Suppression of hepatocellular carcinoma by baculovirus-mediated expression of long non-coding RNA PTENP1 and MicroRNA regulation

Biomaterials

Volumn 44, Issue , 2015, Pages 71-81

  Chen, Chiu Ling ^a   Tseng, Yen Wen ^a   Wu, Jaw Ching ^b,c   Chen, Guan Yu ^a   Lin, Kuan Chen ^a   Hwang, Shiaw Min ^d   Hu, Yu Chen ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d FOOD INDUSTRY RESEARCH AND DEVELOPMENT INSTITUTE   (Taiwan)

Author keywords

Baculovirus; Cancer therapy; Hepatocellular carcinoma; LncRNA; MiRNA; PTENP1

Indexed keywords

CELL DEATH; CELL PROLIFERATION; DISEASES; GENES; MAMMALS; TUMORS; VECTORS;

BACULOVIRUS; CANCER THERAPY; HEPATOCELLULAR CARCINOMA; LNCRNA; MIRNA; PTENP1;

RNA;

MICRORNA; UNTRANSLATED RNA; VIRUS VECTOR; LONG UNTRANSLATED RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SLEEPING BEAUTY TRANSPOSASE, HUMAN; TRANSPOSASE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; BACULOVIRIDAE; CANCER THERAPY; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; HUMAN; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BAGG ALBINO MOUSE; CELL SURVIVAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; LIVER TUMOR; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); NUDE MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION; VASCULARIZATION;

MUS;

ANIMALS; APOPTOSIS; AUTOPHAGY; BACULOVIRIDAE; CARCINOMA, HEPATOCELLULAR; CELL SURVIVAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MICE, INBRED BALB C; MICE, NUDE; MICRORNAS; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RNA, LONG NONCODING; SIGNAL TRANSDUCTION; TRANSPOSASES;

EID: 84921265137     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.12.023     Document Type: Article

References (51)

1. Garzon R., Marcucci G., Croce C.M. Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov 2010, 9:775-789.
2. Yoon J.H., Abdelmohsen K., Gorospe M. Posttranscriptional gene regulation by long noncoding RNA. JMol Biol 2013, 425:3723-3730.
3. Guil S., Esteller M. Cis-acting noncoding RNAs: friends and foes. Nat Struct Mol Biol 2012, 19:1068-1075.
4. Mercer T.R., Dinger M.E., Mattick J.S. Long non-coding RNAs: insights into functions. Nat Rev Genet 2009, 10:155-159.
5. Tay Y., Kats L., Salmena L., Weiss D., Tan S.M., Ala U., et al. Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell 2011, 147:344-357.
6. Hollander M.C., Blumenthal G.M., Dennis P.A. PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat Rev Cancer 2011, 11:289-301.
7. Poliseno L., Salmena L., Zhang J., Carver B., Haveman W.J., Pandolfi P.P. Acoding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature 2010, 465:1033-1038.
8. Xia H., Ooi L.L., Hui K.M. MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer. Hepatology 2013, 58:629-641.
9. Huarte M., Rinn J.L. Large non-coding RNAs: missing links in cancer?. Hum Mol Genet 2010, 19:R152-R161.
10. Prensner J.R., Chinnaiyan A.M. The emergence of lncRNAs in cancer biology. Cancer Discov 2011, 1:391-407.
11. He Y., Meng X.M., Huang C., Wu B.M., Zhang L., Lv X.W., et al. Long noncoding RNAs: novel insights into hepatocelluar carcinoma. Cancer Lett 2014, 344:20-27.
12. Spizzo R., Almeida M.I., Colombatti A., Calin G.A. Long non-coding RNAs and cancer: a new frontier of translational research?. Oncogene 2012, 31:1-11.
13. Levine B., Mizushima N., Virgin H.W. Autophagy in immunity and inflammation. Nature 2011, 469:323-335.
14. Yang Z.J., Chee C.E., Huang S., Sinicrope F.A. The role of autophagy in cancer: therapeutic implications. Mol Cancer Ther 2011, 10:1533-1541.
15. Fullgrabe J., Klionsky D.J., Joseph B. The return of the nucleus: transcriptional and epigenetic control of autophagy. Nat Rev Mol Cell Biol 2014, 15:65-74.
16. Chen C.-L., Luo W.-Y., Lo W.-H., Lin K.-J., Sung L.-Y., Shih Y.-S., et al. Development of hybrid baculovirus vectors for artificial MicroRNA delivery and prolonged gene suppression. Biotechnol Bioeng 2011, 108:2958-2967.
17. Luo W.Y., Shih Y.S., Hung C.L., Lo K.W., Chiang C.S., Lo W.H., et al. Development of the hybrid sleeping beauty: baculovirus vector for sustained gene expression and cancer therapy. Gene Ther 2012, 19:844-851.
18. Chen C.-L., Wu J.-W., Chen G.-Y., Yuan P.-H., Tseng Y.-W., Li K.-C., et al. Baculovirus-mediated miRNA regulation to suppress hepatocellular carcinoma tumorigenicity and metastasis. Mol Ther 2014, Epub ahead of print. 10.1038/mt.2014.126.
19. Lin C.-Y., Chang Y.-H., Li K.-C., Lu C.-H., Sung L.-Y., Yeh C.-L., et al. The use of ASCs engineered to express BMP2 or TGF-β3 within scaffold constructs to promote calvarial bone repair. Biomaterials 2013, 34:9401-9412.
20. Sung L.-Y., Chen C.-L., Lin S.-Y., Li K.-C., Yeh C.-L., Chen G.-Y., et al. Efficient gene delivery into cell lines and stem cells using baculovirus. Nat Protoc 2014, 9:1882-1899.
21. Sung L.Y., Chen C.L., Lin S.Y., Hwang S.M., Lu C.H., Li K.C., et al. Enhanced and prolonged baculovirus-mediated expression by incorporating recombinase system and in cis elements: a comparative study. Nucleic Acids Res 2013, 41:e139.
22. Chen G.Y., Chen C.L., Tuan H.Y., Yuan P.X., Li K.C., Yang H.J., et al. Graphene oxide triggers toll-like receptors/autophagy responses invitro and inhibits tumor growth invivo. Adv Health Mater 2014, 3:1486-1495.
23. Chen G.-Y., Yang H.-J., Lu C.-H., Chao Y.-C., Hwang S.-M., Chen C.-L., et al. Simultaneous induction of autophagy and toll-like receptor signaling pathways by graphene oxide. Biomaterials 2012, 33:6559-6569.
24. Karreth F.A., Pandolfi P.P. ceRNA cross-talk in cancer: when ce-bling rivalries go awry. Cancer Discov 2013, 3:1113-1121.
25. Matter M.S., Decaens T., Andersen J.B., Thorgeirsson S.S. Targeting the mTOR pathway in hepatocellular carcinoma: current state and future trends. JHepatol 2014, 60:855-865.
26. Hemmings B.A., Restuccia D.F. PI3K-PKB/Akt pathway. Cold Spring Harb Perspect Biol 2012, 4:a011189.
27. Newton A.C., Trotman L.C. Turning off AKT: PHLPP as a drug target. Annu Rev Pharmacol Toxicol 2014, 54:537-558.
28. Gewirtz D.A. The four faces of autophagy: implications for cancer therapy. Cancer Res 2014, 74:647-651.
29. Braconi C., Kogure T., Valeri N., Huang N., Nuovo G., Costinean S., et al. microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer. Oncogene 2011, 30:4750-4756.
30. Fan Q.W., Weiss W.A. Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance. Curr Top Microbiol Immunol 2010, 347:279-296.
31. Yothaisong S., Dokduang H., Techasen A., Namwat N., Yongvanit P., Bhudhisawasdi V., et al. Increased activation of PI3K/AKT signaling pathway is associated with cholangiocarcinoma metastasis and PI3K/mTOR inhibition presents a possible therapeutic strategy. Tumour Biol 2013, 34:3637-3648.
32. Wander S., Zhao D., Besser A., Hong F., Wei J., Ince T., et al. PI3K/mTOR inhibition can impair tumor invasion and metastasis invivo despite a lack of antiproliferative action invitro: implications for targeted therapy. Breast Cancer Res Treat 2013, 138:369-381.
33. Lai M.C., Yang Z., Zhou L., Zhu Q.Q., Xie H.Y., Zhang F., et al. Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation. Med Oncol 2012, 29:1810-1816.
34. Gupta R.A., Shah N., Wang K.C., Kim J., Horlings H.M., Wong D.J., et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 2010, 464:1071-1076.
35. Ishibashi M., Kogo R., Shibata K., Sawada G., Takahashi Y., Kurashige J., et al. Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma. Oncol Rep 2013, 29:946-950.
36. Wang J., Liu X., Wu H., Ni P., Gu Z., Qiao Y., et al. CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer. Nucleic Acids Res 2010, 38:5366-5383.
37. Xie H., Ma H., Zhou D. Plasma HULC as a promising novel biomarker for the detection of hepatocellular carcinoma. Biomed Res Int 2013, 2013:136106.
38. Yuan S.-X., Yang F., Yang Y., Tao Q.-F., Zhang J., Huang G., et al. Long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma promotes angiogenesis and serves as a predictor for hepatocellular carcinoma patients' poor recurrence-free survival after hepatectomy. Hepatology 2012, 56:2231-2241.
39. Yang F., Zhang L., Huo X-s, Yuan J-h, Xu D., Yuan S-x, et al. Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans. Hepatology 2011, 54:1679-1689.
40. Quagliata L., Matter M.S., Piscuoglio S., Arabi L., Ruiz C., Procino A., et al. Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients. Hepatology 2014, 59:911-923.
41. Poliseno L., Haimovic A., Christos P.J., YSdMEC Vega, Shapiro R., Pavlick A., et al. Deletion of PTENP1 pseudogene in human melanoma. JInvest Dermatol 2011, 131:2497-2500.
42. Petrocca F., Visone R., Onelli M.R., Shah M.H., Nicoloso M.S., de Martino I., et al. E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell 2008, 13:272-286.
43. Olive V., Bennett M.J., Walker J.C., Ma C., Jiang I., Cordon-Cardo C., et al. miR-19 is a key oncogenic component of mir-17-92. Genes Dev 2009, 23:2839-2849.
44. Gao T.Y., Furnari F., Newton A.C. PHLPP: a phosphatase that directly dephosphorylates akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 2005, 18:13-24.
45. Law P.T., Wong N. Emerging roles of microRNA in the intracellular signaling networks of hepatocellular carcinoma. JGastroenterol Hepatol 2011, 26:437-449.
46. Liu B., Wen X., Cheng Y. Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer. Cell Death Dis 2013, 4:e892.
47. Cheong H., Lu C., Lindsten T., Thompson C.B. Therapeutic targets in cancer cell metabolism and autophagy. Nat Biotechnol 2012, 30:671-678.
48. Zhang D.-M., Liu J.-S., Deng L.-J., Chen M.-F., Yiu A., Cao H.-H., et al. Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Carcinogenesis 2013, 34:1331-1342.
49. Ding Z.-B., Shi Y.-H., Zhou J., Qiu S.-J., Xu Y., Dai Z., et al. Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Res 2008, 68:9167-9175.
50. Lan S.H., Wu S.Y., Zuchini R., Lin X.Z., Su I.J., Tsai T.F., et al. Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of microRNA-224. Hepatology 2014, 59:505-517.
51. Fu L.L., Wen X., Bao J.K., Liu B. MicroRNA-modulated autophagic signaling networks in cancer. Int J Biochem Cell Biol 2012, 44:733-736.