Baculovirus-mediated gene delivery and RNAi applications

Viruses

Volumn 7, Issue 4, 2015, Pages 2099-2125

  Makkonen, Kaisa Emilia ^a   Airenne, Kari ^a   Ylä Herttulala, Seppo ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Baculovirus; Gene transfer; RNAi; Viral vector

Indexed keywords

BACULOVIRUS VECTOR; BETA ACTIN; DNA BINDING PROTEIN; DNA METHYLTRANSFERASE INHIBITOR; INTERFERON; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MICRORNA 26A; MICRORNA 29B; NOCODAZOLE; PHORBOL 12 ACETATE 13 MYRISTATE; POLYHEDRIN; PROTEOHEPARAN SULFATE; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; VINBLASTINE; VIRUS ENVELOPE PROTEIN;

ADENO ASSOCIATED VIRUS; AUTOGRAPHA CALIFORNICA; BACULOVIRIDAE; ENDOCYTOSIS; GENE EXPRESSION; GENE SEQUENCE; GENE TRANSFER; GENETIC TRANSDUCTION; GLIOBLASTOMA; HUMAN; IMMUNE SYSTEM; LENTIVIRINAE; LIVER CANCER; NASOPHARYNX CANCER; NONHUMAN; OVARY CANCER; PESTE-DES-PETITS-RUMINANTS VIRUS; REVIEW; RNA INTERFERENCE; SPODOPTERA; SPODOPTERA FRUGIPERDA; STOMACH CANCER; TRICHOPLUSIA NI; VIRAL GENE DELIVERY SYSTEM; VIRAL TROPISM; VIRUS ATTACHMENT; VIRUS ENTRY; ANIMAL; ARTHROPOD; GENE VECTOR; GENETICS; PHYSIOLOGY; VERTEBRATE;

HEXAPODA; VERTEBRATA;

ANIMALS; ARTHROPODS; BACULOVIRIDAE; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; RNA INTERFERENCE; TRANSDUCTION, GENETIC; VERTEBRATES;

EID: 84928975124     PISSN: 19994915     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v7042099     Document Type: Review

References (257)

1. Summers, M.D. Milestones leading to the genetic engineering of baculoviruses as expression vector systems and viral pesticides. Adv. Virus Res. 2006, 68, 3-73.
2. Miller, L.K. The Baculoviruses; Plenum Press: New York, NY, USA, 1997.
3. Kost, T.A.; Condreay, J.P. Innovations-Biotechnology: Baculovirus vectors as gene transfer vectors for mammalian cells: Biosafety considerations. J. Am. Biol. Saf. Assoc. 2002, 7, 167-169.
4. Burges, H.; Croizier, G.; Huger, J. A rewiew of safety tests on baculoviruses. Entomaphaga 1980, 25, 329-339.
5. Black, B.C.; Brennan, L.A.; Dierks, P.M.; Gard, I.E. Commercialization of baculoviral insecticides. In The Baculoviruses; Miller, L.K., Ed.; Plenum Press: New York, NY, USA, 1997; p. 341.
6. Herniou, E.; Arif, B.; Becnel, J.; Blissard, G.; Bonning, B.; Harrison, R.; Jehle, J.; Theilmann, D.; Vlak, J. Virus Taxonomy: Classification and Nomenclature of Viruses Ninth Report of the International Committee on Taxonomy of Viruses; King, A., Adams, M., Carstens, E., Lefkowitz, E., Eds.; Elsevier: London, UK, 2012.
7. Martignoni, M.; Iwai, P. A Catalog of Viral Diseases of Insects, Mites and Ticks, 4th ed.; US Department of Agriculture, Forest Service, Pacific Northwest Research Station: Portland, OR, USA, 1986.
8. Gröner, A. Specificity and Safety of Baculoviruses; Granados, R., Federici, B., Eds.; CRC Press: Boca Raton, FL, USA, 1977.
9. Summers, M.D.; Anderson, D.L. Granulosis virus deoxyribonucleic acid: A closed, double-stranded molecule. J. Virol. 1972, 9, 710-713.
10. Burgess, S. Molecular weights of lepidopteran baculovirus DNAs: Derivation by electron microscopy. J. Gen. Virol. 1977, 37, 501-510.
11. Herniou, E.A.; Arif, B.M.; Becnel, J.J.; Blissard, G.W.; Bonning, B.; Harrison, R.; Jehle, J.A.; Theilmann, D.A.; Vlak, J.M. Baculoviridae. In Virus Taxonomy: VIIIth Report of the International Committee on Taxonomy of Viruses; Fauquet, C.M., Mayo, M.A., Maniloff, J., Desselberger, U., Ball, L.A., Eds.; Elsevier/Academic Press: London, UK, 2005; pp. 177-185.
12. Tweeten, K.A.; Bulla, L.A.; Consigli, R.A. Characterization of an extremely basic protein derived from granulosis virus nucleocapsids. J. Virol. 1980, 33, 866-876.
13. Williams, G.V.; Faulkner, P. Cytological changes and viral morphogenesis during baculovirus infection. In The Baculoviruses; Miller, L.K., Ed.; Plenum Press: New York, NY, USA, 1997; pp. 61-107.
14. Harrap, K.A. The structure of nuclear polyhedrosis viruses. II. The virus particle. Virology 1972, 50, 124-132.
15. Van Loo, N.D.; Fortunati, E.; Ehlert, E.; Rabelink, M.; Grosveld, F.; Scholte, B.J. Baculovirus infection of nondividing mammalian cells: Mechanisms of entry and nuclear transport of capsids. J. Virol. 2001, 75, 961-970.
16. Fraser, M.J. Ultrastructural observations of virion maturation in Autographa califomica nuclear polyhedrosis virus-infected Spodoptera frugiperda cell cultures. J. Ultrastruct. Mol. Struct. Res. 1986, 95, 189-195.
17. O’Reilly, D.R.; Miller, L.K.; Luckov, V.A. Baculovirus Expression Vectors: A Laboratory Manual; Oxford University Press: New York, NY, USA, 1994.
18. Jehle, J.A.; Blissard, G.W.; Bonning, B.C.; Cory, J.S.; Herniou, E.A.; Rohrmann, G.F.; Theilmann, D.A.; Thiem, S.M.; Vlak, J.M. On the classification and nomenclature of baculoviruses: A proposal for revision. Arch. Virol. 2006, 151, 1257-1266.
19. Miller, L.K. Baculoviruses as gene expression vectors. Annu. Rev. Microbiol. 1988, 42, 177-199.
20. Granados, R.R.; Federici, B.A. The Biology of Baculoviruses; CRC Press: Boca Raton, FL, USA, 1986.
21. Herniou, E.A.; Olszewski, J.A.; Cory, J.S.; O’Reilly, D.R. The genome sequence and evolution of baculoviruses. Annu. Rev. Entomol. 2003, 48, 211-234.
22. Szewczyk, B.; Hoyos-Carvajal, L.; Paluszek, M.; Skrzecz, I.; Lobo de Souza, M. Baculoviruses-Re-emerging biopesticides. Biotechnol. Adv. 2006, 24, 143-160.
23. Harrap, K.A.; Longworth, J.F. An evaluation of purification methods for baculoviruses. J. Invertebr. Pathol. 1974, 24, 55-62.
24. Granados, R.R.; Lawler, K.A. In vivo pathway of Autographa californica baculovirus invasion and infection. Virology 1981, 108, 297-308.
25. Keddie, B.A.; Aponte, G.W.; Volkman, L.E. The pathway of infection of Autographa californica nuclear polyhedrosis virus in an insect host. Science 1989, 243, 1728-1730.
26. Federici, B. Baculovirus pathogenesis. In The baculoviruses; Miller, L.K., Ed.; Plenum Press: New York, NY, USA, 1997; pp. 33-59.
27. Ohkawa, T.; Washburn, J.O.; Sitapara, R.; Sid, E.; Volkman, L.E. Specific binding of Autographa californica M nucleopolyhedrovirus occlusion-derived virus to midgut cells of Heliothis virescens larvae is mediated by products of pif genes Ac119 and Ac022 but not by Ac. J. Virol. 2005, 79, 15258-15264.
28. Washburn, J.O.; Lyons, E.H.; Haas-Stapleton, E.J.; Volkman, L.E. Multiple nucleocapsid packaging of Autographa californica nucleopolyhedrovirus accelerates the onset of systemic infection in Trichoplusia ni. J. Virol. 1999, 73, 411-416.
29. Engelhard, E.K.; Kam-Morgan, L.N.; Washburn, J.O.; Volkman, L.E. The insect tracheal system: A conduit for the systemic spread of Autographa californica M nuclear polyhedrosis virus. Proc. Natl. Acad. Sci. USA 1994, 91, 3224-3227.
30. Braunagel, S.C.; Summers, M.D. Autographa californica nuclear polyhedrosis virus, PDV, and ECV viral envelopes and nucleocapsids: Structural proteins, antigens, lipid and fatty acid profiles. Virology 1994, 202, 315-328.
31. Funk, C.; Braunagel, S.; Rohrmann, G. Baculovirus structure. In The baculoviruses; Miller, L.K., Ed.; Plenum Press: New York, NY, USA, 1997; pp. 33-59.
32. Wang, P.; Hammer, D.A.; Granados, R.R. Binding and fusion of Autographa californica nucleopolyhedrovirus to cultured insect cells. J. Gen. Virol. 1997, 78, 3081-3089.
33. Granados, R.R. Early events in the infection of Hiliothis zea midgut cells by a baculovirus. Virology 1978, 90, 170-174.
34. Summers, M.D. Electron microscopic observations on granulosis virus entry, uncoating and replication processes during infection of the midgut cells of Trichoplusia ni. J. Ultrastruct. Res. 1971, 35, 606-625.
35. Volkman, L.E.; Goldsmith, P.A. Mechanism of neutralization of budded Autographa californica nuclear polyhedrosis virus by a monoclonal antibody: Inhibition of entry by adsorptive endocytosis. Virology 1985, 143, 185-195.
36. Ayres, M.D.; Howard, S.C.; Kuzio, J.; Lopez-Ferber, M.; Possee, R.D. The complete DNA sequence of Autographa californica nuclear polyhedrosis virus. Virology 1994, 202, 586-605.
37. Chen, Y.-R.; Zhong, S.; Fei, Z.; Hashimoto, Y.; Xiang, J.Z.; Zhang, S.; Blissard, G.W. The transcriptome of the baculovirus Autographa californica Multiple Nucleopolyhedrovirus (AcMNPV) in Trichoplusia ni cells. J. Virol. 2013, 87, 6391-6405.
38. Hefferon, K.L.; Oomens, A.G.; Monsma, S.A.; Finnerty, C.M.; Blissard, G.W. Host cell receptor binding by baculovirus GP64 and kinetics of virion entry. Virology 1999, 258, 455-468.
39. Wilson, M.E.; Consigli, R.A. Characterization of a protein kinase activity associated with purified capsids of the granulosis virus infecting Plodia interpunctella. Virology 1985, 143, 516-525.
40. Wilson, M.E.; Consigli, R.A. Functions of a protein kinase activity associated with purified capsids of the granulosis virus infecting Plodia interpunctella. Virology 1985, 143, 526-535.
41. Blissard, G.W. Baculovirus-insect cell interactions. Cytotechnology 1996, 20, 73-93.
42. Blissard, G.W.; Wenz, J.R. Baculovirus gp64 envelope glycoprotein is sufficient to mediate pH-dependent membrane fusion. J. Virol. 1992, 66, 6829-6835.
43. Oomens, A.G.; Blissard, G.W. Requirement for GP64 to drive efficient budding of Autographa californica multicapsid nucleopolyhedrovirus. Virology 1999, 254, 297-314.
44. Rohrmann, G.F. Baculovirus structural proteins. J. Gen. Virol. 1992, 73, 749-761.
45. Kost, T.A.; Condreay, J.P.; Jarvis, D.L. Baculovirus as versatile vectors for protein expression in insect and mammalian cells. Nat. Biotechnol. 2005, 23, 567-575.
46. Hitchman, R.B.; Possee, R.D.; King, L.A. Baculovirus expression systems for recombinant protein production in insect cells. Recent Pat. Biotechnol. 2009, 3, 46-54.
47. Lin, S.-Y.; Chen, G.-Y.; Hu, Y.-C. Recent patents on the baculovirus systems. Recent Pat. Biotechnol. 2011, 5, 1-11.
48. McPherson, C.E. Development of a novel recombinant influenza vaccine in insect cells. Biologicals 2008, 36, 350-353.
49. Vaughn, J.L.; Goodwin, R.H.; Tompkins, G.J.; McCawley, P. The establishment of two cell lines from the insect Spodoptera frugiperda (Lepidoptera; Noctuidae). In Vitro 1977, 13, 213-217.
50. Ikonomou, L.; Schneider, Y.-J.; Agathos, S.N. Insect cell culture for industrial production of recombinant proteins. Appl. Microbiol. Biotechnol. 2003, 62, 1-20.
51. Harrison, R.L.; Jarvis, D.L. Protein N-glycosylation in the baculovirus-insect cell expression system and engineering of insect cells to produce “mammalianized” recombinant glycoproteins. Adv. Virus Res. 2006, 68, 159-191.
52. Mabashi-Asazuma, H.; Shi, X.; Geisler, C.; Kuo, C.-W.; Khoo, K.-H.; Jarvis, D.L. Impact of a human CMP-sialic acid transporter on recombinant glycoprotein sialylation in glycoengineered insect cells. Glycobiology 2013, 23, 199-210.
53. Aumiller, J.J.; Mabashi-Asazuma, H.; Hillar, A.; Shi, X.; Jarvis, D.L. A new glycoengineered insect cell line with an inducibly mammalianized protein N-glycosylation pathway. Glycobiology 2012, 22, 417-428.
54. Hu, Y. Baculovirus as a highly efficient expression vector in insect and mammalian cells. Acta Pharmacol. Sin. 2005, 26, 405-416.
55. Oker-Blom, C.; Airenne, K.J.; Grabherr, R. Baculovirus display strategies: Emerging tools for eukaryotic libraries and gene delivery. Brief. Funct. Genomic Proteomic. 2003, 2, 244-253.
56. Hu, Y.-C.C.; Yao, K.; Wu, T.-Y.Y. Baculovirus as an expression and/or delivery vehicle for vaccine antigens. Expert Rev. Vaccines 2008, 7, 363-371.
57. Kost, T.A.; Condreay, J.P.; Ames, R.S.; Rees, S.; Romanos, M.A. Implementation of BacMam virus gene delivery technology in a drug discovery setting. Drug Discov. Today 2007, 12, 396-403.
58. Noad, R.; Roy, P. Virus-like particles as immunogens. Trends Microbiol. 2003, 11, 438-444.
59. Urabe, M.; Ding, C.; Kotin, R.M. Insect cells as a factory to produce adeno-associated virus type 2 vectors. Hum. Gene Ther. 2002, 13, 1935-1943.
60. Lesch, H.P.; Turpeinen, S.; Niskanen, E.A.; Mähönen, A.J.; Airenne, K.J.; Ylä-Herttuala, S.; Mahonen, A.J.; Yla-Herttuala, S. Generation of lentivirus vectors using recombinant baculoviruses. Gene Ther. 2008, 15, 1280-1286.
61. Volkman, L.E.; Goldsmith, P.A. In Vitro survey of autographa californica nuclear polyhedrosis virus interaction with nontarget vertebrate host cells. Appl. Environ. Microbiol. 1983, 45, 1085-1093.
62. Hofmann, C.; Sandig, V.; Jennings, G.; Rudolph, M.; Schlag, P.; Strauss, M. Efficient gene transfer into human hepatocytes by baculovirus vectors. Proc. Natl. Acad. Sci. USA 1995, 92, 10099-10103.
63. Boyce, F.M.; Bucher, N.L. Baculovirus-mediated gene transfer into mammalian cells. Proc. Natl. Acad. Sci. USA 1996, 93, 2348-2352.
64. Lee, H.-P.; Chen, Y.-L.; Shen, H.-C.; Lo, W.-H.; Hu, Y.-C. Baculovirus transduction of rat articular chondrocytes: Roles of cell cycle. J. Gene Med. 2007, 9, 33-43.
65. Laakkonen, J.P.; Kaikkonen, M.U.; Ronkainen, P.H.A.; Ihalainen, T.O.; Niskanen, E.A.; Häkkinen, M.; Salminen, M.; Kulomaa, M.S.; Ylä-Herttuala, S.; Airenne, K.J., et al. Baculovirus-mediated immediate-early gene expression and nuclear reorganization in human cells. Cell. Microbiol. 2008, 10, 667-681.
66. Pan, Y.; Liu, S.; Wu, H.; Lv, J.; Xu, X.; Zhang, Y. Baculovirus as an ideal radionuclide reporter gene vector: A new strategy for monitoring the fate of human stem cells in vivo. PLOS ONE 2013, 8, e61305.
67. Takata, Y.; Kishine, H.; Sone, T.; Andoh, T.; Nozaki, M.; Poderycki, M.; Chesnut, J.D.; Imamoto, F. Generation of iPS cells using a BacMam multigene expression system. Cell Struct. Funct. 2011, 36, 209-222.
68. Lei, Y.; Lee, C.-L.; Joo, K.-I.; Zarzar, J.; Liu, Y.; Dai, B.; Fox, V.; Wang, P. Gene editing of human embryonic stem cells via an engineered baculoviral vector carrying zinc-finger nucleases. Mol. Ther. 2011, 19, 942-950.
69. Chen, C.-Y.; Lin, C.-Y.; Chen, G.-Y.; Hu, Y.-C. Baculovirus as a gene delivery vector: Recent understandings of molecular alterations in transduced cells and latest applications. Biotechnol. Adv. 2011, 29, 618-631.
70. Airenne, K.J.; Hu, Y.-C.; Kost, T.A.; Smith, R.H.; Kotin, R.M.; Ono, C.; Matsuura, Y.; Wang, S.; Ylä-Herttuala, S. Baculovirus: An insect-derived vector for diverse gene transfer applications. Mol. Ther. 2013, 21, 739-749.
71. Condreay, J.P.; Witherspoon, S.M.; Clay, W.C.; Kost, T.A. Transient and stable gene expression in mammalian cells transduced with a recombinant baculovirus vector. Proc. Natl. Acad. Sci. USA 1999, 96, 127-132.
72. Kost, T.A.; Condreay, J.P. Recombinant baculoviruses as mammalian cell gene-delivery vectors. Trends Biotechnol. 2002, 20, 173-180.
73. Shoji, I.; Aizaki, H.; Tani, H.; Ishii, K.; Chiba, T.; Saito, I.; Miyamura, T.; Matsuura, Y. Efficient gene transfer into various mammalian cells, including non-hepatic cells, by baculovirus vectors. J. Gen. Virol. 1997, 78, 2657-2664.
74. Yap, C.C.; Ishii, K.; Aoki, Y.; Aizaki, H.; Tani, H.; Shimizu, H.; Ueno, Y.; Miyamura, T.; Matsuura, Y. A hybrid baculovirus-T7 RNA polymerase system for recovery of an infectious virus from cDNA. Virology 1997, 231, 192-200.
75. Barsoum, J.; Brown, R.; McKee, M.; Boyce, F.M. Efficient transduction of mammalian cells by a recombinant baculovirus having the vesicular stomatitis virus G glycoprotein. Hum. Gene Ther. 1997, 8, 2011-2018.
76. Ping, W.; Ge, J.; Li, S.; Zhou, H.; Wang, K.; Feng, Y.; Lou, Z. Baculovirus-mediated gene expression in chicken primary cells. Avian Dis. 2006, 50, 59-63.
77. Hofmann, C.; Wolfgang, L.; Strauss, M. The baculovirus vector system for gene delivery into hepatocytes. Gene Ther. Mol. Biol. 1998, 1, 231-239.
78. Matsuo, E.; Tani, H.; Lim, C.K.; Komoda, Y.; Okamoto, T.; Miyamoto, H.; Moriishi, K.; Yagi, S.; Patel, A.H.; Miyamura, T., et al. Characterization of HCV-like particles produced in a human hepatoma cell line by a recombinant baculovirus. Biochem. Biophys. Res. Commun. 2006, 340, 200-208.
79. Mähönen, A.J.; Airenne, K.J.; Purola, S.; Peltomaa, E.; Kaikkonen, M.U.; Riekkinen, M.S.; Heikura, T.; Kinnunen, K.; Roschier, M.M.; Wirth, T., et al. Post-transcriptional regulatory element boosts baculovirus-mediated gene expression in vertebrate cells. J. Biotechnol. 2007, 131, 1-8.
80. Mähönen, A.J.; Makkonen, K.-E.E.; Laakkonen, J.P.; Ihalainen, T.O.; Kukkonen, S.P.; Kaikkonen, M.U.; Vihinen-Ranta, M.; Ylä-Herttuala, S.; Airenne, K.J.; Mahonen, A.J., et al. Culture medium induced vimentin reorganization associates with enhanced baculovirus-mediated gene delivery. J. Biotechnol. 2010, 145, 111-119.
81. Airenne, K. Optimization of baculovirus-mediated gene delivery into vertebrate cells. BioProcess J. 2009, 8, 54-59.
82. Dukkipati, A.; Park, H.H.; Waghray, D.; Fischer, S.; Garcia, K.C. BacMam system for high-level expression of recombinant soluble and membrane glycoproteins for structural studies. Protein Expr. Purif. 2008, 62, 160-170.
83. Airenne, K.J.; Laitinen, O.H.; Mähönen, A.J.; Ylä-Herttuala, S. Safe, simple, and high-capacity gene delivery into insect and vertebrate cells by recombinant baculoviruses. In Gene Transfer: Delivery and Expression of DNA and RNA; Friedmann, T., Rossi, J., Eds.; Cold Spring Harbor Laboratory Press: New York, NY, USA, 2007; pp. 313-325.
84. Leisy, D.J.; Lewis, T.D.; Leong, J.-A.C.; Rohrmann, G.F. Transduction of cultured fish cells with recombinant baculoviruses. J. Gen. Virol. 2003, 84, 1173-1178.
85. Hsu, C.-S.; Ho, Y.-C.; Wang, K.-C.; Hu, Y.-C. Investigation of optimal transduction conditions for baculovirus-mediated gene delivery into mammalian cells. Biotechnol. Bioeng. 2004, 88, 42-51.
86. Ramos, L.; Kopec, L.A.; Sweitzer, S.M.; Fornwald, J.A.; Zhao, H.; McAllister, P.; McNulty, D.E.; Trill, J.J.; Kane, J.F. Rapid expression of recombinant proteins in modified CHO cells using the baculovirus system. Cytotechnology 2002, 38, 37-41.
87. Hu, Y.-C.; Tsai, C.-T.; Chang, Y.-J.; Huang, J.-H. Enhancement and prolongation of baculovirus-mediated expression in mammalian cells: Focuses on strategic infection and feeding. Biotechnol. Prog. 2003, 19, 373-379.
88. Cheng, T.; Xu, C.-Y.; Wang, Y.-B.; Chen, M.; Wu, T.; Zhang, J.; Xia, N.-S. A rapid and efficient method to express target genes in mammalian cells by baculovirus. World J. Gastroenterol. 2004, 10, 1612-1618.
89. Wang, K.-C.; Wu, J.-C.; Chung, Y.-C.; Ho, Y.-C.; Chang, M.D.-T.; Hu, Y.-C. Baculovirus as a highly efficient gene delivery vector for the expression of hepatitis delta virus antigens in mammalian cells. Biotechnol. Bioeng. 2005, 89, 464-473.
90. Turkki, P.; Makkonen, K.-E.; Huttunen, M.; Laakkonen, J.P.; Ylä-Herttuala, S.; Airenne, K.J.; Marjomäki, V. Cell susceptibility to baculovirus transduction and echovirus infection is modified by PKC phosphorylation and vimentin organization. J. Virol. 2013, 87, 9822-9835.
91. Kukkonen, S.P.; Airenne, K.J.; Marjomaki, V.; Laitinen, O.H.; Lehtolainen, P.; Kankaanpaa, P.; Mahonen, A.J.; Raty, J.K.; Nordlund, H.R.; Oker-Blom, C., et al. Baculovirus capsid display: A novel tool for transduction imaging. Mol. Ther. 2003, 8, 853-862.
92. Shen, H.-C.; Lee, H.-P.; Lo, W.-H.; Yang, D.-G.; Hu, Y.-C. Baculovirus-mediated gene transfer is attenuated by sodium bicarbonate. J. Gene Med. 2007, 9, 470-478.
93. Airenne, K.J.; Hiltunen, M.O.; Turunen, M.P.; Turunen, A.M.; Laitinen, O.H.; Kulomaa, M.S.; Yla-Herttuala, S.; Ylä-Herttuala, S. Baculovirus-mediated periadventitial gene transfer to rabbit carotid artery. Gene Ther. 2009, 7, 1499-1504.
94. Salminen, M.; Airenne, K.J.; Rinnankoski, R.; Reimari, J.; Välilehto, O.; Rinne, J.; Suikkanen, S.; Kukkonen, S.; Ylä-Herttuala, S.; Kulomaa, M.S., et al. Improvement in nuclear entry and transgene expression of baculoviruses by disintegration of microtubules in human hepatocytes. J. Virol. 2005, 79, 2720-2728.
95. Wang, X.; Yin, J.; Huang, X.; Zhong, J. DNA methyltransferase inhibitors increase baculovirus-mediated gene expression in mammalian cells when applied before infection. Anal. Biochem. 2010, 396, 322-324.
96. Hunt, L.; Batard, P.; Jordan, M.; Wurm, F.M. Fluorescent proteins in animal cells for process development: Optimization of sodium butyrate treatment as an example. Biotechnol. Bioeng. 2002, 77, 528-537.
97. Mäkelä, A.R.; Oker-Blom, C. Baculovirus display: A multifunctional technology for gene delivery and eukaryotic library development. Adv. Virus Res. 2006, 68, 91-112.
98. Liang, C.; Song, J.; Chen, X. The GP64 protein of Autographa californica multiple nucleopolyhedrovirus rescues Helicoverpa armigera nucleopolyhedrovirus transduction in mammalian cells. J. Gen. Virol. 2005, 86, 1629-1635.
99. Tani, H.; Limn, C.K.; Yap, C.C.; Onishi, M.; Nozaki, M.; Nishimune, Y.; Okahashi, N.; Kitagawa, Y.; Watanabe, R.; Mochizuki, R., et al. In vitro and in vivo gene delivery by recombinant baculoviruses. J. Virol. 2003, 77, 9799-9808.
100. Boublik, Y.; Di Bonito, P.; Jones, I.M. Eukaryotic virus display: Engineering the major surface glycoprotein of the Autographa californica nuclear polyhedrosis virus (AcNPV) for the presentation of foreign proteins on the virus surface. Biotechnology 1995, 13, 1079-1084.
101. Chapple, S.D.J.; Jones, I.M. Non-polar distribution of green fluorescent protein on the surface of Autographa californica nucleopolyhedrovirus using a heterologous membrane anchor. J. Biotechnol. 2002, 95, 269-275.
102. Tani, H.; Nishijima, M.; Ushijima, H.; Miyamura, T.; Matsuura, Y. Characterization of cell-surface determinants important for baculovirus infection. Virology 2001, 279, 343-353.
103. Kaikkonen, M.U.; Räty, J.K.; Airenne, K.J.; Wirth, T.; Heikura, T.; Ylä-Herttuala, S.; Raty, J.K.; Yla-Herttuala, S. Truncated vesicular stomatitis virus G protein improves baculovirus transduction efficiency in vitro and in vivo. Gene Ther. 2006, 13, 304-312.
104. Kitagawa, Y.; Tani, H.; Limn, C.K.; Matsunaga, T.M.; Moriishi, K.; Matsuura, Y. Ligand-directed gene targeting to mammalian cells by pseudotype baculoviruses. J. Virol. 2005, 79, 3639-3652.
105. Pieroni, L.; Maione, D.; La Monica, N. In vivo gene transfer in mouse skeletal muscle mediated by baculovirus vectors. Hum. Gene Ther. 2001, 12, 871-881.
106. Matilainen, H.; Mäkelä, A.R.; Riikonen, R.; Saloniemi, T.; Korhonen, E.; Hyypiä, T.; Heino, J.; Grabherr, R.; Oker-Blom, C. RGD motifs on the surface of baculovirus enhance transduction of human lung carcinoma cells. J. Biotechnol. 2006, 125, 114-126.
107. Mäkelä, A.R.; Matilainen, H.; White, D.J.; Ruoslahti, E.; Oker-Blom, C. Enhanced baculovirus-mediated transduction of human cancer cells by tumor-homing peptides. J. Virol. 2006, 80, 6603-6611.
108. Ojala, K.; Mottershead, D.G.; Suokko, A.; Oker-Blom, C. Specific binding of baculoviruses displaying gp64 fusion proteins to mammalian cells. Biochem. Biophys. Res. Commun. 2001, 284, 777-784.
109. Ojala, K.; Koski, J.; Ernst, W.; Grabherr, R.; Jones, I.; Oker-Blom, C. Improved display of synthetic IgG-binding domains on the baculovirus surface. Technol. Cancer Res. Treat. 2004, 3, 77-84.
110. Riikonen, R.; Sc, M.; Matilainen, H.; Rajala, N.; Pentikäinen, O.; Johnson, M.; Heino, J.; Oker-blom, C.; Pentikainen, O. Functional Display of an α 2 Integrin-Specific Motif ( RKK ) on the Surface of Baculovirus Particles. Technol. Cancer Res. Treat. 2005, 4, 437-445.
111. Räty, J.K.; Airenne, K.J.; Marttila, A.T.; Marjomäki, V.; Hytönen, V.P.; Lehtolainen, P.; Laitinen, O.H.; Mähönen, A.J.; Kulomaa, M.S.; Ylä-Herttuala, S. Enhanced gene delivery by avidin-displaying baculovirus. Mol. Ther. 2004, 9, 282-291.
112. Kaikkonen, M.U.; Viholainen, J.I.; Närvänen, A.; Ylä-Herttuala, S.; Airenne, K.J. Targeting and purification of metabolically biotinylated baculovirus. Hum. Gene Ther. 2008, 19, 589-600.
113. Mäkelä, A.R.; Enbäck, J.; Laakkonen, J.P.; Vihinen-Ranta, M.; Laakkonen, P.; Oker-Blom, C. Tumor targeting of baculovirus displaying a lymphatic homing peptide. J. Gene Med. 2008, 10, 1019-1031.
114. Kim, Y.-K.; Park, I.-K.; Jiang, H.-L.; Choi, J.-Y.; Je, Y.-H.; Jin, H.; Kim, H.-W.; Cho, M.-H.; Cho, C.-S. Regulation of transduction efficiency by pegylation of baculovirus vector in vitro and in vivo. J. Biotechnol. 2006, 125, 104-109.
115. Kim, Y.-K.; Choi, J.Y.; Jiang, H.-L.; Arote, R.; Jere, D.; Cho, M.-H.; Je, Y.H.; Cho, C.-S. Hybrid of baculovirus and galactosylated PEI for efficient gene carrier. Virology 2009, 387, 89-97.
116. Kim, Y.-K.; Choi, J.Y.; Yoo, M.-K.; Jiang, H.-L.; Arote, R.; Je, Y.H.; Cho, M.-H.; Cho, C.-S. Receptor-mediated gene delivery by folate-PEG-baculovirus in vitro. J. Biotechnol. 2007, 131, 353-361.
117. Kim, Y.-K.; Kwon, J.-T.; Choi, J.Y.; Jiang, H.-L.; Arote, R.; Jere, D.; Je, Y.H.; Cho, M.-H.; Cho, C.-S. Suppression of tumor growth in xenograft model mice by programmed cell death 4 gene delivery using folate-PEG-baculovirus. Cancer Gene Ther. 2010, 17, 751-760.
118. Yang, Y.; Lo, S.-L.; Yang, J.; Yang, J.; Goh, S.S.L.; Wu, C.; Feng, S.-S.; Wang, S. Polyethylenimine coating to produce serum-resistant baculoviral vectors for in vivo gene delivery. Biomaterials 2009, 30, 5767-5774.
119. Spenger, A.; Ernst, W.; Condreay, J.P.; Kost, T.A.; Grabherr, R. Influence of promoter choice and trichostatin A treatment on expression of baculovirus delivered genes in mammalian cells. Protein Expr. Purif. 2004, 38, 17-23.
120. Park, S.W.; Lee, H.K.; Kim, T.G.; Yoon, S.K.; Paik, S.Y. Hepatocyte-specific gene expression by baculovirus pseudotyped with vesicular stomatitis virus envelope glycoprotein. Biochem. Biophys. Res. Commun. 2001, 289, 444-450.
121. Li, Y.; Yang, Y.; Wang, S. Neuronal gene transfer by baculovirus-derived vectors accommodating a neurone-specific promoter. Exp. Physiol. 2005, 90, 39-44.
122. Wang, C.Y.; Wang, S. Astrocytic expression of transgene in the rat brain mediated by baculovirus vectors containing an astrocyte-specific promoter. Gene Ther. 2006, 13, 1447-1456.
123. Guo, R.; Tian, L.; Han, B.; Xu, H.; Zhang, M.; Li, B. Feasibility of a novel positive feedback effect of 131I-promoted Bac-Egr1-hNIS expression in malignant glioma via baculovirus. Nucl. Med. Biol. 2011, 38, 599-604.
124. McCormick, C.J.; Challinor, L.; Macdonald, A.; Rowlands, D.J.; Harris, M. Introduction of replication-competent hepatitis C virus transcripts using a tetracycline-regulable baculovirus delivery system. J. Gen. Virol. 2004, 85, 429-439.
125. Palombo, F.; Monciotti, A.; Recchia, A.; Cortese, R.; Ciliberto, G.; La Monica, N. Site-specific integration in mammalian cells mediated by a new hybrid baculovirus-adeno-associated virus vector. J. Virol. 1998, 72, 5025-5034.
126. Wang, C.-Y.; Wang, S. Adeno-associated virus inverted terminal repeats improve neuronal transgene expression mediated by baculoviral vectors in rat brain. Hum. Gene Ther. 2005, 16, 1219-1226.
127. Shan, L.; Wang, L.; Yin, J.; Zhong, P.; Zhong, J. An OriP/EBNA-1-based baculovirus vector with prolonged and enhanced transgene expression. J. Gene Med. 2006, 8, 1400-1406.
128. Luo, W.-Y.; Shih, Y.-S.; Hung, C.-L.; Lo, K.-W.; Chiang, C.-S.; Lo, W.-H.; Huang, S.-F.; Wang, S.-C.; Yu, C.-F.; Chien, C.-H., et al. Development of the hybrid Sleeping Beauty: Baculovirus vector for sustained gene expression and cancer therapy. Gene Ther. 2012, 19, 844-851.
129. Abe, T.; Takahashi, H.; Hamazaki, H.; Miyano-Kurosaki, N.; Matsuura, Y.; Takaku, H. Baculovirus induces an innate immune response and confers protection from lethal influenza virus infection in mice. J. Immunol. 2003, 171, 1133-1139.
130. Beck, N.B.; Sidhu, J.S.; Omiecinski, C.J. Baculovirus vectors repress phenobarbital-mediated gene induction and stimulate cytokine expression in primary cultures of rat hepatocytes. Gene Ther. 2000, 7, 1274-1283.
131. Gronowski, A.M.; Hilbert, D.M.; Sheehan, K.C.; Garotta, G.; Schreiber, R.D. Baculovirus stimulates antiviral effects in mammalian cells. J. Virol. 1999, 73, 9944-9951.
132. Abe, T.; Hemmi, H.; Miyamoto, H.; Moriishi, K.; Tamura, S.; Takaku, H.; Akira, S.; Matsuura, Y. Involvement of the Toll-like receptor 9 signaling pathway in the induction of innate immunity by baculovirus. J. Virol. 2005, 79, 2847-2858.
133. Abe, T.; Kaname, Y.; Wen, X.; Tani, H.; Moriishi, K.; Uematsu, S.; Takeuchi, O.; Ishii, K.J.; Kawai, T.; Akira, S., et al. Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner. J. Virol. 2009, 83, 7629-7640.
134. Boulaire, J.; Zhao, Y.; Wang, S. Gene expression profiling to define host response to baculoviral transduction in the brain. J. Neurochem. 2009, 109, 1203-1214.
135. Chen, G.-Y.; Shiah, H.-C.; Su, H.-J.; Chen, C.-Y.; Chuang, Y.-J.; Lo, W.-H.; Huang, J.-L.; Chuang, C.-K.; Hwang, S.-M.; Hu, Y.-C. Baculovirus transduction of mesenchymal stem cells triggers the toll-like receptor 3 pathway. J. Virol. 2009, 83, 10548-10556.
136. Han, Y.; Niu, M.; An, L.; Li, W. Upregulation of proinflammatory cytokines and NO production in BV-activated avian macrophage-like cell line (HD11) requires MAPK and NF-kappaB pathways. Int. Immunopharmacol. 2009, 9, 817-823.
137. Wilson, S.; Baird, M.; Ward, V.K. Delivery of vaccine peptides by rapid conjugation to baculovirus particles. Vaccine 2008, 26, 2451-2456.
138. Abe, T. Analysis of the application of host innate immune response to control and prevent infection. Uirusu 2012, 62, 103-112.
139. Suzuki, T.; Chang, M.O.; Kitajima, M.; Takaku, H. Baculovirus activates murine dendritic cells and induces non-specific NK cell and T cell immune responses. Cell. Immunol. 2010, 262, 35-43.
140. Li, K.-C.; Chang, Y.-H.; Lin, C.-Y.; Hwang, S.-M.; Wang, T.-H.; Hu, Y.-C. Preclinical safety evaluation of ASCs engineered by FLPo/Frt-based hybrid baculovirus: In Vitro and large animal studies. Tissue Eng. A 2015, doi:10.1089/ten.TEA.2014.0465.
141. Wickham, T.J.; Shuler, M.L.; Hammer, D.A.; Granados, R.R.; Wood, H.A. Equilibrium and kinetic analysis of Autographa californica nuclear polyhedrosis virus attachment to different insect cell lines. J. Gen. Virol. 1992, 73, 3185-3194.
142. Matilainen, H.; Rinne, J.; Gilbert, L.; Marjomäki, V.; Reunanen, H.; Oker-Blom, C. Baculovirus entry into human hepatoma cells. J. Virol. 2005, 79, 15452-15459.
143. Long, G.; Pan, X.; Kormelink, R.; Vlak, J.M. Functional entry of baculovirus into insect and mammalian cells is dependent on clathrin-mediated endocytosis. J. Virol. 2006, 80, 8830-8833.
144. Kataoka, C.; Kaname, Y.; Taguwa, S.; Abe, T.; Fukuhara, T.; Tani, H.; Moriishi, K.; Matsuura, Y. Baculovirus GP64-mediated entry into mammalian cells. J. Virol. 2012, 86, 2610-2620.
145. Moller-Tank, S.; Kondratowicz, A.S.; Davey, R.A.; Rennert, P.D.; Maury, W. Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry. J. Virol. 2013, 87, 8327-8341.
146. Laakkonen, J.P.; Makela, A.R.; Kakkonen, E.; Turkki, P.; Kukkonen, S.; Peranen, J.; Yla-Herttuala, S.; Airenne, K.J.; Oker-Blom, C.; Vihinen-Ranta, M., et al. Clathrin-independent entry of baculovirus triggers uptake of E. coli in non-phagocytic human cells. PLOS ONE 2009, 4, e5093.
147. Marsh, M.; Helenius, A. Virus entry: Open sesame. Cell 2006, 124, 729-740.
148. Wu, C.; Wang, S. A pH-sensitive heparin-binding sequence from baculovirus gp64 protein is important for binding to mammalian cells but not to Sf. J. Virol. 2012, 86, 484-491.
149. O’Flynn, N.M.J.; Patel, A.; Kadlec, J.; Jones, I.M. Improving promiscuous mammalian cell entry by the baculovirus Autographa californica multiple nuclear polyhedrosis virus. Biosci. Rep. 2013, 33, 23-36.
150. Duisit, G.; Saleun, S.; Douthe, S.; Barsoum, J.; Chadeuf, G.; Moullier, P. Baculovirus vector requires electrostatic interactions including heparan sulfate for efficient gene transfer in mammalian cells. J. Gene Med. 1999, 1, 93-102.
151. Makkonen, K.-E.; Turkki, P.; Laakkonen, J.P.; Ylä-Herttuala, S.; Marjomäki, V.; Airenne, K.J. 6-O sulfated and N-sulfated Syndecan-1 promotes baculovirus binding and entry into mammalian cells. J. Virol. 2013, 87, 11148-11159.
152. Kamiya, K.; Kobayashi, J.; Yoshimura, T.; Tsumoto, K. Confocal microscopic observation of fusion between baculovirus budded virus envelopes and single giant unilamellar vesicles. Biochim. Biophys. Acta 2010, 1798, 1625-1631.
153. Backovic, M.; Jardetzky, T.S. Class III viral membrane fusion proteins. Adv. Exp. Med. Biol. 2011, 714, 91-101.
154. Goley, E.D.; Ohkawa, T.; Mancuso, J.; Woodruff, J.B.; D’Alessio, J.A.; Cande, W.Z.; Volkman, L.E.; Welch, M.D. Dynamic nuclear actin assembly by Arp2/3 complex and a baculovirus WASP-like protein. Science 2006, 314, 464-467.
155. Ohkawa, T.; Volkman, L.E.; Welch, M.D. Actin-based motility drives baculovirus transit to the nucleus and cell surface. J. Cell Biol. 2010, 190, 187-195.
156. Au, S.; Panté, N.; Pante, N. Nuclear transport of baculovirus: Revealing the nuclear pore complex passage. J. Struct. Biol. 2012, 177, 90-98.
157. Strauss, R.; Hüser, A.; Ni, S.; Tuve, S.; Kiviat, N.; Sow, P.S.; Hofmann, C.; Lieber, A.; Huser, A. Baculovirus-based vaccination vectors allow for efficient induction of immune responses against plasmodium falciparum circumsporozoite protein. Mol. Ther. 2007, 15, 193-202.
158. Hofmann, C.; Strauss, M. Baculovirus-mediated gene transfer in the presence of human serum or blood facilitated by inhibition of the complement system. Gene Ther. 1998, 5, 531-536.
159. Georgopoulos, L.J.; Elgue, G.; Sanchez, J.; Dussupt, V.; Magotti, P.; Lambris, J.D.; Tötterman, T.H.; Maitland, N.J.; Nilsson, B. Preclinical evaluation of innate immunity to baculovirus gene therapy vectors in whole human blood. Mol. Immunol. 2009, 46, 2911-2917.
160. Hoare, J.; Waddington, S.; Thomas, H.C.; Coutelle, C.; McGarvey, M.J. Complement inhibition rescued mice allowing observation of transgene expression following intraportal delivery of baculovirus in mice. J. Gene Med. 2005, 7, 325-333.
161. Sandig, V.; Hofmann, C.; Steinert, S.; Jennings, G.; Schlag, P.; Strauss, M. Gene transfer into hepatocytes and human liver tissue by baculovirus vectors. Hum. Gene Ther. 1996, 7, 1937-1945.
162. Kinnunen, K.; Kalesnykas, G.; Mahonen, A.J.; Laidinen, S.; Holma, L.; Heikura, T.; Airenne, K.; Uusitalo, H.; Yla-Herttuala, S. Baculovirus is an efficient vector for the transduction of the eye: Comparison of baculovirus- and adenovirus-mediated intravitreal vascular endothelial growth factor D gene transfer in the rabbit eye. J. Gene Med. 2009, 11, 382-389.
163. Lehtolainen, P.; Tyynela, K.; Kannasto, J.; Airenne, K.J.; Yla-Herttuala, S. Baculoviruses exhibit restricted cell type specificity in rat brain: A comparison of baculovirus- and adenovirus-mediated intracerebral gene transfer in vivo. Gene Ther. 2002, 9, 1693-1699.
164. Wu, C.; Lin, J.; Hong, M.; Choudhury, Y.; Balani, P.; Leung, D.; Dang, L.H.; Zhao, Y.; Zeng, J.; Wang, S. Combinatorial control of suicide gene expression by tissue-specific promoter and microRNA regulation for cancer therapy. Mol. Ther. 2009, 17, 2058-2066.
165. Park, H.J.; Lee, W.Y.; Kim, J.H.; Kim, J.H.; Jung, H.J.; Kim, N.H.; Kim, B.K.; Song, H. Interstitial tissue-specific gene expression in mouse testis by intra-tunica albuguineal injection of recombinant baculovirus. Asian J. Androl. 2009, 11, 342-350.
166. Wang, X.; Wang, C.; Zeng, J.; Xu, X.; Hwang, P.Y.K.; Yee, W.-C.; Ng, Y.-K.; Wang, S. Gene transfer to dorsal root ganglia by intrathecal injection: Effects on regeneration of peripheral nerves. Mol. Ther. 2005, 12, 314-320.
167. Liu, X.; Li, K.; Song, J.; Liang, C.; Wang, X.; Chen, X. Efficient and stable gene expression in rabbit intervertebral disc cells transduced with a recombinant baculovirus vector. Spine 2006, 31, 732-735.
168. Airenne, K.J.; Makkonen, K.-E.; Mähönen, A.J.; Ylä-Herttuala, S. In vivo application and tracking of baculovirus. Curr. Gene Ther. 2010, 10, 187-194.
169. Sarkis, C.; Serguera, C.; Petres, S.; Buchet, D.; Ridet, J.L.; Edelman, L.; Mallet, J. Efficient transduction of neural cells in vitro and in vivo by a baculovirus-derived vector. Proc. Natl. Acad. Sci. USA 2000, 97, 14638-14643.
170. Huser, A.; Rudolph, M.; Hofmann, C. Incorporation of decay-accelerating factor into the baculovirus envelope generates complement-resistant gene transfer vectors. Nat. Biotechnol. 2001, 19, 451-455.
171. Kaikkonen, M.U.; Maatta, A.I.; Yla-Herttuala, S.; Airenne, K.J.; Ylä-Herttuala, S. Screening of complement inhibitors: Shielded baculoviruses increase the safety and efficacy of gene delivery. Mol. Ther. 2010, 18, 987-992.
172. Kircheis, R.; Wightman, L.; Schreiber, A.; Robitza, B.; Rössler, V.; Kursa, M.; Wagner, E. Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application. Gene Ther. 2001, 8, 28-40.
173. Laitinen, O.H.; Airenne, K.J.; Hytönen, V.P.; Peltomaa, E.; Mähönen, A.J.; Wirth, T.; Lind, M.M.; Mäkelä, K.A.; Toivanen, P.I.; Schenkwein, D., et al. A multipurpose vector system for the screening of libraries in bacteria, insect and mammalian cells and expression in vivo. Nucleic Acids Res. 2005, 33, e42.
174. Räty, J.K.; Liimatainen, T.; Wirth, T.; Airenne, K.J.; Ihalainen, T.O.; Huhtala, T.; Hamerlynck, E.; Vihinen-Ranta, M.; Närvänen, A.; Ylä-Herttuala, S., et al. Magnetic resonance imaging of viral particle biodistribution in vivo. Gene Ther. 2006, 13, 1440-1446.
175. Liu, B.H.; Yang, Y.; Paton, J.F.R.; Li, F.; Boulaire, J.; Kasparov, S.; Wang, S. GAL4-NF-kappaB fusion protein augments transgene expression from neuronal promoters in the rat brain. Mol. Ther. 2006, 14, 872-882.
176. Li, Y.; Wang, X.; Guo, H.; Wang, S. Axonal transport of recombinant baculovirus vectors. Mol. Ther. 2004, 10, 1121-1129.
177. Haeseleer, F.; Imanishi, Y.; Saperstein, D.A.; Palczewski, K. Gene transfer mediated by recombinant baculovirus into mouse eye. Invest. Ophthalmol. Vis. Sci. 2001, 42, 3294-3300.
178. Turunen, T.A.K.; Laakkonen, J.P.; Alasaarela, L.; Airenne, K.J.; Ylä-Herttuala, S. Sleeping Beauty baculovirus hybrid vectors for long-term gene expression in the eye. J. Gene Med. 2014, 16, 40-53.
179. Luz-Madrigal, A.; Clapp, C.; Aranda, J.; Vaca, L. In vivo transcriptional targeting into the retinal vasculature using recombinant baculovirus carrying the human flt-1 promoter. Virol. J. 2007, 4, e88.
180. Torres-Vega, M.A.; Vargas-Jerónimo, R.Y.; Montiel-Martínez, A.G.; Muñoz-Fuentes, R.M.; Zamorano-Carrillo, A.; Pastor, A.R.; Palomares, L.A. Delivery of glutamine synthetase gene by baculovirus vectors: A proof of concept for the treatment of acute hyperammonemia. Gene Ther. 2015, 22, 58-64.
181. Heikura, T.; Nieminen, T.; Roschier, M.M.; Karvinen, H.; Kaikkonen, M.U.; Mähönen, A.J.; Lesch, H.P.; Rissanen, T.T.; Laitinen, O.H.; Airenne, K.J., et al. Baculovirus-mediated vascular endothelial growth factor-D(ΔNΔC) gene transfer induces angiogenesis in rabbit skeletal muscle. J. Gene Med. 2012, 14, 35-43.
182. Yanev, P.; Jolkkonen, J.; Airenne, K.; Ylä-Herttuala, S.; Wirth, T. Enhanced angiogenesis and reduced infarct size by vascular endothelial growth factor D is not translated to behavioral outcome in a rat model of ischemic stroke. J. Exp. Stroke Transl. Med. 2010, 3, 1-12.
183. Paul, A.; Nayan, M.; Khan, A.A.; Shum-Tim, D.; Prakash, S. Angiopoietin-1-expressing adipose stem cells genetically modified with baculovirus nanocomplex: Investigation in rat heart with acute infarction. Int. J. Nanomed. 2012, 7, 663-682.
184. Paul, A.; Binsalamah, Z.M.; Khan, A.A.; Abbasia, S.; Elias, C.B.; Shum-Tim, D.; Prakash, S. A nanobiohybrid complex of recombinant baculovirus and Tat/DNA nanoparticles for delivery of Ang-1 transgene in myocardial infarction therapy. Biomaterials 2011, 32, 8304-8318.
185. Paul, A.; Elias, C.B.; Shum-Tim, D.; Prakash, S. Bioactive baculovirus nanohybrids for stent based rapid vascular re-endothelialization. Sci. Rep. 2013, 3, 2366.
186. Nishibe, Y.; Kaneko, H.; Suzuki, H.; Abe, T.; Matsuura, Y.; Takaku, H. Baculovirus-mediated interferon alleviates dimethylnitrosamine-induced liver cirrhosis symptoms in a murine model. Gene Ther. 2008, 15, 990-997.
187. Räty, J.K.; Liimatainen, T.; Huhtala, T.; Kaikkonen, M.U.; Airenne, K.J.; Hakumäki, J.M.; Närvänen, A.; Ylä-Herttuala, S. SPECT/CT imaging of baculovirus biodistribution in rat. Gene Ther. 2007, 14, 930-938.
188. Corridon, P.R.; Rhodes, G.J.; Leonard, E.C.; Basile, D.P.; Gattone, V.H.; Bacallao, R.L.; Atkinson, S.J. A method to facilitate and monitor expression of exogenous genes in the rat kidney using plasmid and viral vectors. Am. J. Physiol. Renal Physiol. 2013, 304, F1217-F1229.
189. Wang, C.-Y.; Li, F.; Yang, Y.; Guo, H.-Y.; Wu, C.-X.; Wang, S. Recombinant baculovirus containing the diphtheria toxin A gene for malignant glioma therapy. Cancer Res. 2006, 66, 5798-5806.
190. Balani, P.; Boulaire, J.; Zhao, Y.; Zeng, J.; Lin, J.; Wang, S. High mobility group box2 promoter-controlled suicide gene expression enables targeted glioblastoma treatment. Mol. Ther. 2009, 17, 1003-1011.
191. Guo, H.; Choudhury, Y.; Yang, J.; Chen, C.; Tay, F.C.; Lim, T.M.; Wang, S. Antiglioma effects of combined use of a baculovirual vector expressing wild-type p53 and sodium butyrate. J. Gene Med. 2011, 13, 26-36.
192. Luo, W.-Y.; Shih, Y.-S.; Lo, W.-H.; Chen, H.-R.; Wang, S.-C.; Wang, C.-H.; Chien, C.-H.; Chiang, C.-S.; Chuang, Y.-J.; Hu, Y.-C. Baculovirus vectors for antiangiogenesis-based cancer gene therapy. Cancer Gene Ther. 2011, 18, 637-645.
193. Swift, S.L.; Rivera, G.C.; Dussupt, V.; Leadley, R.M.; Hudson, L.C.; Ma de Ridder, C.; Kraaij, R.; Burns, J.E.; Maitland, N.J.; Georgopoulos, L.J. Evaluating baculovirus as a vector for human prostate cancer gene therapy. PLOS ONE 2013, 8, e65557.
194. Zhang, M.; Guo, R.; Shi, S.; Miao, Y.; Zhang, Y.; Li, B. Baculovirus vector-mediated transfer of sodium iodide symporter and plasminogen kringle 5 genes for tumor radioiodide therapy. PLOS ONE 2014, 9, e92326.
195. Huang, W.; Tian, X.-L.; Wu, Y.-L.; Zhong, J.; Yu, L.-F.; Hu, S.-P.; Li, B. Suppression of gastric cancer growth by baculovirus vector-mediated transfer of normal epithelial cell specific-1 gene. World J. Gastroenterol. 2008, 14, 5810-5815.
196. Pan, Y.; Fang, L.; Fan, H.; Luo, R.; Zhao, Q.; Chen, H.; Xiao, S. Antitumor effects of a recombinant pseudotype baculovirus expressing Apoptin in vitro and in vivo. Int. J. Cancer 2010, 126, 2741-2751.
197. Chen, C.-L.; Wu, J.-C.; Chen, G.-Y.; Yuan, P.-H.; Tseng, Y.-W.; Li, K.-C.; Hwang, S.-M.; Hu, Y.-C. Baculovirus-mediated mirna regulation to suppress hepatocellular carcinoma tumorigenicity and metastasis. Mol. Ther. 2015, 23, 79-88.
198. Kitajima, M.; Abe, T.; Miyano-Kurosaki, N.; Taniguchi, M.; Nakayama, T.; Takaku, H. Induction of natural killer cell-dependent antitumor immunity by the Autographa californica multiple nuclear polyhedrosis virus. Mol. Ther. 2008, 16, 261-268.
199. Suzuki, T.; Oo Chang, M.; Kitajima, M.; Takaku, H. Induction of antitumor immunity against mouse carcinoma by baculovirus-infected dendritic cells. Cell. Mol. Immunol. 2010, 7, 440-446.
200. Molinari, P.; Crespo, M.I.; Gravisaco, M.J.; Taboga, O.; Morón, G. Baculovirus capsid display potentiates OVA cytotoxic and innate immune responses. PLOS ONE 2011, 6, e24108.
201. Wang, L.; Shan, L.; Lo, K.W.; Yin, J.; Zhang, Y.; Sun, R.; Zhong, J. Inhibition of nasopharyngeal carcinoma growth by RTA-expressing baculovirus vectors containing oriP. J. Gene Med. 2008, 10, 1124-1133.
202. Bak, X.Y.; Yang, J.; Wang, S. Baculovirus-transduced bone marrow mesenchymal stem cells for systemic cancer therapy. Cancer Gene Ther. 2010, 17, 721-729.
203. Bak, X.Y.; Lam, D.H.; Yang, J.; Ye, K.; Wei, E.L.X.; Lim, S.K.; Wang, S. Human embryonic stem cell-derived mesenchymal stem cells as cellular delivery vehicles for prodrug gene therapy of glioblastoma. Hum. Gene Ther. 2011, 22, 1365-1377.
204. Zhao, Y.; Lam, D.H.; Yang, J.; Lin, J.; Tham, C.K.; Ng, W.H.; Wang, S. Targeted suicide gene therapy for glioma using human embryonic stem cell-derived neural stem cells genetically modified by baculoviral vectors. 2012, 9, 189-200.
205. Lee, E.X.; Lam, D.H.; Wu, C.; Yang, J.; Tham, C.K.; Ng, W.H.; Wang, S. Glioma gene therapy using induced pluripotent stem cell derived neural stem cells. Mol. Pharm. 2011, 8, 1515-1524.
206. Yang, J.; Lam, D.H.; Goh, S.S.; Lee, E.X.; Zhao, Y.; Tay, F.C.; Chen, C.; Du, S.; Balasundaram, G.; Shahbazi, M., et al. Tumor tropism of intravenously injected human-induced pluripotent stem cell-derived neural stem cells and their gene therapy application in a metastatic breast cancer model. Stem Cells 2012, 30, 1021-1029.
207. Zhu, D.; Chen, C.; Purwanti, Y.I.; Du, S.; Lam, D.H.; Wu, C.; Zeng, J.; Toh, H.C.; Wang, S. Induced pluripotent stem cell-derived neural stem cells transduced with baculovirus encoding CD40 ligand for immunogene therapy in mouse models of breast cancer. Hum. Gene Ther. 2014, 25, 747-758.
208. Sung, L.-Y.; Lo, W.-H.; Chiu, H.-Y.; Chen, H.-C.; Chung, C.-K.; Lee, H.-P.; Hu, Y.-C. Modulation of chondrocyte phenotype via baculovirus-mediated growth factor expression. Biomaterials 2007, 28, 3437-3447.
209. Chen, H.-C.; Lee, H.-P.; Ho, Y.-C.; Sung, M.-L.; Hu, Y.-C. Combination of baculovirus-mediated gene transfer and rotating-shaft bioreactor for cartilage tissue engineering. Biomaterials 2006, 27, 3154-3162.
210. Sung, L.-Y.; Chiu, H.-Y.; Chen, H.-C.; Chen, Y.-L.; Chuang, C.-K.; Hu, Y.-C. Baculovirus-mediated growth factor expression in dedifferentiated chondrocytes accelerates redifferentiation: Effects of combinational transduction. Tissue Eng. A 2009, 15, 1353-1362.
211. Chen, H.-C.; Sung, L.-Y.; Lo, W.-H.; Chuang, C.-K.; Wang, Y.-H.; Lin, J.-L.; Hu, Y.-C. Combination of baculovirus-expressed BMP-2 and rotating-shaft bioreactor culture synergistically enhances cartilage formation. Gene Ther. 2008, 15, 309-317.
212. Chen, H.-C.; Chang, Y.-H.; Chuang, C.-K.; Lin, C.-Y.; Sung, L.-Y.; Wang, Y.-H.; Hu, Y.-C. The repair of osteochondral defects using baculovirus-mediated gene transfer with de-differentiated chondrocytes in bioreactor culture. Biomaterials 2009, 30, 674-681.
213. Chuang, C.-K.; Lin, K.-J.; Lin, C.-Y.; Chang, Y.-H.; Yen, T.-C.; Hwang, S.-M.; Sung, L.-Y.; Chen, H.-C.; Hu, Y.-C. Xenotransplantation of human mesenchymal stem cells into immunocompetent rats for calvarial bone repair. Tissue Eng. Part A 2010, 16, 479-488.
214. Lin, C.-Y.; Chang, Y.-H.; Lin, K.-J.; Yen, T.-C.; Tai, C.-L.; Chen, C.-Y.; Lo, W.-H.; Hsiao, I.-T.; Hu, Y.-C. The healing of critical-sized femoral segmental bone defects in rabbits using baculovirus-engineered mesenchymal stem cells. Biomaterials 2010, 31, 3222-3230.
215. Lin, C.-Y.; Lin, K.-J.; Kao, C.-Y.; Chen, M.-C.; Lo, W.-H.; Yen, T.-C.; Chang, Y.-H.; Hu, Y.-C. The role of adipose-derived stem cells engineered with the persistently expressing hybrid baculovirus in the healing of massive bone defects. Biomaterials 2011, 32, 6505-6514.
216. Lin, C.-Y.; Chang, Y.-H.; Kao, C.-Y.; Lu, C.-H.; Sung, L.-Y.; Yen, T.-C.; Lin, K.-J.; Hu, Y.-C. Augmented healing of critical-size calvarial defects by baculovirus-engineered MSCs that persistently express growth factors. Biomaterials 2012, 33, 3682-3692.
217. Lu, C.-H.; Lin, K.-J.; Chiu, H.-Y.; Chen, C.-Y.; Yen, T.-C.; Hwang, S.-M.; Chang, Y.-H.; Hu, Y.-C. Improved chondrogenesis and engineered cartilage formation from TGF-β3-expressing adipose-derived stem cells cultured in the rotating-shaft bioreactor. Tissue Eng. A 2012, 18, 2114-2124.
218. Lu, C.-H.; Yeh, T.-S.; Yeh, C.-L.; Fang, Y.-H.D.; Sung, L.-Y.; Lin, S.-Y.; Yen, T.-C.; Chang, Y.-H.; Hu, Y.-C. Regenerating cartilages by engineered ASCs: Prolonged TGF-β3/BMP-6 expression improved articular cartilage formation and restored zonal structure. Mol. Ther. 2014, 22, 186-195.
219. Chen, C.-Y.; Wu, H.-H.; Chen, C.-P.; Chern, S.-R.; Hwang, S.-M.; Huang, S.-F.; Lo, W.-H.; Chen, G.-Y.; Hu, Y.-C. Biosafety assessment of human mesenchymal stem cells engineered by hybrid baculovirus vectors. Mol. Pharm. 2011, 8, 1505-1514.
220. Pan, Y.; Yin, H.; Lv, J.; Ju, H.; Zhou, X.; Zhang, Y. A novel hybrid baculovirus-adeno-associated viral vector-mediated radionuclide reporter gene imaging system for stem cells transplantation monitoring. Appl. Microbiol. Biotechnol. 2015, 99, 1415-1426.
221. Uren, A.G.; Kool, J.; Berns, A.; van Lohuizen, M. Retroviral insertional mutagenesis: Past, present and future. Oncogene 2005, 24, 7656-7672.
222. Jooss, K.; Chirmule, N. Immunity to adenovirus and adeno-associated viral vectors: Implications for gene therapy. Gene Ther. 2003, 10, 955-963.
223. Wang, S.; Ang, W. A*STAR Institute of Bioengineering and Nanotechnology. Singapore, Singapore. Personal communication, 2015.
224. Fewell, G.D.; Schmitt, K. Vector-based RNAi approaches for stable, inducible and genome-wide screens. Drug Discov. Today 2006, 11, 975-982.
225. Kim, D.H.; Rossi, J.J. Strategies for silencing human disease using RNA interference. Nat. Rev. Genet. 2007, 8, 173-184.
226. Mack, G.S. MicroRNA gets down to business. Nat. Biotechnol. 2007, 25, 631-638.
227. Davidson, B.L.; McCray, P.B. Current prospects for RNA interference-based therapies. Nat. Rev. Genet. 2011, 12, 329-340.
228. Wang, L.; Shan, L.; Yin, J.; Zhao, M.; Su, D.; Zhong, J. The activation of lytic replication of Epstein-Barr virus by baculovirus-mediated gene transduction. Arch. Virol. 2006, 151, 2047-2053.
229. Andersson, M.; Warolén, M.; Nilsson, J.; Selander, M.; Sterky, C.; Bergdahl, K.; Sörving, C.; James, S.R.; Doverskog, M. Baculovirus-mediated gene transfer and recombinant protein expression do not interfere with insulin dependent phosphorylation of PKB/Akt in human SHSY-5Y and C3A cells. BMC Cell Biol. 2007, 8, e6.
230. Airenne, K.J. Improved generation of recombinant baculovirus genomes in Escherichia coli. Nucleic Acids Res. 2003, 31, e101.
231. Asgari, S. MicroRNA functions in insects. Insect Biochem. Mol. Biol. 2013, 43, 388-397.
232. Salem, T.Z.; Maruniak, J.E. A universal transgene silencing approach in baculovirus-insect cell system. J. Virol. Methods 2007, 145, 1-8.
233. Marek, M.; van Oers, M.M.; Devaraj, F.F.; Vlak, J.M.; Merten, O.-W. Engineering of baculovirus vectors for the manufacture of virion-free biopharmaceuticals. Biotechnol. Bioeng. 2011, 108, 1056-1067.
234. Singh, J.; Singh, C.P.; Bhavani, A.; Nagaraju, J. Discovering microRNAs from Bombyx mori nucleopolyhedrosis virus. Virology 2010, 407, 120-128.
235. Mehrabadi, M.; Hussain, M.; Asgari, S. MicroRNAome of Spodoptera frugiperda cells (Sf9) and its alteration following baculovirus infection. J. Gen. Virol. 2013, 94, 1385-1397.
236. Jayachandran, B.; Hussain, M.; Asgari, S. Regulation of Helicoverpa armigera ecdysone receptor by miR-14 and its potential link to baculovirus infection. J. Invertebr. Pathol. 2013, 114, 151-157.
237. Valdes, V.J.; Sampieri, A.; Sepulveda, J.; Vaca, L. Using double-stranded RNA to prevent in vitro and in vivo viral infections by recombinant baculovirus. J. Biol. Chem. 2003, 278, 19317-19324.
238. Zhou, F.; Chen, R.-T.; Lu, Y.; Liang, S.; Wang, M.-X.; Miao, Y.-G. Piggybac transposon-derived targeting shRNA interference against the Bombyx mori nucleopolyhedrovirus (BmNPV). Mol. Biol. Rep. 2014, 41, 8247-8254.
239. Zhang, P.; Wang, J.; Lu, Y.; Hu, Y.; Xue, R.; Cao, G.; Gong, C. Resistance of transgenic silkworm to BmNPV could be improved by silencing ie-1 and lef-1 genes. Gene Ther. 2014, 21, 81-88.
240. Kanginakudru, S.; Royer, C.; Edupalli, S.V.; Jalabert, A.; Mauchamp, B.; Prasad, S.V.; Chavancy, G.; Couble, P.; Nagaraju, J. Targeting ie-1 gene by RNAi induces baculoviral resistance in lepidopteran cell lines and in transgenic silkworms. Insect Mol. Biol. 2007, 16, 635-644.
241. Singh, C.P.; Singh, J.; Nagaraju, J. A baculovirus-encoded MicroRNA (miRNA) suppresses its host miRNA biogenesis by regulating the exportin-5 cofactor Ran. J. Virol. 2012, 86, 7867-7879.
242. Singh, C.P.; Singh, J.; Nagaraju, J. Bmnpv-miR-3 facilitates BmNPV infection by modulating the expression of viral P6.9 and other late genes in Bombyx mori. Insect Biochem. Mol. Biol. 2014, 49, 59-69.
243. Zhu, M.; Wang, J.; Deng, R.; Xiong, P.; Liang, H.; Wang, X. A microRNA encoded by Autographa californica nucleopolyhedrovirus regulates expression of viral gene ODV-E. J. Virol. 2013, 87, 13029-13034.
244. Hebert, C.G.; Valdes, J.J.; Bentley, W.E. In vitro and in vivo RNA interference mediated suppression of Tn-caspase-1 for improved recombinant protein production in High Five cell culture with the baculovirus expression vector system. Biotechnol. Bioeng. 2009, 104, 390-399.
245. Nicholson, L.J.; Philippe, M.; Paine, A.J.; Mann, D.A.; Dolphin, C.T. RNA interference mediated in human primary cells via recombinant baculoviral vectors. Mol. Ther. 2005, 11, 638-644.
246. Ong, S.T.; Li, F.; Du, J.; Tan, Y.W.; Wang, S. Hybrid cytomegalovirus enhancer-h1 promoter-based plasmid and baculovirus vectors mediate effective RNA interference. Hum. Gene Ther. 2005, 16, 1404-1412.
247. Chen, C.-L.; Luo, W.-Y.; Lo, W.-H.; Lin, K.-J.; Sung, L.-Y.; Shih, Y.-S.; Chang, Y.-H.; Hu, Y.-C. Development of hybrid baculovirus vectors for artificial MicroRNA delivery and prolonged gene suppression. Biotechnol. Bioeng. 2011, 108, 2958-2967.
248. Chen, C.-L.; Tseng, Y.-W.; Wu, J.-C.; Chen, G.-Y.; Lin, K.-C.; Hwang, S.-M.; Hu, Y.-C. Suppression of hepatocellular carcinoma by baculovirus-mediated expression of long non-coding RNA PTENP1 and MicroRNA regulation. Biomaterials 2015, 44, 71-81.
249. Lin, J.; Teo, S.; Lam, D.H.; Jeyaseelan, K.; Wang, S. MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiforme. Cell Death Dis. 2012, 3, e398.
250. Liao, Y.-H.; Chang, Y.-H.; Sung, L.-Y.; Li, K.-C.; Yeh, C.-L.; Yen, T.-C.; Hwang, S.-M.; Lin, K.-J.; Hu, Y.-C. Osteogenic differentiation of adipose-derived stem cells and calvarial defect repair using baculovirus-mediated co-expression of BMP-2 and miR-148b. Biomaterials 2014, 35, 4901-4910.
251. Nizamani, Z.A.; Keil, G.M.; Albina, E.; Holz, C.; Minet, C.; Kwiatek, O.; Libeau, G.; Servan de Almeida, R. Potential of adenovirus and baculovirus vectors for the delivery of shRNA against morbilliviruses. Antiviral Res. 2011, 90, 98-101.
252. Lu, L.; Ho, Y.; Kwang, J. Suppression of porcine arterivirus replication by baculovirus-delivered shRNA targeting nucleoprotein. Biochem. Biophys. Res. Commun. 2006, 340, 1178-1183.
253. Suzuki, H.; Tamai, N.; Habu, Y.; Chang, M.O.O.; Takaku, H. Suppression of hepatitis C virus replication by baculovirus vector-mediated short-hairpin RNA expression. FEBS Lett. 2008, 582, 3085-3089.
254. Suzuki, H.; Matsumoto, N.; Suzuki, T.; Chang, M.O.; Takaku, H. Stable replication of the EBNA1/OriP-mediated baculovirus vector and its application to anti-HCV gene therapy. Virol. J. 2009, 6, e156.
255. Starkey, J.L.; Chiari, E.F.; Isom, H.C. Hepatitis B virus (HBV)-specific short hairpin RNA is capable of reducing the formation of HBV covalently closed circular (CCC) DNA but has no effect on established CCC DNA in vitro. J. Gen. Virol. 2009, 90, 115-126.
256. Suzuki, H.; Saitoh, H.; Suzuki, T.; Takaku, H. Baculovirus-mediated bispecific short-hairpin small-interfering RNAs have remarkable ability to cope with both influenza viruses A and B. Oligonucleotides 2009, 19, 307-316.
257. Kaneko, H.; Suzuki, H.; Abe, T.; Miyano-Kurosaki, N.; Takaku, H. Inhibition of HIV-1 replication by vesicular stomatitis virus envelope glycoprotein pseudotyped baculovirus vector-transduced ribozyme in mammalian cells. Biochem. Biophys. Res. Commun. 2006, 349, 1220-1227.