Sodium hyaluronate as a mucoadhesive component in nasal formulation enhances delivery of molecules to brain tissue

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 72, Issue 1, 2009, Pages 252-259

  Horvát, Sándor ^a,b   Fehér, András ^b   Wolburg, Hartwig ^c   Sipos, Péter ^b   Veszelka, Szilvia ^a   Tóth, Andrea ^a   Kis, Lóránd ^a   Kurunczi, Anita ^a   Balogh, Gábor ^d   Kürti, Levente ^b   Eros, István ^b   Szabó Révész, Piroska ^b   Deli, Mária A ^a  

^a INSTITUTE OF BIOCHEMISTRY   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^d INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Absorption enhancer; Blood brain barrier; Brain targeting; FITC dextran; Hyaluronic acid; In vitro drug release; Mucoadhesive; Nasal drug delivery; Rheology

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE DEXTRAN; HYALURONIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BRAIN LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG TRANSPORT; HIPPOCAMPUS; MALE; MUCOADHESION; NONHUMAN; OLFACTORY BULB; PARIETAL LOBE; RAT; SPECTROPHOTOMETRY;

ADMINISTRATION, INTRANASAL; ANIMALS; BRAIN; DEXTRANS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FLUORESCEIN-5-ISOTHIOCYANATE; HYALURONIC ACID; MALE; RATS; RATS, WISTAR; RHEOLOGY; SPECTROMETRY, FLUORESCENCE; TISSUE DISTRIBUTION;

EID: 62949136634     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.10.009     Document Type: Article

References (39)

1. Pardridge W.M. The blood-brain barrier: bottleneck in brain drug development. NeuroRx 2 (2005) 3-14
2. Deli M.A., Ábrahám C.S., Kataoka Y., and Niwa M. Permeability studies on in vitro blood-brain barrier models: physiology, pathology and pharmacology. Cell Mol. Neurobiol. 25 (2005) 59-127
3. Egleton R.D., and Davis T.P. Development of neuropeptide drugs that cross the blood-brain barrier. NeuroRx 2 (2005) 44-53
4. Schnyder A., and Huwyler J. Drug transport to brain with targeted liposomes. NeuroRx 2 (2005) 99-107
5. Garcia-Garcia E., Andrieux K., Gilb S., and Couvreur P. Colloidal carriers and blood-brain barrier (BBB) translocation: a way to deliver drugs to the brain?. Int. J. Pharm. 298 (2005) 274-292
6. Somogyi G., Nishitani S., Nomi D., Buchwald P., Prokai L., and Bodor N. Targeted drug delivery to the brain via phosphonate derivatives I. Design, synthesis and evaluation of an anionic chemical delivery system for testosterone. Int. J. Pharm. 166 (1998) 15-26
7. Neuwelt E.A., Maravilla K.R., Frenkel E.P., Rapoport S.I., Hill S.A., and Barnett P.A. Osmotic blood-brain barrier disruption. J. Clin. Invest. 64 (1979) 684-688
8. Temsamani J., Scherrmann J.M., Rees A.R., and Kaczorek M. Brain drug delivery technologies: novel approaches for transporting therapeutics. Pharm. Sci. Technol. Today 3 (2000) 155-162
9. Illum L. Transport of drugs from the nasal cavity to the central nervous system. Eur. J. Pharm. Sci. 11 (2000) 1-18
10. Illum L. Nasal drug delivery: new developments and strategies. Drug Discov. Today 7 (2002) 1184-1189
11. Illum L. Nasal drug delivery-possibilities, problems and solutions. J. Control. Release 87 (2003) 187-198
12. Zhang Q., Jiang X., Jiang W., Lu W., Su L., and Shi Z. Preparation of nimodipine-loaded microemulsion for intranasal delivery and evaluation on the targeting efficiency to the brain. Int. J. Pharm. 275 (2004) 85-96
13. Thorne R.G., Pronk G.J., Padmanabhan V., and Frey W.H. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 127 (2004) 481-496
14. Behl C.R., Pimplaskar H.K., Sileno A.P., deMeireles J., and Romeo V.D. Effects of physicochemical properties and other factors on systemic nasal drug delivery. Adv. Drug Deliv. Rev. 29 (1998) 89-116
15. Costantino H.R., Illum L., Brandt G., Johnson P.H., and Quaya S.C. Intranasal delivery: physicochemical and therapeutic aspects. Int. J. Pharm. 337 (2007) 1-24
16. Ugwoke M.I., Agu R.U., Verbeke N., and Kinget R. Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives. Adv. Drug Deliv. Rev. 57 (2005) 1640-1665
17. Khafagy E.-S., Morishita M., Onuki Y., and Takayama K. Current challenges in non-invasive insulin delivery systems: a comparative review. Adv. Drug Deliv. Rev. 59 (2007) 1521-1546
18. Wolburg H., Wolburg-Buchholz K., Sam H., Horvát S., Deli M.A., and Mack A.F. Epithelial and endothelial barriers in the olfactory region of the nasal cavity of the rat. Histochem. Cell Biol. 130 (2008) 127-140
19. Lehr C.-M. Lectin-mediated drug delivery: the second generation of bioadhesives. J. Control. Release 65 (2000) 19-29
20. Narang A.S., Delmarre D., and Gao D. Stable drug encapsulation in micelles and microemulsions. Int. J. Pharm. 345 (2007) 9-25
21. Regea B.D., Kaob J.P.Y., and Polli J.E. Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers. Eur. J. Pharm. Sci. 16 (2002) 237-246
22. Pouton C.W. Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. Eur. J. Pharm. Sci. 29 (2006) 278-287
23. Takano M., Yumoto R., and Murakami T. Expression and function of efflux drug transporters in the intestine. Pharmacol. Therapeut. 109 (2006) 137-161
24. Liao Y.H., Jones S.A., Forbes B., Martin G.P., and Brown M.B. Hyaluronan: pharmaceutical characterization and drug delivery. Drug Deliv. 12 (2005) 327-342
25. Jiang D., Liang J., and Noble P.W. Hyaluron in tissue injury and repair. Annu. Rev. Cell Dev. Biol. 23 (2007) 435-461
26. Ludwig A. The use of mucoadhesive polymers in ocular drug delivery. Adv. Drug Deliv. Rev. 57 (2005) 1595-1639
27. Prestwich G.D., and Vercruysse K.P. Therapeutic application of hyaluronic acid and hyaluronan derivatives. Pharm. Sci. Technol. Today 1 (1998) 42-43
28. Cho K.Y., Chung T.W., Kim B.C., Kim M.K., Lee J.H., Wee W.R., and Cho C.S. Release of ciprofloxacin from poloxamer-graft-hyaluronic acid hydrogels in vitro. Int. J. Pharm. 260 (2003) 83-91
29. Lim S.T., Martin G.P., Berry D.J., and Brown M.B. Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microspheres of hyaluronic acid and chitosan. J. Control. Release 66 (2000) 281-292
30. Bonferoni M.C., Giunchedi P., Scalia S., Rossi S., Sandri G., and Caramella C. Chitosan gels for the vaginal delivery of lactic acid: relevance of formulation parameters to mucoadhesion and release mechanisms. AAPS Pharm. Sci. Tech. 7 (2006) 104
31. Shah V.P., Tsong Y., Sathe P., and Liu J.-P. In vitro dissolution profile comparison - statistics and analysis of the similarity factor. Pharm. Res. 15 (1998) 889-896
32. Guidance for Industry, Dissolution Testing of Immediate Release Solid Oral Dosage Forms. US Food and Drug Administration, Rockville, MD, 1997. http://www.fda.gov/cder/Guidance/1713bp1.pdf.
33. O'Hara T., Dunne A., Butler J., and Devane J. A review of methods used to compare dissolution profile data. Pharm. Sci. Technol. Today 1 (1998) 214-223
34. Pringels E., Vervaet C., Verbeeck R., Foreman P., and Remon J.P. The addition of calcium ions to starch/Carbopol(R) mixtures enhances the nasal bioavailability of insulin. Eur. J. Pharm. Biopharm. 68 (2008) 201-206
35. Morimoto K., Yamaguchi H., Iwakura Y., Marisaka K., Ohashi Y., and Nakai Y. Effect of viscous hialuronate-sodium on the nasal absorption of vasopressin and an analogue. Pharm. Res. 8 (1991) 471-474
36. Banks W.A. Blood-brain barrier transport of cytokines: a mechanism for neuropathology. Curr. Pharm. Des. 11 (2005) 973-984
37. Jansson B., Hägerström H., Fransén N., Edsman K., and Björk E. The influence of gellan gum on the transfer of fluorescein dextran across rat nasal epithelium in vivo. Eur. J. Pharm. Biopharm. 59 (2005) 557-564
38. Charlton S.T., Davis S.S., and Illum L. Evaluation of effect of ephedrine on the transport of drugs from the nasal cavity to the systemic circulation and the central nervous system. J. Drug Target. 15 (2007) 370-377
39. In: Rowe R.C., Sheskey P.J., and Owen S.C. (Eds). Handbook of Pharmaceutical Excipients (2005), Pharmaceutical Press, London pp. 572-579