Ablation of the p16 INK4a tumour suppressor reverses ageing phenotypes of klotho mice

Nature Communications

Volumn 6, Issue , 2015, Pages

  Sato, Seidai ^a,b,c   Kawamata, Yuka ^a,d   Takahashi, Akiko ^a   Imai, Yoshinori ^a   Hanyu, Aki ^a   Okuma, Atsushi ^a   Takasugi, Masaki ^a   Yamakoshi, Kimi ^a,g   Sorimachi, Hiroyuki ^e   Kanda, Hiroaki ^a   Ishikawa, Yuichi ^a   Sone, Saburo ^b   Nishioka, Yasuhiko ^b   Ohtani, Naoko ^a,c,d   Hara, Eiji ^a,c,f  

^a CANCER INSTITUTE   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d TOKYO UNIVERSITY OF SCIENCE   (Japan)

^e TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^f OSAKA UNIVERSITY   (Japan)

^g NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; BETA GLUCURONIDASE; KLOTHO PROTEIN;

CANCER; GENE EXPRESSION; MUTATION; PHENOTYPE; RODENT; SIGNALING; TUMOR;

AGING; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HOMOZYGOSITY; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; LONGEVITY; MALE; MOUSE; NEOPLASM; NONHUMAN; PHENOTYPE; PROMOTER REGION; SENESCENCE; STEM CELL; SUPPRESSOR GENE; ANIMAL; C57BL MOUSE; CELL CULTURE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; TUMOR SUPPRESSOR GENE;

MUS;

AGING; ANIMALS; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; GENE EXPRESSION REGULATION; GENES, P16; GLUCURONIDASE; HUMANS; MALE; MICE; MICE, INBRED C57BL; PHENOTYPE; PROMOTER REGIONS, GENETIC;

EID: 84928946424     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms8035     Document Type: Article

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