메뉴 건너뛰기




Volumn 139, Issue 5, 2015, Pages 594-601

Molecular genetic biomarkers in myeloid malignancies

Author keywords

[No Author keywords available]

Indexed keywords

GENETIC MARKER; TUMOR MARKER;

EID: 84928955014     PISSN: 00039985     EISSN: 15432165     Source Type: Journal    
DOI: 10.5858/arpa.2014-0096-RA     Document Type: Review
Times cited : (10)

References (144)
  • 1
    • 4544277651 scopus 로고    scopus 로고
    • Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis
    • Tong W, Lodish HF. Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis. J Exp Med. 2004;200(5):569-580.
    • (2004) J Exp Med , vol.200 , Issue.5 , pp. 569-580
    • Tong, W.1    Lodish, H.F.2
  • 2
    • 20444426803 scopus 로고    scopus 로고
    • Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways
    • Tong W, Zhang J, Lodish HF. Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways. Blood. 2005;105(12):4604-4612.
    • (2005) Blood , vol.105 , Issue.12 , pp. 4604-4612
    • Tong, W.1    Zhang, J.2    Lodish, H.F.3
  • 3
    • 0033828672 scopus 로고    scopus 로고
    • SOCS: Physiological suppressors of cytokine signaling
    • Krebs DL, Hilton DJ. SOCS: physiological suppressors of cytokine signaling. J Cell Sci. 2000;113(pt 16):2813-2819.
    • (2000) J Cell Sci , vol.113 , pp. 2813-2819
    • Krebs, D.L.1    Hilton, D.J.2
  • 4
    • 80051931772 scopus 로고    scopus 로고
    • New mutations and pathogenesis of myeloproliferative neoplasms
    • Vainchenker W, Delhommeau F, Constantinescu SN, Bernard OA. New mutations and pathogenesis of myeloproliferative neoplasms. Blood. 2011;118(7):1723-1735.
    • (2011) Blood , vol.118 , Issue.7 , pp. 1723-1735
    • Vainchenker, W.1    Delhommeau, F.2    Constantinescu, S.N.3    Bernard, O.A.4
  • 5
    • 77954661906 scopus 로고    scopus 로고
    • DNA hypomethylation in cancer cells
    • Ehrlich M. DNA hypomethylation in cancer cells. Epigenomics. 2009;1(2):239-259.
    • (2009) Epigenomics , vol.1 , Issue.2 , pp. 239-259
    • Ehrlich, M.1
  • 6
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M. Epigenetics in cancer. N Engl J Med. 2008;358(11):1148-1159.
    • (2008) N Engl J Med , vol.358 , Issue.11 , pp. 1148-1159
    • Esteller, M.1
  • 8
    • 33845417885 scopus 로고    scopus 로고
    • The cancer epigenome - Components and functional correlates
    • Ting AH, McGarvey KM, Baylin SB. The cancer epigenome - components and functional correlates. Genes Dev. 2006;20(23):3215-3231.
    • (2006) Genes Dev , vol.20 , Issue.23 , pp. 3215-3231
    • Ting, A.H.1    McGarvey, K.M.2    Baylin, S.B.3
  • 9
    • 39649122136 scopus 로고    scopus 로고
    • Cancer epigenetics: Modifications, screening, and therapy
    • Gal-Yam EN, Saito Y, Egger G, Jones PA. Cancer epigenetics: modifications, screening, and therapy. Annu Rev Med. 2008;59:267-280.
    • (2008) Annu Rev Med , vol.59 , pp. 267-280
    • Gal-Yam, E.N.1    Saito, Y.2    Egger, G.3    Jones, P.A.4
  • 10
    • 77957174102 scopus 로고    scopus 로고
    • Genome-wide conserved consensus transcription factor binding motifs are hypermethylated
    • Choy MK, Movassagh M, Goh HG, Bennett MR, Down TA, Foo RS. Genome-wide conserved consensus transcription factor binding motifs are hypermethylated. BMC Genomics. 2010;11:519.
    • (2010) BMC Genomics , vol.11 , pp. 519
    • Choy, M.K.1    Movassagh, M.2    Goh, H.G.3    Bennett, M.R.4    Down, T.A.5    Foo, R.S.6
  • 11
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med. 2010;363(25):2424-2433.
    • (2010) N Engl J Med , vol.363 , Issue.25 , pp. 2424-2433
    • Ley, T.J.1    Ding, L.2    Walter, M.J.3
  • 12
    • 67651065502 scopus 로고    scopus 로고
    • Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
    • Abdel-Wahab O, Mullally A, Hedvat C, et al. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood. 2009;114(1):144-147.
    • (2009) Blood , vol.114 , Issue.1 , pp. 144-147
    • Abdel-Wahab, O.1    Mullally, A.2    Hedvat, C.3
  • 13
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis ER, Ding L, Dooling DJ, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med. 2009;361(11):1058-1066.
    • (2009) N Engl J Med , vol.361 , Issue.11 , pp. 1058-1066
    • Mardis, E.R.1    Ding, L.2    Dooling, D.J.3
  • 14
    • 84880159302 scopus 로고    scopus 로고
    • Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism
    • Rendina AR, Pietrak B, Smallwood A, et al. Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism. Biochemistry. 2013;52(26):4563-4577.
    • (2013) Biochemistry , vol.52 , Issue.26 , pp. 4563-4577
    • Rendina, A.R.1    Pietrak, B.2    Smallwood, A.3
  • 15
    • 0001129080 scopus 로고
    • The bases of the nucleic acids of some bacterial and animal viruses: The occurrence of 5-hydroxymethylcytosine
    • Wyatt GR, Cohen SS. The bases of the nucleic acids of some bacterial and animal viruses: the occurrence of 5-hydroxymethylcytosine. Biochem J. 1953;55(5):774-782.
    • (1953) Biochem J , vol.55 , Issue.5 , pp. 774-782
    • Wyatt, G.R.1    Cohen, S.S.2
  • 16
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • Tahiliani M, Koh KP, Shen Y, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science. 2009;324(5929):930-935.
    • (2009) Science , vol.324 , Issue.5929 , pp. 930-935
    • Tahiliani, M.1    Koh, K.P.2    Shen, Y.3
  • 17
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
    • Xu W, Yang H, Liu Y, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011;19(1):17-30.
    • (2011) Cancer Cell , vol.19 , Issue.1 , pp. 17-30
    • Xu, W.1    Yang, H.2    Liu, Y.3
  • 18
    • 84877620952 scopus 로고    scopus 로고
    • Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
    • Wang F, Travins J, DeLaBarre B, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013;340(6132):622-626.
    • (2013) Science , vol.340 , Issue.6132 , pp. 622-626
    • Wang, F.1    Travins, J.2    DeLaBarre, B.3
  • 19
    • 66849124925 scopus 로고    scopus 로고
    • Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia
    • Gelsi-Boyer V, Trouplin V, Adelaide J, et al. Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia. Br J Haematol. 2009;145(6):788-800.
    • (2009) Br J Haematol , vol.145 , Issue.6 , pp. 788-800
    • Gelsi-Boyer, V.1    Trouplin, V.2    Adelaide, J.3
  • 20
    • 84871204903 scopus 로고    scopus 로고
    • EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms
    • Ueda T, Sanada M, Matsui H, et al. EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms. Leukemia. 2012;26(12):2557-2560.
    • (2012) Leukemia , vol.26 , Issue.12 , pp. 2557-2560
    • Ueda, T.1    Sanada, M.2    Matsui, H.3
  • 21
    • 73349127026 scopus 로고    scopus 로고
    • Cohesin: Its roles and mechanisms
    • Nasmyth K, Haering CH. Cohesin: its roles and mechanisms. Annu Rev Genet. 2009;43:525-558.
    • (2009) Annu Rev Genet , vol.43 , pp. 525-558
    • Nasmyth, K.1    Haering, C.H.2
  • 22
    • 34447549077 scopus 로고    scopus 로고
    • Postreplicative formation of cohesion is required for repair and induced by a single DNA break
    • Strom L, Karlsson C, Lindroos HB, et al. Postreplicative formation of cohesion is required for repair and induced by a single DNA break. Science. 2007;317(5835):242-245.
    • (2007) Science , vol.317 , Issue.5835 , pp. 242-245
    • Strom, L.1    Karlsson, C.2    Lindroos, H.B.3
  • 23
    • 69849103550 scopus 로고    scopus 로고
    • The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells
    • Watrin E, Peters JM. The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells. EMBO J. 2009;28(17):2625-2635.
    • (2009) EMBO J , vol.28 , Issue.17 , pp. 2625-2635
    • Watrin, E.1    Peters, J.M.2
  • 24
    • 63049139061 scopus 로고    scopus 로고
    • Cohesin, gene expression and development: Lessons from Drosophila
    • Dorsett D. Cohesin, gene expression and development: lessons from Drosophila. Chromosome Res. 2009;17(2):185-200.
    • (2009) Chromosome Res , vol.17 , Issue.2 , pp. 185-200
    • Dorsett, D.1
  • 25
    • 28044453063 scopus 로고    scopus 로고
    • Effects of sister chromatid cohesion proteins on cut gene expression during wing development in Drosophila
    • Dorsett D, Eissenberg JC, Misulovin Z, Martens A, Redding B, McKim K. Effects of sister chromatid cohesion proteins on cut gene expression during wing development in Drosophila. Development. 2005;132(21):4743-4753.
    • (2005) Development , vol.132 , Issue.21 , pp. 4743-4753
    • Dorsett, D.1    Eissenberg, J.C.2    Misulovin, Z.3    Martens, A.4    Redding, B.5    McKim, K.6
  • 26
    • 34547762839 scopus 로고    scopus 로고
    • Cohesin-dependent regulation of Runx genes
    • Horsfield JA, Anagnostou SH, Hu JK, et al. Cohesin-dependent regulation of Runx genes. Development. 2007;134(14):2639-2649.
    • (2007) Development , vol.134 , Issue.14 , pp. 2639-2649
    • Horsfield, J.A.1    Anagnostou, S.H.2    Hu, J.K.3
  • 27
    • 38849121606 scopus 로고    scopus 로고
    • Cohesins functionally associate with CTCF on mammalian chromosome arms
    • Parelho V, Hadjur S, Spivakov M, et al. Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell. 2008;132(3):422-433.
    • (2008) Cell , vol.132 , Issue.3 , pp. 422-433
    • Parelho, V.1    Hadjur, S.2    Spivakov, M.3
  • 28
    • 39149121436 scopus 로고    scopus 로고
    • Cohesin mediates transcriptional insulation by CCCTC-binding factor
    • Wendt KS, Yoshida K, Itoh T, et al. Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature. 2008;451(7180):796-801.
    • (2008) Nature , vol.451 , Issue.7180 , pp. 796-801
    • Wendt, K.S.1    Yoshida, K.2    Itoh, T.3
  • 29
    • 0037459376 scopus 로고    scopus 로고
    • Chromosomal cohesin forms a ring
    • Gruber S, Haering CH, Nasmyth K. Chromosomal cohesin forms a ring. Cell. 2003;112(6):765-777.
    • (2003) Cell , vol.112 , Issue.6 , pp. 765-777
    • Gruber, S.1    Haering, C.H.2    Nasmyth, K.3
  • 30
    • 84885021313 scopus 로고    scopus 로고
    • Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms
    • Kon A, Shih LY, Minamino M, et al. Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms. Nat Genet. 2013;45(10):1232-1237.
    • (2013) Nat Genet , vol.45 , Issue.10 , pp. 1232-1237
    • Kon, A.1    Shih, L.Y.2    Minamino, M.3
  • 31
    • 84878372012 scopus 로고    scopus 로고
    • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
    • Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med. 2013;368(22):2059-2074.
    • (2013) N Engl J Med , vol.368 , Issue.22 , pp. 2059-2074
    • Cancer Genome Atlas Research Network1
  • 32
    • 84872819734 scopus 로고    scopus 로고
    • Spliceosome mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia
    • Chesnais V, Kosmider O, Damm F, et al. Spliceosome mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia. Oncotarget. 2012;3(11):1284-1293.
    • (2012) Oncotarget , vol.3 , Issue.11 , pp. 1284-1293
    • Chesnais, V.1    Kosmider, O.2    Damm, F.3
  • 33
    • 67349191499 scopus 로고    scopus 로고
    • miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities
    • Mraz M, Malinova K, Kotaskova J, et al. miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities. Leukemia. 2009;23(6):1159-1163.
    • (2009) Leukemia , vol.23 , Issue.6 , pp. 1159-1163
    • Mraz, M.1    Malinova, K.2    Kotaskova, J.3
  • 34
    • 0038277105 scopus 로고    scopus 로고
    • Tumor cell senescence in cancer treatment
    • Roninson IB. Tumor cell senescence in cancer treatment. Cancer Res. 2003;63(11):2705-2715.
    • (2003) Cancer Res , vol.63 , Issue.11 , pp. 2705-2715
    • Roninson, I.B.1
  • 35
    • 77950521214 scopus 로고    scopus 로고
    • Mutant p53 gain-of-function in cancer
    • Oren M, Rotter V. Mutant p53 gain-of-function in cancer. Cold Spring Harb Perspect Biol. 2010;2(2):a001107.
    • (2010) Cold Spring Harb Perspect Biol , vol.2 , Issue.2 , pp. a001107
    • Oren, M.1    Rotter, V.2
  • 36
    • 33748294150 scopus 로고    scopus 로고
    • Nucleophosmin: A versatile molecule associated with hematological malignancies
    • Naoe T, Suzuki T, Kiyoi H, Urano T. Nucleophosmin: a versatile molecule associated with hematological malignancies. Cancer Sci. 2006;97(10):963-969.
    • (2006) Cancer Sci , vol.97 , Issue.10 , pp. 963-969
    • Naoe, T.1    Suzuki, T.2    Kiyoi, H.3    Urano, T.4
  • 37
    • 20144363192 scopus 로고    scopus 로고
    • Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    • Baxter EJ, Scott LM, Campbell PJ, et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. 2005;365(9464):1054-1061.
    • (2005) Lancet , vol.365 , Issue.9464 , pp. 1054-1061
    • Baxter, E.J.1    Scott, L.M.2    Campbell, P.J.3
  • 38
    • 17844383458 scopus 로고    scopus 로고
    • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    • James C, Ugo V, Le Couedic JP, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005;434(7037):1144-1148.
    • (2005) Nature , vol.434 , Issue.7037 , pp. 1144-1148
    • James, C.1    Ugo, V.2    Le Couedic, J.P.3
  • 39
    • 17644424955 scopus 로고    scopus 로고
    • A gain-of-function mutation of JAK2 in myeloproliferative disorders
    • Kralovics R, Passamonti F, Buser AS, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005;352(17):1779-1790.
    • (2005) N Engl J Med , vol.352 , Issue.17 , pp. 1779-1790
    • Kralovics, R.1    Passamonti, F.2    Buser, A.S.3
  • 40
    • 20244369569 scopus 로고    scopus 로고
    • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
    • Levine RL, Wadleigh M, Cools J, et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005;7(4):387-397.
    • (2005) Cancer Cell , vol.7 , Issue.4 , pp. 387-397
    • Levine, R.L.1    Wadleigh, M.2    Cools, J.3
  • 41
    • 33846660947 scopus 로고    scopus 로고
    • JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis
    • Scott LM, Tong W, Levine RL, et al. JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med. 2007;356(5):459-468.
    • (2007) N Engl J Med , vol.356 , Issue.5 , pp. 459-468
    • Scott, L.M.1    Tong, W.2    Levine, R.L.3
  • 42
    • 0020522444 scopus 로고
    • Individual BFU-E in polycythemia vera produce both erythropoietin dependent and independent progeny
    • Cashman J, Henkelman D, Humphries K, Eaves C, Eaves A. Individual BFU-E in polycythemia vera produce both erythropoietin dependent and independent progeny. Blood. 1983;61(5):876-884.
    • (1983) Blood , vol.61 , Issue.5 , pp. 876-884
    • Cashman, J.1    Henkelman, D.2    Humphries, K.3    Eaves, C.4    Eaves, A.5
  • 43
    • 38949160429 scopus 로고    scopus 로고
    • Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders
    • Pietra D, Li S, Brisci A, et al. Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders. Blood. 2008;111(3):1686-1689.
    • (2008) Blood , vol.111 , Issue.3 , pp. 1686-1689
    • Pietra, D.1    Li, S.2    Brisci, A.3
  • 44
    • 47249092413 scopus 로고    scopus 로고
    • MPL mutations in myeloproliferative disorders: Analysis of the PT-1 cohort
    • Beer PA, Campbell PJ, Scott LM, et al. MPL mutations in myeloproliferative disorders: analysis of the PT-1 cohort. Blood. 2008;112(1):141-149.
    • (2008) Blood , vol.112 , Issue.1 , pp. 141-149
    • Beer, P.A.1    Campbell, P.J.2    Scott, L.M.3
  • 45
    • 33746437130 scopus 로고    scopus 로고
    • MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
    • Pikman Y, Lee BH, Mercher T, et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 2006;3(7):e270.
    • (2006) PLoS Med , vol.3 , Issue.7 , pp. e270
    • Pikman, Y.1    Lee, B.H.2    Mercher, T.3
  • 46
    • 77949810252 scopus 로고    scopus 로고
    • Clinical utility of routine MPL exon 10 analysis in the diagnosis of essential thrombocythaemia and primary myelofibrosis
    • Boyd EM, Bench AJ, Goday-Fernandez A, et al. Clinical utility of routine MPL exon 10 analysis in the diagnosis of essential thrombocythaemia and primary myelofibrosis. Br J Haematol. 2010;149(2):250-257.
    • (2010) Br J Haematol , vol.149 , Issue.2 , pp. 250-257
    • Boyd, E.M.1    Bench, A.J.2    Goday-Fernandez, A.3
  • 47
    • 49449094277 scopus 로고    scopus 로고
    • New mutations of MPL in primitive myelofibrosis: Only the MPL W515 mutations promote a G1/S-phase transition
    • Chaligne R, Tonetti C, Besancenot R, et al. New mutations of MPL in primitive myelofibrosis: only the MPL W515 mutations promote a G1/S-phase transition. Leukemia. 2008;22(8):1557-1566.
    • (2008) Leukemia , vol.22 , Issue.8 , pp. 1557-1566
    • Chaligne, R.1    Tonetti, C.2    Besancenot, R.3
  • 48
    • 84890328032 scopus 로고    scopus 로고
    • Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2
    • Nangalia J, Massie CE, Baxter EJ, et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med. 2013;369(25):2391-2405.
    • (2013) N Engl J Med , vol.369 , Issue.25 , pp. 2391-2405
    • Nangalia, J.1    Massie, C.E.2    Baxter, E.J.3
  • 49
    • 84890372480 scopus 로고    scopus 로고
    • Somatic mutations of calreticulin in myeloproliferative neoplasms
    • Klampfl T, Gisslinger H, Harutyunyan AS, et al. Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med. 2013;369(25):2379-2390.
    • (2013) N Engl J Med , vol.369 , Issue.25 , pp. 2379-2390
    • Klampfl, T.1    Gisslinger, H.2    Harutyunyan, A.S.3
  • 50
    • 77953485892 scopus 로고    scopus 로고
    • Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms
    • Oh ST, Simonds EF, Jones C, et al. Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms. Blood. 2010;116(6):988-992.
    • (2010) Blood , vol.116 , Issue.6 , pp. 988-992
    • Oh, S.T.1    Simonds, E.F.2    Jones, C.3
  • 51
    • 77958021645 scopus 로고    scopus 로고
    • LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations
    • Pardanani A, Lasho T, Finke C, Oh ST, Gotlib J, Tefferi A. LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations. Leukemia. 2010;24(10):1713-1718.
    • (2010) Leukemia , vol.24 , Issue.10 , pp. 1713-1718
    • Pardanani, A.1    Lasho, T.2    Finke, C.3    Oh, S.T.4    Gotlib, J.5    Tefferi, A.6
  • 52
    • 77949525475 scopus 로고    scopus 로고
    • Ubiquitination and degradation of the thrombopoietin receptor c-Mpl
    • Saur SJ, Sangkhae V, Geddis AE, Kaushansky K, Hitchcock IS. Ubiquitination and degradation of the thrombopoietin receptor c-Mpl. Blood. 2010;115(6):1254-1263.
    • (2010) Blood , vol.115 , Issue.6 , pp. 1254-1263
    • Saur, S.J.1    Sangkhae, V.2    Geddis, A.E.3    Kaushansky, K.4    Hitchcock, I.S.5
  • 53
    • 67650401377 scopus 로고    scopus 로고
    • Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms
    • Grand FH, Hidalgo-Curtis CE, Ernst T, et al. Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms. Blood. 2009;113(24):6182-6192.
    • (2009) Blood , vol.113 , Issue.24 , pp. 6182-6192
    • Grand, F.H.1    Hidalgo-Curtis, C.E.2    Ernst, T.3
  • 54
    • 70350455110 scopus 로고    scopus 로고
    • A new polycythaemia vera-associated SOCS3 SH2 mutant (SOCS3F136L) cannot regulate erythropoietin responses
    • Suessmuth Y, Elliott J, Percy MJ, et al. A new polycythaemia vera-associated SOCS3 SH2 mutant (SOCS3F136L) cannot regulate erythropoietin responses. Br J Haematol. 2009;147(4):450-458.
    • (2009) Br J Haematol , vol.147 , Issue.4 , pp. 450-458
    • Suessmuth, Y.1    Elliott, J.2    Percy, M.J.3
  • 55
    • 0037350661 scopus 로고    scopus 로고
    • TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23)
    • Lorsbach RB, Moore J, Mathew S, Raimondi SC, Mukatira ST, Downing JR. TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). Leukemia. 2003;17(3):637-641.
    • (2003) Leukemia , vol.17 , Issue.3 , pp. 637-641
    • Lorsbach, R.B.1    Moore, J.2    Mathew, S.3    Raimondi, S.C.4    Mukatira, S.T.5    Downing, J.R.6
  • 56
    • 77955085750 scopus 로고    scopus 로고
    • Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
    • Ernst T, Chase AJ, Score J, et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet. 2010;42(8):722-726.
    • (2010) Nat Genet , vol.42 , Issue.8 , pp. 722-726
    • Ernst, T.1    Chase, A.J.2    Score, J.3
  • 57
    • 70450239681 scopus 로고    scopus 로고
    • Mutations of ASXL1 gene in myeloproliferative neoplasms
    • Carbuccia N, Murati A, Trouplin V, et al. Mutations of ASXL1 gene in myeloproliferative neoplasms. Leukemia. 2009;23(11):2183-2186.
    • (2009) Leukemia , vol.23 , Issue.11 , pp. 2183-2186
    • Carbuccia, N.1    Murati, A.2    Trouplin, V.3
  • 58
    • 77954581139 scopus 로고    scopus 로고
    • Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1
    • Tefferi A. Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1. Leukemia. 2010;24(6):1128-1138.
    • (2010) Leukemia , vol.24 , Issue.6 , pp. 1128-1138
    • Tefferi, A.1
  • 59
    • 66249137734 scopus 로고    scopus 로고
    • Mutation in TET2 in myeloid cancers
    • Delhommeau F, Dupont S, Della Valle V, et al. Mutation in TET2 in myeloid cancers. N Engl J Med. 2009;360(22):2289-2301.
    • (2009) N Engl J Med , vol.360 , Issue.22 , pp. 2289-2301
    • Delhommeau, F.1    Dupont, S.2    Della Valle, V.3
  • 60
    • 67349124376 scopus 로고    scopus 로고
    • TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis
    • Tefferi A, Pardanani A, Lim KH, et al. TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis. Leukemia. 2009;23(5):905-911.
    • (2009) Leukemia , vol.23 , Issue.5 , pp. 905-911
    • Tefferi, A.1    Pardanani, A.2    Lim, K.H.3
  • 61
    • 77954573304 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms
    • Pardanani A, Lasho TL, Finke CM, Mai M, McClure RF, Tefferi A. IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms. Leukemia. 2010;24(6):1146-1151.
    • (2010) Leukemia , vol.24 , Issue.6 , pp. 1146-1151
    • Pardanani, A.1    Lasho, T.L.2    Finke, C.M.3    Mai, M.4    McClure, R.F.5    Tefferi, A.6
  • 62
    • 0036519296 scopus 로고    scopus 로고
    • Haematopoietic cell-fate decisions, chromatin regulation and ikaros
    • Georgopoulos K. Haematopoietic cell-fate decisions, chromatin regulation and ikaros. Nat Rev Immunol. 2002;2(3):162-174.
    • (2002) Nat Rev Immunol , vol.2 , Issue.3 , pp. 162-174
    • Georgopoulos, K.1
  • 63
    • 77954661062 scopus 로고    scopus 로고
    • Deletions of the transcription factor Ikaros in myeloproliferative neoplasms
    • Jager R, Gisslinger H, Passamonti F, et al. Deletions of the transcription factor Ikaros in myeloproliferative neoplasms. Leukemia. 2010;24(7):1290-1298.
    • (2010) Leukemia , vol.24 , Issue.7 , pp. 1290-1298
    • Jager, R.1    Gisslinger, H.2    Passamonti, F.3
  • 64
    • 77956538421 scopus 로고    scopus 로고
    • Independently acquired biallelic JAK2 mutations are present in a minority of patients with essential thrombocythemia
    • Beer PA, Ortmann CA, Campbell PJ, Green AR. Independently acquired biallelic JAK2 mutations are present in a minority of patients with essential thrombocythemia. Blood. 2010;116(6):1013-1014.
    • (2010) Blood , vol.116 , Issue.6 , pp. 1013-1014
    • Beer, P.A.1    Ortmann, C.A.2    Campbell, P.J.3    Green, A.R.4
  • 65
    • 77950977381 scopus 로고    scopus 로고
    • Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm
    • Beer PA, Delhommeau F, LeCouedic JP, et al. Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm. Blood. 2010;115(14):2891-2900.
    • (2010) Blood , vol.115 , Issue.14 , pp. 2891-2900
    • Beer, P.A.1    Delhommeau, F.2    LeCouedic, J.P.3
  • 67
    • 77955087290 scopus 로고    scopus 로고
    • Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
    • Nikoloski G, Langemeijer SM, Kuiper RP, et al. Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nat Genet. 2010;42(8):665-667.
    • (2010) Nat Genet , vol.42 , Issue.8 , pp. 665-667
    • Nikoloski, G.1    Langemeijer, S.M.2    Kuiper, R.P.3
  • 68
    • 84861813715 scopus 로고    scopus 로고
    • Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia
    • Beekman R, Valkhof MG, Sanders MA, et al. Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia. Blood. 2012;119(22):5071-5077.
    • (2012) Blood , vol.119 , Issue.22 , pp. 5071-5077
    • Beekman, R.1    Valkhof, M.G.2    Sanders, M.A.3
  • 69
    • 0029129034 scopus 로고
    • Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia
    • Dong F, Brynes RK, Tidow N, Welte K, Lowenberg B, Touw IP. Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia. N Engl J Med. 1995;333(8):487-493.
    • (1995) N Engl J Med , vol.333 , Issue.8 , pp. 487-493
    • Dong, F.1    Brynes, R.K.2    Tidow, N.3    Welte, K.4    Lowenberg, B.5    Touw, I.P.6
  • 70
    • 33845972945 scopus 로고    scopus 로고
    • Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: Results of a long-term survey
    • Germeshausen M, Ballmaier M, Welte K. Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: results of a long-term survey. Blood. 2007;109(1):93-99.
    • (2007) Blood , vol.109 , Issue.1 , pp. 93-99
    • Germeshausen, M.1    Ballmaier, M.2    Welte, K.3
  • 71
    • 84877608004 scopus 로고    scopus 로고
    • Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML
    • Maxson JE, Gotlib J, Pollyea DA, et al. Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. N Engl J Med. 2013;368(19):1781-1790.
    • (2013) N Engl J Med , vol.368 , Issue.19 , pp. 1781-1790
    • Maxson, J.E.1    Gotlib, J.2    Pollyea, D.A.3
  • 72
    • 0346880065 scopus 로고    scopus 로고
    • Clinical, genetic, and therapeutic insights into systemic mast cell disease
    • Tefferi A, Pardanani A. Clinical, genetic, and therapeutic insights into systemic mast cell disease. Curr Opin Hematol. 2004;11(1):58-64.
    • (2004) Curr Opin Hematol , vol.11 , Issue.1 , pp. 58-64
    • Tefferi, A.1    Pardanani, A.2
  • 73
    • 0036493872 scopus 로고    scopus 로고
    • The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wildtype kinases and those with regulatory-type mutations
    • Ma Y, Zeng S, Metcalfe DD, et al. The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wildtype kinases and those with regulatory-type mutations. Blood. 2002;99(5):1741-1744.
    • (2002) Blood , vol.99 , Issue.5 , pp. 1741-1744
    • Ma, Y.1    Zeng, S.2    Metcalfe, D.D.3
  • 75
    • 79955945973 scopus 로고    scopus 로고
    • Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignancies
    • Tiu RV, Gondek LP, O'Keefe CL, et al. Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignancies. Blood. 2011;117(17):4552-4560.
    • (2011) Blood , vol.117 , Issue.17 , pp. 4552-4560
    • Tiu, R.V.1    Gondek, L.P.2    O'Keefe, C.L.3
  • 76
    • 84878900540 scopus 로고    scopus 로고
    • Clonal diversity of recurrently mutated genes in myelodysplastic syndromes
    • Walter MJ, Shen D, Shao J, et al. Clonal diversity of recurrently mutated genes in myelodysplastic syndromes. Leukemia. 2013;27(6):1275-1282.
    • (2013) Leukemia , vol.27 , Issue.6 , pp. 1275-1282
    • Walter, M.J.1    Shen, D.2    Shao, J.3
  • 77
    • 80054010617 scopus 로고    scopus 로고
    • Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts
    • Papaemmanuil E, Cazzola M, Boultwood J, et al. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med. 2011;365(15):1384-1395.
    • (2011) N Engl J Med , vol.365 , Issue.15 , pp. 1384-1395
    • Papaemmanuil, E.1    Cazzola, M.2    Boultwood, J.3
  • 78
    • 84857994411 scopus 로고    scopus 로고
    • SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts
    • Visconte V, Makishima H, Jankowska A, et al. SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts. Leukemia. 2012;26(3):542-545.
    • (2012) Leukemia , vol.26 , Issue.3 , pp. 542-545
    • Visconte, V.1    Makishima, H.2    Jankowska, A.3
  • 79
    • 80053900941 scopus 로고    scopus 로고
    • Frequent pathway mutations of splicing machinery in myelodysplasia
    • Yoshida K, Sanada M, Shiraishi Y, et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature. 2011;478(7367):64-69.
    • (2011) Nature , vol.478 , Issue.7367 , pp. 64-69
    • Yoshida, K.1    Sanada, M.2    Shiraishi, Y.3
  • 80
    • 84555192302 scopus 로고    scopus 로고
    • Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes
    • Graubert TA, Shen D, Ding L, et al. Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nat Genet. 2012;44(1):53-57.
    • (2012) Nat Genet , vol.44 , Issue.1 , pp. 53-57
    • Graubert, T.A.1    Shen, D.2    Ding, L.3
  • 81
    • 84888219405 scopus 로고    scopus 로고
    • Clinical and biological implications of driver mutations in myelodysplastic syndromes
    • Papaemmanuil E, Gerstung M, Malcovati L, et al. Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood. 2013;122(22):3616-3627.
    • (2013) Blood , vol.122 , Issue.22 , pp. 3616-3627
    • Papaemmanuil, E.1    Gerstung, M.2    Malcovati, L.3
  • 82
    • 84859595800 scopus 로고    scopus 로고
    • Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes
    • Damm F, Kosmider O, Gelsi-Boyer V, et al. Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes. Blood . 2012;119(14):3211-3218.
    • (2012) Blood , vol.119 , Issue.14 , pp. 3211-3218
    • Damm, F.1    Kosmider, O.2    Gelsi-Boyer, V.3
  • 83
    • 84859856420 scopus 로고    scopus 로고
    • Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes
    • Thol F, Kade S, Schlarmann C, et al. Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes. Blood . 2012;119(15):3578-3584.
    • (2012) Blood , vol.119 , Issue.15 , pp. 3578-3584
    • Thol, F.1    Kade, S.2    Schlarmann, C.3
  • 84
    • 83455234787 scopus 로고    scopus 로고
    • Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms
    • Malcovati L, Papaemmanuil E, Bowen DT, et al. Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms. Blood . 2011;118(24):6239-6246.
    • (2011) Blood , vol.118 , Issue.24 , pp. 6239-6246
    • Malcovati, L.1    Papaemmanuil, E.2    Bowen, D.T.3
  • 85
    • 79959794787 scopus 로고    scopus 로고
    • Clinical effect of point mutations in myelodysplastic syndromes
    • Bejar R, Stevenson K, Abdel-Wahab O, et al. Clinical effect of point mutations in myelodysplastic syndromes. N Engl J Med . 2011;364(26):2496-2506.
    • (2011) N Engl J Med , vol.364 , Issue.26 , pp. 2496-2506
    • Bejar, R.1    Stevenson, K.2    Abdel-Wahab, O.3
  • 86
    • 84873995626 scopus 로고    scopus 로고
    • TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis
    • Kulasekararaj AG, Smith AE, Mian SA, et al. TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis. Br J Haematol. 2013;160(5):660-672.
    • (2013) Br J Haematol , vol.160 , Issue.5 , pp. 660-672
    • Kulasekararaj, A.G.1    Smith, A.E.2    Mian, S.A.3
  • 87
    • 77952421834 scopus 로고    scopus 로고
    • Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia
    • Boultwood J, Perry J, Pellagatti A, et al. Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia. Leukemia. 2010;24(5):1062-1065.
    • (2010) Leukemia , vol.24 , Issue.5 , pp. 1062-1065
    • Boultwood, J.1    Perry, J.2    Pellagatti, A.3
  • 88
    • 77954089584 scopus 로고    scopus 로고
    • Array-based genomic resequencing of human leukemia
    • Yamashita Y, Yuan J, Suetake I, et al. Array-based genomic resequencing of human leukemia. Oncogene. 2010;29(25):3723-3731.
    • (2010) Oncogene , vol.29 , Issue.25 , pp. 3723-3731
    • Yamashita, Y.1    Yuan, J.2    Suetake, I.3
  • 89
    • 79960255863 scopus 로고    scopus 로고
    • Recurrent DNMT3A mutations in patients with myelodysplastic syndromes
    • Walter MJ, Ding L, Shen D, et al. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia. 2011;25(7):1153-1158.
    • (2011) Leukemia , vol.25 , Issue.7 , pp. 1153-1158
    • Walter, M.J.1    Ding, L.2    Shen, D.3
  • 90
    • 79960257531 scopus 로고    scopus 로고
    • DNMT3a mutations in high-risk myelodysplastic syndrome parallel those found in acute myeloid leukemia
    • Ewalt M, Galili NG, Mumtaz M, et al. DNMT3a mutations in high-risk myelodysplastic syndrome parallel those found in acute myeloid leukemia. Blood Cancer J. 2011;1(3):e9.
    • (2011) Blood Cancer J , vol.1 , Issue.3 , pp. e9
    • Ewalt, M.1    Galili, N.G.2    Mumtaz, M.3
  • 91
    • 77957806536 scopus 로고    scopus 로고
    • IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis
    • Thol F, Weissinger EM, Krauter J, et al. IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis. Haematologica . 2010;95(10):1668-1674.
    • (2010) Haematologica , vol.95 , Issue.10 , pp. 1668-1674
    • Thol, F.1    Weissinger, E.M.2    Krauter, J.3
  • 92
    • 77952426827 scopus 로고    scopus 로고
    • Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms
    • Kosmider O, Gelsi-Boyer V, Slama L, et al. Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms. Leukemia. 2010;24(5):1094-1096.
    • (2010) Leukemia , vol.24 , Issue.5 , pp. 1094-1096
    • Kosmider, O.1    Gelsi-Boyer, V.2    Slama, L.3
  • 93
    • 78651343257 scopus 로고    scopus 로고
    • A nonsense mutation of IDH1 in myelodysplastic syndromes and related disorders
    • Yoshida K, Sanada M, Kato M, et al. A nonsense mutation of IDH1 in myelodysplastic syndromes and related disorders. Leukemia. 2011;25(1):184-186.
    • (2011) Leukemia , vol.25 , Issue.1 , pp. 184-186
    • Yoshida, K.1    Sanada, M.2    Kato, M.3
  • 94
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa ME, Abdel-Wahab O, Lu C, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. 2010;18(6):553-567.
    • (2010) Cancer Cell , vol.18 , Issue.6 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3
  • 95
    • 77957987676 scopus 로고    scopus 로고
    • Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies
    • Makishima H, Jankowska AM, Tiu RV, et al. Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies. Leukemia. 2010;24(10):1799-1804.
    • (2010) Leukemia , vol.24 , Issue.10 , pp. 1799-1804
    • Makishima, H.1    Jankowska, A.M.2    Tiu, R.V.3
  • 96
    • 84855841586 scopus 로고    scopus 로고
    • SF3B1 mutations are prevalent in myelodysplastic syndromes with ring sideroblasts but do not hold independent prognostic value
    • Patnaik MM, Lasho TL, Hodnefield JM, et al. SF3B1 mutations are prevalent in myelodysplastic syndromes with ring sideroblasts but do not hold independent prognostic value. Blood . 2012;119(2):569-572.
    • (2012) Blood , vol.119 , Issue.2 , pp. 569-572
    • Patnaik, M.M.1    Lasho, T.L.2    Hodnefield, J.M.3
  • 97
    • 84868091622 scopus 로고    scopus 로고
    • SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes
    • Visconte V, Rogers HJ, Singh J, et al. SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes. Blood. 2012;120(16):3173-3186.
    • (2012) Blood , vol.120 , Issue.16 , pp. 3173-3186
    • Visconte, V.1    Rogers, H.J.2    Singh, J.3
  • 98
    • 84866339584 scopus 로고    scopus 로고
    • Clinical importance of SF3B1 mutations in Chinese with myelodysplastic syndromes with ring sideroblasts
    • Cui R, Gale RP, Xu Z, et al. Clinical importance of SF3B1 mutations in Chinese with myelodysplastic syndromes with ring sideroblasts. Leuk Res. 2012;36(11):1428-1433.
    • (2012) Leuk Res , vol.36 , Issue.11 , pp. 1428-1433
    • Cui, R.1    Gale, R.P.2    Xu, Z.3
  • 99
    • 85027920926 scopus 로고    scopus 로고
    • An accumulation of cytogenetic and molecular genetic events characterizes the progression from MDS to secondary AML: An analysis of 38 paired samples analyzed by cytogenetics, molecular mutation analysis and SNP microarray profiling
    • Flach J, Dicker F, Schnittger S, et al. An accumulation of cytogenetic and molecular genetic events characterizes the progression from MDS to secondary AML: an analysis of 38 paired samples analyzed by cytogenetics, molecular mutation analysis and SNP microarray profiling. Leukemia. 2011;25(4):713-718.
    • (2011) Leukemia , vol.25 , Issue.4 , pp. 713-718
    • Flach, J.1    Dicker, F.2    Schnittger, S.3
  • 100
    • 34347236177 scopus 로고    scopus 로고
    • A comparative study of molecular mutations in 381 patients with myelodysplastic syndrome and in 4130 patients with acute myeloid leukemia
    • Bacher U, Haferlach T, Kern W, Haferlach C, Schnittger S. A comparative study of molecular mutations in 381 patients with myelodysplastic syndrome and in 4130 patients with acute myeloid leukemia. Haematologica. 2007;92(6):744-752.
    • (2007) Haematologica , vol.92 , Issue.6 , pp. 744-752
    • Bacher, U.1    Haferlach, T.2    Kern, W.3    Haferlach, C.4    Schnittger, S.5
  • 101
    • 77950629000 scopus 로고    scopus 로고
    • Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia
    • Qian Z, Joslin JM, Tennant TR, et al. Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia. Chem Biol Interact. 2010;184(1-2):50-57.
    • (2010) Chem Biol Interact , vol.184 , Issue.1-2 , pp. 50-57
    • Qian, Z.1    Joslin, J.M.2    Tennant, T.R.3
  • 102
    • 84891301466 scopus 로고    scopus 로고
    • The genetic basis of myelodysplasia and its clinical relevance
    • Cazzola M, Della Porta MG, Malcovati L. The genetic basis of myelodysplasia and its clinical relevance. Blood. 2013;122(25):4021-4034.
    • (2013) Blood , vol.122 , Issue.25 , pp. 4021-4034
    • Cazzola, M.1    Della Porta, M.G.2    Malcovati, L.3
  • 103
    • 84881020319 scopus 로고    scopus 로고
    • Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia
    • Sakaguchi H, Okuno Y, Muramatsu H, et al. Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia. Nat Genet . 2013;45(8):937-941.
    • (2013) Nat Genet , vol.45 , Issue.8 , pp. 937-941
    • Sakaguchi, H.1    Okuno, Y.2    Muramatsu, H.3
  • 104
    • 84255176496 scopus 로고    scopus 로고
    • ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category
    • Metzeler KH, Becker H, Maharry K, et al. ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category. Blood. 2011;118(26):6920-6929.
    • (2011) Blood , vol.118 , Issue.26 , pp. 6920-6929
    • Metzeler, K.H.1    Becker, H.2    Maharry, K.3
  • 105
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemiaassociated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
    • Ward PS, Patel J, Wise DR, et al. The common feature of leukemiaassociated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell. 2010;17(3):225-234.
    • (2010) Cancer Cell , vol.17 , Issue.3 , pp. 225-234
    • Ward, P.S.1    Patel, J.2    Wise, D.R.3
  • 106
    • 77952536841 scopus 로고    scopus 로고
    • IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Marcucci G, Maharry K, Wu YZ, et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol . 2010;28(14):2348-2355.
    • (2010) J Clin Oncol , vol.28 , Issue.14 , pp. 2348-2355
    • Marcucci, G.1    Maharry, K.2    Wu, Y.Z.3
  • 107
    • 79953176952 scopus 로고    scopus 로고
    • Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
    • Yan XJ, Xu J, Gu ZH, et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet. 2011;43(4):309-315.
    • (2011) Nat Genet , vol.43 , Issue.4 , pp. 309-315
    • Yan, X.J.1    Xu, J.2    Gu, Z.H.3
  • 108
    • 78651299314 scopus 로고    scopus 로고
    • PHF6 mutations in adult acute myeloid leukemia
    • Van Vlierberghe P, Patel J, Abdel-Wahab O, et al. PHF6 mutations in adult acute myeloid leukemia. Leukemia. 2011;25(1):130-134.
    • (2011) Leukemia , vol.25 , Issue.1 , pp. 130-134
    • Van Vlierberghe, P.1    Patel, J.2    Abdel-Wahab, O.3
  • 109
    • 84864255882 scopus 로고    scopus 로고
    • The origin and evolution of mutations in acute myeloid leukemia
    • Welch JS, Ley TJ, Link DC, et al. The origin and evolution of mutations in acute myeloid leukemia. Cell. 2012;150(2):264-278.
    • (2012) Cell , vol.150 , Issue.2 , pp. 264-278
    • Welch, J.S.1    Ley, T.J.2    Link, D.C.3
  • 110
    • 84891884794 scopus 로고    scopus 로고
    • Integration of cytogenetic and molecular alterations in risk stratification of 318 patients with de novo non-M3 acute myeloid leukemia
    • Hou HA, Lin CC, Chou WC, et al. Integration of cytogenetic and molecular alterations in risk stratification of 318 patients with de novo non-M3 acute myeloid leukemia. Leukemia. 2014;28(1):50-58.
    • (2014) Leukemia , vol.28 , Issue.1 , pp. 50-58
    • Hou, H.A.1    Lin, C.C.2    Chou, W.C.3
  • 111
    • 84863393263 scopus 로고    scopus 로고
    • Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
    • Patel JP, Gonen M, Figueroa ME, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med. 2012;366(12):1079-1089.
    • (2012) N Engl J Med , vol.366 , Issue.12 , pp. 1079-1089
    • Patel, J.P.1    Gonen, M.2    Figueroa, M.E.3
  • 112
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood. 2001;98(6):1752-1759.
    • (2001) Blood , vol.98 , Issue.6 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3
  • 113
    • 0036659931 scopus 로고    scopus 로고
    • Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
    • Schnittger S, Schoch C, Dugas M, et al. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood. 2002;100(1):59-66.
    • (2002) Blood , vol.100 , Issue.1 , pp. 59-66
    • Schnittger, S.1    Schoch, C.2    Dugas, M.3
  • 114
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C, Steudel C, Mohr B, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood. 2002;99(12):4326-4335.
    • (2002) Blood , vol.99 , Issue.12 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3
  • 115
    • 0035871889 scopus 로고    scopus 로고
    • Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
    • Yamamoto Y, Kiyoi H, Nakano Y, et al. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood. 2001;97(8):2434-2439.
    • (2001) Blood , vol.97 , Issue.8 , pp. 2434-2439
    • Yamamoto, Y.1    Kiyoi, H.2    Nakano, Y.3
  • 116
    • 19944427850 scopus 로고    scopus 로고
    • Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype
    • Falini B, Mecucci C, Tiacci E, et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med. 2005;352(3):254-266.
    • (2005) N Engl J Med , vol.352 , Issue.3 , pp. 254-266
    • Falini, B.1    Mecucci, C.2    Tiacci, E.3
  • 117
    • 84862502902 scopus 로고    scopus 로고
    • Mutant DNMT3A: A marker of poor prognosis in acute myeloid leukemia
    • Ribeiro AF, Pratcorona M, Erpelinck-Verschueren C, et al. Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia. Blood.2012;119(24):5824-5831.
    • (2012) Blood , vol.119 , Issue.24 , pp. 5824-5831
    • Ribeiro, A.F.1    Pratcorona, M.2    Erpelinck-Verschueren, C.3
  • 118
    • 84863116398 scopus 로고    scopus 로고
    • Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia
    • Marcucci G, Metzeler KH, Schwind S, et al. Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia. J Clin Oncol. 2012;30(7):742-750.
    • (2012) J Clin Oncol , vol.30 , Issue.7 , pp. 742-750
    • Marcucci, G.1    Metzeler, K.H.2    Schwind, S.3
  • 119
    • 84862007674 scopus 로고    scopus 로고
    • Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: A study by the Acute Leukemia French Association
    • Renneville A, Boissel N, Nibourel O, et al. Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: a study by the Acute Leukemia French Association. Leukemia. 2012;26(6):1247-1254.
    • (2012) Leukemia , vol.26 , Issue.6 , pp. 1247-1254
    • Renneville, A.1    Boissel, N.2    Nibourel, O.3
  • 120
    • 84862909358 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia: Stability during disease evolution and clinical implications
    • Hou HA, Kuo YY, Liu CY, et al. DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications. Blood. 2012;119(2):559-568.
    • (2012) Blood , vol.119 , Issue.2 , pp. 559-568
    • Hou, H.A.1    Kuo, Y.Y.2    Liu, C.Y.3
  • 121
    • 81555228423 scopus 로고    scopus 로고
    • Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia
    • Shen Y, Zhu YM, Fan X, et al. Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia. Blood. 2011;118(20):5593-5603.
    • (2011) Blood , vol.118 , Issue.20 , pp. 5593-5603
    • Shen, Y.1    Zhu, Y.M.2    Fan, X.3
  • 122
    • 79960735923 scopus 로고    scopus 로고
    • Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia
    • Thol F, Damm F, Ludeking A, et al. Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia. J Clin Oncol. 2011;29(21):2889-2896.
    • (2011) J Clin Oncol , vol.29 , Issue.21 , pp. 2889-2896
    • Thol, F.1    Damm, F.2    Ludeking, A.3
  • 123
    • 60849115270 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in gliomas
    • Yan H, Parsons DW, Jin G, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009;360(8):765-773.
    • (2009) N Engl J Med , vol.360 , Issue.8 , pp. 765-773
    • Yan, H.1    Parsons, D.W.2    Jin, G.3
  • 124
    • 77957192661 scopus 로고    scopus 로고
    • Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: Prevalence and prognostic value
    • Abbas S, Lugthart S, Kavelaars FG, et al. Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value. Blood. 2010;116(12):2122-2126.
    • (2010) Blood , vol.116 , Issue.12 , pp. 2122-2126
    • Abbas, S.1    Lugthart, S.2    Kavelaars, F.G.3
  • 125
    • 77955907891 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
    • Paschka P, Schlenk RF, Gaidzik VI, et al. IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol. 2010;28(22):3636-3643.
    • (2010) J Clin Oncol , vol.28 , Issue.22 , pp. 3636-3643
    • Paschka, P.1    Schlenk, R.F.2    Gaidzik, V.I.3
  • 126
    • 77957286222 scopus 로고    scopus 로고
    • Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: A study by the Acute Leukemia French Association group
    • Boissel N, Nibourel O, Renneville A, et al. Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association group. J Clin Oncol. 2010;28(23):3717-3723.
    • (2010) J Clin Oncol , vol.28 , Issue.23 , pp. 3717-3723
    • Boissel, N.1    Nibourel, O.2    Renneville, A.3
  • 127
    • 0035093813 scopus 로고    scopus 로고
    • Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia
    • Pabst T, Mueller BU, Zhang P, et al. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Nat Genet. 2001;27(3):263-270.
    • (2001) Nat Genet , vol.27 , Issue.3 , pp. 263-270
    • Pabst, T.1    Mueller, B.U.2    Zhang, P.3
  • 128
    • 78751702245 scopus 로고    scopus 로고
    • Combined testing for CCAAT/enhancer-binding protein alpha (CEBPA) mutations and promoter methylation in acute myeloid leukemia demonstrates shared phenotypic features
    • Szankasi P, Ho AK, Bahler DW, Efimova O, Kelley TW. Combined testing for CCAAT/enhancer-binding protein alpha (CEBPA) mutations and promoter methylation in acute myeloid leukemia demonstrates shared phenotypic features. Leuk Res. 2011;35(2):200-207.
    • (2011) Leuk Res , vol.35 , Issue.2 , pp. 200-207
    • Szankasi, P.1    Ho, A.K.2    Bahler, D.W.3    Efimova, O.4    Kelley, T.W.5
  • 129
    • 42949142189 scopus 로고    scopus 로고
    • Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
    • Schlenk RF, Dohner K, Krauter J, et al. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med. 2008;358(18):1909-1918.
    • (2008) N Engl J Med , vol.358 , Issue.18 , pp. 1909-1918
    • Schlenk, R.F.1    Dohner, K.2    Krauter, J.3
  • 130
    • 0141465061 scopus 로고    scopus 로고
    • The role of FLT3 in haematopoietic malignancies
    • Stirewalt DL, Radich JP. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer. 2003;3(9):650-665.
    • (2003) Nat Rev Cancer , vol.3 , Issue.9 , pp. 650-665
    • Stirewalt, D.L.1    Radich, J.P.2
  • 131
    • 33744487375 scopus 로고    scopus 로고
    • Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML)
    • Boissel N, Leroy H, Brethon B, et al. Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML). Leukemia. 2006;20(6):965-970.
    • (2006) Leukemia , vol.20 , Issue.6 , pp. 965-970
    • Boissel, N.1    Leroy, H.2    Brethon, B.3
  • 132
    • 28444473100 scopus 로고    scopus 로고
    • Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: Interaction with other gene mutations
    • Dohner K, Schlenk RF, Habdank M, et al. Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations. Blood. 2005;106(12):3740-3746.
    • (2005) Blood , vol.106 , Issue.12 , pp. 3740-3746
    • Dohner, K.1    Schlenk, R.F.2    Habdank, M.3
  • 133
    • 33646557337 scopus 로고    scopus 로고
    • Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
    • Thiede C, Koch S, Creutzig E, et al. Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood. 2006;107(10):4011-4020.
    • (2006) Blood , vol.107 , Issue.10 , pp. 4011-4020
    • Thiede, C.1    Koch, S.2    Creutzig, E.3
  • 134
    • 77955715121 scopus 로고    scopus 로고
    • Mutation analysis for RUNX1, MLL-PTD, FLT3-ITD, NPM1 and NRAS in 269 patients with MDS or secondary AML
    • Dicker F, Haferlach C, Sundermann J, et al. Mutation analysis for RUNX1, MLL-PTD, FLT3-ITD, NPM1 and NRAS in 269 patients with MDS or secondary AML. Leukemia. 2010;24(8):1528-1532.
    • (2010) Leukemia , vol.24 , Issue.8 , pp. 1528-1532
    • Dicker, F.1    Haferlach, C.2    Sundermann, J.3
  • 135
    • 65749089229 scopus 로고    scopus 로고
    • Association of MLL amplification with poor outcome in acute myeloid leukemia
    • Maitta RW, Cannizzaro LA, Ramesh KH. Association of MLL amplification with poor outcome in acute myeloid leukemia. Cancer Genet Cytogenet. 2009;192(1):40-43.
    • (2009) Cancer Genet Cytogenet , vol.192 , Issue.1 , pp. 40-43
    • Maitta, R.W.1    Cannizzaro, L.A.2    Ramesh, K.H.3
  • 136
    • 71149117664 scopus 로고    scopus 로고
    • A partial nontandem duplication of the MLL gene in four patients with acute myeloid leukemia
    • Sarova I, Brezinova J, Zemanova Z, et al. A partial nontandem duplication of the MLL gene in four patients with acute myeloid leukemia. Cancer Genet Cytogenet. 2009;195(2):150-156.
    • (2009) Cancer Genet Cytogenet , vol.195 , Issue.2 , pp. 150-156
    • Sarova, I.1    Brezinova, J.2    Zemanova, Z.3
  • 137
    • 79952286086 scopus 로고    scopus 로고
    • C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice
    • Wang YY, Zhao LJ, Wu CF, et al. C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice. Proc Natl Acad Sci U S A. 2011;108(6):2450-2455.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.6 , pp. 2450-2455
    • Wang, Y.Y.1    Zhao, L.J.2    Wu, C.F.3
  • 138
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • Dohner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010;115(3):453-474.
    • (2010) Blood , vol.115 , Issue.3 , pp. 453-474
    • Dohner, H.1    Estey, E.H.2    Amadori, S.3
  • 139
    • 77950968519 scopus 로고    scopus 로고
    • Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation
    • Chou WC, Hou HA, Chen CY, et al. Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation. Blood. 2010;115(14):2749-2754.
    • (2010) Blood , vol.115 , Issue.14 , pp. 2749-2754
    • Chou, W.C.1    Hou, H.A.2    Chen, C.Y.3
  • 140
    • 77957771067 scopus 로고    scopus 로고
    • IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status
    • Schnittger S, Haferlach C, Ulke M, Alpermann T, Kern W, Haferlach T. IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status. Blood. 2010;116(25):5486-5496.
    • (2010) Blood , vol.116 , Issue.25 , pp. 5486-5496
    • Schnittger, S.1    Haferlach, C.2    Ulke, M.3    Alpermann, T.4    Kern, W.5    Haferlach, T.6
  • 141
    • 80755140131 scopus 로고    scopus 로고
    • Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: A study of the AML-BFM and DCOG study groups
    • Damm F, Thol F, Hollink I, et al. Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML-BFM and DCOG study groups. Leukemia. 2011;25(11):1704-1710.
    • (2011) Leukemia , vol.25 , Issue.11 , pp. 1704-1710
    • Damm, F.1    Thol, F.2    Hollink, I.3
  • 142
    • 33750295930 scopus 로고    scopus 로고
    • Wilms' tumor 1 mutation accumulated during therapy in acute myeloid leukemia: Biological and clinical implications
    • Nyvold CG, Stentoft J, Braendstrup K, et al. Wilms' tumor 1 mutation accumulated during therapy in acute myeloid leukemia: biological and clinical implications. Leukemia. 2006;20(11):2051-2054.
    • (2006) Leukemia , vol.20 , Issue.11 , pp. 2051-2054
    • Nyvold, C.G.1    Stentoft, J.2    Braendstrup, K.3
  • 143
    • 84888265282 scopus 로고    scopus 로고
    • Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML
    • Chaturvedi A, Araujo Cruz MM, Jyotsana N, et al. Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML. Blood. 2013;122(16):2877-2887.
    • (2013) Blood , vol.122 , Issue.16 , pp. 2877-2887
    • Chaturvedi, A.1    Araujo Cruz, M.M.2    Jyotsana, N.3
  • 144
    • 84897557274 scopus 로고    scopus 로고
    • TTT-3002 is a novel FLT3 tyrosine kinase inhibitor with activity against FLT3-associated leukemias in vitro and in vivo
    • published online ahead of print January 9, 2014
    • Ma H, Nguyen B, Li L, et al. TTT-3002 is a novel FLT3 tyrosine kinase inhibitor with activity against FLT3-associated leukemias in vitro and in vivo [published online ahead of print January 9, 2014]. Blood . doi:10.1182/blood-2013-08-523035.
    • Blood
    • Ma, H.1    Nguyen, B.2    Li, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.