PLGA and chitosan-coated PLGA microparticles. Colloids Surfaces B 67, 166-170 (2008).
41. R. Abu-Dahab, U.F. Schäfer, and C.M. Lehr, Lectin-functionalized liposomes for pulmonary drug delivery: Effect of nebulization on stability and bioadhesion. Eur. J. Pharm. Sci. 14, 37-46 (2001).
42. K.H. Leong, L.Y. Chung, M.I. Noordin, Y. Onuk, M. Mariko, and T. Kozo, Lectin-functionalized carboxymethylated kappa-carrageenan microparticles for oral insulin delivery. Carbohydrate Polymers 86, 555-565 (2011).
43. A. Makhlof, S. Fujimoto, Y. Tozuka, and H. Takeuchi, In vitro and in vivo evaluation of WGA-carbopol modified liposomes as carriers for oral peptide delivery. Eur. J. Pharm. Biopharm. 77, 216-224 (2011).
44. M.A. Arangoa, G. Ponchel, A.M. Orecchioni, M.J. Renedo, D. Duchene, and J.M. Irache, Bioadhesive potential of gliadin nanoparticulate systems. Eur. J. Pharm. Sci. 11, 333-341 (2000).
45. H. Wu, J. Li, Q. Zhang, X. Yan, L. Guo, X. Gao, M. Qiu, X. Jiang, R. Lai R, and H.Chen, A novel small odorranalectin-bearing cubosomes: Preparation, brain delivery and pharmacodynamic study on amyloid-b25-35-treated rats following intranasal administration. Eur. J. Pharm. Biopharm. 80, 368-378 (2012).
46. S. Saremi, F. Atyabi, S.P. Akhlaghi, S.N. Ostad, and R. Dinarvand, Thiolated chitosan nanoparticles for enhancing oral absorption of docetaxel: Preparation, in vitro and ex vivo evaluation. Int. J. Nanomedicine 12, 119-128 (2011).
47. M.R. Saboktakin, R.M. Tabatabaie, A. Maharramov, and M.A. Ramazanov, Development and in vitro evaluation of thiolated chitosan-poly (methacrylic acid) nanoparticles as a local mucoadhesive delivery system. Int. J. Biol. Macromol. 48, 403-407 (2011).
48. V. Grabovac, and A. Bernkop-Schnürch, Development and in vitro evaluation of surface modified poly(lactide-co-glycolide) nanoparticles with chitosan-4-thiobutylamidine. Drug Dev. Ind. Pharm. 33, 767-774 (2007).
49. A. Bernkop-Schnürch, M. Hornof, and T. Zoidl, Thiolated polymers-thiomers: Synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates. Int. J. Pharm. 260, 229-237 (2003).
50. G. Millotti, G. Perera, C. Vig, K. Pick, F.M. Sinner, and A. Bernkop-Schnürch, The use of chitosan-6-mercaptonicotinic acid nanoparticles for oral peptide drug delivery. Drug Deliv. 18, 190-197 (2011).
51. J.S. Quan, H.L. Jiang, E.M. Kim, H.J. Jeong, Y.J. Choi, D.D. Guo, M.K. Yoo, H.G. Lee, and C.S. Cho, pH-sensitive and mucoadhesive thiolated Eudragit-coated chitosan microspheres. Int. J. Pharm. 359, 205-210 (2008).
52. K. Kafedjiiski, F. Föger, M. Werle, and A. Bernkop-Schnürch, Synthesis and in vitro evaluation of a novel chitosan-glutathione conjugate. Pharm. Res. 22, 1480-1488 (2005).
53. A. Bernkop-Schnürch, C.E. Kast, and M.F. Richter, Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine. J. Controlled Release 71, 277-285 (2001).
54. J. Iqbal, G. Shahnaz, S. Dünnhaupt, C. Müller, F. Hintzen, and A. Bernkop-Schnürch, Preactivated thiomers as mucoadhesive polymers for drug delivery. Biomaterials. 33, 1528-1535 (2012).
55. E. Cevher, D. Sensoy, M.A. Taha, and A. Araman, Effect of thiolated polymers to textural and mucoadhesive properties of vaginal gel formulations prepared with polycarbophil and chitosan. AAPS PharmSciTech. 9, 953-965 (2008).
56. G. Shahnaz, G. Perera, D. Sakloetsakun, D. Rahmat, and A. Bernkop-Schnürch, Synthesis, characterization, mucoadhesion and biocompatibility of thiolated carboxymethyl dextran-cysteine conjugate. J. Controlled Release 144, 32-38 (2010).
57. R. Sharma, and M. Ahuja, Thiolated pectin: Synthesis, characterization and evaluation as a mucoadhesive polymer. Carbohydrate Polymers 85, 658-663 (2011).
58. M.A. Islam, P. Bajracharya, S.K. Kang, C.H. Yun, E.M. Kim, H.J. Jeong, Y.J. Choi, E.B. Kim, and C.S. Cho, Mucoadhesive alginate/poly (L-lysine)/thiolated alginate microcapsules for oral delivery of Lactobacillus salivarius 29. J. Nanosci. Nanotechnol. 11, 7091-7095 (2011).
59. X. Li, G. Yu, K. Jin, and Z. Yin, Hyaluronic acid L-cysteine conjugate exhibits controlledrelease potential for mucoadhesive drug delivery. Pharmazie 67, 224-228 (2012).
60. F. Sarti, J. Iqbal, C. Müller, G. Shahnaz, D. Rahmat, and A. Bernkop-Schnürch, Poly(acrylic acid)-cysteine for oral vitamin B12 delivery. Anal. Biochem. 420, 13-19 (2012).
61. F. Sarti, A. Staaf, D. Sakloetsakun, and A. Bernkop-Schnürch, Thiolated hydroxyethylcellulose: synthesis and in vitro evaluation. Eur. J. Pharm. Biopharm. 76, 421-427 (2010).
62. J. Shen, Y. Wang, Q. Ping, Y. Xiao, and X. Huang, Mucoadhesive effect of thiolated PEG stearate and its modified NLC for ocular drug delivery. J. Controlled Release 137, 217-23 (2009).
63. M. Werle, K. Hironaka, H. Takeuchi, and H. Hoyer, Development and in vitro characterization of liposomes coated with thiolated poly(acrylic acid) for oral drug delivery. Drug Dev. Ind. Pharm. 35, 209-215 (2009).
64. S. Majzoob, F. Atyabi, F. Dorkoosh, K. Kafedjiiski, B. Loretz and A. Bernkop-Schnürch, Pectin-cysteine conjugate: Synthesis, and in-vitro evaluation of its potential for drug delivery. J. Pharm. Pharmacol. 58, 1601-1610 (2006).
65. A. Bernkop-Schnürch, V. König, V.M. Leitner, A.H. Krauland, and I. Brodnik, Preparation and characterisation of thiolated poly(methacrylic acid)-starch compositions. Eur. J. Pharm. Biopharm. 57, 219-224 (2004).
66. M. Davidovich-Pinhas, and H. Bianco-Peled, Physical and structural characteristics of acrylated poly (ethylene glycol)-alginate conjugates. Acta Biomater. 7, 2817-2825 (2011).
67. V.M. Patel, B.G. Prajapati, and M.M. Patel. Effect of hydrophilic polymers on buccoadhesive Eudragit patches of propranolol hydrochloride using factorial design. AAPS PharmSciTech. 8, Article 45 (2007).
68. G. Sandri, M.C. Bonferoni, S. Rossi, F. Ferrari, S. Gibin, Y. Zambito, G.D. Colo, and C. Caramella, Nanoparticles based on N-trimethylchitosan: Evaluation of absorption properties using in vitro (Caco-2 cells) and ex vivo (excised rat jejunum) models. Eur. J. Pharm. Biopharm. 65, 68-77 (2007).
69. J. Akbari, M. Saeedi, R. Enayatifard, and M.S. Doost, Development and evaluation of mucoadhesive chlorhexidine tablet formulations. Tropical J. Pharm. Res. 9, 321-327 (2010). Schematic representation of various mucoadhesion.
70. S.L. Tao, M.W. Lubeley, and T.A. Desai, Synthesis of cytoadhesive poly (methyl methacrylate) for applications in targeted drug delivery. J. Biomed. Mater. Res. A 67, 369-375 (2003).
71. S.A. Yehia, O.N. El-Gazayerly, and E.B. Basalious, Fluconazole mucoadhesive buccal films: In vitro/in vivo performance. Curr. Drug Deliv. 6, 17-27 (2009).
72. P.F. Builders, N. Ibekwe, L.C. Okpako, A.A. Attama, and O.O. Kunle, Preparation and characterization of mucinated cellulose microparticles for therapeutic and drug delivery purposes. Eur. J. Pharm. Biopharm. 72, 34-41 (2009).
73. Y. Tao, Y. Lu, Y. Sun, B. Gu, W. Lu, and J. Pan, Development of mucoadhesive microspheres of acyclovir with enhanced bioavailability. Int. J. Pharm. 378, 30-36 (2009).